2024
------------------------------
Title: Aggregation of the amyloid-β peptide (Aβ40) within condensates generated through liquid–liquid phase separation
Authors: OM Morris, Z Toprakcioglu, A Röntgen, M Cali, TPJ Knowles, ...
Journal: Scientific Reports 14 (1)
------------------------------
Title: Single-molecule digital sizing of proteins in solution
Authors: G Krainer, RPB Jacquat, MM Schneider, TJ Welsh, J Fan, QAE Peter, ...
Journal: Nature Communications 15 (1)
------------------------------
Title: Unraveling the Structure and Dynamics of Ac-PHF6-NH2 Tau Segment Oligomers
Authors: I Stroganova, Z Toprakcioglu, H Willenberg, TPJ Knowles, AM Rijs
Journal: ACS Chemical Neuroscience 15 (18)
------------------------------
Title: Formation of Nanofibrillar Self-Healing Hydrogels Using Antimicrobial Peptides
Authors: EG Wiita, Z Toprakcioglu, AK Jayaram, TPJ Knowles
Journal: ACS Applied Materials & Interfaces 16 (35)
------------------------------
Title: a-Synuclein oligomers form by secondary nucleation
Authors: C Xu, G Meisl, E Andrzejewska, G Krainer, A Dear, M Castellana Cruz, ...
Journal: Nature Portfolio
------------------------------
Title: α-Synuclein oligomers form by secondary nucleation
Authors: CK Xu, G Meisl, EA Andrzejewska, G Krainer, AJ Dear, M Castellana-Cruz, ...
Journal: Nature Communications 15 (1)
------------------------------
Title: Dominance analysis to assess solute contributions to multicomponent phase equilibria
Authors: D Qian, H Ausserwoger, T Sneideris, M Farag, RV Pappu, TPJ Knowles
Journal: Proceedings of the National Academy of Sciences 121 (33)
------------------------------
Title: Synapsin condensation is governed by sequence-encoded molecular grammars
Authors: C Hoffmann, KM Ruff, IA Edu, MK Shinn, JV Tromm, MR King, A Pant, ...
Journal: bioRxiv
------------------------------
Title: Driving forces for condensation of synapsin are governed by sequence-encoded molecular grammars
Authors: C Hoffmann, KM Ruff, IA Edu, MK Shinn, JV Tromm, MR King, A Pant, ...
Journal: bioRxiv: the preprint server for biology
------------------------------
Title: Molecular properties and diagnostic potential of monoclonal antibodies targeting cytotoxic α-synuclein oligomers
Authors: J Nielsen, J Lauritsen, JN Pedersen, JS Nowak, MK Bendtsen, ...
Journal: npj Parkinson's Disease 10 (1)
------------------------------
Title: Protein Condensate Atlas from predictive models of heteromolecular condensate composition
Authors: KL Saar, RM Scrutton, K Bloznelyte, AS Morgunov, LL Good, AA Lee, ...
Journal: Nature Communications 15 (1)
------------------------------
Title: Thermodynamic profiles for cotranslational trigger factor substrate recognition
Authors: TW Herling, AME Cassaignau, AS Wentink, QAE Peter, PC Kumar, ...
Journal: Science Advances 10 (28)
------------------------------
Title: Biomolecular condensates are characterized by interphase electric potentials
Authors: AE Posey, A Bremer, NA Erkamp, A Pant, TPJ Knowles, Y Dai, T Mittag, ...
Journal: Journal of the American Chemical Society
------------------------------
Title: Protein Condensate Atlas from predictive models of heteromolecular condensate composition
Authors: R Scrutton, K Bloznelyte, A Morgunov, L Good, S Teichmann, T Knowles
Journal: Nature Portfolio
------------------------------
Title: α-synuclein oligomers displace monomeric α-synuclein from lipid membranes
Authors: G Šneiderienė, MA Czekalska, CK Xu, AK Jayaram, G Krainer, ...
Journal: ACS nano 18 (27)
------------------------------
Title: The role of shear forces in primary and secondary nucleation of amyloid fibrils
Authors: E Axell, J Hu, M Lindberg, AJ Dear, L Ortigosa-Pascual, EA Andrzejewska, ...
Journal: Proceedings of the National Academy of Sciences 121 (25)
------------------------------
Title: Electrolyte‐gated organic field‐effect transistors with high operational stability and lifetime in practical electrolytes
Authors: D Simatos, M Nikolka, J Charmet, LJ Spalek, Z Toprakcioglu, IE Jacobs, ...
Journal: SmartMat
------------------------------
Title: Biomolecular condensates with complex architectures via controlled nucleation
Authors: NA Erkamp, MAM Verwiel, D Qian, T Sneideris, FA Spaepen, DA Weitz, ...
Journal: Nature Chemical Engineering
------------------------------
Title: droplets out of equilibrium
Authors: NA Erkamp, TPJ Knowles
Journal: Nature 1
------------------------------
Title: Polysaccharide functionalization reduces lipid vesicle stiffness
Authors: K Jahnke, M Pavlovic, W Xu, A Chen, TPJ Knowles, LR Arriaga, DA Weitz
Journal: Proceedings of the National Academy of Sciences 121 (22)
------------------------------
Title: Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces
Authors: AJ Dear, D Thacker, S Wennmalm, L Ortigosa-Pascual, EA Andrzejewska, ...
Journal: ACS Chemical Neuroscience
------------------------------
Title: Solutes unmask differences in clustering versus phase separation of FET proteins
Authors: M Kar, LT Vogel, G Chauhan, S Felekyan, H Ausserwöger, TJ Welsh, ...
Journal: Nature communications 15 (1)
------------------------------
Title: An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions
Authors: G Cereghetti, VM Kissling, LM Koch, A Arm, CC Schmidt, Y Thüringer, ...
Journal: Developmental Cell
------------------------------
Title: Ab oligomer dissociation is catalyzed by fibril surfaces
Authors: A Dear, D Thacker, S Wennmalm, L Ortigosa-Pascual, EA Andrzejewska, ...
Journal: American Chemical Society
------------------------------
Title: Pharmacological inhibition of α-synuclein aggregation within liquid condensates
Authors: ST Dada, Z Toprakcioglu, MP Cali, A Röntgen, MC Hardenberg, ...
Journal: Nature Communications 15 (1)
------------------------------
Title: Maximum entropy determination of mammalian proteome dynamics
Authors: AJ Dear, GA Garcia, G Meisl, GA Collins, TPJ Knowles, AL Goldberg
Journal: Proceedings of the National Academy of Sciences 121 (18)
------------------------------
Title: Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning
Authors: RI Horne, EA Andrzejewska, P Alam, ZF Brotzakis, A Srivastava, A Aubert, ...
Journal: Nature Chemical Biology
------------------------------
Title: Microfluidics-based screening platform identifies a novel therapeutic approach to targeting EML4-ALK driven cancers
Authors: RC Centore, M Watson, J Doh, J Cattin, C Sgambato, A Alex, J Sawant, ...
Journal: Cancer Research 84 (6_Supplement)
------------------------------
Title: Discovery of novel biomolecular condensate drug targets in oncology using in silico predictive tools
Authors: KL Saar, M Rebmann, M Kanchwala, S Qamar, P Radhakrishnan, ...
Journal: Cancer Research 84 (6_Supplement)
------------------------------
Title: Pharmacological inhibition of the m6A RNA reader, YTHDC1, as a novel approach to targeting biomolecular condensates in cancer
Authors: RC Centore, M Charles, M Arora, Y Chen, M Watson, J Sawant, C Kelley, ...
Journal: Cancer Research 84 (6_Supplement)
------------------------------
Title: Design of amyloidogenic peptide traps
Authors: DD Sahtoe, EA Andrzejewska, HL Han, E Rennella, MM Schneider, ...
Journal: Nature Chemical Biology
------------------------------
Title: Fabrication of gradient hydrogels using a thermophoretic approach in microfluidics
Authors: AK Papadimitriou, SW Chong, Y Shen, OS Lee, TPJ Knowles, LM Grover, ...
Journal: Biofabrication 16 (2)
------------------------------
Title: A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions
Authors: S Chia, RL Cataldi, FS Ruggeri, R Limbocker, I Condado-Morales, ...
Journal: ACS Chemical Neuroscience 15 (6)
------------------------------
Title: Self-replication of Aβ42 aggregates occurs on small and isolated fibril sites
Authors: S Curk, J Krausser, G Meisl, D Frenkel, S Linse, TCT Michaels, ...
Journal: Proceedings of the National Academy of Sciences 121 (7)
------------------------------
Title: Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin–Drug Conjugates
Authors: B Bernardim, J Conde, T Hakala, JB Becher, M Canzano, AV Vasco, ...
Journal: Bioconjugate Chemistry 35 (2)
------------------------------
Title: Molecular chaperones and their role in amyloid formation
Authors: MM Schneider, A Bracher, EA Andrzejewska, G Krainer, LU Lin, R Riek, ...
Journal: Biophysical Journal 123 (3)
------------------------------
Title: Thermodynamics of temperature modulation in biomolecular phase separation
Authors: CM Fischer, H Ausserwöger, T Sneideris, D Qian, R Scrutton, S Qamar, ...
Journal: Biophysical Journal 123 (3)
------------------------------
Title: Novel methods to study amyloid oligomers
Authors: LO Pascual, EA Andrzejewska, T Pálmadóttir, TP Knowles, S Linse
Journal: Biophysical Journal 123 (3)
------------------------------
Title: Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils
Authors: A Miller, S Chia, E Klimont, TPJ Knowles, M Vendruscolo, FS Ruggeri
Journal: Communications Biology 7 (1)
------------------------------
Title: Suggested searches
Authors: DA Arnold, GA Breed, JS Laufenberg, ND Berg, MR Bertram, K Kielland, ...
Journal: Perspective
------------------------------
Title: Suggested searches
Authors: E Axell, J Hu, M Lindberg, AJ Dear, L Ortigosa-Pascual, EA Andrzejewska, ...
Journal: Perspective
------------------------------
Title: The Alzheimer’s Aβ peptide forms biomolecular condensates that trigger amyloid aggregation
Authors: G Šneiderienė, AG Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, ...
Journal: bioRxiv
------------------------------
Title: Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD20 …
Authors: A Priddey, MXH Chen-Xu, DJ Cooper, S MacMillan, G Meisl, CK Xu, ...
Journal: Frontiers in Immunology 14
------------------------------
Title: Serine phosphorylation mimics of Aβ form distinct, non-cross-seeding fibril morphs
Authors: K Sanagavarapu, G Meisl, V Lattanzi, K Bernfur, B Frohm, U Olsson, ...
Journal: Chemical Science
------------------------------
Title: Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Authors: T Knowles, Y Yao, NA Erkamp, T Sneideris, X Yang, R Scrutton, ...
Journal: bioRxiv
------------------------------
Title: Mechanical Profiling of Biopolymer Condensates through Acoustic Trapping
Authors: K Nakajima, T Sneideris, LL Good, NA Erkamp, H Ogi, T Knowles
Journal: bioRxiv
------------------------------
Title: Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates
Authors: NA Erkamp, M Farag, Y Qiu, D Qian, T Sneideris, T Wu, TJ Welsh, ...
Journal: bioRxiv
------------------------------
Title: Surface effects on functional amyloid formation
Authors: AJ Dear, G Meisl, CG Taylor, UC Palmiero, SN Stubbe, Q Liu, P Arosio, ...
Journal: Nanoscale 16 (34)
------------------------------
Title: Hierarchical Protofilament Intertwining Rules the Formation of Mixed‐Curvature Amyloid Polymorphs
Authors: J Zhou, S Assenza, M Tatli, J Tian, IM Ilie, EL Starostin, A Caflisch, ...
Journal: Advanced Science
------------------------------
Title: The Cystic Fibrosis Transmembrane Regulator Controls Tolerogenic Responses to Food Allergens in Mice and Humans
Authors: M Emmenegger, C Zografou, Y Dai, LR Hoyt, R Gudneppanavar, ...
Journal: medRxiv
------------------------------
Title: Biomolecular condensates sustain pH gradients at equilibrium driven by charge neutralisation
Authors: H Ausserwoeger, RM Scrutton, T Sneideris, CM Fischer, D Qian, ...
Journal: bioRxiv
------------------------------
Title: Kinetic models reveal the interplay of protein production and aggregation
Authors: J Wei, G Meisl, A Dear, M Oosterhuis, R Melki, C Emanuelsson, S Linse, ...
Journal: Chemical Science 15 (22)
------------------------------
Title: Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
Authors: TLC Ng, MP Hoare, MJ Maristany, EJ Wilde, T Sneideris, J Huertas, ...
Journal: bioRxiv
------------------------------
Title: Temperature-induced changes in protein interactions control RNA recruitment to G3BP1 condensates
Authors: CM Fischer, H Ausserwoger, T Sneideris, D Qian, R Scrutton, S Qamar, ...
Journal: bioRxiv
------------------------------
Title: Selenium-silk microgels as antifungal and antibacterial agents
Authors: EG Wiita, Z Toprakcioglu, AK Jayaram, TPJ Knowles
Journal: Nanoscale Horizons 9 (4)
------------------------------
Title: Molecular mechanism of α-synuclein aggregation on lipid membranes revealed
Authors: AJ Dear, X Teng, SR Ball, J Lewin, RI Horne, D Clow, A Stevenson, ...
Journal: Chemical Science 15 (19)
------------------------------
2023
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Title: Nonspecificity fingerprints for clinical-stage antibodies in solution
Authors: TW Herling, G Invernizzi, H Ausserwöger, JR Bjelke, T Egebjerg, S Lund, ...
Journal: Proceedings of the National Academy of Sciences 120 (52)
------------------------------
Title: Targeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides
Authors: T Sneideris, NA Erkamp, H Ausserwöger, KL Saar, TJ Welsh, D Qian, ...
Journal: Nature Communications 14 (1)
------------------------------
Title: Linking modulation of bio-molecular phase behaviour with collective interactions
Authors: D Qian, H Ausserwoger, WE Arter, R Scrutton, TJ Welsh, T Kartanas, ...
Journal: bioRxiv
------------------------------
Title: Effects of processing‐induced contamination on organic electronic devices
Authors: D Simatos, IE Jacobs, I Dobryden, M Nguyen, A Savva, ...
Journal: Small methods 7 (11)
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Title: Droplet dynamics in asymmetric microfluidic junctions
Authors: H Yang, Y Xu, T Knowles
Journal: European Journal of Mechanics-B/Fluids 102
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Title: Electrophysiological In Vitro Study of Long‐Range Signal Transmission by Astrocytic Networks
Authors: N Hastings, YL Yu, B Huang, S Middya, M Inaoka, NA Erkamp, RJ Mason, ...
Journal: Advanced Science 10 (29)
------------------------------
Title: De novo human angiotensin-converting enzyme 2 decoy NL-CVX1 protects mice from severe disease after severe acute respiratory syndrome coronavirus 2 infection
Authors: M Rebelo, C Tang, AR Coelho, C Labão-Almeida, MM Schneider, ...
Journal: The Journal of infectious diseases 228 (6)
------------------------------
Title: Ganglioside Lipids Inhibit the Aggregation of the Alzheimer’s Related Peptide Amyloid-β
Authors: Z Toprakcioglu, AK Jayaram, TPJ Knowles
Journal: BioRxiv
------------------------------
Title: The liquid-to-solid transition of FUS is promoted by the condensate surface
Authors: Y Shen, A Chen, W Wang, Y Shen, FS Ruggeri, S Aime, Z Wang, S Qamar, ...
Journal: Proceedings of the National Academy of Sciences 120 (33)
------------------------------
Title: Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions
Authors: M Kar, LT Vogel, G Chauhan, H Ausserwöger, TJ Welsh, AR Kamath, ...
Journal: Research Square
------------------------------
Title: Amyloid formation as a protein phase transition
Authors: TCT Michaels, D Qian, A Šarić, M Vendruscolo, S Linse, TPJ Knowles
Journal: Nature Reviews Physics 5 (7)
------------------------------
Title: Positional influence on cellular transcriptional identity revealed through spatially segmented single-cell transcriptomics
Authors: DB Morse, AM Michalowski, M Ceribelli, J De Jonghe, M Vias, D Riley, ...
Journal: Cell systems 14 (6)
------------------------------
Title: Dominant energetics in multi-component bio-molecular condensates
Authors: D Qian, H Ausserwoger, T Sneideris, M Farag, RV Pappu, TPJ Knowles
Journal: BioRxiv
------------------------------
Title: Dominance metric in multi-component binary phase equilibria
Authors: D Qian, H Ausserwoger, T Sneideris, R Pappu, TPJ Knowles
Journal: bioRxiv
------------------------------
Title: Formation of protein nanoparticles in microdroplet flow reactors
Authors: Q Zhang, Z Toprakcioglu, AK Jayaram, G Guo, X Wang, TPJ Knowles
Journal: ACS nano 17 (12)
------------------------------
Title: Condensate partitioning governs the mechanism of action of FUS phase separation modulators
Authors: H Ausserwöger, D Qian, G Krainer, TJ Welsh, T Sneideris, TM Franzmann, ...
Journal: bioRxiv
------------------------------
Title: Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains
Authors: A Miller, J Wei, S Meehan, CM Dobson, ME Welland, D Klenerman, ...
Journal: Proceedings of the National Academy of Sciences 120 (21)
------------------------------
Title: Label-free detection of proteins with optofluidic hollow-core photonic crystal fibre sensors
Authors: JR Heck, E Miele, R Mouthaan, MH Frosz, TPJ Knowles, TG Euser
Journal: SPIE Future Sensing Technologies 2023 12327
------------------------------
Title: Microfluidic antibody affinity profiling of alloantibody-HLA interactions in human serum
Authors: MM Schneider, T Scheidt, AJ Priddey, CK Xu, M Hu, G Meisl, ...
Journal: Biosensors and Bioelectronics 228
------------------------------
Title: Theoretical and data-driven approaches for biomolecular condensates
Authors: KL Saar, D Qian, LL Good, AS Morgunov, R Collepardo-Guevara, ...
Journal: Chemical Reviews 123 (14)
------------------------------
Title: Frontiers in Protein Folding and Related Areas–in Memory of Professor Sir Christopher M. Dobson (1949–2019)
Authors: K Kuwajima, Y Okamoto, T Knowles, M Vendruscolo
Journal: MDPI-Multidisciplinary Digital Publishing Institute
------------------------------
Title: O010 A novel microfluidic immunoassay for in-solution quantification of alloantibody affinity and concentration in transplantation and beyond
Authors: A Priddey, G Karahan, M Schneider, G Meisl, T Scheidt, C Xu, S Peacock, ...
Journal: British Journal of Surgery 110 (Supplement_3)
------------------------------
Title: Surface patches induce nonspecific binding and phase separation of antibodies
Authors: H Ausserwöger, G Krainer, TJ Welsh, N Thorsteinson, E de Csilléry, ...
Journal: Proceedings of the National Academy of Sciences 120 (15)
------------------------------
Title: ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
Authors: J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, ...
Journal: BioRxiv
------------------------------
Title: Protocol to determine antibody affinity and concentration in complex solutions using microfluidic antibody affinity profiling
Authors: M Emmenegger, R Worth, S Fiedler, SRA Devenish, TPJ Knowles, ...
Journal: STAR protocols 4 (1)
------------------------------
Title: Multidimensional protein solubility optimization with an ultrahigh-throughput microfluidic platform
Authors: NA Erkamp, M Oeller, T Sneideris, H Ausserwoger, A Levin, TJ Welsh, ...
Journal: Analytical Chemistry 95 (12)
------------------------------
Title: Kinetic Analysis Reveals the Role of Secondary Nucleation in Regenerated Silk Fibroin Self-Assembly
Authors: A Kamada, Z Toprakcioglu, TPJ Knowles
Journal: Biomacromolecules 24 (4)
------------------------------
Title: Modulating nucleic acid phase transitions as a mechanism of action for cell-penetrating antimicrobial peptides
Authors: T Sneideris, NA Erkamp, H Ausserwöger, KL Saar, TJ Welsh, D Qian, ...
Journal: Biorxiv
------------------------------
Title: Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH
Authors: ST Dada, MC Hardenberg, Z Toprakcioglu, LK Mrugalla, MP Cali, ...
Journal: Proceedings of the National Academy of Sciences 120 (9)
------------------------------
Title: Single-Molecule Sizing through Nanocavity Confinement
Authors: RPB Jacquat, G Krainer, QAE Peter, AN Babar, O Vanderpoorten, CK Xu, ...
Journal: Nano Letters 23 (5)
------------------------------
Title: Selenium silk nanostructured films with antifungal and antibacterial activity
Authors: Z Toprakcioglu, EG Wiita, AK Jayaram, RC Gregory, TPJ Knowles
Journal: ACS Applied Materials & Interfaces 15 (8)
------------------------------
Title: Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region
Authors: M Emmenegger, E De Cecco, D Lamparter, RPB Jacquat, J Riou, ...
Journal: Iscience 26 (2)
------------------------------
Title: Characterizing protein interactions in biomolecular phase separation
Authors: H Ausserwöger, G Krainer, D Qian, T Welsh, T Sneideris, MM Schneider, ...
Journal: Biophysical Journal 122 (3)
------------------------------
Title: Designer proteins as potential therapeutic biomolecular condensates
Authors: TLC Ng, M Hoare, T Welsh, S Tomas, E Wilde, TPJ Knowles, LS Itzhaki, ...
Journal: Biophysical Journal 122 (3)
------------------------------
Title: Approximate analytical solution to the Flory-Huggins model
Authors: D Qian, TCT Michaels, TPJ Knowles
Journal: Biophysical Journal 122 (3)
------------------------------
Title: Spatially non-uniform condensates emerge from dynamically arrested phase separation
Authors: NA Erkamp, T Sneideris, H Ausserwöger, D Qian, S Qamar, J Nixon-Abell, ...
Journal: Nature Communications 14 (1)
------------------------------
Title: Direct digital sensing of protein biomarkers in solution
Authors: G Krainer, KL Saar, WE Arter, TJ Welsh, MA Czekalska, RPB Jacquat, ...
Journal: Nature Communications 14 (1)
------------------------------
Title: Bioprinting microporous functional living materials from protein-based core-shell microgels
Authors: Y Ou, S Cao, Y Zhang, H Zhu, C Guo, W Yan, F Xin, W Dong, Y Zhang, ...
Journal: Nature Communications 14 (1)
------------------------------
Title: Adsorption of RNA to interfaces of biomolecular condensates enables wetting transitions
Authors: NA Erkamp, M Farag, D Qian, T Sneideris, TJ Welsh, H Ausserwöger, ...
Journal: BioRxiv
------------------------------
Title: Enhanced surface nanoanalytics of transient biomolecular processes
Authors: A Miller, S Chia, Z Toprakcioglu, T Hakala, R Schmid, Y Feng, T Kartanas, ...
Journal: Science Advances 9 (2)
------------------------------
Title: The chromatin regulator HMGA1a undergoes phase separation in the nucleus
Authors: H Zhu, M Narita, JA Joseph, G Krainer, WE Arter, I Olan, KL Saar, ...
Journal: ChemBioChem 24 (1)
------------------------------
Title: Dominance formulation in multi-component binary phase equilibria
Authors: D Qian, H Ausserwoger, T Sneideris, R Pappu, TPJ Knowles
Journal: bioRxiv
------------------------------
Title: Quantifying collective interactions in biomolecular phase separation
Authors: H Ausserwöger, D Qian, G Krainer, E de Csilléry, TJ Welsh, T Sneideris, ...
Journal: bioRxiv 31 (2023)
------------------------------
Title: Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates
Authors: A Miller, Z Toprakcioglu, S Qamar, P St. George-Hyslop, FS Ruggeri, ...
Journal: bioRxiv
------------------------------
Title: Amyloids and protein aggregation
Authors: S Linse, T Knowles
Journal: Chemical Science 14 (24)
------------------------------
Title: Devices and applications at the micro-and nanoscale rsc. li/loc
Authors: NA Erkamp, R Qi, TJ Welsh, TPJ Knowles, G Imparato, F Urciuolo, ...
Journal: Lab Chip 23
------------------------------
Title: Microfluidics for multiscale studies of biomolecular condensates
Authors: NA Erkamp, R Qi, TJ Welsh, TPJ Knowles
Journal: Lab on a Chip 23 (1)
------------------------------
2022
------------------------------
Title: A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ42 Aggregation
Authors: KN Baumann, G Šneiderienė, M Sanguanini, M Schneider, O Rimon, ...
Journal: ACS Chemical Neuroscience 14 (2)
------------------------------
Title: Biomolecular condensate phase diagrams with a combinatorial microdroplet platform
Authors: WE Arter, R Qi, NA Erkamp, G Krainer, K Didi, TJ Welsh, J Acker, ...
Journal: Nature Communications 13 (1)
------------------------------
Title: Perphenazine–macrocycle conjugates rapidly sequester the Aβ42 monomer and prevent formation of toxic oligomers and amyloid
Authors: SR Ball, JSP Adamson, MA Sullivan, MR Zimmermann, V Lo, ...
Journal: ACS Chemical Neuroscience 14 (1)
------------------------------
Title: Selenium Silk Nanostructured Films for Antifungal and Antibacterial Treatments
Authors: Z Toprakcioglu, EG Wiita, AK Jayaram, RC Gregory, TPJ Knowles
Journal: bioRxiv
------------------------------
Title: Core–Shell Spheroid‐Laden Microgels Crosslinked under Biocompatible Conditions for Probing Cancer‐Stromal Communication
Authors: H Zhu, LWY Roode, AJ Parry, NA Erkamp, M Rodriguez-Garcia, M Narita, ...
Journal: Advanced NanoBiomed Research 2 (12)
------------------------------
Title: Non-specificity as the sticky problem in therapeutic antibody development
Authors: H Ausserwöger, MM Schneider, TW Herling, P Arosio, G Invernizzi, ...
Journal: Nature Reviews Chemistry 6 (12)
------------------------------
Title: Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration
Authors: S Fiedler, SRA Devenish, AS Morgunov, A Ilsley, F Ricci, M Emmenegger, ...
Journal: Scientific Reports 12 (1)
------------------------------
Title: Characterization of full-length p53 aggregates and their kinetics of formation
Authors: L Julian, JC Sang, Y Wu, G Meisl, JH Brelstaff, A Miller, MR Cheetham, ...
Journal: Biophysical Journal 121 (22)
------------------------------
Title: Structure-based discovery of small-molecule inhibitors of the autocatalytic proliferation of α-Synuclein aggregates
Authors: S Chia, Z Faidon Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, ...
Journal: Molecular Pharmaceutics 20 (1)
------------------------------
Title: Microscale diffusiophoresis of proteins
Authors: QAE Peter, RPB Jacquat, TW Herling, PK Challa, T Kartanas, ...
Journal: The Journal of Physical Chemistry B 126 (44)
------------------------------
Title: A chip-based supersonic microfluidic nebulizer for efficient sample introduction into inductively coupled plasma–Mass spectrometry
Authors: E Mavrakis, Z Toprakcioglu, N Lydakis-Simantiris, TPJ Knowles, ...
Journal: Analytica Chimica Acta 1229
------------------------------
Title: Intracellular FUS protein accumulation leads to cytoskeletal, organelle and cellular homeostasis perturbations
Authors: CW Chung, AJ Zhou, I Mela, AD Stephens, A Miyashita, ...
Journal: bioRxiv
------------------------------
Title: Tie-line analysis reveals interactions driving heteromolecular condensate formation
Authors: D Qian, TJ Welsh, NA Erkamp, S Qamar, J Nixon-Abell, G Krainer, ...
Journal: Physical Review X 12 (4)
------------------------------
Title: Hydrodynamics of Droplet Sorting in Asymmetric Acute Junctions
Authors: H Yang, TPJ Knowles
Journal: Micromachines 13 (10)
------------------------------
Title: Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
Authors: D Emin, YP Zhang, E Lobanova, A Miller, X Li, Z Xia, H Dakin, DI Sideris, ...
Journal: Nature communications 13 (1)
------------------------------
Title: Label-free monitoring of proteins in optofluidic hollow-core photonic crystal fibres
Authors: JR Heck, E Miele, R Mouthaan, MH Frosz, TPJ Knowles, TG Euser
Journal: Methods and Applications in Fluorescence 10 (4)
------------------------------
Title: Influence of denaturants on amyloid β42 aggregation kinetics
Authors: T Weiffert, G Meisl, S Curk, R Cukalevski, A Šarić, TPJ Knowles, S Linse
Journal: Frontiers in Neuroscience 16
------------------------------
Title: Structure-specific amyloid precipitation in biofluids
Authors: M Rodrigues, P Bhattacharjee, A Brinkmalm, DT Do, CM Pearson, S De, ...
Journal: Nature Chemistry 14 (9)
------------------------------
Title: Both COVID-19 infection and vaccination induce high-affinity cross-clade responses to SARS-CoV-2 variants
Authors: M Emmenegger, S Fiedler, SD Brugger, SRA Devenish, AS Morgunov, ...
Journal: Iscience 25 (8)
------------------------------
Title: Analytical solution to the Flory–Huggins model
Authors: D Qian, TCT Michaels, TPJ Knowles
Journal: The journal of physical chemistry letters 13 (33)
------------------------------
Title: Solid/liquid coexistence during aging of FUS condensates
Authors: Y Shen, A Chen, W Wang, Y Shen, FS Ruggeri, S Aime, Z Wang, S Qamar, ...
Journal: bioRxiv
------------------------------
Title: Uncovering the universality of self-replication in protein aggregation and its link to disease
Authors: G Meisl, CK Xu, JD Taylor, TCT Michaels, A Levin, D Otzen, D Klenerman, ...
Journal: Science Advances 8 (31)
------------------------------
Title: Adsorption free energy predicts amyloid protein nucleation rates
Authors: Z Toprakcioglu, A Kamada, TCT Michaels, M Xie, J Krausser, J Wei, ...
Journal: Proceedings of the National Academy of Sciences 119 (31)
------------------------------
Title: Recent advances in microgels: from biomolecules to functionality
Authors: Y Xu, H Zhu, A Denduluri, Y Ou, NA Erkamp, R Qi, Y Shen, TPJ Knowles
Journal: Small 18 (34)
------------------------------
Title: A conformational switch controlling the toxicity of the prion protein
Authors: K Frontzek, M Bardelli, A Senatore, A Henzi, RR Reimann, S Bedir, ...
Journal: Nature Structural & Molecular Biology 29 (8)
------------------------------
Title: DNA–liposome hybrid carriers for triggered cargo release
Authors: KN Baumann, T Schröder, PS Ciryam, D Morzy, P Tinnefeld, ...
Journal: ACS Applied Bio Materials 5 (8)
------------------------------
Title: Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions
Authors: M Kar, F Dar, TJ Welsh, LT Vogel, R Kühnemuth, A Majumdar, G Krainer, ...
Journal: Proceedings of the National Academy of Sciences 119 (28)
------------------------------
Title: Thermodynamics of oligomeric alph-asynuclein-membrane interactions
Authors: G Musteikyte, C Xu, M Czekalska, Q Peter, G Krainer, S Devenish, ...
Journal: FEBS OPEN BIO 12
------------------------------
Title: Mechanistic models of protein aggregation across length-scales and time-scales: from the test tube to neurodegenerative disease
Authors: G Meisl, TPJ Knowles, D Klenerman
Journal: Frontiers in neuroscience 16
------------------------------
Title: Aging can transform single-component protein condensates into multiphase architectures
Authors: A Garaizar, JR Espinosa, JA Joseph, G Krainer, Y Shen, TPJ Knowles, ...
Journal: Proceedings of the National Academy of Sciences 119 (26)
------------------------------
Title: Kinetic profiling of therapeutic strategies for inhibiting the formation of amyloid oligomers
Authors: TCT Michaels, AJ Dear, SIA Cohen, M Vendruscolo, TPJ Knowles
Journal: The Journal of Chemical Physics 156 (16)
------------------------------
Title: Analytical solution to the Flory Huggins model reveals scaling behaviour and enables quantitative interpretation of experimental data
Authors: D Qian, TCT Michaels, TPJ Knowles
Journal: bioRxiv
------------------------------
Title: A Kinetic Map of the Influence of Biomimetic Lipid Membrane Models on Aβ42 Aggregation
Authors: KN Baumann, M Sanguanini, O Rimon, G Šneiderienė, H Greer, ...
Journal: bioRxiv
------------------------------
Title: Microfluidic antibody affinity profiling reveals the role of memory reactivation and cross-reactivity in the defense against SARS-CoV-2
Authors: V Denninger, CK Xu, G Meisl, AS Morgunov, S Fiedler, A Ilsley, ...
Journal: ACS Infectious Diseases 8 (4)
------------------------------
Title: Surface interaction patches link non-specific binding and phase separation of antibodies
Authors: H Ausserwöger, G Krainer, TJ Welsh, T Sneideris, MM Schneider, ...
Journal: BioRxiv
------------------------------
Title: The pathological G51D mutation in alpha-synuclein oligomers confers distinct structural attributes and cellular toxicity
Authors: CK Xu, M Castellana-Cruz, SW Chen, Z Du, G Meisl, A Levin, B Mannini, ...
Journal: Molecules 27 (4)
------------------------------
Title: Using microscopy techniques to structurally characterise TDP-43 inclusions present in mammalian cell models
Authors: NS Matharu, CW Chung, JR Kumita, GS Kaminski, TP Knowles
Journal: Biophysical Journal 121 (3)
------------------------------
Title: Mechanism of secondary nucleation from the direct observation of Aβ42 aggregation at the single fibril level
Authors: MR Zimmermann, SC Bera, G Meisl, S Dasadhikari, S Ghosh, S Linse, ...
Journal: Biophysical Journal 121 (3)
------------------------------
Title: Simultaneous fractionation and characterization of pre-fibrillar aggregates in solution with single-molecule microfluidics
Authors: EA Andrzejewska, G Krainer, CK Xu, R Jacquat, MM Schneider, W Arter, ...
Journal: Biophysical Journal 121 (3)
------------------------------
Title: Universal lab-on-a-chip microfluidic spray deposition for bulk and single-molecule analytical methods on surfaces
Authors: AM Miller, SKR Chia, T Hakala, Z Toprakcioglu, M Vendruscolo, ...
Journal: Biophysical Journal 121 (3)
------------------------------
Title: Hsc70 mediated disaggregation of α-synuclein fibrils
Authors: MM Schneider, S Gautam, TW Herling, G Krainer, E Andrzejewska, ...
Journal: Biophysical Journal 121 (3)
------------------------------
Title: Multiphase condensates from a kinetically arrested phase transition
Authors: NA Erkamp, T Sneideris, H Ausserwöger, D Qian, S Qamar, J Nixon-Abell, ...
Journal: bioRxiv
------------------------------
Title: The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization
Authors: A Farzadfard, JN Pedersen, G Meisl, AK Somavarapu, P Alam, L Goksøyr, ...
Journal: Communications biology 5 (1)
------------------------------
Title: Nanofluidic Traps by Two-Photon Fabrication for Extended Detection of Single Macromolecules and Colloids in Solution
Authors: O Vanderpoorten, AN Babar, G Krainer, RPB Jacquat, PK Challa, Q Peter, ...
Journal: ACS applied nano materials 5 (2)
------------------------------
Title: Micromechanics of soft materials using microfluidics
Authors: Y Xu, H Zhu, Y Shen, APM Guttenplan, KL Saar, Y Lu, D Vigolo, LS Itzhaki, ...
Journal: MRS Bulletin 47 (2)
------------------------------
Title: Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma
Authors: MM Schneider, M Emmenegger, CK Xu, IC Morales, G Meisl, P Turelli, ...
Journal: Life science alliance 5 (2)
------------------------------
Title: Microchip Free-Flow Electrophoresis for Bioanalysis, Sensing, and Purification
Authors: WE Arter, KL Saar, TW Herling, TPJ Knowles
Journal: Biomedical Engineering Technologies: Volume 2
------------------------------
Title: Surface electrostatics govern the emulsion stability of biomolecular condensates
Authors: TJ Welsh, G Krainer, JR Espinosa, JA Joseph, A Sridhar, M Jahnel, ...
Journal: Nano letters 22 (2)
------------------------------
Title: Hydrodynamics of Droplet Sorting in Asymmetric Acute Junctions. Micromachines 2022, 13, 1640
Authors: H Yang, TPJ Knowles
Journal: s Note: MDPI stays neutral with regard to jurisdictional claims in published …
------------------------------
Title: Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic
Authors: R Limbocker, S Errico, D Barbut, TPJ Knowles, M Vendruscolo, F Chiti, ...
Journal: Natural Product Reports 39 (4)
------------------------------
Title: Biomembranes in bioelectronic sensing
Authors: AK Jayaram, AM Pappa, S Ghosh, ZA Manzer, WC Traberg, TPJ Knowles, ...
Journal: Trends in Biotechnology 40 (1)
------------------------------
2021
------------------------------
Title: Rate‐limiting processes of tau aggregate accumulation in Alzheimer's disease
Authors: G Meisl, Y Zuo, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, ...
Journal: Alzheimer's & Dementia 17
------------------------------
Title: 2-photon-fabricated nano-fluidic traps for extended detection of single macromolecules and colloids in solution
Authors: O Vanderpoorten, AN Babar, G Krainer, RPB Jacquat, PK Challa, Q Peter, ...
Journal: bioRxiv
------------------------------
Title: Proliferation of tau 304–380 fragment aggregates through autocatalytic secondary nucleation
Authors: DC Rodriguez Camargo, E Sileikis, S Chia, E Axell, K Bernfur, RL Cataldi, ...
Journal: ACS Chemical Neuroscience 12 (23)
------------------------------
Title: Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson’s Disease
Authors: K Nishioka, E Vayndorf, PJ Kahle, EAA Nollen, M Vendruscolo, FA Aprile, ...
Journal: Intracellular Mechanisms of α-Synuclein Processing
------------------------------
Title: Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses
Authors: F Geiger, J Acker, G Papa, X Wang, WE Arter, KL Saar, NA Erkamp, R Qi, ...
Journal: The EMBO Journal 40 (21)
------------------------------
Title: Surface-catalyzed secondary nucleation dominates the generation of toxic IAPP aggregates
Authors: DC Rodriguez Camargo, S Chia, J Menzies, B Mannini, G Meisl, ...
Journal: Frontiers in Molecular Biosciences 8
------------------------------
Title: In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease
Authors: G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, ...
Journal: Science advances 7 (44)
------------------------------
Title: Kinetic and thermodynamic driving factors in the assembly of phenylalanine-based modules
Authors: D Zaguri, MR Zimmermann, G Meisl, A Levin, S Rencus-Lazar, ...
Journal: ACS nano 15 (11)
------------------------------
Title: The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends
Authors: MM Schneider, S Gautam, TW Herling, E Andrzejewska, G Krainer, ...
Journal: Nature Communications 12 (1)
------------------------------
Title: Can single-component protein condensates form multiphase architectures?
Authors: A Garaizar, JR Espinosa, JA Joseph, G Krainer, Y Shen, TPJ Knowles, ...
Journal: bioRxiv
------------------------------
Title: Accelerating reaction rates of biomolecules by using shear stress in artificial capillary systems
Authors: TA Hakala, EV Yates, PK Challa, Z Toprakcioglu, K Nadendla, ...
Journal: Journal of the American Chemical Society 143 (40)
------------------------------
Title: New frontiers for machine learning in protein science
Authors: AS Morgunov, KL Saar, M Vendruscolo, TPJ Knowles
Journal: Journal of Molecular Biology 433 (20)
------------------------------
Title: Deformable and Robust Core–Shell Protein Microcapsules Templated by Liquid–Liquid Phase‐Separated Microdroplets
Authors: Y Xu, Y Shen, TCT Michaels, KN Baumann, D Vigolo, Q Peter, Y Lu, ...
Journal: Advanced Materials Interfaces 8 (19)
------------------------------
Title: Sequential storage and release of microdroplets
Authors: Z Toprakcioglu, TPJ Knowles
Journal: Microsystems & Nanoengineering 7 (1)
------------------------------
Title: Mechanism of secondary nucleation at the single fibril level from direct observations of Aβ42 aggregation
Authors: MR Zimmermann, SC Bera, G Meisl, S Dasadhikari, S Ghosh, S Linse, ...
Journal: Journal of the American Chemical Society 143 (40)
------------------------------
Title: The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces
Authors: T Scheidt, JA Carozza, CC Kolbe, FA Aprile, O Tkachenko, MMJ Bellaiche, ...
Journal: Proceedings of the National Academy of Sciences 118 (38)
------------------------------
Title: LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies
Authors: M Emmenegger, E De Cecco, M Hruska‐Plochan, T Eninger, ...
Journal: EMBO molecular medicine 13 (9)
------------------------------
Title: Unraveling the physicochemical determinants of protein liquid-liquid phase separation by nanoscale infrared vibrational spectroscopy
Authors: FS Ruggeri, AM Miller, M Vendruscolo, TPJ Knowles
Journal: Bio-protocol 11 (16)
------------------------------
Title: Feedback control of protein aggregation
Authors: AJ Dear, TCT Michaels, TPJ Knowles, L Mahadevan
Journal: The Journal of Chemical Physics 155 (6)
------------------------------
Title: Conformational expansion of tau in condensates promotes irreversible aggregation
Authors: J Wen, L Hong, G Krainer, QQ Yao, TPJ Knowles, S Wu, S Perrett
Journal: Journal of the American Chemical Society 143 (33)
------------------------------
Title: Detection and Quantification of Immunologically Relevant Alloantibody-HLA Interactions Using Microfluidic Antibody Affinity Profiling
Authors: A Priddey, M Schneider, G Karahan, T Scheidt, C Xu, G Meisl, H Copley, ...
Journal: TRANSPLANT INTERNATIONAL 34
------------------------------
Title: Liquid–Liquid Phase‐Separated Systems from Reversible Gel–Sol Transition of Protein Microgels (Adv. Mater. 33/2021)
Authors: Y Xu, R Qi, H Zhu, B Li, Y Shen, G Krainer, D Klenerman, TPJ Knowles
Journal: Advanced Materials 33 (33)
------------------------------
Title: Liquid–Liquid Phase‐Separated Systems from Reversible Gel–Sol Transition of Protein Microgels
Authors: Y Xu, R Qi, H Zhu, B Li, Y Shen, G Krainer, D Klenerman, TPJ Knowles
Journal: Advanced Materials 33 (33)
------------------------------
Title: Mutations in two SARS-CoV-2 variants of concern reflect two distinct strategies of antibody escape
Authors: S Fiedler, V Denninger, AS Morgunov, A Ilsley, R Worth, G Meisl, CK Xu, ...
Journal: bioRxiv
------------------------------
Title: Understanding the role of memory re-activation and cross-reactivity in the defense against SARS-CoV-2
Authors: V Denninger, CK Xu, G Meisl, AS Morgunov, S Fiedler, A Ilsley, ...
Journal: bioRxiv
------------------------------
Title: Protein conjugation by electrophilic alkynylation using 5-(alkynyl) dibenzothiophenium triflates
Authors: V Laserna, A Istrate, K Kafuta, TA Hakala, TPJ Knowles, M Alcarazo, ...
Journal: Bioconjugate Chemistry 32 (8)
------------------------------
Title: pH‐Responsive Capsules with a Fibril Scaffold Shell Assembled from an Amyloidogenic Peptide
Authors: U Shimanovich, A Levin, D Eliaz, T Michaels, Z Toprakcioglu, B Frohm, ...
Journal: Small 17 (26)
------------------------------
Title: Squalamine and its derivatives modulate the aggregation of amyloid-β and α-synuclein and suppress the toxicity of their oligomers
Authors: R Limbocker, R Staats, S Chia, FS Ruggeri, B Mannini, CK Xu, M Perni, ...
Journal: Frontiers in Neuroscience 15
------------------------------
Title: Controlled self-assembly of plant proteins into high-performance multifunctional nanostructured films
Authors: A Kamada, M Rodriguez-Garcia, FS Ruggeri, Y Shen, A Levin, ...
Journal: Nature Communications 12 (1)
------------------------------
Title: In Situ Sub‐Cellular Identification of Functional Amyloids in Bacteria and Archaea by Infrared Nanospectroscopy
Authors: DE Otzen, MS Dueholm, Z Najarzadeh, TPJ Knowles, FS Ruggeri
Journal: Small Methods 5 (6)
------------------------------
Title: Pulsed Hydrogen–Deuterium Exchange Reveals Altered Structures and Mechanisms in the Aggregation of Familial Alzheimer’s Disease Mutants
Authors: E Illes-Toth, G Meisl, DL Rempel, TPJ Knowles, ML Gross
Journal: ACS chemical neuroscience 12 (11)
------------------------------
Title: Antibody affinity governs the inhibition of SARS-CoV-2 spike/ACE2 binding in patient serum
Authors: S Fiedler, MA Piziorska, V Denninger, AS Morgunov, A Ilsley, AY Malik, ...
Journal: ACS Infectious Diseases 7 (8)
------------------------------
Title: Learning the molecular grammar of protein condensates from sequence determinants and embeddings
Authors: KL Saar, AS Morgunov, R Qi, WE Arter, G Krainer, AA Lee, TPJ Knowles
Journal: Proceedings of the National Academy of Sciences 118 (15)
------------------------------
Title: Scaling analysis reveals the mechanism and rates of prion replication in vivo
Authors: G Meisl, T Kurt, I Condado-Morales, C Bett, S Sorce, M Nuvolone, ...
Journal: Nature structural & molecular biology 28 (4)
------------------------------
Title: Interactions of α-synuclein oligomers with lipid membranes
Authors: G Musteikytė, AK Jayaram, CK Xu, M Vendruscolo, G Krainer, ...
Journal: Biochimica et Biophysica Acta (BBA)-Biomembranes 1863 (4)
------------------------------
Title: Supramolecular peptide nanofibrils with optimized sequences and molecular structures for efficient retroviral transduction
Authors: S Sieste, T Mack, E Lump, M Hayn, D Schütz, A Röcker, C Meier, ...
Journal: Advanced Functional Materials 31 (17)
------------------------------
Title: The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases
Authors: TB Thompson, G Meisl, TPJ Knowles, A Goriely
Journal: The Journal of chemical physics 154 (12)
------------------------------
Title: From protein building blocks to functional materials
Authors: Y Shen, A Levin, A Kamada, Z Toprakcioglu, M Rodriguez-Garcia, Y Xu, ...
Journal: ACS nano 15 (4)
------------------------------
Title: Shear-mediated sol-gel transition of regenerated silk allows the formation of Janus-like microgels
Authors: Z Toprakcioglu, TPJ Knowles
Journal: Scientific Reports 11 (1)
------------------------------
Title: Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease
Authors: M Perni, A Van der Goot, R Limbocker, TJ Van Ham, FA Aprile, CK Xu, ...
Journal: Frontiers in Cell and Developmental Biology 9
------------------------------
Title: Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans
Authors: T Sinnige, G Meisl, TCT Michaels, M Vendruscolo, TPJ Knowles, ...
Journal: Proceedings of the National Academy of Sciences 118 (11)
------------------------------
Title: Rapid highly sensitive general protein quantification through on-chip chemiluminescence
Authors: HK Chiu, T Kartanas, KL Saar, CM Luxhøj, S Devenish, TPJ Knowles
Journal: Biomicrofluidics 15 (2)
------------------------------
Title: Direct digital sensing of proteins in solution through single-molecule optofluidics
Authors: G Krainer, KL Saar, WE Arter, TPJ Knowles
Journal: Biophysical Journal 120 (3)
------------------------------
Title: Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
Authors: G Krainer, TJ Welsh, JA Joseph, P St George-Hyslop, AA Hyman, ...
Journal: Biophysical Journal 120 (3)
------------------------------
Title: One-step generation of multisomes from lipid-stabilized double emulsions
Authors: MA Czekalska, AMJ Jacobs, Z Toprakcioglu, L Kong, KN Baumann, ...
Journal: ACS Applied Materials & Interfaces 13 (5)
------------------------------
Title: Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers
Authors: FS Ruggeri, J Habchi, S Chia, RI Horne, M Vendruscolo, TPJ Knowles
Journal: Nature Communications 12 (1)
------------------------------
Title: Label-free protein analysis using liquid chromatography with gravimetric detection
Authors: T Kartanas, A Levin, Z Toprakcioglu, T Scheidt, TA Hakala, J Charmet, ...
Journal: Analytical Chemistry 93 (5)
------------------------------
Title: In situ kinetic measurements of α-synuclein aggregation reveal large population of short-lived oligomers
Authors: E Zurlo, P Kumar, G Meisl, AJ Dear, D Mondal, MMAE Claessens, ...
Journal: PLoS One 16 (1)
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Title: A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
Authors: R Cataldi, S Chia, K Pisani, FS Ruggeri, CK Xu, T Šneideris, M Perni, ...
Journal: Communications Biology 4 (1)
------------------------------
Title: Microfluidic diffusional sizing for studying protein-protein interactions
Authors: MM Schneider, CM Dobson, A Aguzzi, FU Hartl, TPJ Knowles
Journal: Springer
------------------------------
Title: The unhappy chaperone
Authors: S Linse, K Thalberg, TPJ Knowles
Journal: QRB discovery 2
------------------------------
Title: Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer’s disease
Authors: DI Sideris, JSH Danial, D Emin, FS Ruggeri, Z Xia, YP Zhang, ...
Journal: Brain communications 3 (3)
------------------------------
Title: Elongation rate and average length of amyloid fibrils in solution using isotope-labelled small-angle neutron scattering
Authors: BJ Eves, JJ Doutch, AE Terry, H Yin, M Moulin, M Haertlein, VT Forsyth, ...
Journal: RSC chemical biology 2 (4)
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Title: Machine learning-aided protein identification from multidimensional signatures
Authors: Y Zhang, MA Wright, KL Saar, P Challa, AS Morgunov, QAE Peter, ...
Journal: Lab on a Chip 21 (15)
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Title: Publisher Correction: A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
Authors: R Cataldi, S Chia, P Katarina, FS Ruggeri, CK Xu, Š Tomas, M Perni, ...
Journal: Communications Biology 4 (1)
------------------------------
Title: Correction: Correction: Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions
Authors: Z Toprakcioglu, TA Hakala, A Levin, CFW Becker, GJL Bernardes, ...
Journal: Soft Matter 17 (1)
------------------------------
Title: Evolution of conformation, nanomechanics, and infrared nanospectroscopy of single amyloid fibrils converting into microcrystals
Authors: J Adamcik, FS Ruggeri, JT Berryman, A Zhang, TPJ Knowles, ...
Journal: Advanced Science 8 (2)
------------------------------
2020
------------------------------
Title: Physical mechanisms of amyloid nucleation on fluid membranes
Authors: J Krausser, TPJ Knowles, A Šarić
Journal: Proceedings of the National Academy of Sciences 117 (52)
------------------------------
Title: Environmental control of amyloid polymorphism by modulation of hydrodynamic stress
Authors: J Zhou, L Venturelli, L Keiser, SK Sekatskii, F Gallaire, S Kasas, G Longo, ...
Journal: ACS nano 15 (1)
------------------------------
Title: In vitro measurements of protein–protein interactions show that antibody affinity governs the inhibition of SARS-CoV-2 spike/ACE2 binding in convalescent serum
Authors: S Fiedler, MA Piziorska, V Denninger, AS Morgunov, A Ilsley, AY Malik, ...
Journal: BioRxiv
------------------------------
Title: Rotavirus replication factories are complex ribonucleoprotein condensates
Authors: F Geiger, G Papa, WE Arter, J Acker, KL Saar, N Erkamp, R Qi, J Bravo, ...
Journal: bioRxiv
------------------------------
Title: Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
Authors: R Staats, TCT Michaels, P Flagmeier, S Chia, RI Horne, J Habchi, S Linse, ...
Journal: Communications Chemistry 3 (1)
------------------------------
Title: Construction of a liquid-liquid phase separation system from the gel-sol transition of elongated protein microgels in a crowding agent
Authors: Y Xu, R Qi, H Zhu, B Li, Y Shen, G Krainer, D Klenerman, TPJ Knowles
Journal: bioRxiv
------------------------------
Title: Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
Authors: S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, ...
Journal: Nature structural & molecular biology 27 (12)
------------------------------
Title: Amplification, not spreading limits rate of tau aggregate accumulation in Alzheimer’s disease
Authors: G Meisl, Y Zuo, K Allinson, T Rittman, S DeVos, JS Sanchez, CK Xu, ...
Journal: bioRxiv
------------------------------
Title: Machine learning aided top-down proteomics on a microfluidic platform
Authors: Y Zhang, MA Wright, KL Saar, P Challa, AS Morgunov, QAE Peter, ...
Journal: BioRxiv
------------------------------
Title: Hamiltonian Dynamics of Saturated Elongation in Amyloid Fiber Formation
Authors: L Hong, X Liu, TCT Michaels, TPJ Knowles
Journal: arXiv preprint arXiv:2011.06222
------------------------------
Title: On the mechanism of self-assembly by a hydrogel-forming peptide
Authors: GA Braun, BE Ary, AJ Dear, MCH Rohn, AM Payson, DSM Lee, RC Parry, ...
Journal: Biomacromolecules 21 (12)
------------------------------
Title: Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
Authors: GT Heller, FA Aprile, TCT Michaels, R Limbocker, M Perni, FS Ruggeri, ...
Journal: Science advances 6 (45)
------------------------------
Title: Biomimetic peptide self-assembly for functional materials
Authors: A Levin, TA Hakala, L Schnaider, GJL Bernardes, E Gazit, TPJ Knowles
Journal: Nature Reviews Chemistry 4 (11)
------------------------------
Title: Machine learning models for predicting protein condensate formation from sequence determinants and embeddings
Authors: KL Saar, AS Morgunov, R Qi, WE Arter, G Krainer, AA Lee, TPJ Knowles
Journal: bioRxiv
------------------------------
Title: Rapid structural, kinetic, and immunochemical analysis of alpha-synuclein oligomers in solution
Authors: WE Arter, CK Xu, M Castellana-Cruz, TW Herling, G Krainer, KL Saar, ...
Journal: Nano letters 20 (11)
------------------------------
Title: The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils
Authors: D Thacker, K Sanagavarapu, B Frohm, G Meisl, TPJ Knowles, S Linse
Journal: Proceedings of the National Academy of Sciences 117 (41)
------------------------------
Title: Autoantibodies against the prion protein in individuals with PRNP mutations
Authors: K Frontzek, M Carta, M Losa, M Epskamp, G Meisl, A Anane, JP Brandel, ...
Journal: Neurology 95 (14)
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Title: Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation
Authors: P Flagmeier, S De, TCT Michaels, X Yang, AJ Dear, C Emanuelsson, ...
Journal: Nature Structural & Molecular Biology 27 (10)
------------------------------
Title: Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition
Authors: Y Shen, FS Ruggeri, D Vigolo, A Kamada, S Qamar, A Levin, C Iserman, ...
Journal: Nature nanotechnology 15 (10)
------------------------------
Title: Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors
Authors: TCT Michaels, A Šarić, G Meisl, GT Heller, S Curk, P Arosio, S Linse, ...
Journal: Proceedings of the National Academy of Sciences 117 (39)
------------------------------
Title: Microfluidic Affinity Profiling reveals a Broad Range of Target Affinities for Anti-SARS-CoV-2 Antibodies in Plasma of COVID-19 Survivors
Authors: MM Schneider, M Emmenegger, CK Xu, IC Morales, G Meisl, P Turelli, ...
Journal: MedRxiv
------------------------------
Title: Converting lateral scanning into axial focusing to speed up three-dimensional microscopy
Authors: T Chakraborty, B Chen, S Daetwyler, BJ Chang, O Vanderpoorten, ...
Journal: Light: Science & Applications 9 (1)
------------------------------
Title: A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease
Authors: T Ikenoue, FA Aprile, P Sormanni, FS Ruggeri, M Perni, GT Heller, ...
Journal: Scientific reports 10 (1)
------------------------------
Title: Mechanism, scaling and rates of protein aggregation from in vivo measurements
Authors: G Meisl, AJ Dear, TCT Michaels, TPJ Knowles
Journal: arXiv preprint arXiv:2008.09699
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Title: Spatially-segmented single-cell transcriptomics by diffusional accessibility to a small-molecule dye
Authors: DB Morse, M Ceribelli, J De Jonghe, A Michalowski, C Muus, M Vias, ...
Journal: Cancer Research 80 (16_Supplement)
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Title: Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
Authors: R Limbocker, B Mannini, FS Ruggeri, R Cascella, CK Xu, M Perni, S Chia, ...
Journal: Communications biology 3 (1)
------------------------------
Title: Kinetic analysis reveals the rates and mechanisms of protein aggregation in a multicellular organism
Authors: T Sinnige, G Meisl, TCT Michaels, M Vendruscolo, TPJ Knowles, ...
Journal: bioRxiv
------------------------------
Title: Microfluidic Templating: Microfluidic Templating of Spatially Inhomogeneous Protein Microgels (Small 32/2020)
Authors: Y Xu, RPB Jacquat, Y Shen, D Vigolo, D Morse, S Zhang, TPJ Knowles
Journal: Small 16 (32)
------------------------------
Title: Microfluidic templating of spatially inhomogeneous protein microgels
Authors: Y Xu, RPB Jacquat, Y Shen, D Vigolo, D Morse, S Zhang, TPJ Knowles
Journal: Small 16 (32)
------------------------------
Title: Phase transition and crystallization kinetics of a supramolecular system in a microfluidic platform
Authors: D Cohen-Gerassi, ZA Arnon, T Guterman, A Levin, M Ghosh, M Aviv, ...
Journal: Chemistry of Materials 32 (19)
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Title: Continuous flow reactors from microfluidic compartmentalization of enzymes within inorganic microparticles
Authors: TA Hakala, F Bialas, Z Toprakcioglu, B Bräuer, KN Baumann, A Levin, ...
Journal: ACS applied materials & interfaces 12 (29)
------------------------------
Title: Rational design of a conformation-specific antibody for the quantification of Aβ oligomers
Authors: FA Aprile, P Sormanni, M Podpolny, S Chhangur, LM Needham, ...
Journal: Proceedings of the National Academy of Sciences 117 (24)
------------------------------
Title: Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy
Authors: FS Ruggeri, B Mannini, R Schmid, M Vendruscolo, TPJ Knowles
Journal: Nature Communications 11 (1)
------------------------------
Title: High resolution and multidimensional protein condensate phase diagrams with a combinatorial microdroplet platform
Authors: WE Arter, R Qi, NA Erkamp, G Krainer, K Didi, TJ Welsh, J Acker, ...
Journal: bioRxiv
------------------------------
Title: Kinetic diversity of amyloid oligomers
Authors: AJ Dear, TCT Michaels, G Meisl, D Klenerman, S Wu, S Perrett, S Linse, ...
Journal: Proceedings of the National Academy of Sciences 117 (22)
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Title: Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform
Authors: M Koopman, Q Peter, RI Seinstra, M Perni, M Vendruscolo, CM Dobson, ...
Journal: Nature protocols 15 (6)
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Title: Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils
Authors: M Törnquist, R Cukalevski, U Weininger, G Meisl, TPJ Knowles, T Leiding, ...
Journal: Proceedings of the National Academy of Sciences 117 (21)
------------------------------
Title: A Microfluidic Co‐Flow Route for Human Serum Albumin‐Drug–Nanoparticle Assembly
Authors: TA Hakala, S Davies, Z Toprakcioglu, B Bernardim, GJL Bernardes, ...
Journal: Chemistry–A European Journal 26 (27)
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Title: Ultrathin polydopamine films with phospholipid nanodiscs containing a glycophorin A domain
Authors: T Marchesi D'Alvise, S Harvey, L Hueske, J Szelwicka, L Veith, ...
Journal: Advanced Functional Materials 30 (21)
------------------------------
Title: Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
Authors: TCT Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, AJ Dear, ...
Journal: Nature chemistry 12 (5)
------------------------------
Title: Single particle zeta-potential measurements reveal the role of electrostatics in protein condensate stability
Authors: TJ Welsh, G Krainer, JR Espinosa, JA Joseph, A Sridhar, M Jahnel, ...
Journal: BioRxiv
------------------------------
Title: Digital sensing and molecular computation by an enzyme-free DNA circuit
Authors: WE Arter, Y Yusim, Q Peter, CG Taylor, D Klenerman, UF Keyser, ...
Journal: ACS nano 14 (5)
------------------------------
Title: Mechanism of droplet-formation in a supersonic microfluidic spray device
Authors: T Kartanas, Z Toprakcioglu, TA Hakala, A Levin, TW Herling, R Daly, ...
Journal: Applied Physics Letters 116 (15)
------------------------------
Title: Microfluidic approaches for the analysis of protein–protein interactions in solution
Authors: WE Arter, A Levin, G Krainer, TPJ Knowles
Journal: Biophysical reviews 12 (2)
------------------------------
Title: The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation
Authors: G Meisl, TPJ Knowles, D Klenerman
Journal: Current opinion in neurobiology 61
------------------------------
Title: Complexity in Lipid Membrane Composition Induces Resilience to Aβ42 Aggregation
Authors: M Sanguanini, KN Baumann, S Preet, S Chia, J Habchi, TPJ Knowles, ...
Journal: ACS chemical neuroscience 11 (9)
------------------------------
Title: Rapid fractionation and characterisation of alpha-synuclein oligomers in solution
Authors: WE Arter, CK Xu, M Castellana-Cruz, TW Herling, G Krainer, KL Saar, ...
Journal: bioRxiv
------------------------------
Title: The influence of pathogenic mutations in α-synuclein on biophysical and structural characteristics of amyloid fibrils
Authors: FS Ruggeri, P Flagmeier, JR Kumita, G Meisl, DY Chirgadze, ...
Journal: ACS nano 14 (5)
------------------------------
Title: Modulating the Mechanical Performance of Macroscale Fibers through Shear‐Induced Alignment and Assembly of Protein Nanofibrils
Authors: A Kamada, A Levin, Z Toprakcioglu, Y Shen, V Lutz‐Bueno, KN Baumann, ...
Journal: Small 16 (9)
------------------------------
Title: Controllable coacervation of recombinantly produced spider silk protein using kosmotropic salts
Authors: P Mohammadi, C Jonkergouw, G Beaune, P Engelhardt, A Kamada, ...
Journal: Journal of colloid and interface science 560
------------------------------
Title: Lipid-stabilized double emulsions generated in planar microfluidic devices
Authors: L Kong, A Levin, Z Toprakcioglu, Y Xu, H Gang, R Ye, BZ Mu, ...
Journal: Langmuir 36 (9)
------------------------------
Title: Biocompatible Hybrid Organic/Inorganic Microhydrogels Promote Bacterial Adherence and Eradication in Vitro and in Vivo
Authors: L Schnaider, Z Toprakcioglu, A Ezra, X Liu, D Bychenko, A Levin, E Gazit, ...
Journal: Nano Letters 20 (3)
------------------------------
Title: Microfluidic Diffusional Sizing for Studying Protein-Protein Interactions
Authors: MM Schneider, T Scheidt, CM Dobson, TPJ Knowles
Journal: Biophysical Journal 118 (3)
------------------------------
Title: Investigation of Natural and Synthetic Aggregation Inhibitors using Microfluidic Applications
Authors: T Scheidt, J Carozza, JL Benesch, P Arosio, S Linse, TPJ Knowles
Journal: Biophysical Journal 118 (3)
------------------------------
Title: Molecular Forces in the Liquid-Liquid Phase Separation of Biomolecules
Authors: TJ Welsh, G Krainer, TP Knowles
Journal: Biophysical Journal 118 (3)
------------------------------
Title: Quantifying the thermodynamic stability of amyloid fibrils
Authors: KL Callaghan, Q Peter, JR Kumita, TP Knowles, CM Dobson
Journal: Biophysical Journal 118 (3)
------------------------------
Title: Attoliter protein nanogels from droplet nanofluidics for intracellular delivery
Authors: Z Toprakcioglu, PK Challa, DB Morse, T Knowles
Journal: Science Advances 6 (6)
------------------------------
Title: Transthyretin inhibits primary and secondary nucleations of amyloid-β peptide aggregation and reduces the toxicity of its oligomers
Authors: SA Ghadami, S Chia, FS Ruggeri, G Meisl, F Bemporad, J Habchi, ...
Journal: Biomacromolecules 21 (3)
------------------------------
Title: Chris Dobson (1949–2019)
Authors: TPJ Knowles, M Vendruscolo
Journal: Nature Chemical Biology 16 (2)
------------------------------
Title: The amyloid phenomenon and its significance in biology and medicine
Authors: CM Dobson, TPJ Knowles, M Vendruscolo
Journal: Cold Spring Harbor perspectives in biology 12 (2)
------------------------------
Title: The catalytic nature of protein aggregation
Authors: AJ Dear, G Meisl, TCT Michaels, MR Zimmermann, S Linse, TPJ Knowles
Journal: The Journal of Chemical Physics 152 (4)
------------------------------
Title: Coating and stabilization of liposomes by clathrin-inspired DNA self-assembly
Authors: KN Baumann, L Piantanida, J García-Nafría, D Sobota, K Voïtchovsky, ...
Journal: Acs Nano 14 (2)
------------------------------
Title: Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils
Authors: J Yang, AJ Dear, QQ Yao, Z Liu, CM Dobson, TPJ Knowles, S Wu, ...
Journal: Nanoscale 12 (36)
------------------------------
Title: Early peak and rapid decline of SARS-CoV-2 seroprevalence in a Swiss metropolitan region
Authors: M Emmenegger, E De Cecco, D Lamparter, RPB Jacquat, D Ebner, ...
Journal: MedRxiv 531
------------------------------
Title: A microfluidic strategy for the detection of membrane protein interactions
Authors: Y Zhang, TW Herling, S Kreida, QAE Peter, T Kartanas, ...
Journal: Lab on a Chip 20 (17)
------------------------------
Title: Half a century of amyloids: past, present and future
Authors: PC Ke, R Zhou, LC Serpell, R Riek, TPJ Knowles, HA Lashuel, E Gazit, ...
Journal: Chemical Society Reviews 49 (15)
------------------------------
Title: Multidimensional protein characterisation using microfluidic post-column analysis
Authors: T Scheidt, T Kartanas, Q Peter, MM Schneider, KL Saar, T Müller, ...
Journal: Lab on a Chip 20 (15)
------------------------------
Title: Early plateau of SARS-CoV-2 seroprevalence identified by tripartite immunoassay in a large population
Authors: M Emmenegger, E De Cecco, D Lamparter, RPB Jacquat, D Ebner, ...
Journal: Medrxiv
------------------------------
Title: Rapid generation of protein condensate phase diagrams using combinatorial droplet microfluidics
Authors: WE Arter, R Qi, G Krainer, TJ Welsh, Y Xu, PS George-Hyslop, S Alberti, ...
Journal: BioRxiv 10 (2020.06)
------------------------------
Title: Identification of on-and off-pathway oligomers in amyloid fibril formation
Authors: AJ Dear, G Meisl, A Šarić, TCT Michaels, M Kjaergaard, S Linse, ...
Journal: Chemical science 11 (24)
------------------------------
Title: Rapid characterisation of protein phase behaviour using droplet microfluidics
Authors: WE Arter
Journal: bioRxiv 10 (2020.06)
------------------------------
Title: Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses
Authors: J Pansieri, IA Iashchishyn, H Fakhouri, L Ostojić, M Malisauskas, ...
Journal: Chemical science 11 (27)
------------------------------
Title: Correction: Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions
Authors: Z Toprakcioglu, TA Hakala, A Levin, CFW Becker, GJL Bernandes, ...
Journal: Soft Matter 16 (14)
------------------------------
Title: Effects of sedimentation, microgravity, hydrodynamic mixing and air–water interface on α-synuclein amyloid formation
Authors: J Zhou, FS Ruggeri, MR Zimmermann, G Meisl, G Longo, SK Sekatskii, ...
Journal: Chemical Science 11 (14)
------------------------------
Title: Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions
Authors: Z Toprakcioglu, TA Hakala, A Levin, CFW Becker, GGL Bernandes, ...
Journal: Soft Matter 16 (12)
------------------------------
2019
------------------------------
Title: Homage to Chris Dobson
Authors: J Baum, F Chiti, A De Simone, TPJ Knowles, JR Kumita, SE Radford, ...
Journal: Frontiers in molecular biosciences 6
------------------------------
Title: Inside Back Cover: Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid–Liquid Phase Separation (Angew. Chem. Int. Ed. 50/2019)
Authors: C Yuan, A Levin, W Chen, R Xing, Q Zou, TW Herling, PK Challa, ...
Journal: Angewandte Chemie International Edition 58 (50)
------------------------------
Title: Innenrücktitelbild: Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid–Liquid Phase Separation (Angew. Chem. 50/2019).
Authors: C Yuan, A Levin, W Chen, R Xing, Q Zou, TW Herling, PK Challa, ...
Journal: Angewandte Chemie 131 (50)
------------------------------
Title: Nucleation and growth of amino acid and peptide supramolecular polymers through liquid–liquid phase separation
Authors: C Yuan, A Levin, W Chen, R Xing, Q Zou, TW Herling, PK Challa, ...
Journal: Angewandte Chemie International Edition 58 (50)
------------------------------
Title: Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression
Authors: S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, ...
Journal: Acta neuropathologica communications 7
------------------------------
Title: Label-free analysis of protein aggregation and phase behavior
Authors: Z Toprakcioglu, P Challa, C Xu, TPJ Knowles
Journal: ACS nano 13 (12)
------------------------------
Title: Top-down proteomics on a microfluidic platform
Authors: Y Zhang, MA Wright, PK Challa, KL Saar, S Devenish, Q Peter, ...
Journal: arXiv preprint arXiv:1910.11861
------------------------------
Title: Kinetic fingerprint of antibody therapies predicts outcomes of Alzheimer clinical trials
Authors: S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, ...
Journal: bioRxiv
------------------------------
Title: Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid
Authors: R Frankel, M Törnquist, G Meisl, O Hansson, U Andreasson, H Zetterberg, ...
Journal: Communications biology 2 (1)
------------------------------
Title: A new platform for drug discovery
Authors: TPJ Knowles
Journal: Future Drug Discovery 1 (2)
------------------------------
Title: RNA granules hitchhike on lysosomes for long-distance transport, using annexin A11 as a molecular tether
Authors: YC Liao, MS Fernandopulle, G Wang, H Choi, L Hao, CM Drerup, R Patel, ...
Journal: Cell 179 (1)
------------------------------
Title: Karakteriseren van individuele eiwit aggregaten door infrarood nano spectroscopie en Atoom kracht microscopie
Authors: FS Ruggeri, T Šneideris, S Chia, M Vendruscolo, TPJ Knowles
Journal: Journal of Visualized Experiments (JoVE)
------------------------------
Title: Characterizing individual protein aggregates by infrared nanospectroscopy and atomic force microscopy
Authors: FS Ruggeri, T Šneideris, S Chia, M Vendruscolo, TPJ Knowles
Journal: JoVE (Journal of Visualized Experiments)
------------------------------
Title: Scalable integration of nano-, and microfluidics with hybrid two-photon lithography
Authors: O Vanderpoorten, Q Peter, PK Challa, UF Keyser, J Baumberg, ...
Journal: Microsystems & nanoengineering 5 (1)
------------------------------
Title: Nanostructured protein capsules
Authors: T Knowles
Journal: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 258
------------------------------
Title: Programmable On‐Chip Artificial Cell Producing Post‐Translationally Modified Ubiquitinated Protein
Authors: S Zilberzwige‐Tal, A Levin, Z Toprakcioglu, TPJ Knowles, E Gazit, J Elbaz
Journal: Small 15 (31)
------------------------------
Title: Enhancement of the anti-aggregation activity of a molecular chaperone using a rationally designed post-translational modification
Authors: PR Lindstedt, FA Aprile, MJ Matos, M Perni, JB Bertoldo, B Bernardim, ...
Journal: ACS Central Science 5 (8)
------------------------------
Title: General sol to gel transition of liquid-liqud phase separated protein under shear
Authors: Y Shen, S Qamar, D Vigolo, A Kamada, S Zhang, P St George-Hyslop, ...
Journal: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 48
------------------------------
Title: Rapid two-dimensional characterisation of proteins in solution
Authors: KL Saar, Q Peter, T Müller, PK Challa, TW Herling, TPJ Knowles
Journal: Microsystems & Nanoengineering 5 (1)
------------------------------
Title: Universality of filamentous aggregation phenomena
Authors: TCT Michaels, AJ Dear, TPJ Knowles
Journal: Physical Review E 99 (6)
------------------------------
Title: Sequence‐optimized peptide nanofibers as growth stimulators for regeneration of peripheral neurons
Authors: C Schilling, T Mack, S Lickfett, S Sieste, FS Ruggeri, T Sneideris, A Dutta, ...
Journal: Advanced Functional Materials 29 (24)
------------------------------
Title: The presence of autoantibodies against the prion protein is independent of PRNP mutations
Authors: K Frontzek, M Carta, M Losa, M Epskamp, G Meisl, U Camenisch, ...
Journal: PRION 13
------------------------------
Title: Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine‐Selective Protein Modification and Charge Modulation
Authors: MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, ...
Journal: Angewandte Chemie International Edition 58 (20)
------------------------------
Title: Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates
Authors: T Scheidt, U Łapińska, JR Kumita, DR Whiten, D Klenerman, MR Wilson, ...
Journal: Science Advances 5 (4)
------------------------------
Title: 3D microfluidics spray nozzle for sample processing and materials deposition
Authors: T Kartanas, R Rodrigues, T Müller, T Herling, T Knowles, J Charmet
Journal: AIP Conference Proceedings 2092 (1)
------------------------------
Title: ADSoluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression
Authors: S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, ...
Journal: bioRxiv
------------------------------
Title: Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
Authors: S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, ...
Journal: Nature communications 10 (1)
------------------------------
Title: Fabrication and characterization of reconstituted silk microgels for the storage and release of small molecules
Authors: X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, ...
Journal: Macromolecular rapid communications 40 (8)
------------------------------
Title: Atomic force microscopy for single molecule characterisation of protein aggregation
Authors: FS Ruggeri, T Šneideris, M Vendruscolo, TPJ Knowles
Journal: Archives of biochemistry and biophysics 664
------------------------------
Title: A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli
Authors: K Sanagavarapu, E Nüske, I Nasir, G Meisl, JN Immink, P Sormanni, ...
Journal: Scientific Reports 9 (1)
------------------------------
Title: Physical determinants of amyloid assembly in biofilm formation
Authors: M Andreasen, G Meisl, JD Taylor, TCT Michaels, A Levin, DE Otzen, ...
Journal: MBio 10 (1)
------------------------------
Title: Increased secondary nucleation underlies accelerated aggregation of the four-residue n-terminally truncated aβ42 species aβ5–42
Authors: T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, ...
Journal: ACS chemical neuroscience 10 (5)
------------------------------
Title: Targeting the Formation of Amyloid Oligomers using Rationally Designed Antibodies
Authors: FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TP Knowles, ...
Journal: Biophysical Journal 116 (3)
------------------------------
Title: Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
Authors: R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, ...
Journal: Nature communications 10 (1)
------------------------------
Title: Protein microgels from amyloid fibril networks
Authors: LWY Roode, U Shimanovich, S Wu, S Perrett, TPJ Knowles
Journal: Biological and Bio-inspired Nanomaterials: Properties and Assembly …
------------------------------
Title: Biological and bio-inspired nanomaterials
Authors: S Perrett, AK Buell, TPJ Knowles
Journal: Springer Singapore
------------------------------
Title: Dynamics and control of peptide self-assembly and aggregation
Authors: G Meisl, TCT Michaels, P Arosio, M Vendruscolo, CM Dobson, ...
Journal: Biological and Bio-inspired Nanomaterials: Properties and Assembly …
------------------------------
Title: Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis
Authors: MA Wright, FS Ruggeri, KL Saar, PK Challa, JLP Benesch, TPJ Knowles
Journal: Analyst 144 (14)
------------------------------
Title: Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species
Authors: JC Sang, JE Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, ...
Journal: Chemical science 10 (17)
------------------------------
Title: Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism
Authors: C Bortolini, T Kartanas, D Copic, IC Morales, Y Zhang, PK Challa, Q Peter, ...
Journal: Lab on a Chip 19 (1)
------------------------------
2018
------------------------------
Title: Mechanobiology of protein droplets: force arises from disorder
Authors: TJ Welsh, Y Shen, A Levin, TPJ Knowles
Journal: Cell 175 (6)
------------------------------
Title: Automated behavioral analysis of large C. elegans populations using a wide field-of-view tracking platform
Authors: M Perni, S Casford, FA Aprile, EA Nollen, TPJ Knowles, M Vendruscolo, ...
Journal: Journal of Visualized Experiments (JoVE)
------------------------------
Title: Reaction rate theory for supramolecular kinetics: application to protein aggregation
Authors: TCT Michaels, LX Liu, S Curk, PG Bolhuis, A Šarić, TPJ Knowles
Journal: Molecular Physics 116 (21-22)
------------------------------
Title: Microfluidic Diffusional Sizing Enables Characterisation of Protein-Protein Interactions Under Native Conditions
Authors: S Devenish, C Thorne, T Scheidt, J Carozza, P Arosio, Y Zhang, A Buell, ...
Journal: PROTEIN SCIENCE 27
------------------------------
Title: On-Chip Measurements of Membrane Protein Interactions
Authors: Y Zhang, T Knowles, S Linse
Journal: PROTEIN SCIENCE 27
------------------------------
Title: Quantifying co-oligomer formation by α-synuclein
Authors: M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, ...
Journal: ACS nano 12 (11)
------------------------------
Title: Statistical mechanics of globular oligomer formation by protein molecules
Authors: AJ Dear, A Šarić, TCT Michaels, CM Dobson, TPJ Knowles
Journal: The Journal of Physical Chemistry B 122 (49)
------------------------------
Title: Direct observation of murine prion protein replication in vitro
Authors: JC Sang, G Meisl, AM Thackray, L Hong, A Ponjavic, TPJ Knowles, ...
Journal: Journal of the American Chemical Society 140 (44)
------------------------------
Title: SAR by kinetics for drug discovery in protein misfolding diseases
Authors: S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, ...
Journal: Proceedings of the National Academy of Sciences 115 (41)
------------------------------
Title: Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity
Authors: FS Ruggeri, J Charmet, T Kartanas, Q Peter, S Chia, J Habchi, ...
Journal: Nature communications 9 (1)
------------------------------
Title: Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes
Authors: Z Li, J Tuffin, IM Lei, FS Ruggeri, NS Lewis, EL Gill, T Savin, L Huleihel, ...
Journal: Acta Biomaterialia 78
------------------------------
Title: Identification of oxidative stress in red blood cells with nanoscale chemical resolution by infrared nanospectroscopy
Authors: FS Ruggeri, C Marcott, S Dinarelli, G Longo, M Girasole, G Dietler, ...
Journal: International journal of molecular sciences 19 (9)
------------------------------
Title: Image-assisted microvessel-on-a-chip platform for studying cancer cell transendothelial migration dynamics
Authors: C Bertulli, M Gerigk, N Piano, Y Liu, D Zhang, T Müller, TJ Knowles, ...
Journal: Scientific reports 8 (1)
------------------------------
Title: DNA-coated functional oil droplets
Authors: A Caciagli, M Zupkauskas, A Levin, TPJ Knowles, C Mugemana, N Bruns, ...
Journal: Langmuir 34 (34)
------------------------------
Title: Self-assembly-mediated release of peptide nanoparticles through jets across microdroplet interfaces
Authors: A Levin, TCT Michaels, TO Mason, T Müller, L Adler-Abramovich, ...
Journal: ACS applied materials & interfaces 10 (33)
------------------------------
Title: Combining affinity selection and specific ion mobility for microchip protein sensing
Authors: WE Arter, J Charmet, J Kong, KL Saar, TW Herling, T Müller, UF Keyser, ...
Journal: Analytical chemistry 90 (17)
------------------------------
Title: Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery
Authors: M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, ...
Journal: Journal of neuroscience methods 306
------------------------------
Title: Extrinsic amyloid-binding dyes for detection of individual protein aggregates in solution
Authors: CG Taylor, G Meisl, MH Horrocks, H Zetterberg, TPJ Knowles, ...
Journal: Analytical chemistry 90 (17)
------------------------------
Title: Conserved S/T residues of the human chaperone DNAJB6 are required for effective inhibition of Aβ42 amyloid fibril formation
Authors: C Mansson, RTP Van Cruchten, U Weininger, X Yang, R Cukalevski, ...
Journal: Biochemistry 57 (32)
------------------------------
Title: Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils
Authors: FS Ruggeri, F Benedetti, TPJ Knowles, HA Lashuel, S Sekatskii, G Dietler
Journal: Proceedings of the National Academy of Sciences 115 (28)
------------------------------
Title: Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions
Authors: B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, ...
Journal: ACS chemical neuroscience 9 (12)
------------------------------
Title: O2‐02‐02: TARGETING AMYLOID FORMATION USING RATIONALLY DESIGNED ANTIBODIES
Authors: FA Aprile, P Sormanni, M Perni, P Arosio, R Limbocker, S Chhangur, ...
Journal: Alzheimer's & Dementia 14 (7S_Part_11)
------------------------------
Title: O3‐01‐05: IN VITRO MEASUREMENTS OF TAU AGGREGATE ELONGATION AND FRAGMENTATION RATES ALLOW THE MODELLING OF PRION‐LIKE SPREADING IN HUMANS
Authors: D Klenerman, F Kundel, B Falcon, T Knowles, M Goedert, L Hong, ...
Journal: Alzheimer's & Dementia 14 (7S_Part_19)
------------------------------
Title: Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
Authors: M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ...
Journal: ACS chemical biology 13 (8)
------------------------------
Title: Oligomer diversity during the aggregation of the repeat region of tau
Authors: M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, ...
Journal: ACS chemical neuroscience 9 (12)
------------------------------
Title: PNAS PLUS
Authors: C Yang, G Meisl, B Frohm, E Thulin, TPJ Knowles, S Linse
Journal: PNAS 115 (26)
------------------------------
Title: On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations
Authors: X Yang, G Meisl, B Frohm, E Thulin, TPJ Knowles, S Linse
Journal: Proceedings of the National Academy of Sciences 115 (26)
------------------------------
Title: Enhancing the resolution of micro free flow electrophoresis through spatially controlled sample injection
Authors: KL Saar, T Müller, J Charmet, PK Challa, TPJ Knowles
Journal: Analytical chemistry 90 (15)
------------------------------
Title: Determination of polypeptide conformation with nanoscale resolution in water
Authors: G Ramer, FS Ruggeri, A Levin, TPJ Knowles, A Centrone
Journal: ACS nano 12 (7)
------------------------------
Title: Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
Authors: J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, ...
Journal: Nature chemistry 10 (6)
------------------------------
Title: Water‐Dispersible Polydopamine‐Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion
Authors: S Sieste, T Mack, CV Synatschke, C Schilling, C Meyer zu Reckendorf, ...
Journal: Advanced Healthcare Materials 7 (11)
------------------------------
Title: Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils
Authors: Y Song, TCT Michaels, Q Ma, Z Liu, H Yuan, S Takayama, TPJ Knowles, ...
Journal: Nature communications 9 (1)
------------------------------
Title: Stochastic calculus of protein filament formation under spatial confinement
Authors: TCT Michaels, AJ Dear, TPJ Knowles
Journal: New journal of physics 20 (5)
------------------------------
Title: Rapid growth of acetylated Aβ (16–20) into macroscopic crystals
Authors: C Bortolini, LH Klausen, SV Hoffmann, NC Jones, D Saadeh, Z Wang, ...
Journal: ACS nano 12 (6)
------------------------------
Title: Cooperative assembly of Hsp70 subdomain clusters
Authors: MA Wright, FA Aprile, MMJ Bellaiche, TCT Michaels, T Müller, P Arosio, ...
Journal: Biochemistry 57 (26)
------------------------------
Title: Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide
Authors: SIA Cohen, R Cukalevski, TCT Michaels, A Šarić, M Törnquist, ...
Journal: Nature chemistry 10 (5)
------------------------------
Title: Chemical kinetics for bridging molecular mechanisms and macroscopic measurements of amyloid fibril formation
Authors: TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, ...
Journal: Annual review of physical chemistry 69 (1)
------------------------------
Title: FUS phase separation is modulated by a molecular chaperone and methylation of arginine cation-π interactions
Authors: S Qamar, GZ Wang, SJ Randle, FS Ruggeri, JA Varela, JQ Lin, ...
Journal: Cell 173 (3)
------------------------------
Title: Biophotonics of native silk fibrils
Authors: U Shimanovich, D Pinotsi, K Shimanovich, N Yu, S Bolisetty, J Adamcik, ...
Journal: Macromolecular bioscience 18 (4)
------------------------------
Title: Measurement of tau filament fragmentation provides insights into prion-like spreading
Authors: F Kundel, L Hong, B Falcon, WA McEwan, TCT Michaels, G Meisl, ...
Journal: ACS chemical neuroscience 9 (6)
------------------------------
Title: Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1
Authors: S George-Hyslop, S Qamar, G Wang, SJ Randle, FS Ruggeri, J Varela, ...
Journal: Elsevier
------------------------------
Title: Microfluidics for protein biophysics
Authors: J Charmet, P Arosio, TPJ Knowles
Journal: Journal of molecular biology 430 (5)
------------------------------
Title: Direct observation of oligomerization by single molecule fluorescence reveals a multistep aggregation mechanism for the yeast prion protein Ure2
Authors: J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Wu, ...
Journal: Journal of the American Chemical Society 140 (7)
------------------------------
Title: Real-time intrinsic fluorescence visualization and sizing of proteins and protein complexes in microfluidic devices
Authors: PK Challa, Q Peter, MA Wright, Y Zhang, KL Saar, JA Carozza, ...
Journal: Analytical chemistry 90 (6)
------------------------------
Title: Revealing the Mechanism of Amyloid Fibril Formation by Combined Single Molecule FRET and Kinetic Modeling
Authors: J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Perrett, ...
Journal: Biophysical Journal 114 (3)
------------------------------
Title: 2-Photon Lithography for Nanofluidic Lab-on-Chip Devices
Authors: O Vanderpoorten, PK Challa, Q Peter, J Charmet, N Curry, TPJ Knowles, ...
Journal: Biophysical Journal 114 (3)
------------------------------
Title: Systematic development of small molecules to inhibit specific microscopic steps of amyloid-beta42 aggregation in Alzheimer's disease
Authors: S Chia, J Habchi, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, ...
Journal: Biophysical Journal 114 (3)
------------------------------
Title: Modulating amyloid-beta aggregation to reduce the toxicity of its oligomeric aggregates
Authors: R Limbocker, B Mannini, S Chia, FS Ruggeri, M Perni, R Cascella, C Xu, ...
Journal: Biophysical Journal 114 (3)
------------------------------
Title: Probing the Interaction of ABETA42 Amyloid Species with an Aggregation Suppressor Molecule by Infrared Nanospectroscopy
Authors: FS Ruggeri, J Habchi, S Chia, M Vendruscolo, TPJ Knowles
Journal: Biophysical Journal 114 (3)
------------------------------
Title: Molecular Mechanism of AB42 Peptide-Fibril Adsorption
Authors: MMJ Bellaiche, TPJ Knowles, RB Best
Journal: Biophysical Journal 114 (3)
------------------------------
Title: Microfluidic diffusion platform for characterizing the sizes of lipid vesicles and the thermodynamics of protein–lipid interactions
Authors: H Gang, C Galvagnion, G Meisl, T Muller, M Pfammatter, AK Buell, ...
Journal: Analytical chemistry 90 (5)
------------------------------
Title: Mimicking Dividing Cells by Assembly of Protein Structures Inside Aqueous Two-Phase Droplets
Authors: HC Shum, Y Song, T Knowles, T Michaels
Journal: Materials Research Society (MRS) Fall Meeting 2018
------------------------------
Title: Observation of molecular self-assembly events in massively parallel microdroplet arrays
Authors: Z Toprakcioglu, PK Challa, A Levin, TPJ Knowles
Journal: Lab on a Chip 18 (21)
------------------------------
Title: Devices and applications at the micro-and nanoscale rsc. li/loc
Authors: TW Herling, A Levin, KL Saar, CM Dobson, TPJ Knowles
Journal: Lab Chip 18 (1026)
------------------------------
Title: Secondary nucleation in amyloid formation
Authors: M Törnquist, TCT Michaels, K Sanagavarapu, X Yang, G Meisl, ...
Journal: Chemical communications 54 (63)
------------------------------
Title: Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils
Authors: JWP Brown, G Meisl, TPJ Knowles, AK Buell, CM Dobson, C Galvagnion
Journal: Chemical Communications 54 (56)
------------------------------
Title: Origin of metastable oligomers and their effects on amyloid fibril self-assembly
Authors: F Hasecke, T Miti, C Perez, J Barton, D Schölzel, L Gremer, CSR Grüning, ...
Journal: Chemical science 9 (27)
------------------------------
Title: Kinetic analysis of amyloid formation
Authors: G Meisl, TCT Michaels, S Linse, TPJ Knowles
Journal: Amyloid Proteins: Methods and Protocols
------------------------------
Title: C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH
Authors: IM van der Wateren, TPJ Knowles, AK Buell, CM Dobson, C Galvagnion
Journal: Chemical science 9 (25)
------------------------------
Title: Microfluidic approaches for probing amyloid assembly and behaviour
Authors: TW Herling, A Levin, KL Saar, CM Dobson, TPJ Knowles
Journal: Lab on a Chip 18 (7)
------------------------------
Title: On-chip measurements of protein unfolding from direct observations of micron-scale diffusion
Authors: Y Zhang, EV Yates, L Hong, KL Saar, G Meisl, CM Dobson, TPJ Knowles
Journal: Chemical science 9 (14)
------------------------------
Title: Enhancing power density of biophotovoltaics by decoupling storage and power delivery
Authors: KL Saar, P Bombelli, DJ Lea-Smith, T Call, EM Aro, T Müller, CJ Howe, ...
Journal: Nature energy 3 (1)
------------------------------
Title: On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products
Authors: KL Saar, Y Zhang, T Müller, CP Kumar, S Devenish, A Lynn, U Łapińska, ...
Journal: Lab on a Chip 18 (1)
------------------------------
2017
------------------------------
Title: Mechanism of biosurfactant adsorption to oil/water interfaces from millisecond scale tensiometry measurements
Authors: L Kong, KL Saar, R Jacquat, L Hong, A Levin, H Gang, R Ye, B Mu, ...
Journal: Interface Focus 7 (6)
------------------------------
Title: Nanoscale click-reactive scaffolds from peptide self-assembly
Authors: APM Guttenplan, LJ Young, D Matak-Vinkovic, CF Kaminski, TPJ Knowles, ...
Journal: Journal of Nanobiotechnology 15
------------------------------
Title: Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species
Authors: M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, ...
Journal: BMC biology 15
------------------------------
Title: Enhanced quality factor label-free biosensing with micro-cantilevers integrated into microfluidic systems
Authors: T Kartanas, V Ostanin, PK Challa, R Daly, J Charmet, TPJ Knowles
Journal: Analytical chemistry 89 (22)
------------------------------
Title: Absolute quantification of amyloid propagons by digital microfluidics
Authors: M Pfammatter, M Andreasen, G Meisl, CG Taylor, J Adamcik, S Bolisetty, ...
Journal: Analytical chemistry 89 (22)
------------------------------
Title: Hierarchical biomolecular emulsions using 3-D microfluidics with uniform surface chemistry
Authors: Z Toprakcioglu, A Levin, TPJ Knowles
Journal: Biomacromolecules 18 (11)
------------------------------
Title: Thermodynamics of polypeptide supramolecular assembly in the short-chain limit
Authors: TO Mason, TCT Michaels, A Levin, CM Dobson, E Gazit, TPJ Knowles, ...
Journal: Journal of the American Chemical Society 139 (45)
------------------------------
Title: Sequential release of proteins from structured multishell microcapsules
Authors: U Shimanovich, TCT Michaels, E De Genst, D Matak-Vinkovic, ...
Journal: Biomacromolecules 18 (10)
------------------------------
Title: Kinetic constraints on self-assembly into closed supramolecular structures
Authors: TCT Michaels, MMJ Bellaiche, MF Hagan, TPJ Knowles
Journal: Scientific reports 7 (1)
------------------------------
Title: Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates
Authors: S Chia, P Flagmeier, J Habchi, V Lattanzi, S Linse, CM Dobson, ...
Journal: Proceedings of the National Academy of Sciences 114 (30)
------------------------------
Title: Silk micrococoons for protein stabilisation and molecular encapsulation
Authors: U Shimanovich, FS Ruggeri, E De Genst, J Adamcik, TP Barros, D Porter, ...
Journal: Nature communications 8 (1)
------------------------------
Title: Silk micrococoons for protein stabilisation and molecular encapsulation
Authors: F Vollrath, D Porter, U Shimanovich, S Ruggeri, E de Genst, J Adamcik, ...
Journal: Nature Communications 8
------------------------------
Title: Evidence for self-replication of Alzheimer-associated A beta 42 amyloid along the sides of fibrils
Authors: M Tornquist, R Cukalevski, U Weininger, G Meisl, TPJ Knowles, T Leiding, ...
Journal: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 46
------------------------------
Title: Measuring the prion-like character of tau by TIRF microscopy
Authors: F Kundel, B Falcon, L Hong, N Esteras, AJ Dear, AY Abramov, ...
Journal: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 46
------------------------------
Title: Single amyloid aggregates chemical and structural analysis by infrared nanospectroscopy
Authors: FS Ruggeri, J Habchi, C Sean, M Vendruscolo, TPJ Knowles
Journal: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 46
------------------------------
Title: Mechanisms of Amyloid-beta 42 oligomer formation from kinetic analysis
Authors: TC Michaels, A Saric, HW Lazell, P Arosio, M Vendruscolo, CM Dobson, ...
Journal: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 46
------------------------------
Title: A microfluidic platform for quantitative protein studies
Authors: TW Herling, P Arosio, T Mueller, DJ O'Connell, MC Bauer, J Persson, ...
Journal: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 46
------------------------------
Title: Self‐assembled Protein Fibril‐metal Oxide Nanocomposites
Authors: A Levin, TO Mason, TPJ Knowles, U Shimanovich
Journal: Israel Journal of Chemistry 57 (7-8)
------------------------------
Title: Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates
Authors: P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, ...
Journal: Angewandte Chemie International Edition 56 (27)
------------------------------
Title: Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
Authors: FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, ...
Journal: Science advances 3 (6)
------------------------------
Title: Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication
Authors: A Munke, J Persson, T Weiffert, E De Genst, G Meisl, P Arosio, ...
Journal: Proceedings of the National Academy of Sciences 114 (25)
------------------------------
Title: Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers
Authors: P Varilly, AP Willard, JB Kirkegaard, TPJ Knowles, D Chandler
Journal: The Journal of Chemical Physics 146 (13)
------------------------------
Title: Acceleration of α-synuclein aggregation
Authors: R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, ...
Journal: Amyloid 24 (sup1)
------------------------------
Title: Exciton coupling of phenylalanine reveals conformational changes of cationic peptides
Authors: C Bortolini, L Liu, SV Hoffmann, NC Jones, TPJ Knowles, M Dong
Journal: ChemistrySelect 2 (8)
------------------------------
Title: Physical principles of filamentous protein self-assembly kinetics
Authors: TCT Michaels, LX Liu, G Meisl, TPJ Knowles
Journal: Journal of Physics: Condensed Matter 29 (15)
------------------------------
Title: Inhibition of α-synuclein fibril elongation by Hsp70 is governed by a kinetic binding competition between α-synuclein species
Authors: FA Aprile, P Arosio, G Fusco, SW Chen, JR Kumita, A Dhulesia, P Tortora, ...
Journal: Biochemistry 56 (9)
------------------------------
Title: A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
Authors: M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ...
Journal: Proceedings of the National Academy of Sciences 114 (6)
------------------------------
Title: Attenuating the Toxicity of Amyloid-Beta Aggregation with Specific Species
Authors: R Limbocker, B Mannini, M Perni, S Chia, G Heller, FS Ruggeri, J Habchi, ...
Journal: Biophysical Journal 112 (3)
------------------------------
Title: Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease
Authors: J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, ...
Journal: Proceedings of the National Academy of Sciences 114 (2)
------------------------------
Title: Scaling behaviour and rate-determining steps in filamentous self-assembly
Authors: G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, ...
Journal: Chemical science 8 (10)
------------------------------
Title: Gradient-free determination of isoelectric points of proteins on chip
Authors: U Łapińska, KL Saar, EV Yates, TW Herling, T Müller, PK Challa, ...
Journal: Physical Chemistry Chemical Physics 19 (34)
------------------------------
Title: Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification
Authors: R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, ...
Journal: Quarterly reviews of biophysics 50
------------------------------
Title: Microfluidic devices fabricated using fast wafer-scale LED-lithography patterning
Authors: PK Challa, T Kartanas, J Charmet, TPJ Knowles
Journal: Biomicrofluidics 11 (1)
------------------------------
Title: Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants
Authors: G Meisl, X Yang, CM Dobson, S Linse, TPJ Knowles
Journal: Chemical science 8 (6)
------------------------------
2016
------------------------------
Title: Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation
Authors: A Šarić, TCT Michaels, A Zaccone, TPJ Knowles, D Frenkel
Journal: The Journal of chemical physics 145 (21)
------------------------------
Title: Dynamics of heteromolecular filament formation
Authors: AJ Dear, TCT Michaels, TPJ Knowles
Journal: The Journal of Chemical Physics 145 (17)
------------------------------
Title: β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces
Authors: JWP Brown, AK Buell, TCT Michaels, G Meisl, J Carozza, P Flagmeier, ...
Journal: Scientific reports 6 (1)
------------------------------
Title: Dynamic microfluidic control of supramolecular peptide self-assembly
Authors: ZA Arnon, A Vitalis, A Levin, TCT Michaels, A Caflisch, TPJ Knowles, ...
Journal: Nature communications 7 (1)
------------------------------
Title: Protein Aggregate‐Ligand Binding Assays Based on Microfluidic Diffusional Separation
Authors: Y Zhang, AK Buell, T Müller, E De Genst, J Benesch, CM Dobson, ...
Journal: ChemBioChem 17 (20)
------------------------------
Title: Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces
Authors: Y Song, U Shimanovich, TCT Michaels, Q Ma, J Li, TPJ Knowles, ...
Journal: Nature Communications 7 (1)
------------------------------
Title: Scaling and dimensionality in the chemical kinetics of protein filament formation
Authors: TCT Michaels, AJ Dear, TPJ Knowles
Journal: International Reviews in Physical Chemistry 35 (4)
------------------------------
Title: Elastic instability-mediated actuation by a supra-molecular polymer
Authors: A Levin, TCT Michaels, L Adler-Abramovich, TO Mason, T Mueller, ...
Journal: Nature Physics 12 (10)
------------------------------
Title: Kinetics of fragmentation and dissociation of two-strand protein filaments: Coarse-grained simulations and experiments
Authors: A Zaccone, I Terentjev, TW Herling, TPJ Knowles, A Aleksandrova, ...
Journal: The Journal of Chemical Physics 145 (10)
------------------------------
Title: Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation
Authors: P Flagmeier, G Meisl, M Vendruscolo, TPJ Knowles, CM Dobson, ...
Journal: Proceedings of the National Academy of Sciences 113 (37)
------------------------------
Title: Physical determinants of the self-replication of protein fibrils
Authors: A Šarić, AK Buell, G Meisl, TCT Michaels, CM Dobson, S Linse, ...
Journal: Nature physics 12 (9)
------------------------------
Title: Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly
Authors: L Adler-Abramovich, P Marco, ZA Arnon, RCG Creasey, TCT Michaels, ...
Journal: ACS nano 10 (8)
------------------------------
Title: Synthesis of nonequilibrium supramolecular peptide polymers on a microfluidic platform
Authors: TO Mason, TCT Michaels, A Levin, E Gazit, CM Dobson, AK Buell, ...
Journal: Journal of the American Chemical Society 138 (30)
------------------------------
Title: Amyloid fibrils as building blocks for natural and artificial functional materials
Authors: TPJ Knowles, R Mezzenga
Journal: Advanced materials 28 (31)
------------------------------
Title: Analysis of the length distribution of amyloid fibrils by centrifugal sedimentation
Authors: P Arosio, T Cedervall, TPJ Knowles, S Linse
Journal: Analytical Biochemistry 504
------------------------------
Title: Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms
Authors: M Iljina, GA Garcia, AJ Dear, J Flint, P Narayan, TCT Michaels, ...
Journal: Scientific reports 6 (1)
------------------------------
Title: Research Data Supporting" Quantifying measurement fluctuations from stochastic surface processes on sensors with heterogeneous sensitivity"
Authors: J Charmet, TCT Michaels, R Daly, A Prasad, P Thiruvenkathanathan, ...
Journal: University of Cambridge
------------------------------
Title: Fluctuations in the kinetics of linear protein self-assembly
Authors: TCT Michaels, AJ Dear, JB Kirkegaard, KL Saar, DA Weitz, TPJ Knowles
Journal: Physical review letters 116 (25)
------------------------------
Title: Quantifying measurement fluctuations from stochastic surface processes on sensors with heterogeneous sensitivity
Authors: J Charmet, TCT Michaels, R Daly, A Prasad, P Thiruvenkathanathan, ...
Journal: Physical Review Applied 5 (6)
------------------------------
Title: Particle-based Monte-Carlo simulations of steady-state mass transport at intermediate Péclet numbers
Authors: T Müller, P Arosio, L Rajah, SIA Cohen, EV Yates, M Vendruscolo, ...
Journal: International Journal of Nonlinear Sciences and Numerical Simulation 17 (3-4 …
------------------------------
Title: A microfluidic platform for real-time detection and quantification of protein-ligand interactions
Authors: TW Herling, DJ O’Connell, MC Bauer, J Persson, U Weininger, ...
Journal: Biophysical journal 110 (9)
------------------------------
Title: Self-assembly of MPG1, a hydrophobin protein from the rice blast fungus that forms functional amyloid coatings, occurs by a surface-driven mechanism
Authors: CLL Pham, A Rey, V Lo, M Soulès, Q Ren, G Meisl, TPJ Knowles, ...
Journal: Scientific reports 6 (1)
------------------------------
Title: Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones
Authors: JD Taylor, WJ Hawthorne, J Lo, A Dear, N Jain, G Meisl, M Andreasen, ...
Journal: Scientific Reports 6 (1)
------------------------------
Title: The S/T-rich motif in the DNAJB6 chaperone delays polyglutamine aggregation and the onset of disease in a mouse model
Authors: V Kakkar, C Månsson, EP de Mattos, S Bergink, M van Der Zwaag, ...
Journal: Molecular cell 62 (2)
------------------------------
Title: Research data supporting" Physical determinants for the self-replication of protein fibrils"
Authors: A Šarić, AK Buell, G Meisl, T Michaels, CM Dobson, S Linse, TPJ Knowles, ...
Journal: University of Cambridge
------------------------------
Title: Microfluidic diffusion viscometer for rapid analysis of complex solutions
Authors: P Arosio, K Hu, FA Aprile, T Müller, TPJ Knowles
Journal: Analytical chemistry 88 (7)
------------------------------
Title: Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation
Authors: P Arosio, TCT Michaels, S Linse, C Månsson, C Emanuelsson, J Presto, ...
Journal: Nature communications 7 (1)
------------------------------
Title: Quantitative thermophoretic study of disease-related protein aggregates
Authors: M Wolff, JJ Mittag, TW Herling, ED Genst, CM Dobson, TPJ Knowles, ...
Journal: Scientific reports 6 (1)
------------------------------
Title: A fragment-based method of creating small-molecule libraries to target the aggregation of intrinsically disordered proteins
Authors: P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo
Journal: ACS combinatorial science 18 (3)
------------------------------
Title: An environmentally sensitive fluorescent dye as a multidimensional probe of amyloid formation
Authors: EV Yates, G Meisl, TPJ Knowles, CM Dobson
Journal: The Journal of Physical Chemistry B 120 (9)
------------------------------
Title: Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
Authors: M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, ...
Journal: Proceedings of the National Academy of Sciences 113 (9)
------------------------------
Title: Oligomers of heat-shock proteins: structures that don’t imply function
Authors: WM Jacobs, TPJ Knowles, D Frenkel
Journal: PLoS computational biology 12 (2)
------------------------------
Title: Consistent treatment of hydrophobicity in protein lattice models accounts for cold denaturation
Authors: E Van Dijk, P Varilly, TPJ Knowles, D Frenkel, S Abeln
Journal: Physical review letters 116 (7)
------------------------------
Title: Combining Single-Molecule Techniques with Microfluidics for Protein Analysis
Authors: C Taylor, T Knowles, D Klenerman
Journal: Biophysical Journal 110 (3)
------------------------------
Title: An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease
Authors: J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, ...
Journal: Science advances 2 (2)
------------------------------
Title: Automated ex situ assays of amyloid formation on a microfluidic platform
Authors: KL Saar, EV Yates, T Müller, S Saunier, CM Dobson, TPJ Knowles
Journal: Biophysical Journal 110 (3)
------------------------------
Title: Molecular mechanisms of protein aggregation from global fitting of kinetic models
Authors: G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, ...
Journal: Nature protocols 11 (2)
------------------------------
Title: Microfluidic diffusion analysis of the sizes and interactions of proteins under native solution conditions
Authors: P Arosio, T Müller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, ...
Journal: ACS nano 10 (1)
------------------------------
Title: Hamiltonian dynamics of protein filament formation
Authors: TCT Michaels, SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
Journal: Physical review letters 116 (3)
------------------------------
Title: Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide
Authors: G Meisl, X Yang, B Frohm, TPJ Knowles, S Linse
Journal: Scientific reports 6 (1)
------------------------------
Title: Micro-and nanoscale hierarchical structure of core–shell protein microgels
Authors: LR Volpatti, U Shimanovich, FS Ruggeri, S Bolisetty, T Müller, TO Mason, ...
Journal: Journal of Materials Chemistry B 4 (48)
------------------------------
2015
------------------------------
Title: N-terminal extensions retard Aβ42 fibril formation but allow cross-seeding and coaggregation with Aβ42
Authors: O Szczepankiewicz, B Linse, G Meisl, E Thulin, B Frohm, C Sala Frigerio, ...
Journal: Journal of the American Chemical Society 137 (46)
------------------------------
Title: Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants
Authors: L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, ...
Journal: Scientific reports 5 (1)
------------------------------
Title: The length distribution of frangible biofilaments
Authors: TCT Michaels, P Yde, JCW Willis, MH Jensen, D Otzen, CM Dobson, ...
Journal: The Journal of chemical physics 143 (16)
------------------------------
Title: Particle-based simulations of steady-state mass transport at high P'eclet numbers
Authors: T Müller, P Arosio, L Rajah, SIA Cohen, EV Yates, M Vendruscolo, ...
Journal: arXiv preprint arXiv:1510.05126
------------------------------
Title: New Insights into Individual Amyloid Aggregates Structure by Infrared Nanospectroscopy
Authors: FS Ruggeri, S Vieweg, G Longo, T Knowles, H Lashuel, G Dietler
Journal: FTIR Spectroscopy in Microbiological and Medical Diagnostics
------------------------------
Title: Sizing and interactions of proteins under native conditions from microfluidic diffusion measurements: application to molecular chaperones and single-step immunoassay
Authors: P Arosio, T Mueller, L Rajah, F Aprile, T Scheidt, J Carrozza, M Wright, ...
Journal: PROTEIN SCIENCE 24
------------------------------
Title: Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity
Authors: EV Yates, T Müller, L Rajah, EJ De Genst, P Arosio, S Linse, ...
Journal: Nature chemistry 7 (10)
------------------------------
Title: Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers
Authors: MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, ...
Journal: Analytical chemistry 87 (17)
------------------------------
Title: Molecular rotors provide insights into microscopic structural changes during protein aggregation
Authors: AJ Thompson, TW Herling, M Kubánková, A Vyšniauskas, TPJ Knowles, ...
Journal: The Journal of Physical Chemistry B 119 (32)
------------------------------
Title: Dynamics of protein aggregation and oligomer formation governed by secondary nucleation
Authors: TCT Michaels, HW Lazell, P Arosio, TPJ Knowles
Journal: The Journal of chemical physics 143 (5)
------------------------------
Title: Force generation by the growth of amyloid aggregates
Authors: TW Herling, GA Garcia, TCT Michaels, W Grentz, J Dean, U Shimanovich, ...
Journal: Proceedings of the National Academy of Sciences 112 (31)
------------------------------
Title: Rapid sizing of proteins in complex solutions
Authors: P Arosio, T Muller, L Rajah, EV Yates, FA Aprile, SIA Cohen, DA White, ...
Journal: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 44
------------------------------
Title: Crucial role of non-specific interactions in amyloid nucleation
Authors: A Saric, YC Chebaro, TPJ Knowles, D Frenkel
Journal: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 44
------------------------------
Title: New insights into the mechanism of amyloid formation by alpha-synuclein
Authors: AK Buell, C Galvagnion, CM Dobson, TPJ Knowles
Journal: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 44
------------------------------
Title: Enzymatically active microgels from self-assembling protein nanofibrils for microflow chemistry
Authors: XM Zhou, U Shimanovich, TW Herling, S Wu, CM Dobson, TPJ Knowles, ...
Journal: ACS nano 9 (6)
------------------------------
Title: Aggregation‐Prone Amyloid‐β⋅ CuII Species Formed on the Millisecond Timescale under Mildly Acidic Conditions
Authors: JT Pedersen, CB Borg, TCT Michaels, TPJ Knowles, P Faller, K Teilum, ...
Journal: ChemBioChem 16 (9)
------------------------------
Title: Neuronal Cx3cr1 deficiency protects against amyloid β-induced neurotoxicity
Authors: J Dworzak, B Renvoisé, J Habchi, EV Yates, C Combadière, TP Knowles, ...
Journal: PloS one 10 (6)
------------------------------
Title: A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
Authors: SL Shammas, GA Garcia, S Kumar, M Kjaergaard, MH Horrocks, N Shivji, ...
Journal: Nature communications 6 (1)
------------------------------
Title: Preventing peptide and protein misbehavior
Authors: P Arosio, G Meisl, M Andreasen, TPJ Knowles
Journal: Proceedings of the National Academy of Sciences 112 (17)
------------------------------
Title: Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
Authors: SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, ...
Journal: Proceedings of the National Academy of Sciences 112 (16)
------------------------------
Title: Tetracycline Nanoparticles as Antibacterial and Gene‐Silencing Agents
Authors: U Shimanovich, A Lipovsky, D Eliaz, S Zigdon, TPJ Knowles, Y Nitzan, ...
Journal: Advanced healthcare materials 4 (5)
------------------------------
Title: Multiphase protein microgels
Authors: U Shimanovich, Y Song, J Brujic, HC Shum, TPJ Knowles
Journal: Macromolecular bioscience 15 (4)
------------------------------
Title: The physical basis of protein misfolding disorders
Authors: TPJ Knowles, M Vendruscolo, CM Dobson
Journal: Physics today 68 (3)
------------------------------
Title: A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
Authors: SIA Cohen, P Arosio, J Presto, FR Kurudenkandy, H Biverstål, L Dolfe, ...
Journal: Nature structural & molecular biology 22 (3)
------------------------------
Title: Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
Authors: C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, ...
Journal: Nature chemical biology 11 (3)
------------------------------
Title: Microfluidic free-flow electrophoresis for the discovery and characterisation of calmodulin binding partners
Authors: T Herling, S Linse, T Knowles
Journal: APS March Meeting Abstracts 2015
------------------------------
Title: Kinetics of protein aggregation
Authors: T Knowles
Journal: APS March Meeting Abstracts 2015
------------------------------
Title: Protein microgels from amyloid fibril networks
Authors: U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, ...
Journal: ACS nano 9 (1)
------------------------------
Title: Kinetic theory of protein filament growth: Self-consistent methods and perturbative techniques
Authors: TCT Michaels, TPJ Knowles
Journal: International Journal of Modern Physics B 29 (02)
------------------------------
Title: Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates
Authors: MA Wright, FA Aprile, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
Journal: Chemical communications 51 (77)
------------------------------
Title: The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation
Authors: R Cukalevski, X Yang, G Meisl, U Weininger, K Bernfur, B Frohm, ...
Journal: Chemical science 6 (7)
------------------------------
Title: A microfluidic platform for quantitative measurements of effective protein charges and single ion binding in solution
Authors: TW Herling, P Arosio, T Müller, S Linse, TPJ Knowles
Journal: Physical Chemistry Chemical Physics 17 (18)
------------------------------
Title: On the lag phase in amyloid fibril formation
Authors: P Arosio, TPJ Knowles, S Linse
Journal: Physical Chemistry Chemical Physics 17 (12)
------------------------------
Title: A high power‐density, mediator‐free, microfluidic biophotovoltaic device for cyanobacterial cells
Authors: P Bombelli, T Müller, TW Herling, CJ Howe, TPJ Knowles
Journal: Advanced energy materials 5 (2)
------------------------------
2014
------------------------------
Title: Crucial role of nonspecific interactions in amyloid nucleation
Authors: A Sˇaric, YC Chebaro, TPJ Knowles, D Frenkel
Journal: Proceedings of the National Academy of Sciences of the United States of …
------------------------------
Title: Crucial role of nonspecific interactions in amyloid nucleation
Authors: A Šarić, YC Chebaro, TPJ Knowles, D Frenkel
Journal: Proceedings of the National Academy of Sciences 111 (50)
------------------------------
Title: Easyworm: an open-source software tool to determine the mechanical properties of worm-like chains
Authors: G Lamour, JB Kirkegaard, H Li, TPJ Knowles, J Gsponer
Journal: Source code for biology and medicine 9
------------------------------
Title: Dry-mass sensing for microfluidics
Authors: T Müller, DA White, TPJ Knowles
Journal: Applied Physics Letters 105 (21)
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Title: Ostwald’s rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers
Authors: A Levin, TO Mason, L Adler-Abramovich, AK Buell, G Meisl, C Galvagnion, ...
Journal: Nature communications 5 (1)
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Title: Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation
Authors: C Månsson, P Arosio, R Hussein, HH Kampinga, RM Hashem, ...
Journal: Journal of Biological Chemistry 289 (45)
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Title: The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation
Authors: AK Buell, CM Dobson, TPJ Knowles
Journal: Essays in biochemistry 56
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Title: Amyloid Beta Peptide A beta 40 and A beta 42 Form Separate Fibrils in Binary Mixtures
Authors: X Yang, R Cukalevski, G Meisl, B Frohm, T Knowles, S Linse
Journal: PROTEIN SCIENCE 23
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Title: Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides
Authors: G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, ...
Journal: Proceedings of the National Academy of Sciences 111 (26)
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Title: Self‐assembly of amyloid fibrils that display active enzymes
Authors: XM Zhou, A Entwistle, H Zhang, AP Jackson, TO Mason, U Shimanovich, ...
Journal: ChemCatChem 6 (7)
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Title: Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization
Authors: TCT Michaels, TPJ Knowles
Journal: The Journal of chemical physics 140 (21)
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Title: The amyloid state and its association with protein misfolding diseases
Authors: TPJ Knowles, M Vendruscolo, CM Dobson
Journal: Nature reviews Molecular cell biology 15 (6)
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Title: Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
Authors: AK Buell, C Galvagnion, R Gaspar, E Sparr, M Vendruscolo, TPJ Knowles, ...
Journal: Proceedings of the National Academy of Sciences 111 (21)
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Title: Asymptotic solutions of the Oosawa model for the length distribution of biofilaments
Authors: TCT Michaels, GA Garcia, TPJ Knowles
Journal: The Journal of chemical physics 140 (19)
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Title: Density-gradient-free microfluidic centrifugation for analytical and preparative separation of nanoparticles
Authors: P Arosio, T Müller, L Mahadevan, TPJ Knowles
Journal: Nano letters 14 (5)
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Title: Mean-field master equation formalism for biofilament growth
Authors: TCT Michaels, TPJ Knowles
Journal: American Journal of Physics 82 (5)
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Title: The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation
Authors: N Lorenzen, SB Nielsen, AK Buell, JD Kaspersen, P Arosio, BS Vad, ...
Journal: Journal of the American Chemical Society 136 (10)
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Title: Spatial propagation of protein polymerization
Authors: SIA Cohen, L Rajah, CH Yoon, AK Buell, DA White, RA Sperling, ...
Journal: Physical Review Letters 112 (9)
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Title: Quantitative sensing of microviscosity in protocells and amyloid materials using fluorescence lifetime imaging of molecular rotors
Authors: AJ Thompson, TYD Tang, TW Herling, CRC Hak, S Mann, TPJ Knowles, ...
Journal: Imaging
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Title: Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters
Authors: GA Garcia, SIA Cohen, CM Dobson, TPJ Knowles
Journal: Physical Review E 89 (3)
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Title: Chemical kinetics for drug discovery to combat protein aggregation diseases
Authors: P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
Journal: Trends in pharmacological sciences 35 (3)
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Title: Dynamic renormalisation group reveals sequential mechanism of the secondary nucleation of proteins
Authors: T Michaels, P Arosio, T Knowles
Journal: APS March Meeting Abstracts 2014
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Title: Expanding the solvent chemical space for self-assembly of dipeptide nanostructures
Authors: TO Mason, DY Chirgadze, A Levin, L Adler-Abramovich, E Gazit, ...
Journal: ACS nano 8 (2)
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Title: Single Point Mutations Induce a Switch in the Molecular Mechanism of the Aggregation of the Alzheimer’s Disease Associated Aβ42 Peptide
Authors: B Bolognesi, SIA Cohen, P Aran Terol, EK Esbjörner, S Giorgetti, ...
Journal: ACS Chemical Biology 9 (2)
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Title: Quantitative Analysis of Diffusive Reactions at the Solid–Liquid Interface in Finite Systems
Authors: TCT Michaels, AK Buell, EM Terentjev, TPJ Knowles
Journal: The Journal of Physical Chemistry Letters 5 (4)
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Title: Polymer physics inspired approaches for the study of the mechanical properties of amyloid fibrils
Authors: LR Volpatti, TPJ Knowles
Journal: Journal of Polymer Science Part B: Polymer Physics 52 (4)
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Title: Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson’s disease
Authors: G Toth, SJ Gardai, W Zago, CW Bertoncini, N Cremades, SL Roy, ...
Journal: PloS one 9 (2)
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Title: Determination of Primary Nucleation Mechanisms of α-Synuclein Amyloid Aggregation
Authors: FA Aprile, G Meisl, AK Buell, P Flagmeier, CM Dobson, M Vendruscolo, ...
Journal: Biophysical Journal 106 (2)
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Title: Insights into the Inhibition Mechanism of Biomolecular Self-Assembly from Chemical Kinetics
Authors: P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
Journal: Biophysical Journal 106 (2)
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Title: Quantification of the concentration of Aβ42 propagons during the lag phase by an amyloid chain reaction assay
Authors: P Arosio, R Cukalevski, B Frohm, TPJ Knowles, S Linse
Journal: Journal of the American Chemical Society 136 (1)
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Title: Diffuse transition state structure for the unfolding of a leucine-rich repeat protein
Authors: SE Kelly, G Meisl, PJE Rowling, SH McLaughlin, T Knowles, LS Itzhaki
Journal: Physical Chemistry Chemical Physics 16 (14)
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Title: Sonochemically-induced spectral shift as a probe of green fluorescent protein release from nano capsules
Authors: U Shimanovich, A Munder, NG Azoia, A Cavaco-Paulo, A Gruzman, ...
Journal: RSC Advances 4 (20)
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Title: Nanoscale spatially resolved infrared spectra from single microdroplets
Authors: T Müller, FS Ruggeri, AJ Kulik, U Shimanovich, TO Mason, TPJ Knowles, ...
Journal: Lab on a Chip 14 (7)
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Title: Protein micro-and nano-capsules for biomedical applications
Authors: U Shimanovich, GJL Bernardes, TPJ Knowles, A Cavaco-Paulo
Journal: Chemical Society Reviews 43 (5)
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2013
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Title: A clear view of polymorphism, twist, and chirality in amyloid fibril formation
Authors: LR Volpatti, M Vendruscolo, CM Dobson, TPJ Knowles
Journal: ACS nano 7 (12)
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Title: Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase
Authors: A Pica, A Merlino, AK Buell, TPJ Knowles, E Pizzo, G D'Alessio, F Sica, ...
Journal: Acta Crystallographica Section D: Biological Crystallography 69 (10)
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Title: Single-molecule measurements of transient biomolecular complexes through microfluidic dilution
Authors: MH Horrocks, L Rajah, P Jönsson, M Kjaergaard, M Vendruscolo, ...
Journal: Analytical chemistry 85 (14)
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Title: Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
Authors: SIA Cohen, S Linse, LM Luheshi, E Hellstrand, DA White, L Rajah, ...
Journal: Proceedings of the National Academy of Sciences 110 (24)
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Title: Integration and characterization of solid wall electrodes in microfluidic devices fabricated in a single photolithography step
Authors: TW Herling, T Müller, L Rajah, JN Skepper, M Vendruscolo, TPJ Knowles
Journal: Applied physics letters 102 (18)
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Title: Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2
Authors: LQ Xu, S Wu, AK Buell, SIA Cohen, LJ Chen, WH Hu, SA Cusack, ...
Journal: Philosophical Transactions of the Royal Society B: Biological Sciences 368 …
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Title: Amyloid beta-protein: the influence of intrinsic and extrinsic factors on fibril formation
Authors: R Cukalevski, X Yang, SI Cohen, B Boland, B Frohm, E Thulin, ...
Journal: JOURNAL OF NEUROCHEMISTRY 125
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Title: Atomic structure and hierarchical assembly of a cross-β amyloid fibril
Authors: AWP Fitzpatrick, GT Debelouchina, MJ Bayro, DK Clare, MA Caporini, ...
Journal: Proceedings of the National Academy of Sciences 110 (14)
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Title: Electrostatic effects in filamentous protein aggregation
Authors: AK Buell, P Hung, X Salvatella, ME Welland, CM Dobson, TPJ Knowles
Journal: Biophysical journal 104 (5)
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Title: Amyloid Self Assembly
Authors: T Knowles
Journal: APS March Meeting Abstracts 2013
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Title: Understanding the mechanisms of secondary nucleation for protein aggregation: an analytical approach
Authors: T Michaels, TPJ Knowles
Journal: APS March Meeting Abstracts 2013
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Title: The kinetics and mechanisms of amyloid formation
Authors: SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
Journal: Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological …
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Title: Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses
Authors: M Yolamanova, C Meier, AK Shaytan, V Vas, CW Bertoncini, F Arnold, ...
Journal: Nature nanotechnology 8 (2)
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2012
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Title: Twisting transition between crystalline and fibrillar phases of aggregated peptides
Authors: TPJ Knowles, A De Simone, AW Fitzpatrick, A Baldwin, S Meehan, ...
Journal: Physical Review Letters 109 (15)
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Title: Connecting macroscopic observables and microscopic assembly events in amyloid formation using coarse grained simulations
Authors: NS Bieler, TPJ Knowles, D Frenkel, R Vácha
Journal: Public Library of Science 8 (10)
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Title: Highly Non-linear Microfluidic Resistor Elements for Flow Rate-dependent Addressing of Microchannels
Authors: L Rajah, DA White, TPJ Knowles
Journal: International Journal of Nonlinear Sciences and Numerical Simulation 13 (5 …
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Title: Fluctuations in water, the hydrophobic effect and self-assembly
Authors: PS Varilly, AJ Patel, SN Jamadagni, H Acharya, MF Hagan, S Garde, ...
Journal: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 244
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Title: From macroscopic measurements to microscopic mechanisms of protein aggregation
Authors: SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
Journal: Journal of molecular biology 421 (2-3)
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Title: Selenium-enhanced electron microscopic imaging of different aggregate forms of a segment of the amyloid β peptide in cells
Authors: EK McGuire, M Motskin, B Bolognesi, SD Bergin, TPJ Knowles, J Skepper, ...
Journal: ACS nano 6 (6)
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Title: Direct observation of the interconversion of normal and toxic forms of α-synuclein
Authors: N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, ...
Journal: Cell 149 (5)
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Title: Detailed analysis of the energy barriers for amyloid fibril growth
Authors: AK Buell, A Dhulesia, DA White, TPJ Knowles, CM Dobson, ME Welland
Journal: Angewandte Chemie International Edition 51 (21)
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Title: Analyse der Energiebarrieren für das Wachstum von Amyloidfibrillen
Authors: AK Buell, A Dhulesia, DA White, TPJ Knowles, CM Dobson, ME Welland
Journal: Angewandte Chemie 21 (124)
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Title: Role of elongation and secondary pathways in S6 amyloid fibril growth
Authors: N Lorenzen, SIA Cohen, SB Nielsen, TW Herling, G Christiansen, ...
Journal: Biophysical journal 102 (9)
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Title: Amyloid growth: combining experiment and kinetic theory
Authors: T Knowles, S Cohen, M Vendruscolo, C Dobson
Journal: APS March Meeting Abstracts 2012
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Title: The Mechanisms of Aberrant Protein Aggregation
Authors: S Cohen, M Vendruscolo, C Dobson, T Knowles
Journal: APS March Meeting Abstracts 2012
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Title: An energy landscape approach to protein aggregation
Authors: A Buell, T Knowles
Journal: APS March Meeting Abstracts 2012
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Title: Scaling exponents report on changes in the mechanism of filamentous growth
Authors: L Rajah, S Cohen, S Linse, E Hellstrand, C Dobson, T Knowles
Journal: APS March Meeting Abstracts 2012
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2011
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Title: Protein solubility and protein homeostasis: a generic view of protein misfolding disorders
Authors: M Vendruscolo, TPJ Knowles, CM Dobson
Journal: Cold Spring Harbor perspectives in biology 3 (12)
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Title: Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation
Authors: AW Fitzpatrick, TPJ Knowles, CA Waudby, M Vendruscolo, CM Dobson
Journal: PLoS computational biology 7 (10)
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Title: Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation
Authors: SL Shammas, CA Waudby, S Wang, AK Buell, TPJ Knowles, H Ecroyd, ...
Journal: Biophysical journal 101 (7)
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Title: Metastability of native proteins and the phenomenon of amyloid formation
Authors: AJ Baldwin, TPJ Knowles, GG Tartaglia, AW Fitzpatrick, GL Devlin, ...
Journal: Journal of the American Chemical Society 133 (36)
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Title: Nucleated polymerisation in the presence of pre-formed seed filaments
Authors: SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
Journal: International journal of molecular sciences 12 (9)
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Title: Observation of spatial propagation of amyloid assembly from single nuclei
Authors: TPJ Knowles, DA White, AR Abate, JJ Agresti, SIA Cohen, RA Sperling, ...
Journal: Proceedings of the National Academy of Sciences 108 (36)
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Title: Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations
Authors: SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
Journal: The Journal of chemical physics 135 (6)
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Title: Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations
Authors: SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
Journal: The Journal of chemical physics 135 (6)
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Title: Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments
Authors: SIA Cohen, M Vendruscolo, ME Welland, CM Dobson, EM Terentjev, ...
Journal: The Journal of chemical physics 135 (6)
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Title: Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein
Authors: K Levitan, D Chereau, SIA Cohen, TPJ Knowles, CM Dobson, AL Fink, ...
Journal: Journal of molecular biology 411 (2)
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Title: Kinetics of protein aggregation
Authors: T Knowles, M Vendruscolo, C Dobson
Journal: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 40
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Title: Direct observation of the interconversion of normal and pathogenic forms of alpha-synuclein
Authors: N Cremades, SIA Cohen, AY Chen, A Orte, M Sandal, RW Clarke, ...
Journal: European Biophysics Journal with Biophysics Letters 40
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Title: Nanomechanics of functional and pathological amyloid materials
Authors: TPJ Knowles, MJ Buehler
Journal: Nature nanotechnology 6 (8)
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Title: P4‐316: Stabilization of neurotoxic Alzheimer amyloid‐beta oligomers by protein engineering
Authors: A Dubnovitsky, A Sandberg, L Luheshi, S Söllvander, TP de Barros, ...
Journal: Alzheimer's & Dementia 7
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Title: Perturbation of the stability of amyloid fibrils through alteration of electrostatic interactions
Authors: SL Shammas, TPJ Knowles, AJ Baldwin, CE MacPhee, ME Welland, ...
Journal: Biophysical journal 100 (11)
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Title: Population of nonnative states of lysozyme variants drives amyloid fibril formation
Authors: AK Buell, A Dhulesia, MF Mossuto, N Cremades, JR Kumita, M Dumoulin, ...
Journal: Journal of the American Chemical Society 133 (20)
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Title: Relationship between prion propensity and the rates of individual molecular steps of fibril assembly
Authors: YQ Wang, AK Buell, XY Wang, ME Welland, CM Dobson, TPJ Knowles, ...
Journal: Journal of Biological Chemistry 286 (14)
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Title: Probing protein aggregation with quartz crystal microbalances
Authors: TPJ Knowles, GL Devlin, CM Dobson, ME Welland
Journal: Protein Folding
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Title: Probing small molecule binding to amyloid fibrils
Authors: AK Buell, EK Esbjörner, PJ Riss, DA White, FI Aigbirhio, G Toth, ...
Journal: Physical Chemistry Chemical Physics 13 (45)
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2010
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Title: Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors
Authors: AK Buell, CM Dobson, TPJ Knowles, ME Welland
Journal: Biophysical journal 99 (10)
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Title: Surface attachment of protein fibrils via covalent modification strategies
Authors: AK Buell, DA White, C Meier, ME Welland, TPJ Knowles, CM Dobson
Journal: The Journal of Physical Chemistry B 114 (34)
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Title: Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering
Authors: A Sandberg, LM Luheshi, S Söllvander, T Pereira de Barros, B Macao, ...
Journal: Proceedings of the National Academy of Sciences 107 (35)
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Title: Imaging Alzheimer's disease-related protein aggregates in human cells using a selenium label
Authors: EK McGuire, M Motskin, TPJ Knowles, CM Dobson, DW McComb, ...
Journal: Journal of Physics: Conference Series 241 (1)
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Title: Frequency factors in a landscape model of filamentous protein aggregation
Authors: AK Buell, JR Blundell, CM Dobson, ME Welland, EM Terentjev, ...
Journal: Physical review letters 104 (22)
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Title: An algorithm and experimental protocol to obtain the kinetic parameters of fibrillar growth from a first-principles general model of breakable filament assembly
Authors: SI Cohen, M Sandal, L Rajah, CM Dobson, M Vendruscolo, TPJ Knowles
Journal: FEBS JOURNAL 277
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Title: Protein aggregation in crowded environments
Authors: DA White, AK Buell, TPJ Knowles, ME Welland, CM Dobson
Journal: Journal of the American Chemical Society 132 (14)
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Title: Fabrication and characterisation of protein fibril–elastomer composites
Authors: T Oppenheim, TPJ Knowles, SP Lacour, ME Welland
Journal: Acta Biomaterialia 6 (4)
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Title: The interaction of αB-crystallin with mature α-synuclein amyloid fibrils inhibits their elongation
Authors: CA Waudby, TPJ Knowles, GL Devlin, JN Skepper, H Ecroyd, JA Carver, ...
Journal: Biophysical journal 98 (5)
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Title: Nanostructured films from hierarchical self-assembly of amyloidogenic proteins
Authors: TPJ Knowles, TW Oppenheim, AK Buell, DY Chirgadze, ME Welland
Journal: Nature nanotechnology 5 (3)
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Title: Quantitative approaches for characterising fibrillar protein nanostructures
Authors: TPJ Knowles, DA White, CM Dobson, ME Welland
Journal: MRS Online Proceedings Library (OPL) 1274
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Title: Methods and models in neurodegenerative and systemic protein aggregation diseases
Authors: AC Brorsson, JR Kumita, I MacLeod, B Bolognesi, E Speretta, LM Luheshi, ...
Journal: Front. Biosci 15 (1)
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2009
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Title: An analytical solution to the kinetics of breakable filament assembly
Authors: TPJ Knowles, CA Waudby, GL Devlin, SIA Cohen, A Aguzzi, ...
Journal: Science 326 (5959)
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Title: Imaging amyloid fibrils within cells using a Se-labelling strategy
Authors: AE Porter, TPJ Knowles, K Muller, S Meehan, E McGuire, J Skepper, ...
Journal: Journal of molecular biology 392 (4)
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Title: Biosensor-based label-free assays of amyloid growth
Authors: DA White, AK Buell, CM Dobson, ME Welland, TPJ Knowles
Journal: FEBS letters 583 (16)
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Title: Strength of nanotubes, filaments and nanowires from sonication-induced scission
Authors: YY Huang, TPJ Knowles, EM Terentjev
Journal: arXiv preprint arXiv:0907.3176
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Title: Position‐dependent electrostatic protection against protein aggregation
Authors: AK Buell, GG Tartaglia, NR Birkett, CA Waudby, M Vendruscolo, ...
Journal: ChemBioChem 10 (8)
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2008
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Title: Chemical and biophysical insights into the propagation of prion strains
Authors: J Falsig, KPR Nilsson, TPJ Knowles, A Aguzzi
Journal: HFSP journal 2 (6)
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Title: Highly specific label-free protein detection from lysed cells using internally referenced microcantilever sensors
Authors: W Shu, S Laurenson, TPJ Knowles, PK Ferrigno, AA Seshia
Journal: Biosensors and Bioelectronics 24 (2)
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Title: Label-free detection of amyloid growth with microcantilever sensors
Authors: TPJ Knowles, W Shu, F Huber, HP Lang, C Gerber, CM Dobson, ...
Journal: Nanotechnology 19 (38)
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Title: Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements
Authors: AJ Baldwin, SJ Anthony‐Cahill, TPJ Knowles, G Lippens, J Christodoulou, ...
Journal: Angewandte Chemie International Edition 47 (18)
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Title: Physical aspects in protein aggregation
Authors: TPJ Knowles
Journal: University of Cambridge
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2007
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Title: Role of intermolecular forces in defining material properties of protein nanofibrils
Authors: TP Knowles, AW Fitzpatrick, S Meehan, HR Mott, M Vendruscolo, ...
Journal: science 318 (5858)
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Title: Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human αA-, αB-and R120G αB-crystallins
Authors: S Meehan, TPJ Knowles, AJ Baldwin, JF Smith, AM Squires, P Clements, ...
Journal: Journal of molecular biology 372 (2)
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Title: Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass
Authors: TPJ Knowles, W Shu, GL Devlin, S Meehan, S Auer, CM Dobson, ...
Journal: Proceedings of the National Academy of Sciences 104 (24)
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2006
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Title: Analysis of structural order in amyloid fibrils
Authors: TPJ Knowles, JF Smith, GL Devlin, CM Dobson, ME Welland
Journal: Nanotechnology 18 (4)
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Title: Characterization of the nanoscale properties of individual amyloid fibrils
Authors: JF Smith, TPJ Knowles, CM Dobson, CE MacPhee, ME Welland
Journal: Proceedings of the National Academy of Sciences 103 (43)
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Title: Enhanced stability of human prion proteins with two disulfide bridges
Authors: TPJ Knowles, R Zahn
Journal: Biophysical journal 91 (4)
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Title: The component polypeptide chains of bovine insulin nucleate or inhibit aggregation of the parent protein in a conformation-dependent manner
Authors: GL Devlin, TPJ Knowles, A Squires, MG McCammon, SL Gras, ...
Journal: Journal of molecular biology 360 (2)
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Title: Spatial persistence of angular correlations in amyloid fibrils
Authors: TPJ Knowles, JF Smith, A Craig, CM Dobson, ME Welland
Journal: Physical review letters 96 (23)
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Title: Inverse Transition of Magnetic Domain Patterns in Ultrathin Fe Films on Cu (001): A Quantitative Analysis
Authors: O Portmann, A Vindigni, T Knowles, A Vaterlaus, D Pescia
Journal: APS March Meeting Abstracts
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2005
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Title: Excitations with negative dispersion in a spin vortex
Authors: M Buess, TPJ Knowles, R Höllinger, T Haug, U Krey, D Weiss, D Pescia, ...
Journal: Physical Review B—Condensed Matter and Materials Physics 71 (10)
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2004
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Title: Phase-resolved pulsed precessional motion at a Schottky barrier
Authors: M Buess, TPJ Knowles, U Ramsperger, D Pescia, CH Back
Journal: Physical Review B 69 (17)
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Title: An inverse transition of magnetic domain patterns in ultrathin Fe films on Cu (001)
Authors: O Portmann, T Knowles, A Vaterlaus, D Pescia
Journal: APS March Meeting Abstracts 2004
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Title: Metallic wires on the nanometer scale: fabrication and electronic transport
Authors: T Knowles, U Ramsperger, A Vaterlaus, U Maier, D Pescia
Journal: APS March Meeting Abstracts 2004
------------------------------