Research in the Knowles Group
We work on the physico-chemical properties and behaviour of biological molecules and soft materials. The research in the group is highly interdisciplinary, and members of the group have a wide range of backgrounds from biochemistry to theoretical physics.
Much of our research has been directed towards understanding the physical basis for the self-assembly of protein molecules. The goal of our research is to define the chemical and physical factors that control the structures and dynamics of biomolecular assemblies, and the connections between the nanoscale characteristics of the component molecules and the physical and material properties of large-scale assemblies and their behaviour on a mesoscopic to macroscopic scale.
The techniques used in our laboratory include biosensors, optical lithography, microfluidic devices and scanning probe microscopy and spectroscopy. We also have an interest in applying theoretical concepts from statistical mechanics and chemical kinetics to protein systems.
We work both with natural and synthetic polymers and our interests range from fundamental chemical physics and biophysics to technological applications in materials science and molecular medicine.