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Knowles Lab

Biophysics & Biophysical Chemistry

Studying at Cambridge

 

Publications

naturecommunications
158. Dynamic microfluidic control of supramolecular peptide self-assembly.
ZA Arnon, A Vitalis, A Levin, TCT Michaels, A Caflisch, TPJ Knowles, L Adler-Abramovich, E Gazit
– Nat Commun
(2016)
7,
13190
impub 804608
naturecommunications
157. Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces.
Y Song, U Shimanovich, TCT Michaels, Q Ma, J Li, TPJ Knowles, HC Shum
– Nature Communications
(2016)
7,
12934
impub 801511
156. Kinetics of fragmentation and dissociation of two-strand protein filaments: Coarse-grained simulations and experiments.
A Zaccone, I Terentjev, TW Herling, TPJ Knowles, A Aleksandrova, EM Terentjev
– J. Chem. Phys.
(2016)
145,
105101
pnas
155. Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.
P Flagmeier, G Meisl, M Vendruscolo, TPJ Knowles, CM Dobson, AK Buell, C Galvagnion
– Proceedings of the National Academy of Sciences of the United States of America
(2016)
113,
10328
154. Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation.
Y Zhang, AK Buell, T Müller, E De Genst, J Benesch, CM Dobson, TPJ Knowles
– Chembiochem
(2016)
17,
1920
nphys logo
153. Physical determinants of the self-replication of protein fibrils
A Šaric, AK Buell, G Meisl, TCT Michaels, CM Dobson, S Linse, TPJ Knowles, D Frenkel
– Nature Physics
(2016)
12,
874
impub 778483
jacs
152. Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform
TO Mason, TCT Michaels, A Levin, E Gazit, CM Dobson, AK Buell, TPJ Knowles
– Journal of the American Chemical Society
(2016)
138,
9589
impub 773627
acsnano
151. Controlling the Physical Dimensions of Peptide Nanotubes by Supramolecular Polymer Coassembly
L Adler-Abramovich, P Marco, ZA Arnon, RCG Creasey, TCT Michaels, A Levin, DJ Scurr, CJ Roberts, TPJ Knowles, SJB Tendler, E Gazit
– ACS Nano
(2016)
10,
7436
impub 773534
150. Quantifying Measurement Fluctuations from Stochastic Surface Processes on Sensors with Heterogeneous Sensitivity
J Charmet, TCT Michaels, R Daly, A Prasad, P Thiruvenkathanathan, RS Langley, TPJ Knowles, AA Seshia
– Physical Review Applied
(2016)
5,
ARTN 064016
impub 778208
physreviewletters
149. Fluctuations in the Kinetics of Linear Protein Self-Assembly
TCT Michaels, AJ Dear, JB Kirkegaard, KL Saar, DA Weitz, TPJ Knowles
– Phys Rev Lett
(2016)
116,
258103
impub 773646
148. Particle-Based Monte-Carlo Simulations of Steady-State Mass Transport at Intermediate Péclet Numbers
T Müller, P Arosio, L Rajah, SIA Cohen, EV Yates, M Vendruscolo, CM Dobson, TPJ Knowles
– International Journal of Nonlinear Sciences and Numerical Simulation
(2016)
175
AdvMater
147. Amyloid Fibrils as Building Blocks for Natural and Artificial Functional Materials
TPJ Knowles, R Mezzenga
– Adv Mater
(2016)
28,
6546
146. A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions.
TW Herling, DJ O'Connell, MC Bauer, J Persson, U Weininger, TPJ Knowles, S Linse
– Biophys J
(2016)
110,
1957
impub 765381
145. The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.
V Kakkar, C Månsson, EP de Mattos, S Bergink, M van der Zwaag, MAWH van Waarde, NJ Kloosterhuis, R Melki, RTP van Cruchten, S Al-Karadaghi, P Arosio, CM Dobson, TPJ Knowles, GP Bates, JM van Deursen, S Linse, B van de Sluis, C Emanuelsson, HH Kampinga
– Molecular Cell
(2016)
62,
272
impub 764017
144. Analysis of the length distribution of amyloid fibrils by centrifugal sedimentation.
P Arosio, T Cedervall, TPJ Knowles, S Linse
– Analytical biochemistry
(2016)
504,
7
impub 759559
143. Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.
P Arosio, K Hu, FA Aprile, T Müller, TPJ Knowles
– Anal Chem
(2016)
88,
3488
impub 753603
142. A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins
P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo
– ACS Comb Sci
(2016)
18,
144
impub 753546
physreviewletters
141. Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation.
E van Dijk, P Varilly, TPJ Knowles, D Frenkel, S Abeln
– Phys Rev Lett
(2016)
116,
078101
impub 753846
pnas
140. Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, AY Abramov, S Gandhi, NW Wood, N Cremades, CM Dobson, TPJ Knowles, D Klenerman
– Proceedings of the National Academy of Sciences of the United States of America
(2016)
113,
E1206
impub 750343
139. An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation.
EV Yates, G Meisl, TPJ Knowles, CM Dobson
– J Phys Chem B
(2016)
120,
2087
impub 751806
138. Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform.
K-L Saar, EV Yates, T Müller, S Saunier, CM Dobson, TPJ Knowles
– Biophys J
(2016)
110,
555
impub 747746
natureprotocols
137. Molecular mechanisms of protein aggregation from global fitting of kinetic models.
G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles
– Nature protocols
(2016)
11,
252
impub 733040
136. An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic A 42 aggregates linked with Alzheimers disease
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, SIA Cohen, MBD Müller, S Linse, EAA Nollen, CM Dobson, TPJ Knowles, M Vendruscolo
– Sci Adv
(2016)
2,
e1501244
135. Oligomers of Heat-Shock Proteins: Structures That Don't Imply Function.
WM Jacobs, TPJ Knowles, D Frenkel
– PLoS computational biology
(2016)
12,
e1004756
impub 753848
physreviewletters
134. Hamiltonian Dynamics of Protein Filament Formation.
TCT Michaels, SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– Phys Rev Lett
(2016)
116,
038101
impub 747745
133. Quantitative thermophoretic study of disease-related protein aggregates
M Wolff, JJ Mittag, TW Herling, ED Genst, CM Dobson, TPJ Knowles, D Braun, AK Buell
– Scientific reports
(2016)
6,
22829
132. Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones
JD Taylor, WJ Hawthorne, J Lo, A Dear, N Jain, G Meisl, M Andreasen, C Fletcher, M Koch, N Darvill, N Scull, A Escalera-Maurer, L Sefer, R Wenman, S Lambert, J Jean, Y Xu, B Turner, SG Kazarian, MR Chapman, D Bubeck, A de Simone, TPJ Knowles, SJ Matthews
– Scientific reports
(2016)
6,
24656
131. Self-assembly of MPG1, a hydrophobin protein from the rice blast fungus that forms functional amyloid coatings, occurs by a surface-driven mechanism
CLL Pham, A Rey, V Lo, M Soulès, Q Ren, G Meisl, TPJ Knowles, AH Kwan, M Sunde
– Scientific reports
(2016)
6,
25288
naturecommunications
130. Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation
P Arosio, TCT Michaels, S Linse, C Månsson, C Emanuelsson, J Presto, J Johansson, M Vendruscolo, CM Dobson, TPJ Knowles
– Nature Communications
(2016)
7,
10948
impub 758060
129. Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide.
G Meisl, X Yang, B Frohm, TPJ Knowles, S Linse
– Scientific reports
(2016)
6,
18728
128. Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms.
M Iljina, GA Garcia, AJ Dear, J Flint, P Narayan, TCT Michaels, CM Dobson, D Frenkel, TPJ Knowles, D Klenerman
– Scientific reports
(2016)
6,
28658
acsnano
127. Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions.
P Arosio, T Müller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, DA White, TW Herling, EJ De Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– ACS Nano
(2016)
10,
333
impub 729852
jacs
126. N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42
O Szczepankiewicz, B Linse, G Meisl, E Thulin, B Frohm, C Sala Frigerio, MT Colvin, AC Jacavone, RG Griffin, T Knowles, DM Walsh, S Linse
– Journal of the American Chemical Society
(2015)
137,
14673
impub 721044
125. The length distribution of frangible biofilaments.
TCT Michaels, P Yde, JCW Willis, MH Jensen, D Otzen, CM Dobson, AK Buell, TPJ Knowles
– The Journal of chemical physics
(2015)
143,
164901
naturechemistry
124. Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity.
EV Yates, T Müller, L Rajah, EJ De Genst, P Arosio, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– Nature Chemistry
(2015)
7,
802
123. Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates
MA Wright, FA Aprile, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Chemical communications (Cambridge, England)
(2015)
51,
14425
impub 703595
122. Fast Flow Microfluidics and Single-Molecule Fluorescence for the Rapid Characterization of α-Synuclein Oligomers
MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, M Dalla Serra, TPJ Knowles, CM Dobson, D Klenerman
– Anal Chem
(2015)
87,
8818
impub 699269
121. Dynamics of protein aggregation and oligomer formation governed by secondary nucleation
TCT Michaels, HW Lazell, P Arosio, TPJ Knowles
– The Journal of chemical physics
(2015)
143,
054901
pnas
120. Force generation by the growth of amyloid aggregates
TW Herling, GA Garcia, TCT Michaels, W Grentz, J Dean, U Shimanovich, H Gang, T Müller, B Kav, EM Terentjev, CM Dobson, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
112,
9524
impub 696637
119. Molecular Rotors Provide Insights into Microscopic Structural Changes During Protein Aggregation.
AJ Thompson, TW Herling, M Kubánková, A Vyšniauskas, TPJ Knowles, MK Kuimova
– J Phys Chem B
(2015)
119,
10170
impub 696676
118. Lipid vesicles trigger alpha-synuclein aggregation by stimulating primary nucleation
C Galvagnion, AK Buell, G Meisl, TC Michaels, M Vendruscolo, TPJ Knowles, CM Dobson
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
S101
117. New insights into the mechanism of amyloid formation by alpha-synuclein
AK Buell, C Galvagnion, CM Dobson, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
S100
116. Kinetics of protein aggregation
TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
S98
115. Crucial role of non-specific interactions in amyloid nucleation
A Saric, YC Chebaro, TPJ Knowles, D Frenkel
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
S161
114. Rapid sizing of proteins in complex solutions
P Arosio, T Muller, L Rajah, EV Yates, FA Aprile, SIA Cohen, DA White, TW Herling, E de Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
S49
acsnano
113. Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry
X-M Zhou, U Shimanovich, TW Herling, S Wu, CM Dobson, TPJ Knowles, S Perrett
– ACS Nano
(2015)
9,
5772
impub 681876
112. Aggregation-Prone Amyloid-Cu-II Species Formed on the Millisecond Timescale under Mildly Acidic Conditions
JT Pedersen, CB Borg, TCT Michaels, TPJ Knowles, P Faller, K Teilum, L Hemmingsen
– Chembiochem
(2015)
16,
1293
pnas
111. Preventing peptide and protein misbehavior.
P Arosio, G Meisl, M Andreasen, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
112,
5267
impub 677391
110. A microfluidic platform for quantitative measurements of effective protein charges and single ion binding in solution.
TW Herling, P Arosio, T Müller, S Linse, TPJ Knowles
– Physical chemistry chemical physics : PCCP
(2015)
17,
12161
impub 676077
pnas
109. Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, EJ De-Genst, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
112,
E1994
impub 675381
108. The physical basis of protein misfolding disorders
TPJ Knowles, M Vendruscolo, CM Dobson
– Physics Today
(2015)
68,
36
107. On the lag phase in amyloid fibril formation
P Arosio, TPJ Knowles, S Linse
– Physical chemistry chemical physics : PCCP
(2015)
17,
7606
impub 671060
naturestructmolbiology
106. A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
SIA Cohen, P Arosio, J Presto, FR Kurudenkandy, H Biverstål, L Dolfe, C Dunning, X Yang, B Frohm, M Vendruscolo, J Johansson, CM Dobson, A Fisahn, TPJ Knowles, S Linse
– Nature Structural & Molecular Biology
(2015)
22,
207
impub 670050
naturechembio
105. Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation.
C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, TPJ Knowles, CM Dobson
– Nature Chemical Biology
(2015)
11,
229
impub 668518
104. Kinetic theory of protein filament growth: Self-consistent methods and perturbative techniques
TCT Michaels, TPJ Knowles
– International Journal of Modern Physics B
(2015)
29,
1530002
103. Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants.
L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, N Cremades, CM Dobson, D Klenerman
– Scientific reports
(2015)
5,
16696
102. Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity.
J Dworzak, B Renvoisé, J Habchi, EV Yates, C Combadière, TP Knowles, CM Dobson, C Blackstone, O Paulsen, PM Murphy
– PLoS One
(2015)
10,
e0127730
impub 681671
naturecommunications
101. A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
SL Shammas, GA Garcia, S Kumar, M Kjaergaard, MH Horrocks, N Shivji, E Mandelkow, TPJ Knowles, E Mandelkow, D Klenerman
– Nature Communications
(2015)
6,
7025
impub 678078
100. The A beta 40 and A beta 42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation
R Cukalevski, X Yang, G Meisl, U Weininger, K Bernfur, B Frohm, TPJ Knowles, S Linse
– Chem. Sci.
(2015)
6,
4215
impub 695661
acsnano
99. Protein Microgels from Amyloid Fibril Networks
U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, S Linse, KS Åkerfeldt, CM Dobson, DA Weitz, TPJ Knowles
– ACS Nano
(2015)
9,
43
impub 662230
pnas
98. Crucial role of nonspecific interactions in amyloid nucleation
A Šarić, YC Chebaro, TPJ Knowles, D Frenkel
– Proceedings of the National Academy of Sciences of the United States of America
(2014)
111,
17869
impub 662138
97. Tetracycline nanoparticles as antibacterial and gene-silencing agents
U Shimanovich, A Lipovsky, D Eliaz, S Zigdon, TPJ Knowles, Y Nitzan, S Michaeli, A Gedanken
– Adv Healthc Mater
(2015)
4,
723
96. Dry-mass sensing for microfluidics
T Mueller, DA White, TPJ Knowles
– Applied Physics Letters
(2014)
105,
214101
95. Multiphase protein microgels
U Shimanovich, Y Song, J Brujic, HC Shum, TPJ Knowles
– Macromolecular Bioscience
(2015)
15,
501
94. Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation.
C Månsson, P Arosio, R Hussein, HH Kampinga, RM Hashem, WC Boelens, CM Dobson, TPJ Knowles, S Linse, C Emanuelsson
– J Biol Chem
(2014)
289,
31066
93. A High Power-Density, Mediator-Free, Microfluidic Biophotovoltaic Device for Cyanobacterial Cells.
P Bombelli, T Müller, TW Herling, CJ Howe, TPJ Knowles
– Advanced Energy Materials
(2015)
5,
1
92. The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation.
AK Buell, CM Dobson, TPJ Knowles
– Essays Biochem
(2014)
56,
11
pnas
91. Differences in nucleation behavior underlie the contrasting aggregation kinetics of the A beta 40 and A beta 42 peptides
G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2014)
111,
9384
impub 638606
90. Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization
TCT Michaels, TPJ Knowles
– The Journal of chemical physics
(2014)
140,
214904
naturereviews
89. The amyloid state and its association with protein misfolding diseases.
TPJ Knowles, M Vendruscolo, CM Dobson
– Nature Reviews Molecular Cell Biology
(2014)
15,
384
88. Asymptotic solutions of the Oosawa model for the length distribution of biofilaments
TCT Michaels, GA Garcia, TPJ Knowles
– The Journal of chemical physics
(2014)
140,
194906
pnas
87. Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
AK Buell, C Galvagnion, R Gaspar, E Sparr, M Vendruscolo, TPJ Knowles, S Linse, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
(2014)
111,
7671
impub 633389
86. Mean-field master equation formalism for biofilament growth
TCT Michaels, TPJ Knowles
– American Journal of Physics
(2014)
82,
476
85. Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters
GA Garcia, SIA Cohen, CM Dobson, TPJ Knowles
– Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
(2014)
89,
ARTN 032712
84. Density-Gradient-Free Microfluidic Centrifugation for Analytical and Preparative Separation of Nanoparticles
P Arosio, T Müller, L Mahadevan, TPJ Knowles
– Nano Lett
(2014)
14,
2365
impub 627390
physreviewletters
83. Spatial Propagation of Protein Polymerization
SIA Cohen, L Rajah, CH Yoon, AK Buell, DA White, RA Sperling, M Vendruscolo, EM Terentjev, CM Dobson, DA Weitz, TPJ Knowles
– Phys Rev Lett
(2014)
112,
098101
impub 628385
82. Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters.
GA Garcia, SIA Cohen, CM Dobson, TPJ Knowles
– Phys Rev E Stat Nonlin Soft Matter Phys
(2014)
89,
032712
impub 629681
jacs
81. The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.
N Lorenzen, SB Nielsen, AK Buell, JD Kaspersen, P Arosio, BS Vad, W Paslawski, G Christiansen, Z Valnickova-Hansen, M Andreasen, JJ Enghild, JS Pedersen, CM Dobson, TPJ Knowles, DE Otzen
– Journal of the American Chemical Society
(2014)
136,
3859
impub 623423
80. Polymer physics inspired approaches for the study of the mechanical properties of amyloid fibrils
LR Volpatti, TPJ Knowles
– Journal of Polymer Science Part B: Polymer Physics
(2014)
52,
281
79. Nanoscale spatially resolved infrared spectra from single microdroplets.
T Müller, FS Ruggeri, AJ Kulik, U Shimanovich, TO Mason, TPJ Knowles, G Dietler
– Lab on a chip
(2014)
14,
1315
impub 622241
78. Determination of Primary Nucleation Mechanisms of alpha-Synuclein Amyloid Aggregation
FA Aprile, G Meisl, AK Buell, P Flagmeier, CM Dobson, M Vendruscolo, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2014)
106,
267A
77. Insights into the Inhibition Mechanism of Biomolecular Self-Assembly from Chemical Kinetics
P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2014)
106,
682A
acsnano
76. Expanding the Solvent Chemical Space for Self-Assembly of Dipeptide Nanostructures
TO Mason, DY Chirgadze, A Levin, L Adler-Abramovich, E Gazit, TPJ Knowles, AK Buell
– ACS Nano
(2014)
8,
1243
impub 605799
75. Quantitative Analysis of Diffusive Reactions at the Solid–Liquid Interface in Finite Systems
TCT Michaels, AK Buell, EM Terentjev, TPJ Knowles
– Journal of Physical Chemistry Letters
(2014)
5,
695
impub 624585
naturecommunications
74. Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers
A Levin, TO Mason, L Adler-Abramovich, AK Buell, G Meisl, C Galvagnion, Y Bram, SA Stratford, CM Dobson, TPJ Knowles, E Gazit
– Nature Communications
(2014)
5,
5219
impub 658535
73. Easyworm: an open-source software tool to determine the mechanical properties of worm-like chains
G Lamour, JB Kirkegaard, H Li, TP Knowles, J Gsponer
– Source Code Biol Med
(2014)
9,
16
72. Chemical kinetics for drug discovery to combat protein aggregation diseases.
P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Trends Pharmacol Sci
(2014)
35,
127
impub 624079
71. Self-Assembly of Amyloid Fibrils That Display Active Enzymes.
X-M Zhou, A Entwistle, H Zhang, AP Jackson, TO Mason, U Shimanovich, TPJ Knowles, AT Smith, EB Sawyer, S Perrett
– ChemCatChem
(2014)
6,
1961
70. Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.
G Tóth, SJ Gardai, W Zago, CW Bertoncini, N Cremades, SL Roy, MA Tambe, J-C Rochet, C Galvagnion, G Skibinski, S Finkbeiner, M Bova, K Regnstrom, S-S Chiou, J Johnston, K Callaway, JP Anderson, MF Jobling, AK Buell, TA Yednock, TPJ Knowles, M Vendruscolo, J Christodoulou, CM Dobson, D Schenk, L McConlogue
– PLoS One
(2014)
9,
e87133
impub 623286
69. Sonochemically-induced spectral shift as a probe of green fluorescent protein release from nano capsules
U Shimanovich, A Munder, NG Azoia, A Cavaco-Paulo, A Gruzman, TPJ Knowles, A Gedanken
– RSC Advances
(2014)
4,
10303
impub 624854
acsnano
68. A Clear View of Polymorphism, Twist, and Chirality in Amyloid Fibril Formation
LR Volpatti, M Vendruscolo, CM Dobson, TPJ Knowles
– ACS Nano
(2013)
7,
10443
impub 603637
67. Protein micro- and nano-capsules for biomedical applications
U Shimanovich, GJL Bernardes, TPJ Knowles, A Cavaco-Paulo
– Chemical Society reviews
(2014)
43,
1361
impub 603864
jacs
66. Quantification of the concentration of Aβ42 propagons during the lag phase by an amyloid chain reaction assay
P Arosio, R Cukalevski, B Frohm, TPJ Knowles, S Linse
– Journal of the American Chemical Society
(2014)
136,
219
impub 603251
65. Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ42 peptide.
B Bolognesi, SIA Cohen, P Aran Terol, EK Esbjörner, S Giorgetti, MF Mossuto, A Natalello, A-C Brorsson, TPJ Knowles, CM Dobson, LM Luheshi
– ACS Chem Biol
(2014)
9,
378
impub 601557
64. Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase.
A Pica, A Merlino, AK Buell, TPJ Knowles, E Pizzo, G D'Alessio, F Sica, L Mazzarella
– Acta Crystallographica Section D: Biological Crystallography
(2013)
69,
2116
63. Single-molecule measurements of transient biomolecular complexes through microfluidic dilution
MH Horrocks, L Rajah, P Jönsson, M Kjaergaard, M Vendruscolo, TPJ Knowles, D Klenerman
– Anal Chem
(2013)
85,
6855
impub 582303
pnas
62. Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
SIA Cohen, S Linse, LM Luheshi, E Hellstrand, DA White, L Rajah, DE Otzen, M Vendruscolo, CM Dobson, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2013)
110,
9758
impub 573683
61. Integration and characterization of solid wall electrodes in microfluidic devices fabricated in a single photolithography step
TW Herling, T Müller, L Rajah, JN Skepper, M Vendruscolo, TPJ Knowles
– Applied Physics Letters
(2013)
102,
184102
60. Amyloid beta-protein: the influence of intrinsic and extrinsic factors on fibril formation
R Cukalevski, X Yang, SI Cohen, B Boland, B Frohm, E Thulin, DM WalsXh, TP Knowles, S Linse
– JOURNAL OF NEUROCHEMISTRY
(2013)
125,
235
pnas
59. Atomic structure and hierarchical assembly of a cross-beta amyloid fibril
AWP Fitzpatrick, GT Debelouchina, MJ Bayro, DK Clare, MA Caporini, VS Bajaj, CP Jaroniec, L Wang, V Ladizhansky, SA Müller, CE MacPhee, CA Waudby, HR Mott, A De Simone, TPJ Knowles, HR Saibil, M Vendruscolo, EV Orlova, RG Griffin, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
(2013)
110,
5468
impub 531240
58. Electrostatic Effects in Filamentous Protein Aggregation
AK Buell, P Hung, X Salvatella, ME Welland, CM Dobson, TPJ Knowles
– Biophys J
(2013)
104,
1116
impub 531226
naturenanotechnology
57. Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses.
M Yolamanova, C Meier, AK Shaytan, V Vas, CW Bertoncini, F Arnold, O Zirafi, SM Usmani, JA Müller, D Sauter, C Goffinet, D Palesch, P Walther, NR Roan, H Geiger, O Lunov, T Simmet, J Bohne, H Schrezenmeier, K Schwarz, L Ständker, W-G Forssmann, X Salvatella, PG Khalatur, AR Khokhlov, TPJ Knowles, T Weil, F Kirchhoff, J Münch
– Nat Nanotechnol
(2013)
8,
130
56. Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2.
L-Q Xu, S Wu, AK Buell, SIA Cohen, L-J Chen, W-H Hu, SA Cusack, LS Itzhaki, H Zhang, TPJ Knowles, CM Dobson, ME Welland, GW Jones, S Perrett
– Philosophical Transactions of the Royal Society B: Biological Sciences
(2013)
368,
20110410
55. Connecting macroscopic observables and microscopic assembly events in amyloid formation using coarse grained simulations.
NS Bieler, TPJ Knowles, D Frenkel, R Vácha
– PLoS computational biology
(2012)
8,
e1002692
impub 465935
54. Highly non-linear microfluidic resistor elements for flow rate-dependent addressing of microchannels
L Rajah, DA White, TPJ Knowles
– International Journal of Nonlinear Sciences and Numerical Simulation
(2012)
13,
319
53. Fluctuations in water, the hydrophobic effect and self-assembly
PS Varilly, AJ Patel, SN Jamadagni, H Acharya, MF Hagan, S Garde, D Chandler, TPJ Knowles, D Frenkel
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2012)
244,
acsnano
52. Selenium-enhanced electron microscopic imaging of different aggregate forms of a segment of the amyloid β peptide in cells.
EK McGuire, M Motskin, B Bolognesi, SD Bergin, TPJ Knowles, J Skepper, LM Luheshi, DW McComb, CM Dobson, AE Porter
– ACS Nano
(2012)
6,
4740
impub 442515
51. Direct Observation of the Interconversion of Normal and Toxic Forms of alpha-Synuclein
N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, NW Wood, TPJ Knowles, CM Dobson, D Klenerman
– Cell
(2012)
149,
1048
impub 442514
angewandte
50. Detailed analysis of the energy barriers for amyloid fibril growth.
AK Buell, A Dhulesia, DA White, TPJ Knowles, CM Dobson, ME Welland
– Angew Chem Int Ed Engl
(2012)
51,
5247
impub 434926
49. From macroscopic measurements to microscopic mechanisms of protein aggregation.
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– Journal of molecular biology
(2012)
421,
160
impub 425869
physreviewletters
48. Twisting transition between crystalline and fibrillar phases of aggregated peptides
TPJ Knowles, A De Simone, AW Fitzpatrick, A Baldwin, S Meehan, L Rajah, M Vendruscolo, ME Welland, CM Dobson, EM Terentjev
– Phys Rev Lett
(2012)
109,
158101
impub 466424
47. Role of elongation and secondary pathways in S6 amyloid fibril growth.
N Lorenzen, SIA Cohen, SB Nielsen, TW Herling, G Christiansen, CM Dobson, TPJ Knowles, D Otzen
– Biophys J
(2012)
102,
2167
impub 444927
46. Probing small molecule binding to amyloid fibrils.
AK Buell, EK Esbjörner, PJ Riss, DA White, FI Aigbirhio, G Toth, ME Welland, CM Dobson, TPJ Knowles
– Physical chemistry chemical physics : PCCP
(2011)
13,
20044
impub 356403
45. Binding of the Molecular Chaperone alpha B-Crystallin to A beta Amyloid Fibrils Inhibits Fibril Elongation
SL Shammas, CA Waudby, S Wang, AK Buell, TPJ Knowles, H Ecroyd, ME Welland, JA Carver, CM Dobson, S Meehan
– Biophys J
(2011)
101,
1681
impub 342012
44. Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation.
AW Fitzpatrick, TPJ Knowles, CA Waudby, M Vendruscolo, CM Dobson
– PLoS computational biology
(2011)
7,
e1002169
impub 380300
pnas
43. Observation of spatial propagation of amyloid assembly from single nuclei.
TPJ Knowles, DA White, AR Abate, JJ Agresti, SIA Cohen, RA Sperling, EJ De Genst, CM Dobson, DA Weitz
– Proceedings of the National Academy of Sciences of the United States of America
(2011)
108,
14746
impub 322201
42. Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments
SIA Cohen, M Vendruscolo, ME Welland, CM Dobson, EM Terentjev, TPJ Knowles
– The Journal of chemical physics
(2011)
135,
065105
41. Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– The Journal of chemical physics
(2011)
135,
065107
40. Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations.
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– The Journal of chemical physics
(2011)
135,
065106
39. Protein solubility and protein homeostasis: a generic view of protein misfolding disorders.
M Vendruscolo, TPJ Knowles, CM Dobson
– Cold Spring Harbor Perspectives in Biology
(2011)
3,
a010454
38. Direct observation of the interconversion of normal and pathogenic forms of alpha-synuclein
N Cremades, SIA Cohen, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, TPJ Knowles, CM Dobson, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2011)
40,
215
37. Conserved C-Terminal Charge Exerts a Profound Influence on the Aggregation Rate of α-Synuclein
K Levitan, D Chereau, SIA Cohen, TPJ Knowles, CM Dobson, AL Fink, JP Anderson, JM Goldstein, GL Millhauser
– Journal of molecular biology
(2011)
411,
329
impub 305062
36. Perturbation of the Stability of Amyloid Fibrils through Alteration of Electrostatic Interactions
SL Shammas, TPJ Knowles, AJ Baldwin, CE Macphee, ME Welland, CM Dobson, GL Devlin
– Biophys J
(2011)
100,
2783
impub 298591
jacs
35. Metastability of native proteins and the phenomenon of amyloid formation.
AJ Baldwin, TPJ Knowles, GG Tartaglia, AW Fitzpatrick, GL Devlin, SL Shammas, CA Waudby, MF Mossuto, S Meehan, SL Gras, J Christodoulou, SJ Anthony-Cahill, PD Barker, M Vendruscolo, CM Dobson
– Journal of the American Chemical Society
(2011)
133,
14160
impub 298556
jacs
34. Population of Nonnative States of Lysozyme Variants Drives Amyloid Fibril Formation
AK Buell, A Dhulesia, MF Mossuto, N Cremades, JR Kumita, M Dumoulin, ME Welland, TPJ Knowles, X Salvatella, CM Dobson
– Journal of the American Chemical Society
(2011)
133,
7737
impub 278350
33. Relationship between prion propensity and the rates of individual molecular steps of fibril assembly.
Y-Q Wang, AK Buell, X-Y Wang, ME Welland, CM Dobson, TPJ Knowles, S Perrett
– J Biol Chem
(2011)
286,
12101
naturenanotechnology
32. Nanomechanics of functional and pathological amyloid materials.
TPJ Knowles, MJ Buehler
– Nat Nanotechnol
(2011)
6,
469
31. Probing protein aggregation with quartz crystal microbalances.
TPJ Knowles, GL Devlin, CM Dobson, ME Welland
– Methods Mol Biol
(2011)
752,
137
30. Nucleated polymerisation in the presence of pre-formed seed filaments.
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– International journal of molecular sciences
(2011)
12,
5844
29. Interactions between Amyloidophilic Dyes and Their Relevance to Studies of Amyloid Inhibitors
AK Buell, CM Dobson, TPJ Knowles, ME Welland
– Biophys J
(2010)
99,
3492
impub 217126
pnas
28. Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering.
A Sandberg, LM Luheshi, S Söllvander, T Pereira de Barros, B Macao, TPJ Knowles, H Biverstål, C Lendel, F Ekholm-Petterson, A Dubnovitsky, L Lannfelt, CM Dobson, T Härd
– Proceedings of the National Academy of Sciences of the United States of America
(2010)
107,
15595
impub 51183
27. Surface attachment of protein fibrils via covalent modification strategies
AK Buell, DA White, C Meier, ME Welland, TPJ Knowles, CM Dobson
– J Phys Chem B
(2010)
114,
10925
impub 49766
physreviewletters
26. Frequency Factors in a Landscape Model of Filamentous Protein Aggregation
AK Buell, JR Blundell, CM Dobson, ME Welland, EM Terentjev, TPJ Knowles
– Phys Rev Lett
(2010)
104,
228101
impub 22297
jacs
25. Protein Aggregation in Crowded Environments
DA White, AK Buell, TPJ Knowles, ME Welland, CM Dobson
– Journal of the American Chemical Society
(2010)
132,
5170
impub 42613
24. Fabrication and characterisation of protein fibril-elastomer composites
T Oppenheim, TPJ Knowles, SP Lacour, ME Welland
– Acta Biomater
(2010)
6,
1337
impub 34113
23. The Interaction of αB-Crystallin with Mature α-Synuclein Amyloid Fibrils Inhibits Their Elongation
CA Waudby, TPJ Knowles, GL Devlin, JN Skepper, H Ecroyd, JA Carver, ME Welland, J Christodoulou, CM Dobson, S Meehan
– Biophys J
(2010)
98,
843
impub 18475
naturenanotechnology
22. Nanostructured films from hierarchical self-assembly of amyloidogenic proteins.
TPJ Knowles, TW Oppenheim, AK Buell, DY Chirgadze, ME Welland
– Nat Nanotechnol
(2010)
5,
204
21. Imaging Alzheimer's disease-related protein aggregates in human cells using a selenium label
EK McGuire, M Motskin, TPJ Knowles, CM Dobson, DW McComb, AE Porter
– ELECTRON MICROSCOPY AND ANALYSIS GROUP CONFERENCE 2009 (EMAG 2009)
(2010)
241,
012020
20. Methods and models in neurodegenerative and systemic protein aggregation diseases.
A-C Brorsson, JR Kumita, I MacLeod, B Bolognesi, E Speretta, LM Luheshi, TPJ Knowles, CM Dobson, DC Crowther
– Frontiers in Bioscience
(2010)
15,
373
(DOI: 10.2741/3626)
science
19. An analytical solution to the kinetics of breakable filament assembly
TPJ Knowles, CA Waudby, GL Devlin, SIA Cohen, A Aguzzi, M Vendruscolo, EM Terentjev, ME Welland, CM Dobson
– Science
(2009)
326,
1533
18. Imaging Amyloid Fibrils within Cells Using a Se-Labelling Strategy
AE Porter, TPJ Knowles, K Muller, S Meehan, E McGuire, J Skepper, ME Welland, CM Dobson
– Journal of molecular biology
(2009)
392,
868
impub 151
17. Biosensor-based label-free assays of amyloid growth.
DA White, AK Buell, CM Dobson, ME Welland, TPJ Knowles
– FEBS letters
(2009)
583,
2587
16. Position-dependent electrostatic protection against protein aggregation.
AK Buell, GG Tartaglia, NR Birkett, CA Waudby, M Vendruscolo, X Salvatella, ME Welland, CM Dobson, TPJ Knowles
– Chembiochem
(2009)
10,
1309
AdvMater
15. Strength of Nanotubes, Filaments, and Nanowires From Sonication-Induced Scission
YY Huang, TPJ Knowles, EM Terentjev
– Advanced Materials
(2009)
21,
3945
14. Chemical and biophysical insights into the propagation of prion strains.
J Falsig, KP Nilsson, TPJ Knowles, A Aguzzi
– HFSP Journal
(2008)
2,
332
13. Highly specific label-free protein detection from lysed cells using internally referenced microcantilever sensors.
W Shu, S Laurenson, TPJ Knowles, P Ko Ferrigno, AA Seshia
– Biosensors and Bioelectronics
(2008)
24,
233
impub 3783
12. Label-free detection of amyloid growth with microcantilever sensors
TPJ Knowles, W Shu, F Huber, HP Lang, C Gerber, CM Dobson, ME Welland
– Nanotechnology
(2008)
19,
384007
angewandte
11. Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements
AJ Baldwin, SJ Anthony-Cahill, TPJ Knowles, G Lippens, J Christodoulou, PD Barker, CM Dobson
– Angew Chem Int Ed Engl
(2008)
47,
3385
impub 29220
science
10. Role of intermolecular forces in defining material properties of protein nanofibrils.
TP Knowles, AW Fitzpatrick, S Meehan, HR Mott, M Vendruscolo, CM Dobson, ME Welland
– Science
(2007)
318,
1900
9. Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins.
S Meehan, TPJ Knowles, AJ Baldwin, JF Smith, AM Squires, P Clements, TM Treweek, H Ecroyd, GG Tartaglia, M Vendruscolo, CE Macphee, CM Dobson, JA Carver
– Journal of molecular biology
(2007)
372,
470
impub 68681
pnas
8. Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass
TPJ Knowles, W Shu, GL Devlin, S Meehan, S Auer, CM Dobson, ME Welland
– Proceedings of the National Academy of Sciences of the United States of America
(2007)
104,
10016
impub 49156
7. Analysis of structural order in amyloid fibrils
TPJ Knowles, JF Smith, GL Devlin, CM Dobson, ME Welland
– Nanotechnology
(2007)
18,
044031
6. Enhanced stability of human prion proteins with two disulfide bridges.
TPJ Knowles, R Zahn
– Biophys J
(2006)
91,
1494
impub 46356
5. The component polypeptide chains of bovine insulin nucleate or inhibit aggregation of the parent protein in a conformation-dependent manner
GL Devlin, TPJ Knowles, A Squires, MG McCammon, SL Gras, MR Nilsson, CV Robinson, CM Dobson, CE MacPhee
– Journal of molecular biology
(2006)
360,
497
impub 15770
physreviewletters
4. Spatial persistence of angular correlations in amyloid fibrils.
TPJ Knowles, JF Smith, A Craig, CM Dobson, ME Welland
– Phys Rev Lett
(2006)
96,
238301
impub 26013
pnas
3. Characterization of the nanoscale properties of individual amyloid fibrils.
JF Smith, TPJ Knowles, CM Dobson, CE Macphee, ME Welland
– Proceedings of the National Academy of Sciences of the United States of America
(2006)
103,
15806
impub 24155
2. Excitations with negative dispersion in a spin vortex
M Buess, TPJ Knowles, R Hollinger, T Haug, U Krey, D Weiss, D Pescia, MR Scheinfein, CH Back
– Physical Review B
(2005)
71,
104415
impub 34400
1. Phase-resolved pulsed precessional motion at a Schottky barrier
M Buess, TPJ Knowles, U Ramsperger, D Pescia, CH Back
– Physical Review B
(2004)
69,
174422