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Knowles Lab

Biophysics & Biophysical Chemistry

We use technology and data to understand, control and design proteins to address challenges in biomedicine and sustainability.


The active processes in a living cell depend on the precise assembly of proteins into functional molecular machinery. Our work integrates concepts and techniques from the physical and life sciences to explore how this assembly occurs, how it can be controlled, and how we can design new self-assembling, functional protein systems. We work collaboratively with colleagues from both academia and industry, focusing on solving problems with significant technological and societal implications. Research in the group has led to the discovery of novel technologies and several start-up companies have emerged from the research.