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Knowles Lab

Biophysics & Biophysical Chemistry

Studying at Cambridge

 

Publications

222. Biophotonics of Native Silk Fibrils.
U Shimanovich, D Pinotsi, K Shimanovich, N Yu, S Bolisetty, J Adamcik, R Mezzenga, J Charmet, F Vollrath, E Gazit, CM Dobson, GK Schierle, C Holland, CF Kaminski, TPJ Knowles
– Macromol Biosci
(2018)
221. Direct observation of oligomerization by single molecule fluorescence reveals a multi-step aggregation mechanism for the yeast prion protein Ure2.
J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Wu, S Perrett
– J Am Chem Soc
(2018)
220. A microfluidic diffusion platform for characterizing the size of lipid vesicles and the thermodynamics of protein-lipid interactions.
H Gang, C Galvagnion, G Meisl, T Müller, AK Buell, A Levin, CM Dobson, B-Z Mu, TPJ Knowles
– Anal Chem
(2018)
219. Enhancing power density of biophotovoltaics by decoupling storage and power delivery
KL Saar, P Bombelli, DJ Lea-Smith, T Call, EM Aro, T Müller, CJ Howe, TPJ Knowles
– Nature Energy
(2018)
3,
75
218. Microfluidics for protein biophysics.
J Charmet, P Arosio, TPJ Knowles
– Journal of molecular biology
(2017)
217. Mechanism of biosurfactant adsorption to oil/water interfaces from millisecond scale tensiometry measurements
L Kong, KL Saar, R Jacquat, L Hong, A Levin, H Gang, R Ye, B Mu, TPJ Knowles
– Interface focus
(2017)
7,
20170013
jacs
216. Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit.
TO Mason, TCT Michaels, A Levin, CM Dobson, E Gazit, TPJ Knowles, AK Buell
– Journal of the American Chemical Society
(2017)
139,
16134
215. Enhanced Quality Factor Label-free Biosensing with Micro-Cantilevers Integrated into Microfluidic Systems
T Kartanas, V Ostanin, PK Challa, R Daly, J Charmet, TPJ Knowles
– Anal Chem
(2017)
89,
11929
214. Absolute Quantification of Amyloid Propagons by Digital Microfluidics
M Pfammatter, M Andreasen, G Meisl, CG Taylor, J Adamcik, S Bolisetty, A Sánchez-Ferrer, D Klenerman, CM Dobson, R Mezzenga, TPJ Knowles, A Aguzzi, S Hornemann
– Anal Chem
(2017)
89,
12306
213. Hierarchical Biomolecular Emulsions Using 3-D Microfluidics with Uniform Surface Chemistry.
Z Toprakcioglu, A Levin, TPJ Knowles
– Biomacromolecules
(2017)
18,
3642
212. Kinetic constraints on self-assembly into closed supramolecular structures
TCT Michaels, MMJ Bellaiche, MF Hagan, TPJ Knowles
– Scientific reports
(2017)
7,
12295
211. Gradient-free determination of isoelectric points of proteins on chip.
U Łapińska, KL Saar, EV Yates, TW Herling, T Müller, PK Challa, CM Dobson, TPJ Knowles
– Physical chemistry chemical physics : PCCP
(2017)
19,
23060
210. Sequential Release of Proteins from Structured Multishell Microcapsules
U Shimanovich, TCT Michaels, E De Genst, D Matak-Vinkovic, CM Dobson, TPJ Knowles
– Biomacromolecules
(2017)
18,
3052
pnas
209. Monomeric and fibrillar alpha-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of A beta 42 aggregates
S Chia, P Flagmeier, J Habchi, V Lattanzi, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
8005
naturecommunications
208. Silk micrococoons for protein stabilisation and molecular encapsulation
U Shimanovich, FS Ruggeri, E De Genst, J Adamcik, TP Barros, D Porter, T Müller, R Mezzenga, CM Dobson, F Vollrath, C Holland, TPJ Knowles
– Nature Communications
(2017)
8,
15902
207. Nanobodies raised against monomeric alpha-synuclein inhibit fibril formation and destabilize toxic oligomeric species
M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, FS Ruggeri, T Guilliams, AK Buell, J-E Lee, S Gandhi, SF Lee, CE Bryant, M Vendruscolo, TPJ Knowles, CM Dobson, E De Genst, D Klenerman
– BMC biology
(2017)
15,
57
206. Evidence for self-replication of Alzheimer-associated A beta 42 amyloid along the sides of fibrils
M Tornquist, R Cukalevski, U Weininger, G Meisl, TPJ Knowles, T Leiding, M Akke, S Linse
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S242
205. Single amyloid aggregates chemical and structural analysis by infrared nanospectroscopy
FS Ruggeri, J Habchi, C Sean, M Vendruscolo, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S370
204. Measuring the prion-like character of tau by TIRF microscopy
F Kundel, B Falcon, L Hong, N Esteras, AJ Dear, AY Abramov, TPJ Knowles, M Goedert, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S240
203. Mechanisms of Amyloid-beta 42 oligomer formation from kinetic analysis
TC Michaels, A Saric, HW Lazell, P Arosio, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S240
202. Self-assembled Protein Fibril-metal Oxide Nanocomposites
A Levin, TO Mason, TPJ Knowles, U Shimanovich
– Israel Journal of Chemistry
(2017)
57,
724
201. Ultrasensitive measurement of Ca2+ influx into lipid vesicles induced by protein aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TP Knowles, S Gandhi, CM Dobson, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S237
200. A microfluidic platform for quantitative protein studies
TW Herling, P Arosio, T Mueller, DJ O'Connell, MC Bauer, J Persson, U Weininger, S Linse, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S345
angewandte
199. Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman
– Angew Chem Int Ed Engl
(2017)
56,
7750
198. Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method.
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo
– Sci Adv
(2017)
3,
e1700488
pnas
197. Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication.
A Munke, J Persson, T Weiffert, E De Genst, G Meisl, P Arosio, A Carnerup, CM Dobson, M Vendruscolo, TPJ Knowles, S Linse
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
6444
196. Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers.
P Varilly, AP Willard, JB Kirkegaard, TPJ Knowles, D Chandler
– The Journal of chemical physics
(2017)
146,
135102
195. A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity (vol 114, pg E1009, 2017)
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Mueller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proceedings of the National Academy of Sciences
(2017)
114,
E2543
194. Exciton Coupling of Phenylalanine Reveals Conformational Changes of Cationic Peptides
C Bortolini, L Liu, SV Hoffmann, NC Jones, TPJ Knowles, M Dong
– ChemistrySelect
(2017)
2,
2476
193. Acceleration of alpha-synuclein aggregation
R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, E Sparr, S Linse
– Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
(2017)
24,
20
192. Inhibition of alpha-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between alpha-Synuclein Species
FA Aprile, P Arosio, G Fusco, SW Chen, JR Kumita, A Dhulesia, P Tortora, TPJ Knowles, M Vendruscolo, CM Dobson, N Cremades
– Biochemistry
(2017)
56,
1177
pnas
191. A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E1009
190. Physical principles of filamentous protein self-assembly kinetics.
TCT Michaels, LX Liu, G Meisl, TPJ Knowles
– Journal of Physics: Condensed Matter
(2017)
29,
153002
189. Attenuating the Toxicity of Amyloid-Beta Aggregation with Specific Species
R Limbocker, B Mannini, M Perni, S Chia, G Heller, FS Ruggeri, J Habchi, G Meisl, PK Challa, M Zasloff, TPJ Knowles, M Vendruscolo, CM Dobson
– Biophysical Journal
(2017)
112,
494a
188. Scaling behaviour and rate-determining steps in filamentous self-assembly.
G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– Chem. Sci.
(2017)
8,
7087
187. Secondary nucleation of monomers on fibril surface dominates alpha-synuclein aggregation and provides autocatalytic amyloid amplification
R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, E Sparr, S Linse
– Quarterly reviews of biophysics
(2017)
50,
e6
186. Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants.
G Meisl, X Yang, CM Dobson, S Linse, TPJ Knowles
– Chem. Sci.
(2017)
8,
4352
185. Microfluidic devices fabricated using fast wafer-scale LED-lithography patterning
PK Challa, T Kartanas, J Charmet, TPJ Knowles
– Biomicrofluidics
(2017)
11,
014113
184. Ultrasensitive Measurement of Ca 2+ Influx into Lipid Vesicles Induced by Protein Aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman
– Angewandte Chemie
(2017)
129,
7858
183. Nanoscale click-reactive scaffolds from peptide self-assembly
APM Guttenplan, LJ Young, D Matak-Vinkovic, CF Kaminski, TPJ Knowles, LS Itzhaki
– Journal of Nanobiotechnology
(2017)
15,
70
182. On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products.
KL Saar, Y Zhang, T Müller, CP Kumar, S Devenish, A Lynn, U Łapińska, X Yang, S Linse, TPJ Knowles
– Lab on a chip
(2017)
18,
162
181. Micro- and nanoscale hierarchical structure of core–shell protein microgels
LR Volpatti, U Shimanovich, FS Ruggeri, S Bolisetty, T Mueller, TO Mason, TCT Michaels, R Mezzenga, G Dietler, TPJ Knowles
– J. Mater. Chem. B
(2016)
4,
7989
180. Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation.
A Šarić, TCT Michaels, A Zaccone, TPJ Knowles, D Frenkel
– The Journal of chemical physics
(2016)
145,
211926
179. Dynamics of heteromolecular filament formation.
AJ Dear, TCT Michaels, TPJ Knowles
– The Journal of chemical physics
(2016)
145,
175101
178. β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.
JWP Brown, AK Buell, TCT Michaels, G Meisl, J Carozza, P Flagmeier, M Vendruscolo, TPJ Knowles, CM Dobson, C Galvagnion
– Scientific reports
(2016)
6,
36010
naturecommunications
177. Dynamic microfluidic control of supramolecular peptide self-assembly.
ZA Arnon, A Vitalis, A Levin, TCT Michaels, A Caflisch, TPJ Knowles, L Adler-Abramovich, E Gazit
– Nature Communications
(2016)
7,
13190
naturecommunications
176. Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces.
Y Song, U Shimanovich, TCT Michaels, Q Ma, J Li, TPJ Knowles, HC Shum
– Nature Communications
(2016)
7,
12934
175. Kinetics of fragmentation and dissociation of two-strand protein filaments: coarse-grained simulations and experiments
A Zaccone, I Terentjev, TW Herling, TPJ Knowles, A Aleksandrova, EM Terentjev
– J. Chem. Phys.
(2016)
145,
105101
nphys logo
174. Physical determinants of the self-replication of protein fibrils
A Šaric, AK Buell, G Meisl, TCT Michaels, CM Dobson, S Linse, TPJ Knowles, D Frenkel
– Nature Physics
(2016)
12,
874
pnas
173. Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.
P Flagmeier, G Meisl, M Vendruscolo, TPJ Knowles, CM Dobson, AK Buell, C Galvagnion
– Proceedings of the National Academy of Sciences of the United States of America
(2016)
113,
10328
172. Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation.
Y Zhang, AK Buell, T Müller, E De Genst, J Benesch, CM Dobson, TPJ Knowles
– Chembiochem
(2016)
17,
1920
jacs
171. Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform
TO Mason, TCT Michaels, A Levin, E Gazit, CM Dobson, AK Buell, TPJ Knowles
– Journal of the American Chemical Society
(2016)
138,
9589
acsnano
170. Controlling the Physical Dimensions of Peptide Nanotubes by Supramolecular Polymer Coassembly
L Adler-Abramovich, P Marco, ZA Arnon, RCG Creasey, TCT Michaels, A Levin, DJ Scurr, CJ Roberts, TPJ Knowles, SJB Tendler, E Gazit
– ACS Nano
(2016)
10,
7436
nphys logo
169. Elastic instability-mediated actuation by a supra-molecular polymer
A Levin, TCT Michaels, L Adler-Abramovich, TO Mason, T MÃ ller, B Zhang, L Mahadevan, E Gazit, TPJ Knowles
– Nature Physics
(2016)
12,
926
168. Quantifying Measurement Fluctuations from Stochastic Surface Processes on Sensors with Heterogeneous Sensitivity
J Charmet, TCT Michaels, R Daly, A Prasad, P Thiruvenkathanathan, RS Langley, TPJ Knowles, AA Seshia
– Physical Review Applied
(2016)
5,
064016
physreviewletters
167. Fluctuations in the Kinetics of Linear Protein Self-Assembly
TCT Michaels, AJ Dear, JB Kirkegaard, KL Saar, DA Weitz, TPJ Knowles
– Phys Rev Lett
(2016)
116,
258103
166. Particle-Based Monte-Carlo Simulations of Steady-State Mass Transport at Intermediate Péclet Numbers
T Müller, P Arosio, L Rajah, SIA Cohen, EV Yates, M Vendruscolo, CM Dobson, TPJ Knowles
– International Journal of Nonlinear Sciences and Numerical Simulation
(2016)
17,
175
AdvMater
165. Amyloid Fibrils as Building Blocks for Natural and Artificial Functional Materials
TPJ Knowles, R Mezzenga
– Adv Mater
(2016)
28,
6546
164. A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions.
TW Herling, DJ O'Connell, MC Bauer, J Persson, U Weininger, TPJ Knowles, S Linse
– Biophys J
(2016)
110,
1957
163. The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.
V Kakkar, C Månsson, EP de Mattos, S Bergink, M van der Zwaag, MAWH van Waarde, NJ Kloosterhuis, R Melki, RTP van Cruchten, S Al-Karadaghi, P Arosio, CM Dobson, TPJ Knowles, GP Bates, JM van Deursen, S Linse, B van de Sluis, C Emanuelsson, HH Kampinga
– Molecular Cell
(2016)
62,
272
162. Analysis of the length distribution of amyloid fibrils by centrifugal sedimentation.
P Arosio, T Cedervall, TPJ Knowles, S Linse
– Analytical biochemistry
(2016)
504,
7
161. An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation.
EV Yates, G Meisl, TPJ Knowles, CM Dobson
– J Phys Chem B
(2016)
120,
2087
160. Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.
P Arosio, K Hu, FA Aprile, T Müller, TPJ Knowles
– Anal Chem
(2016)
88,
3488
159. A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins
P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo
– ACS Comb Sci
(2016)
18,
144
physreviewletters
158. Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation.
E van Dijk, P Varilly, TPJ Knowles, D Frenkel, S Abeln
– Phys Rev Lett
(2016)
116,
078101
pnas
157. Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, AY Abramov, S Gandhi, NW Wood, N Cremades, CM Dobson, TPJ Knowles, D Klenerman
– Proceedings of the National Academy of Sciences of the United States of America
(2016)
113,
E1206
156. Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform.
K-L Saar, EV Yates, T Müller, S Saunier, CM Dobson, TPJ Knowles
– Biophys J
(2016)
110,
555
155. Oligomers of Heat-Shock Proteins: Structures That Don't Imply Function.
WM Jacobs, TPJ Knowles, D Frenkel
– PLoS computational biology
(2016)
12,
e1004756
154. An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic A 42 aggregates linked with Alzheimers disease
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, SIA Cohen, MBD Müller, S Linse, EAA Nollen, CM Dobson, TPJ Knowles, M Vendruscolo
– Sci Adv
(2016)
2,
e1501244
natureprotocols
153. Molecular mechanisms of protein aggregation from global fitting of kinetic models.
G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles
– Nature protocols
(2016)
11,
252
physreviewletters
152. Hamiltonian Dynamics of Protein Filament Formation.
TCT Michaels, SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– Phys Rev Lett
(2016)
116,
038101
151. Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones
JD Taylor, WJ Hawthorne, J Lo, A Dear, N Jain, G Meisl, M Andreasen, C Fletcher, M Koch, N Darvill, N Scull, A Escalera-Maurer, L Sefer, R Wenman, S Lambert, J Jean, Y Xu, B Turner, SG Kazarian, MR Chapman, D Bubeck, A de Simone, TPJ Knowles, SJ Matthews
– Scientific reports
(2016)
6,
24656
150. Self-assembly of MPG1, a hydrophobin protein from the rice blast fungus that forms functional amyloid coatings, occurs by a surface-driven mechanism
CLL Pham, A Rey, V Lo, M Soulès, Q Ren, G Meisl, TPJ Knowles, AH Kwan, M Sunde
– Scientific reports
(2016)
6,
25288
naturecommunications
149. Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation
P Arosio, TCT Michaels, S Linse, C Månsson, C Emanuelsson, J Presto, J Johansson, M Vendruscolo, CM Dobson, TPJ Knowles
– Nature Communications
(2016)
7,
10948
148. Microfluidic devices fabricated using soft lithography for the study of protein structures using synchrotron radiation circular dichroism
J Charmet, C Bortolini, D Copic, IC Morales, Y Zhang, PK Challa, T Jávorfi, R Hussain, G Siligardi, TPJ Knowles
– 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
(2016)
1079
147. Scaling and dimensionality in the chemical kinetics of protein filament formation
TCT Michaels, AJ Dear, TPJ Knowles
– International Reviews in Physical Chemistry
(2016)
35,
679
146. Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide.
G Meisl, X Yang, B Frohm, TPJ Knowles, S Linse
– Scientific reports
(2016)
6,
18728
145. Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms.
M Iljina, GA Garcia, AJ Dear, J Flint, P Narayan, TCT Michaels, CM Dobson, D Frenkel, TPJ Knowles, D Klenerman
– Scientific reports
(2016)
6,
28658
144. Quantitative thermophoretic study of disease-related protein aggregates
M Wolff, JJ Mittag, TW Herling, ED Genst, CM Dobson, TPJ Knowles, D Braun, AK Buell
– Scientific reports
(2016)
6,
22829
pnas
143. Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease
J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2016)
114,
E200
acsnano
142. Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions.
P Arosio, T Müller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, DA White, TW Herling, EJ De Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– ACS Nano
(2016)
10,
333
jacs
141. N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42
O Szczepankiewicz, B Linse, G Meisl, E Thulin, B Frohm, C Sala Frigerio, MT Colvin, AC Jacavone, RG Griffin, T Knowles, DM Walsh, S Linse
– Journal of the American Chemical Society
(2015)
137,
14673
140. The length distribution of frangible biofilaments.
TCT Michaels, P Yde, JCW Willis, MH Jensen, D Otzen, CM Dobson, AK Buell, TPJ Knowles
– The Journal of chemical physics
(2015)
143,
164901
naturechemistry
139. Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity.
EV Yates, T Müller, L Rajah, EJ De Genst, P Arosio, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– Nature Chemistry
(2015)
7,
802
138. Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates
MA Wright, FA Aprile, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Chemical communications (Cambridge, England)
(2015)
51,
14425
137. Fast Flow Microfluidics and Single-Molecule Fluorescence for the Rapid Characterization of α-Synuclein Oligomers
MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, M Dalla Serra, TPJ Knowles, CM Dobson, D Klenerman
– Anal Chem
(2015)
87,
8818
136. Dynamics of protein aggregation and oligomer formation governed by secondary nucleation
TCT Michaels, HW Lazell, P Arosio, TPJ Knowles
– The Journal of chemical physics
(2015)
143,
054901
pnas
135. Force generation by the growth of amyloid aggregates
TW Herling, GA Garcia, TCT Michaels, W Grentz, J Dean, U Shimanovich, H Gang, T Müller, B Kav, EM Terentjev, CM Dobson, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
112,
9524
134. Molecular Rotors Provide Insights into Microscopic Structural Changes During Protein Aggregation.
AJ Thompson, TW Herling, M Kubánková, A Vyšniauskas, TPJ Knowles, MK Kuimova
– J Phys Chem B
(2015)
119,
10170
133. Kinetics of protein aggregation
TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
S98
132. Lipid vesicles trigger alpha-synuclein aggregation by stimulating primary nucleation
C Galvagnion, AK Buell, G Meisl, TC Michaels, M Vendruscolo, TPJ Knowles, CM Dobson
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
S101
131. Rapid sizing of proteins in complex solutions
P Arosio, T Muller, L Rajah, EV Yates, FA Aprile, SIA Cohen, DA White, TW Herling, E de Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
S49
130. New insights into the mechanism of amyloid formation by alpha-synuclein
AK Buell, C Galvagnion, CM Dobson, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
S100
129. Crucial role of non-specific interactions in amyloid nucleation
A Saric, YC Chebaro, TPJ Knowles, D Frenkel
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
S161
acsnano
128. Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry
X-M Zhou, U Shimanovich, TW Herling, S Wu, CM Dobson, TPJ Knowles, S Perrett
– ACS Nano
(2015)
9,
5772
127. Aggregation-Prone Amyloid-Cu-II Species Formed on the Millisecond Timescale under Mildly Acidic Conditions
JT Pedersen, CB Borg, TCT Michaels, TPJ Knowles, P Faller, K Teilum, L Hemmingsen
– Chembiochem
(2015)
16,
1293
pnas
126. Preventing peptide and protein misbehavior.
P Arosio, G Meisl, M Andreasen, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
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112,
5267
125. A microfluidic platform for quantitative measurements of effective protein charges and single ion binding in solution.
TW Herling, P Arosio, T Müller, S Linse, TPJ Knowles
– Physical chemistry chemical physics : PCCP
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17,
12161
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124. Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, EJ De-Genst, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
112,
E1994
123. A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
SIA Cohen, P Arosio, J Presto, FR Kurudenkandy, H Biverstål, L Dolfe, C Dunning, X Yang, B Frohm, M Vendruscolo, J Johansson, CM Dobson, A Fisahn, TPJ Knowles, S Linse
– Nature Structural and Molecular Biology
(2015)
22,
207
122. The physical basis of protein misfolding disorders
TPJ Knowles, M Vendruscolo, CM Dobson
– Physics Today
(2015)
68,
36
121. On the lag phase in amyloid fibril formation
P Arosio, TPJ Knowles, S Linse
– Physical chemistry chemical physics : PCCP
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17,
7606
naturechembio
120. Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation.
C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, TPJ Knowles, CM Dobson
– Nature Chemical Biology
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11,
229
119. Kinetic theory of protein filament growth: Self-consistent methods and perturbative techniques
TCT Michaels, TPJ Knowles
– International Journal of Modern Physics B
(2015)
29,
1530002
118. Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity.
J Dworzak, B Renvoisé, J Habchi, EV Yates, C Combadière, TP Knowles, CM Dobson, C Blackstone, O Paulsen, PM Murphy
– PLoS One
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10,
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117. The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation.
R Cukalevski, X Yang, G Meisl, U Weininger, K Bernfur, B Frohm, TPJ Knowles, S Linse
– Chem. Sci.
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6,
4215
116. Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants.
L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, N Cremades, CM Dobson, D Klenerman
– Scientific reports
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5,
16696
115. A high power-density, mediator-free, microfluidic biophotovoltaic device for cyanobacterial cells
P Bombelli, T Müller, TW Herling, CJ Howe, TPJ Knowles
– Advanced Energy Materials
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5,
naturechembio
114. Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, TPJ Knowles, CM Dobson
– Nature Chemical Biology
(2015)
11,
229
naturecommunications
113. A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
SL Shammas, GA Garcia, S Kumar, M Kjaergaard, MH Horrocks, N Shivji, E Mandelkow, TPJ Knowles, E Mandelkow, D Klenerman
– Nature Communications
(2015)
6,
7025
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112. Protein Microgels from Amyloid Fibril Networks
U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, S Linse, KS Åkerfeldt, CM Dobson, DA Weitz, TPJ Knowles
– ACS Nano
(2015)
9,
43
111. Tetracycline nanoparticles as antibacterial and gene-silencing agents
U Shimanovich, A Lipovsky, D Eliaz, S Zigdon, TPJ Knowles, Y Nitzan, S Michaeli, A Gedanken
– Adv Healthc Mater
(2015)
4,
723
110. Multiphase protein microgels
U Shimanovich, Y Song, J Brujic, HC Shum, TPJ Knowles
– Macromolecular Bioscience
(2015)
15,
501
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109. Crucial role of nonspecific interactions in amyloid nucleation
A Šarić, YC Chebaro, TPJ Knowles, D Frenkel
– Proceedings of the National Academy of Sciences of the United States of America
(2014)
111,
17869
108. Dry-mass sensing for microfluidics
T Mueller, DA White, TPJ Knowles
– Applied Physics Letters
(2014)
105,
214101
107. Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation.
C Månsson, P Arosio, R Hussein, HH Kampinga, RM Hashem, WC Boelens, CM Dobson, TPJ Knowles, S Linse, C Emanuelsson
– J Biol Chem
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289,
31066
106. A High Power-Density, Mediator-Free, Microfluidic Biophotovoltaic Device for Cyanobacterial Cells.
P Bombelli, T Müller, TW Herling, CJ Howe, TPJ Knowles
– Advanced Energy Materials
(2014)
5,
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105. The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation.
AK Buell, CM Dobson, TPJ Knowles
– Essays Biochem
(2014)
56,
11
pnas
104. Differences in nucleation behavior underlie the contrasting aggregation kinetics of the A beta 40 and A beta 42 peptides
G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2014)
111,
9384
103. Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization
TCT Michaels, TPJ Knowles
– The Journal of chemical physics
(2014)
140,
214904
naturereviews
102. The amyloid state and its association with protein misfolding diseases.
TPJ Knowles, M Vendruscolo, CM Dobson
– Nature Reviews Molecular Cell Biology
(2014)
15,
384
101. Asymptotic solutions of the Oosawa model for the length distribution of biofilaments
TCT Michaels, GA Garcia, TPJ Knowles
– The Journal of chemical physics
(2014)
140,
194906
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100. Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
AK Buell, C Galvagnion, R Gaspar, E Sparr, M Vendruscolo, TPJ Knowles, S Linse, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
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111,
7671
99. Mean-field master equation formalism for biofilament growth
TCT Michaels, TPJ Knowles
– American Journal of Physics
(2014)
82,
476
98. Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters
GA Garcia, SIA Cohen, CM Dobson, TPJ Knowles
– Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
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89,
ARTN 032712
97. Density-Gradient-Free Microfluidic Centrifugation for Analytical and Preparative Separation of Nanoparticles
P Arosio, T Müller, L Mahadevan, TPJ Knowles
– Nano Lett
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14,
2365
physreviewletters
96. Spatial Propagation of Protein Polymerization
SIA Cohen, L Rajah, CH Yoon, AK Buell, DA White, RA Sperling, M Vendruscolo, EM Terentjev, CM Dobson, DA Weitz, TPJ Knowles
– Phys Rev Lett
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112,
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95. Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters.
GA Garcia, SIA Cohen, CM Dobson, TPJ Knowles
– Phys Rev E Stat Nonlin Soft Matter Phys
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89,
032712
94. Diffuse transition state structure for the unfolding of a leucine-rich repeat protein
SE Kelly, G Meisl, PJE Rowling, SH McLaughlin, T Knowles, LS Itzhaki
– Physical chemistry chemical physics : PCCP
(2014)
16,
6448
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93. The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.
N Lorenzen, SB Nielsen, AK Buell, JD Kaspersen, P Arosio, BS Vad, W Paslawski, G Christiansen, Z Valnickova-Hansen, M Andreasen, JJ Enghild, JS Pedersen, CM Dobson, TPJ Knowles, DE Otzen
– Journal of the American Chemical Society
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136,
3859
92. Polymer physics inspired approaches for the study of the mechanical properties of amyloid fibrils
LR Volpatti, TPJ Knowles
– Journal of Polymer Science Part B: Polymer Physics
(2014)
52,
281
91. Nanoscale spatially resolved infrared spectra from single microdroplets.
T Müller, FS Ruggeri, AJ Kulik, U Shimanovich, TO Mason, TPJ Knowles, G Dietler
– Lab on a chip
(2014)
14,
1315
90. Determination of Primary Nucleation Mechanisms of alpha-Synuclein Amyloid Aggregation
FA Aprile, G Meisl, AK Buell, P Flagmeier, CM Dobson, M Vendruscolo, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2014)
106,
267A
89. Insights into the Inhibition Mechanism of Biomolecular Self-Assembly from Chemical Kinetics
P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Biophysical Journal
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106,
682a
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88. Expanding the Solvent Chemical Space for Self-Assembly of Dipeptide Nanostructures
TO Mason, DY Chirgadze, A Levin, L Adler-Abramovich, E Gazit, TPJ Knowles, AK Buell
– ACS Nano
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8,
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87. Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.
G Tóth, SJ Gardai, W Zago, CW Bertoncini, N Cremades, SL Roy, MA Tambe, J-C Rochet, C Galvagnion, G Skibinski, S Finkbeiner, M Bova, K Regnstrom, S-S Chiou, J Johnston, K Callaway, JP Anderson, MF Jobling, AK Buell, TA Yednock, TPJ Knowles, M Vendruscolo, J Christodoulou, CM Dobson, D Schenk, L McConlogue
– PLoS One
(2014)
9,
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86. Self-Assembly of Amyloid Fibrils That Display Active Enzymes
XM Zhou, A Entwistle, H Zhang, AP Jackson, TO Mason, U Shimanovich, TPJ Knowles, AT Smith, EB Sawyer, S Perrett
– ChemCatChem
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6,
1961
85. Chemical kinetics for drug discovery to combat protein aggregation diseases
P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Trends in Pharmacological Sciences
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35,
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84. Self-Assembly of Amyloid Fibrils That Display Active Enzymes.
X-M Zhou, A Entwistle, H Zhang, AP Jackson, TO Mason, U Shimanovich, TPJ Knowles, AT Smith, EB Sawyer, S Perrett
– ChemCatChem
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6,
1961
83. Quantitative sensing of microviscosity in protocells and amyloid materials using fluorescence lifetime imaging of molecular rotors
AJ Thompson, TYD Tang, TW Herling, CR Che Hak, S Mann, TPJ Knowles, MK Kuimova
– Progress in Biomedical Optics and Imaging - Proceedings of SPIE
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8947,
UNSP 89471C
naturereviews
82. Erratum: The amyloid state and its association with protein misfolding diseases (Nature Reviews Molecular Cell Biology (2014) 15 (384-396))
TPJ Knowles, M Vendruscolo, CM Dobson
– Nature Reviews Molecular Cell Biology
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15,
496
81. Sonochemically-induced spectral shift as a probe of green fluorescent protein release from nano capsules
U Shimanovich, A Munder, NG Azoia, A Cavaco-Paulo, A Gruzman, TPJ Knowles, A Gedanken
– RSC Advances
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4,
10303
80. Quantitative Analysis of Diffusive Reactions at the Solid–Liquid Interface in Finite Systems
TCT Michaels, AK Buell, EM Terentjev, TPJ Knowles
– Journal of Physical Chemistry Letters
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5,
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79. Chemical kinetics for drug discovery to combat protein aggregation diseases.
P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Trends Pharmacol Sci
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35,
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78. Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ<inf>42</inf> peptide
B Bolognesi, SIA Cohen, P Aran Terol, EK Esbjörner, S Giorgetti, MF Mossuto, A Natalello, AC Brorsson, TPJ Knowles, CM Dobson, LM Luheshi
– ACS Chemical Biology
(2014)
9,
378
77. Easyworm: An open-source software tool to determine the mechanical properties of worm-like chains
G Lamour, JB Kirkegaard, H Li, TP Knowles, J Gsponer
– Source Code Biol Med
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9,
16
naturecommunications
76. Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers
A Levin, TO Mason, L Adler-Abramovich, AK Buell, G Meisl, C Galvagnion, Y Bram, SA Stratford, CM Dobson, TPJ Knowles, E Gazit
– Nature Communications
(2014)
5,
5219
75. Protein micro- and nano-capsules for biomedical applications
U Shimanovich, GJL Bernardes, TPJ Knowles, A Cavaco-Paulo
– Chemical Society reviews
(2014)
43,
1361
jacs
74. Quantification of the concentration of Aβ42 propagons during the lag phase by an amyloid chain reaction assay
P Arosio, R Cukalevski, B Frohm, TPJ Knowles, S Linse
– Journal of the American Chemical Society
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136,
219
73. Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ42 peptide.
B Bolognesi, SIA Cohen, P Aran Terol, EK Esbjörner, S Giorgetti, MF Mossuto, A Natalello, A-C Brorsson, TPJ Knowles, CM Dobson, LM Luheshi
– ACS Chem Biol
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72. A Clear View of Polymorphism, Twist, and Chirality in Amyloid Fibril Formation
LR Volpatti, M Vendruscolo, CM Dobson, TPJ Knowles
– ACS Nano
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7,
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71. Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase.
A Pica, A Merlino, AK Buell, TPJ Knowles, E Pizzo, G D'Alessio, F Sica, L Mazzarella
– Acta Crystallographica Section D: Biological Crystallography
(2013)
69,
2116
70. Single-molecule measurements of transient biomolecular complexes through microfluidic dilution
MH Horrocks, L Rajah, P Jönsson, M Kjaergaard, M Vendruscolo, TPJ Knowles, D Klenerman
– Anal Chem
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85,
6855
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69. Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
SIA Cohen, S Linse, LM Luheshi, E Hellstrand, DA White, L Rajah, DE Otzen, M Vendruscolo, CM Dobson, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
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110,
9758
68. Integration and characterization of solid wall electrodes in microfluidic devices fabricated in a single photolithography step
TW Herling, T Müller, L Rajah, JN Skepper, M Vendruscolo, TPJ Knowles
– Applied Physics Letters
(2013)
102,
184102
67. Amyloid beta-protein: the influence of intrinsic and extrinsic factors on fibril formation
R Cukalevski, X Yang, SI Cohen, B Boland, B Frohm, E Thulin, DM WalsXh, TP Knowles, S Linse
– JOURNAL OF NEUROCHEMISTRY
(2013)
125,
235
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66. Atomic structure and hierarchical assembly of a cross-beta amyloid fibril
AWP Fitzpatrick, GT Debelouchina, MJ Bayro, DK Clare, MA Caporini, VS Bajaj, CP Jaroniec, L Wang, V Ladizhansky, SA Müller, CE MacPhee, CA Waudby, HR Mott, A De Simone, TPJ Knowles, HR Saibil, M Vendruscolo, EV Orlova, RG Griffin, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
(2013)
110,
5468
65. Electrostatic Effects in Filamentous Protein Aggregation
AK Buell, P Hung, X Salvatella, ME Welland, CM Dobson, TPJ Knowles
– Biophys J
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104,
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64. Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses.
M Yolamanova, C Meier, AK Shaytan, V Vas, CW Bertoncini, F Arnold, O Zirafi, SM Usmani, JA Müller, D Sauter, C Goffinet, D Palesch, P Walther, NR Roan, H Geiger, O Lunov, T Simmet, J Bohne, H Schrezenmeier, K Schwarz, L Ständker, W-G Forssmann, X Salvatella, PG Khalatur, AR Khokhlov, TPJ Knowles, T Weil, F Kirchhoff, J Münch
– Nat Nanotechnol
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8,
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63. Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2.
LQ Xu, S Wu, AK Buell, SIA Cohen, LJ Chen, WH Hu, SA Cusack, LS Itzhaki, H Zhang, TPJ Knowles, CM Dobson, ME Welland, GW Jones, S Perrett
– Philosophical transactions of the Royal Society of London. Series B, Biological sciences
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368,
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62. The Kinetics and Mechanisms of Amyloid Formation
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties
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183
61. Connecting macroscopic observables and microscopic assembly events in amyloid formation using coarse grained simulations.
NS Bieler, TPJ Knowles, D Frenkel, R Vácha
– PLoS computational biology
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8,
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60. Highly non-linear microfluidic resistor elements for flow rate-dependent addressing of microchannels
L Rajah, DA White, TPJ Knowles
– International Journal of Nonlinear Sciences and Numerical Simulation
(2012)
13,
319
59. Fluctuations in water, the hydrophobic effect and self-assembly
PS Varilly, AJ Patel, SN Jamadagni, H Acharya, MF Hagan, S Garde, D Chandler, TPJ Knowles, D Frenkel
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
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244,
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58. Selenium-enhanced electron microscopic imaging of different aggregate forms of a segment of the amyloid β peptide in cells.
EK McGuire, M Motskin, B Bolognesi, SD Bergin, TPJ Knowles, J Skepper, LM Luheshi, DW McComb, CM Dobson, AE Porter
– ACS Nano
(2012)
6,
4740
57. Direct Observation of the Interconversion of Normal and Toxic Forms of alpha-Synuclein
N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, NW Wood, TPJ Knowles, CM Dobson, D Klenerman
– Cell
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149,
1048
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56. Detailed analysis of the energy barriers for amyloid fibril growth.
AK Buell, A Dhulesia, DA White, TPJ Knowles, CM Dobson, ME Welland
– Angew Chem Int Ed Engl
(2012)
51,
5247
55. From macroscopic measurements to microscopic mechanisms of protein aggregation.
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– Journal of molecular biology
(2012)
421,
160
54. From macroscopic measurements to microscopic mechanisms of protein aggregation
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– Journal of Molecular Biology
(2012)
421,
160
physreviewletters
53. Twisting transition between crystalline and fibrillar phases of aggregated peptides
TPJ Knowles, A De Simone, AW Fitzpatrick, A Baldwin, S Meehan, L Rajah, M Vendruscolo, ME Welland, CM Dobson, EM Terentjev
– Phys Rev Lett
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109,
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52. Role of elongation and secondary pathways in S6 amyloid fibril growth.
N Lorenzen, SIA Cohen, SB Nielsen, TW Herling, G Christiansen, CM Dobson, TPJ Knowles, D Otzen
– Biophys J
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102,
2167
51. Probing small molecule binding to amyloid fibrils.
AK Buell, EK Esbjörner, PJ Riss, DA White, FI Aigbirhio, G Toth, ME Welland, CM Dobson, TPJ Knowles
– Physical chemistry chemical physics : PCCP
(2011)
13,
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50. Binding of the Molecular Chaperone alpha B-Crystallin to A beta Amyloid Fibrils Inhibits Fibril Elongation
SL Shammas, CA Waudby, S Wang, AK Buell, TPJ Knowles, H Ecroyd, ME Welland, JA Carver, CM Dobson, S Meehan
– Biophys J
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101,
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49. Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation.
AW Fitzpatrick, TPJ Knowles, CA Waudby, M Vendruscolo, CM Dobson
– PLoS computational biology
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7,
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48. Observation of spatial propagation of amyloid assembly from single nuclei.
TPJ Knowles, DA White, AR Abate, JJ Agresti, SIA Cohen, RA Sperling, EJ De Genst, CM Dobson, DA Weitz
– Proceedings of the National Academy of Sciences of the United States of America
(2011)
108,
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47. Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments
SIA Cohen, M Vendruscolo, ME Welland, CM Dobson, EM Terentjev, TPJ Knowles
– The Journal of chemical physics
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135,
065105
46. Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– The Journal of chemical physics
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135,
065107
45. Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations.
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– The Journal of chemical physics
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135,
065106
44. Protein solubility and protein homeostasis: a generic view of protein misfolding disorders.
M Vendruscolo, TPJ Knowles, CM Dobson
– Cold Spring Harbor Perspectives in Biology
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3,
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43. Direct observation of the interconversion of normal and pathogenic forms of alpha-synuclein
N Cremades, SIA Cohen, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, TPJ Knowles, CM Dobson, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
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40,
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42. Conserved C-Terminal Charge Exerts a Profound Influence on the Aggregation Rate of α-Synuclein
K Levitan, D Chereau, SIA Cohen, TPJ Knowles, CM Dobson, AL Fink, JP Anderson, JM Goldstein, GL Millhauser
– Journal of molecular biology
(2011)
411,
329
41. Perturbation of the Stability of Amyloid Fibrils through Alteration of Electrostatic Interactions
SL Shammas, TPJ Knowles, AJ Baldwin, CE Macphee, ME Welland, CM Dobson, GL Devlin
– Biophys J
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100,
2783
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40. Metastability of native proteins and the phenomenon of amyloid formation.
AJ Baldwin, TPJ Knowles, GG Tartaglia, AW Fitzpatrick, GL Devlin, SL Shammas, CA Waudby, MF Mossuto, S Meehan, SL Gras, J Christodoulou, SJ Anthony-Cahill, PD Barker, M Vendruscolo, CM Dobson
– Journal of the American Chemical Society
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133,
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39. Population of Nonnative States of Lysozyme Variants Drives Amyloid Fibril Formation
AK Buell, A Dhulesia, MF Mossuto, N Cremades, JR Kumita, M Dumoulin, ME Welland, TPJ Knowles, X Salvatella, CM Dobson
– Journal of the American Chemical Society
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133,
7737
38. Relationship between prion propensity and the rates of individual molecular steps of fibril assembly.
Y-Q Wang, AK Buell, X-Y Wang, ME Welland, CM Dobson, TPJ Knowles, S Perrett
– J Biol Chem
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286,
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37. Probing protein aggregation with quartz crystal microbalances.
TPJ Knowles, GL Devlin, CM Dobson, ME Welland
– Methods Mol Biol
(2011)
752,
137
36. Nucleated polymerisation in the presence of pre-formed seed filaments.
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– International journal of molecular sciences
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12,
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35. Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein
K Levitan, D Chereau, SIA Cohen, TPJ Knowles, CM Dobson, AL Fink, JP Anderson, JM Goldstein, GL Millhauser
– Journal of Molecular Biology
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411,
329
34. Protein solubility and protein homeostasis: A generic view of protein misfolding disorders
M Vendruscolo, TPJ Knowles, CM Dobson
– Cold Spring Harbor Perspectives in Biology
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3,
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33. Nanomechanics of functional and pathological amyloid materials.
TPJ Knowles, MJ Buehler
– Nat Nanotechnol
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6,
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32. Interactions between Amyloidophilic Dyes and Their Relevance to Studies of Amyloid Inhibitors
AK Buell, CM Dobson, TPJ Knowles, ME Welland
– Biophys J
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99,
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31. Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering.
A Sandberg, LM Luheshi, S Söllvander, T Pereira de Barros, B Macao, TPJ Knowles, H Biverstål, C Lendel, F Ekholm-Petterson, A Dubnovitsky, L Lannfelt, CM Dobson, T Härd
– Proceedings of the National Academy of Sciences of the United States of America
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107,
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30. Surface attachment of protein fibrils via covalent modification strategies
AK Buell, DA White, C Meier, ME Welland, TPJ Knowles, CM Dobson
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114,
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29. An algorithm and experimental protocol to obtain the kinetic parameters of fibrillar growth from a first-principles general model of breakable filament assembly
SI Cohen, M Sandal, L Rajah, CM Dobson, M Vendruscolo, TPJ Knowles
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277,
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28. Frequency Factors in a Landscape Model of Filamentous Protein Aggregation
AK Buell, JR Blundell, CM Dobson, ME Welland, EM Terentjev, TPJ Knowles
– Phys Rev Lett
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104,
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27. Protein Aggregation in Crowded Environments
DA White, AK Buell, TPJ Knowles, ME Welland, CM Dobson
– Journal of the American Chemical Society
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132,
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26. Fabrication and characterisation of protein fibril-elastomer composites
T Oppenheim, TPJ Knowles, SP Lacour, ME Welland
– Acta Biomater
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6,
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25. The Interaction of αB-Crystallin with Mature α-Synuclein Amyloid Fibrils Inhibits Their Elongation
CA Waudby, TPJ Knowles, GL Devlin, JN Skepper, H Ecroyd, JA Carver, ME Welland, J Christodoulou, CM Dobson, S Meehan
– Biophys J
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98,
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24. Nanostructured films from hierarchical self-assembly of amyloidogenic proteins.
TPJ Knowles, TW Oppenheim, AK Buell, DY Chirgadze, ME Welland
– Nat Nanotechnol
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5,
204
23. Imaging Alzheimer's disease-related protein aggregates in human cells using a selenium label
EK McGuire, M Motskin, TPJ Knowles, CM Dobson, DW McComb, AE Porter
– ELECTRON MICROSCOPY AND ANALYSIS GROUP CONFERENCE 2009 (EMAG 2009)
(2010)
241,
012020
22. Methods and models in neurodegenerative and systemic protein aggregation diseases.
A-C Brorsson, JR Kumita, I MacLeod, B Bolognesi, E Speretta, LM Luheshi, TPJ Knowles, CM Dobson, DC Crowther
– Frontiers in Bioscience
(2010)
15,
373
21. Quantitative approaches for characterising fibrillar protein nanostructures
DA White, CM Dobson, ME Welland, TPJ Knowles
– Materials Research Society Symposium Proceedings
(2010)
1274,
33
science
20. An analytical solution to the kinetics of breakable filament assembly
TPJ Knowles, CA Waudby, GL Devlin, SIA Cohen, A Aguzzi, M Vendruscolo, EM Terentjev, ME Welland, CM Dobson
– Science
(2009)
326,
1533
19. Imaging Amyloid Fibrils within Cells Using a Se-Labelling Strategy
AE Porter, TPJ Knowles, K Muller, S Meehan, E McGuire, J Skepper, ME Welland, CM Dobson
– Journal of molecular biology
(2009)
392,
868
18. Biosensor-based label-free assays of amyloid growth.
DA White, AK Buell, CM Dobson, ME Welland, TPJ Knowles
– FEBS letters
(2009)
583,
2587
17. Position-dependent electrostatic protection against protein aggregation.
AK Buell, GG Tartaglia, NR Birkett, CA Waudby, M Vendruscolo, X Salvatella, ME Welland, CM Dobson, TPJ Knowles
– Chembiochem
(2009)
10,
1309
AdvMater
16. Strength of Nanotubes, Filaments, and Nanowires From Sonication-Induced Scission
YY Huang, TPJ Knowles, EM Terentjev
– Advanced Materials
(2009)
21,
3945
15. Chemical and biophysical insights into the propagation of prion strains.
J Falsig, KP Nilsson, TPJ Knowles, A Aguzzi
– HFSP Journal
(2008)
2,
332
14. Highly specific label-free protein detection from lysed cells using internally referenced microcantilever sensors.
W Shu, S Laurenson, TPJ Knowles, P Ko Ferrigno, AA Seshia
– Biosensors and Bioelectronics
(2008)
24,
233
13. Label-free detection of amyloid growth with microcantilever sensors
TPJ Knowles, W Shu, F Huber, HP Lang, C Gerber, CM Dobson, ME Welland
– Nanotechnology
(2008)
19,
384007
angewandte
12. Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements
AJ Baldwin, SJ Anthony-Cahill, TPJ Knowles, G Lippens, J Christodoulou, PD Barker, CM Dobson
– Angew Chem Int Ed Engl
(2008)
47,
3385
science
11. Role of intermolecular forces in defining material properties of protein nanofibrils.
TP Knowles, AW Fitzpatrick, S Meehan, HR Mott, M Vendruscolo, CM Dobson, ME Welland
– Science
(2007)
318,
1900
10. Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins.
S Meehan, TPJ Knowles, AJ Baldwin, JF Smith, AM Squires, P Clements, TM Treweek, H Ecroyd, GG Tartaglia, M Vendruscolo, CE Macphee, CM Dobson, JA Carver
– Journal of molecular biology
(2007)
372,
470
pnas
9. Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass
TPJ Knowles, W Shu, GL Devlin, S Meehan, S Auer, CM Dobson, ME Welland
– Proceedings of the National Academy of Sciences of the United States of America
(2007)
104,
10016
8. Analysis of structural order in amyloid fibrils
TPJ Knowles, JF Smith, GL Devlin, CM Dobson, ME Welland
– Nanotechnology
(2007)
18,
044031
7. Enhanced stability of human prion proteins with two disulfide bridges.
TPJ Knowles, R Zahn
– Biophys J
(2006)
91,
1494
6. The component polypeptide chains of bovine insulin nucleate or inhibit aggregation of the parent protein in a conformation-dependent manner
GL Devlin, TPJ Knowles, A Squires, MG McCammon, SL Gras, MR Nilsson, CV Robinson, CM Dobson, CE MacPhee
– Journal of molecular biology
(2006)
360,
497
pnas
5. Characterization of the nanoscale properties of individual amyloid fibrils.
JF Smith, TPJ Knowles, CM Dobson, CE Macphee, ME Welland
– Proceedings of the National Academy of Sciences of the United States of America
(2006)
103,
15806
physreviewletters
4. Spatial persistence of angular correlations in amyloid fibrils.
TPJ Knowles, JF Smith, A Craig, CM Dobson, ME Welland
– Phys Rev Lett
(2006)
96,
238301
3. Excitations with negative dispersion in a spin vortex
M Buess, TPJ Knowles, R Hollinger, T Haug, U Krey, D Weiss, D Pescia, MR Scheinfein, CH Back
– Physical Review B
(2005)
71,
104415
2. Phase-resolved pulsed precessional motion at a Schottky barrier
M Buess, TPJ Knowles, U Ramsperger, D Pescia, CH Back
– Physical Review B
(2004)
69,
174422
1. Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1
PH St George-Hyslop, S Qamar, G Wang, SJ Randle, FS Ruggeri, J Varela, CF Kaminski, GS Kaminski, M Vendruscolo, TPJ Knowles, D Klenerman, CE Holt, Q Lin, W meadows
– Cell
(None)