Biography
2019-current: PhD in Chemistry, University of Cambridge, UK
2018-2019: MPhil in Chemistry, University of Cambridge, UK
2014-2018: Bachelor of Science with triple major in: Chemistry (Honors), Biochemistry, and Applied Mathematics, Univeristy of Washinton, USA
Tim is passionate about microfluidics, understanding biological systems from physical and chemical perspectives, and always learning new things. When not in the lab, Tim is found pursuing his secondary interest in casual and competitive cycling which has led him to success in national level competitions both in the USA and the UK.
Research
Tim is in employing novel biophysical techniques to study key questions regarding the assembly processes of biomolecules. In particular, these methods include the electrostatic, kinetic, and thermodynamic characterization of proteins and nucleic acids undergoing liquid-liquid phase separation. Tim is also interested in the effects that a wide range of molecules may have on assembly processes and how these effects may be manipulated for a therapeutic benefit.
Publications
Krainer, G.*, Welsh, T. J.*, Joseph, J. A.*… Hyman, A. A., Collepardo-Guevara, R., Alberti, S, Knowles, T.P.J. Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions. Nature Communications. 12, 1085 (2021).
Arter, W.E., Qi, R., Krainer, G., Welsh, T. J., Xu. Y, St.George-Hyslop, P., Alberti, S., Rapid generation of protein condensate phase diagrams using combinatorial droplet microfluidics. bioRxiv, (2020)
Welsh, T. J.*, Krainer, G.*, Espinosa, J. R.*, Joseph, J. A., … Collepardo-Guevara, R., Alberti, S., Knowles, T.P.J. Surface electrostatics govern the emulsion stability of biomolecular condensates. bioRxiv, (2020)
Welsh, T.J. Biophysics in Isolation: Pushing Beyond the Niche. The Biophysicist, 1, 8 (2020).
Welsh, T. J., Shen, Y., Levin, A., Knowles, T.P.J. Mechanobiology of protein droplets: force arises from disorder. Cell. 175, 1457-1459 (2018)
Welsh, T. J., Loveland, W., Yanez, R., Barrett, J.S., McCutchan, E.A., Sonzogni, A.A. Johnson, T., Zhu, S. Greene, J.P., Ayangeakaa, A.D., Carpenter, M.P., Lauritsen, T., Harker, J.L., Walters, W.B., Amro, B.M.S., Copp, P. Modeling multi-nucleon transfer in symmetric collisions of massive nuclei. Physics Letter B, 119-124 (2017)
