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Knowles Lab

Biophysics & Biophysical Chemistry
 

Biography

PhD in Chemistry, University of Cambridge, UK (2020-2023)

MRes in Sensor Technologies and applications (Sensors CDT), University of Cambridge, UK (2019-2020)

Master‘s degree in Bioengineering, Vilnius Gediminas Technical University, Lithuania (2017-2019)

Bachelor‘s degree in Biochemistry, Vilnius University, Lithuania (2013-2017)

Research

Greta is interested in protein aggregation and protein-membrane interactions linked to neurodegenerative disorders.

Publications

Key publications: 

Musteikyte, G., Jayaram, A., Xu, C., Vendruscolo, M., Krainer, G., & Knowles, T. (2021). Interactions of α-synuclein oligomers with lipid membranes. Biochimica Et Biophysica Acta (BBA) - Biomembranes1863(4), 183536. doi: 10.1016/j.bbamem.2020.183536

Other publications: 

Chaudhary, H., Iashchishyn, I., Romanova, N., Rambaran, M., Musteikyte, G., & Smirnovas, V. et al. (2021). Polyoxometalates as Effective Nano-inhibitors of Amyloid Aggregation of Pro-inflammatory S100A9 Protein Involved in Neurodegenerative Diseases. ACS Applied Materials & Interfaces13(23), 26721-26734. doi: 10.1021/acsami.1c04163

Leri, M., Chaudhary, H., Iashchishyn, I., Pansieri, J., Svedružić, Ž., & Gómez Alcalde, S. et al. (2021). Natural Compound from Olive Oil Inhibits S100A9 Amyloid Formation and Cytotoxicity: Implications for Preventing Alzheimer’s Disease. ACS Chemical Neuroscience12(11), 1905-1918. doi: 10.1021/acschemneuro.0c00828

Liao, Y., Fernandopulle, M., Wang, G., Choi, H., Hao, L., & Drerup, C. et al. (2019). RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether. Cell179(1), 147-164.e20. doi: 10.1016/j.cell.2019.08.050

Musteikyte, G., Ziaunys, M., & Smirnovas, V. (2020). Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils. Peerj8, e9719. doi: 10.7717/peerj.9719

Pansieri, J., Iashchishyn, I., Fakhouri, H., Ostojić, L., Malisauskas, M., & Musteikyte, G. et al. (2020). Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses. Chemical Science11(27), 7031-7039. doi: 10.1039/c9sc05905a

Arabuli, L., Iashchishyn, I., Romanova, N., Musteikyte, G., Smirnovas, V., & Chaudhary, H. et al. (2021). Co-Aggregation of S100A9 with DOPA and Cyclen-Based Compounds Manifested in Amyloid Fibril Thickening without Altering Rates of Self-Assembly. International Journal Of Molecular Sciences22(16), 8556. doi: 10.3390/ijms22168556

Teaching and Supervisions

Teaching: 

Michaelmas 2020 - Part IA Chemistry -  Lab Demonstration

Staff

 Greta  Musteikyte