376. Correction: Correction: Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions
Z Toprakcioglu, TA Hakala, A Levin, CFW Becker, GJL Bernarde, TPJ Knowles
– Soft matter
(2021)
17,
375. Chris Dobson (1949-2019) Obituary
TPJ Knowles, M Vendruscolo
– Nature Chemical Biology
(2020)
16,
374. The catalytic nature of protein aggregation
AJ Dear, G Meisl, TCT Michaels, MR Zimmermann, S Linse, TPJ Knowles
– The Journal of Chemical Physics
(2020)
152,
373. Coating and Stabilization of Liposomes by Clathrin-Inspired DNA Self-Assembly.
KN Baumann, L Piantanida, J García-Nafría, D Sobota, K Voïtchovsky, TPJ Knowles, S Hernández-Ainsa
– ACS Nano
(2020)
14,
372. Controllable coacervation of recombinantly produced spider silk protein using kosmotropic salts.
P Mohammadi, C Jonkergouw, G Beaune, P Engelhardt, A Kamada, JVI Timonen, TPJ Knowles, M Penttila, MB Linder
– Journal of colloid and interface science
(2020)
560,
371. Attolitre protein nanogels from droplet nanofluidics for intracellular delivery
Z Toprakcioglu, PK Challa, DB Morse, T Knowles
– Science Advances
(2020)
6,
370. Rapid Generation of Protein Condensate Phase Diagrams Using Combinatorial Droplet Microfluidics
W Arter, R Qi, G Krainer, T Welsh, Y Xu, PS George-Hyslop, S Alberti, TPJ Knowles
– None
(2020)
369. Rational design of a conformation-specific antibody for the quantification of Aβ oligomers.
FA Aprile, P Sormanni, M Podpolny, S Chhangur, L-M Needham, FS Ruggeri, M Perni, R Limbocker, GT Heller, T Sneideris, T Scheidt, B Mannini, J Habchi, SF Lee, PC Salinas, TPJ Knowles, CM Dobson, M Vendruscolo
– Proceedings of the National Academy of Sciences
(2020)
117,
368. Direct digital sensing of proteins in solution through single-molecule optofluidics
G Krainer, K Saar, W Arter, RPB Jacquat, Q Peter, P Challa, C Taylor, D Klenerman, TPJ Knowles
– None
(2020)
367. Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils.
M Törnquist, R Cukalevski, U Weininger, G Meisl, TPJ Knowles, T Leiding, A Malmendal, M Akke, S Linse
– Proceedings of the National Academy of Sciences of the United States of America
(2020)
117,
366. Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform.
M Koopman, Q Peter, RI Seinstra, M Perni, M Vendruscolo, CM Dobson, TPJ Knowles, EAA Nollen
– Nature Protocols
(2020)
15,
365. Kinetic diversity of amyloid oligomers.
AJ Dear, TCT Michaels, G Meisl, D Klenerman, S Wu, S Perrett, S Linse, CM Dobson, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2020)
117,
364. A Microfluidic Co-Flow Route for Human Serum Albumin-Drug–Nanoparticle Assembly
TA Hakala, S Davies, Z Toprakcioglu, B Bernardim, GJL Bernardes, TPJ Knowles
– Chemistry - A European Journal
(2020)
26,
363. Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
G Krainer, T Welsh, J Joseph, J Espinosa, S Wittmann, ED Csilléry, A Sridhar, Z Toprakcioglu, G Gudiškytė, M Czekalska, W Arter, PS George-Hyslop, A Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles
– None
(2020)
362. Complexity in Lipid Membrane Composition Induces Resilience to A beta(42) Aggregation
M Sanguanini, KN Baumann, S Preet, S Chia, J Habchi, TPJ Knowles, M Vendruscolo
– ACS chemical neuroscience
(2020)
11,
361. Dynamics of oligomer populations formed during the aggregation of Alzheimer's A beta 42 peptide (vol 12, pg 445, 2020)
TCT Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, AJ Dear, SIA Cohen, CM Dobson, M Vendruscolo, S Linse, TPJ Knowles
– Nature chemistry
(2020)
12,
360. Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
TCT Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, AJ Dear, SIA Cohen, CM Dobson, M Vendruscolo, S Linse, TPJ Knowles
– Nature chemistry
(2020)
12,
359. Single particle zeta-potential measurements reveal the role of electrostatics in protein condensate stability
T Welsh, G Krainer, J Espinosa, J Joseph, A Sridhar, M Jahnel, W Arter, K Saar, S Alberti, R Collepardo-Guevara, TPJ Knowles
– None
(2020)
358. Digital Sensing and Molecular Computation by an Enzyme-Free DNA Circuit.
WE Arter, Y Yusim, Q Peter, CG Taylor, D Klenerman, UF Keyser, TPJ Knowles
– ACS nano
(2020)
14,
357. Mechanism of droplet-formation in a supersonic microfluidic spray device
T Kartanas, Z Toprakcioglu, TA Hakala, A Levin, TW Herling, R Daly, J Charmet, TPJ Knowles
– Applied Physics Letters
(2020)
116,
356. Effects of sedimentation, microgravity, hydrodynamic mixing and air-water interface on α-synuclein amyloid formation
J Zhou, FS Ruggeri, MR Zimmermann, G Meisl, G Longo, SK Sekatskii, TPJ Knowles, G Dietler
– Chemical Science
(2020)
11,
355. Microfluidic approaches for the analysis of protein–protein interactions in solution
WE Arter, A Levin, G Krainer, TPJ Knowles
– Biophysical Reviews
(2020)
12,
354. The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.
G Meisl, TP Knowles, D Klenerman
– Current opinion in neurobiology
(2020)
61,
353. Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions (vol 31, pg 125, 2020)
Z Toprakcioglu, TA Hakala, A Levin, CFW Becker, GJL Bernandes, TPJ Knowles
– Soft matter
(2020)
16,
352. Ultrathin Polydopamine Films with Phospholipid Nanodiscs Containing a Glycophorin A Domain
T Marchesi D'Alvise, S Harvey, L Hueske, J Szelwicka, L Veith, TPJ Knowles, D Kubiczek, C Flaig, F Port, KE Gottschalk, F Rosenau, B Graczykowski, G Fytas, FS Ruggeri, K Wunderlich, T Weil
– Advanced Functional Materials
(2020)
30,
351. The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils.
FS Ruggeri, P Flagmeier, JR Kumita, G Meisl, DY Chirgadze, MN Bongiovanni, TPJ Knowles, CM Dobson
– ACS Nano
(2020)
14,
350. Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions
Z Toprakcioglu, TA Hakala, A Levin, CFW Becker, GGL Bernandes, TPJ Knowles
– Soft Matter
(2020)
16,
349. Lipid-Stabilized Double Emulsions Generated in Planar Microfluidic Devices.
L Kong, A Levin, Z Toprakcioglu, Y Xu, H Gang, R Ye, B-Z Mu, TPJ Knowles
– Langmuir : the ACS journal of surfaces and colloids
(2020)
36,
348. Biocompatible Hybrid Organic/Inorganic Microhydrogels Promote Bacterial Adherence and Eradication in Vitro and in Vivo
L Schnaider, Z Toprakcioglu, A Ezra, X Liu, D Bychenko, A Levin, E Gazit, TPJ Knowles
– Nano Letters
(2020)
20,
347. Quantifying the Thermodynamic Stability of Amyloid Fibrils
KL Callaghan, Q Peter, JR Kumita, TP Knowles, CM Dobson
– BIOPHYSICAL JOURNAL
(2020)
118,
346. Microfluidic Diffusional Sizing for Studying Protein-Protein Interactions
MM Schneider, T Scheidt, CM Dobson, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2020)
118,
345. Molecular Forces in the Liquid-Liquid Phase Separation of Biomolecules
TJ Welsh, G Krainer, TP Knowles
– BIOPHYSICAL JOURNAL
(2020)
118,
344. Investigation of Natural and Synthetic Aggregation Inhibitors using Microfluidic Applications
T Scheidt, J Carozza, JL Benesch, P Arosio, S Linse, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2020)
118,
343. Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-beta Peptide Aggregation and Reduces the Toxicity of Its Oligomers
SA Ghadami, S Chia, FS Ruggeri, G Meisl, F Bemporad, J Habchi, R Cascella, CM Dobson, M Vendruscolo, TPJ Knowles, F Chiti
– Biomacromolecules
(2020)
21,
342. Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy
FS Ruggeri, B Mannini, R Schmid, M Vendruscolo, TPJ Knowles
– Nature Communications
(2020)
11,
341. Identification of on- and off-pathway oligomers in amyloid fibril formation
AJ Dear, G Meisl, A Šarić, TCT Michaels, M Kjaergaard, S Linse, TPJ Knowles
– Chemical Science
(2020)
11,
340. Microfluidic Templating of Spatially Inhomogeneous Protein Microgels.
Y Xu, RPB Jacquat, Y Shen, D Vigolo, D Morse, S Zhang, TPJ Knowles
– Small (Weinheim an der Bergstrasse, Germany)
(2020)
16,
339. Multidimensional protein characterisation using microfluidic post-column analysis
T Scheidt, T Kartanas, Q Peter, MM Schneider, KL Saar, T Müller, PK Challa, A Levin, S Devenish, TPJ Knowles
– Lab on a Chip
(2020)
20,
338. Interactions of α-synuclein oligomers with lipid membranes
G Musteikytė, AK Jayaram, CK Xu, M Vendruscolo, G Krainer, TPJ Knowles
– Biochimica et biophysica acta. Biomembranes
(2020)
337. Environmental Control of Amyloid Polymorphism by Modulation of Hydrodynamic Stress.
J Zhou, L Venturelli, L Keiser, SK Sekatskii, F Gallaire, S Kasas, G Longo, TPJ Knowles, FS Ruggeri, G Dietler
– ACS nano
(2020)
336. Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
R Staats, TCT Michaels, P Flagmeier, S Chia, RI Horne, J Habchi, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo
– Communications Chemistry
(2020)
3,
335. Physical mechanisms of amyloid nucleation on fluid membranes
J Krausser, TPJ Knowles, A Šarić
– Proceedings of the National Academy of Sciences
(2020)
117,
334. New solution for fast axial scanning in fluorescence microscopy
W Zong
– Light Sci Appl
(2020)
9,
333. Evolution of Conformation, Nanomechanics, and Infrared Nanospectroscopy of Single Amyloid Fibrils Converting into Microcrystals
J Adamcik, FS Ruggeri, JT Berryman, A Zhang, TPJ Knowles, R Mezzenga
– Advanced Science
(2020)
332. Machine learning aided top-down proteomics on a microfluidic platform
Y Zhang, M Wright, K Saar, P Challa, A Morgunov, Q Peter, S Devenish, C Dobson, TPJ Knowles
– None
(2020)
331. On the Mechanism of Self-Assembly by a Hydrogel-Forming Peptide
GA Braun, BE Ary, AJ Dear, MCH Rohn, AM Payson, DSM Lee, RC Parry, C Friedman, TPJ Knowles, S Linse, KS Åkerfeldt
– Biomacromolecules
(2020)
21,
330. Amyloid precipitation in biofluids using a structure-specific chemical antibody
M Rodrigues, P Bhattacharjee, A Brinkmalm, D Do, C Pearson, S De, A Ponjavic, J Varela, F Ruggeri, I Baudrexel, J Lee, A Carr, K Kulenkampff, T Knowles, H Zetterberg, T Snaddon, S Gandhi, S Lee, D Klenerman
– None
(2020)
329. Microscale diffusiophoresis of proteins
Q Peter, R Jacquat, T Herling, P Challa, T Kartanas, T Knowles
– None
(2020)
328. Rapid structural, kinetic, and immunochemical analysis of alpha-synuclein oligomers in solution
WE Arter, CK Xu, M Castellana-Cruz, TW Herling, G Krainer, KL Saar, JR Kumita, CM Dobson, TPJ Knowles
– Nano Lett
(2020)
20,
327. The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils.
D Thacker, K Sanagavarapu, B Frohm, G Meisl, TPJ Knowles, S Linse
– Proceedings of the National Academy of Sciences
(2020)
117,
326. Kinetic fingerprints differentiate the mechanisms of action of anti-A beta antibodies
S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, E Sileikis, M Lundqvist, F Qian, T O'Malley, T Bussiere, PH Weinreb, CK Xu, G Meisl, SRA Devenish, TPJ Knowles, O Hansson
– Nat Struct Mol Biol
(2020)
27,
325. Converting lateral scanning into axial focusing to speed up three-dimensional microscopy
T Chakraborty, B Chen, S Daetwyler, B-J Chang, O Vanderpoorten, E Sapoznik, CF Kaminski, TPJ Knowles, KM Dean, R Fiolka
– Light: Science and Applications
(2020)
9,
324. A rationally designed bicyclic peptide remodels A beta 42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer's disease
T Ikenoue, FA Aprile, P Sormanni, FS Ruggeri, M Perni, GT Heller, CP Haas, C Middel, R Limbocker, B Mannini, TCT Michaels, TPJ Knowles, CM Dobson, M Vendruscolo
– Scientific Reports
(2020)
10,
323. Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition
Y Shen, FS Ruggeri, D Vigolo, A Kamada, S Qamar, A Levin, C Iserman, S Alberti, PS George-Hyslop, TPJ Knowles
– Nat Nanotechnol
(2020)
15,
322. Biomimetic peptide self-assembly for functional materials
A Levin, TA Hakala, L Schnaider, GJL Bernardes, E Gazit, TPJ Knowles
– Nature Reviews Chemistry
(2020)
4,
321. Microfluidic Antibody Affinity Profiling for In-Solution Characterisation of Alloantibody - HLA Interactions in Human Serum
M Schneider, T Scheidt, A Priddey, C Xu, M Hu, S Devenish, G Meisl, C Dobson, V Kosmoliaptsis, T Knowles
– bioRxiv
(2020)
320. Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors.
TCT Michaels, A Šarić, G Meisl, GT Heller, S Curk, P Arosio, S Linse, CM Dobson, M Vendruscolo, TPJ Knowles
– Proc Natl Acad Sci U S A
(2020)
117,
319. Abstract 5879: Spatially-segmented single-cell transcriptomics by diffusional accessibility to a small-molecule dye
DB Morse, M Ceribelli, J De Jonghe, A Michalowski, C Muus, M Vias, S Boyle, DA Weitz, J Brenton, JD Buenrostro, C Thomas, TP Knowles
– Molecular and Cellular Biology / Genetics
(2020)
318. Kinetic analysis reveals the rates and mechanisms of protein aggregation in a multicellular organism
T Sinnige, G Meisl, T Michaels, M Vendruscolo, TPJ Knowles, R Morimoto
– None
(2020)
317. Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
R Limbocker, B Mannini, FS Ruggeri, R Cascella, CK Xu, M Perni, S Chia, SW Chen, J Habchi, A Bigi, RP Kreiser, AK Wright, JA Albright, T Kartanas, JR Kumita, N Cremades, M Zasloff, C Cecchi, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Communications Biology
(2020)
3,
316. Microfluidic Templating: Microfluidic Templating of Spatially Inhomogeneous Protein Microgels (Small 32/2020)
Y Xu, RPB Jacquat, Y Shen, D Vigolo, D Morse, S Zhang, TPJ Knowles
– Small
(2020)
16,
315. Direct measurement of lipid membrane disruption connects kinetics and toxicity of A beta 42 aggregation
P Flagmeier, S De, TCT Michaels, X Yang, AJ Dear, C Emanuelsson, M Vendruscolo, S Linse, D Klenerman, TPJ Knowles, CM Dobson
– Nature structural & molecular biology
(2020)
27,
314. Phase Transition and Crystallization Kinetics of a Supramolecular System in a Microfluidic Platform
D Cohen-Gerassi, ZA Arnon, T Guterman, A Levin, M Ghosh, M Aviv, D Levy, TPJ Knowles, Y Shacham-Diamand, L Adler-Abramovich
– Chemistry of Materials
(2020)
32,
313. Continuous Flow Reactors from Microfluidic Compartmentalization of Enzymes within Inorganic Microparticles.
TA Hakala, F Bialas, Z Toprakcioglu, B Bräuer, KN Baumann, A Levin, GJL Bernardes, CFW Becker, TPJ Knowles
– ACS Applied Materials & Interfaces
(2020)
12,
312. Local micro and nano patterning of microfluidic devices using the solid on liquid deposition process
J Charmet, A Homsy, M Wood, J Covington, L Isa, M Textor, TPJ Knowles, H Keppner
– 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
(2020)
311. Microfluidic Affinity Profiling reveals a Broad Range of Target Affinities for Anti-SARS-CoV-2 Antibodies in Plasma of Covid Survivors
MM Schneider, M Emmenegger, CK Xu, I Condado Morales, P Turelli, MR Zimmermann, BM Frey, S Fiedler, V Denninger, G Meisl, V Kosmoliaptsis, H Fiegler, D Trono, TPJ Knowles, AAA Aguzzi
– medRxiv
(2020)
310. Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils
J Yang, AJ Dear, Q-Q Yao, Z Liu, CM Dobson, TPJ Knowles, S Wu, S Perrett
– Nanoscale
(2020)
12,
309. A microfluidic strategy for the detection of membrane protein interactions.
Y Zhang, TW Herling, S Kreida, QAE Peter, T Kartanas, S Törnroth-Horsefield, S Linse, TPJ Knowles
– Lab on a chip
(2020)
20,
308. Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses
J Pansieri, IA Iashchishyn, H Fakhouri, L Ostojić, M Malisauskas, G Musteikyte, V Smirnovas, MM Schneider, T Scheidt, CK Xu, G Meisl, TPJ Knowles, E Gazit, R Antoine, LA Morozova-Roche
– Chemical Science
(2020)
11,
307. Half a century of amyloids: past, present and future.
PC Ke, R Zhou, LC Serpell, R Riek, TPJ Knowles, HA Lashuel, E Gazit, IW Hamley, TP Davis, M Fändrich, DE Otzen, MR Chapman, CM Dobson, DS Eisenberg, R Mezzenga
– Chem Soc Rev
(2020)
49,
306. Trodusquemine enhances A beta(42) aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nature Communications
(2019)
10,
305. Physical Determinants of Amyloid Assembly in Biofilm Formation
M Andreasen, G Meisl, JD Taylor, TCT Michaels, A Levin, DE Otzen, MR Chapman, CM Dobson, SJ Matthews, TPJ Knowles
– mBio
(2019)
10,
304. Rapid two-dimensional characterisation of proteins in solution
KL Saar, Q Peter, T Müller, PK Challa, TW Herling, TPJ Knowles
– Microsystems and Nanoengineering
(2019)
5,
303. Scalable integration of nano-, and microfluidics with hybrid two-photon lithography
O Vanderpoorten, Q Peter, PK Challa, UF Keyser, J Baumberg, CF Kaminski, TPJ Knowles
– Microsystems and Nanoengineering
(2019)
5,
302. Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
– Nature communications
(2019)
10,
301. Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification
PR Lindstedt, FA Aprile, MJ Matos, M Perni, JB Bertoldo, B Bernardim, Q Peter, G Jiménez-Osés, TPJ Knowles, CM Dobson, F Corzana, M Vendruscolo, GJL Bernardes
– ACS Central Science
(2019)
5,
300. Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
G Heller, F Aprile, T Michaels, R Limbocker, M Perni, FS Ruggeri, B Mannini, T Löhr, M Bonomi, A De Simone, I Felli, R Pierattelli, T Knowles, C Dobson, M Vendruscolo
– None
(2019)
299. Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression
S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman
– Acta neuropathologica communications
(2019)
7,
298. Analysis of alpha B-crystallin polydispersity in solution through native microfluidic electrophoresis
MA Wright, FS Ruggeri, KL Saar, PK Challa, JLP Benesch, TPJ Knowles
– The Analyst
(2019)
144,
297. Universality of filamentous aggregation phenomena
TCT Michaels, AJ Dear, TPJ Knowles
– Physical Review E
(2019)
99,
296. Programmable On-Chip Artificial Cell Producing Post-Translationally Modified Ubiquitinated Protein.
S Zilberzwige-Tal, A Levin, Z Toprakcioglu, TPJ Knowles, E Gazit, J Elbaz
– Small (Weinheim an der Bergstrasse, Germany)
(2019)
15,
295. Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates
T Scheidt, U Łapińska, JR Kumita, DR Whiten, D Klenerman, MR Wilson, SIA Cohen, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles, P Arosio
– Science advances
(2019)
5,
294. The Amyloid Phenomenon and Its Significance in Biology and Medicine
CM Dobson, TPJ Knowles, M Vendruscolo
– Cold Spring Harbor perspectives in biology
(2019)
12,
293. Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species
JC Sang, J-E Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, TPJ Knowles, D Klenerman
– Chemical science
(2019)
10,
292. Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation
MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, B Bernardim, KL Saar, I Compañón, F Corzana, TPJ Knowles, G Jiménez-Osés, GJL Bernardes
– Angewandte Chemie (International ed. in English)
(2019)
131,
291. Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules.
X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, JR Kumita, M Andreasen, CM Dobson, U Shimanovich, TPJ Knowles
– Macromolecular rapid communications
(2019)
40,
290. A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli.
K Sanagavarapu, E Nüske, I Nasir, G Meisl, JN Immink, P Sormanni, M Vendruscolo, TPJ Knowles, A Malmendal, C Cabaleiro-Lago, S Linse
– Scientific reports
(2019)
9,
289. Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated A beta 42 Species A beta 5-42
T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse
– ACS chemical neuroscience
(2019)
10,
288. Targeting the Formation of Amyloid Oligomers using Rationally Designed Antibodies
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TP Knowles, CM Dobson, M Vendruscolo
– Biophysical Journal
(2019)
116,
287. Atomic force microscopy for single molecule characterisation of protein aggregation.
R Cataldi, S Chia, K Pisani, FS Ruggeri, CK Xu, T Šneideris, M Perni, S Sarwat, P Joshi, JR Kumita, S Linse, J Habchi, TPJ Knowles, B Mannini, CM Dobson, M Vendruscolo
– Archives of biochemistry and biophysics
(2019)
664,
286. Sequence‐Optimized Peptide Nanofibers as Growth Stimulators for Regeneration of Peripheral Neurons
C Schilling, T Mack, S Lickfett, S Sieste, FS Ruggeri, T Sneideris, A Dutta, T Bereau, R Naraghi, D Sinske, TPJ Knowles, CV Synatschke, T Weil, B Knöll
– Advanced Functional Materials
(2019)
29,
285. Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism.
C Bortolini, T Kartanas, D Copic, I Condado Morales, Y Zhang, PK Challa, Q Peter, T Jávorfi, R Hussain, M Dong, G Siligardi, TPJ Knowles, J Charmet
– Lab on a chip
(2019)
19,
284. Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy.
FS Ruggeri, T Šneideris, S Chia, M Vendruscolo, TPJ Knowles
– Journal of visualized experiments : JoVE
(2019)
2019,
283. Nucleation and Growth of Amino-acid and Peptide Supramolecular Polymers through Liquid-liquid Phase Separation.
X Yan, C Yuan, A Levin, W Chen, R Xing, Q Zou, TW Herling, PK Challa, TPJ Knowles
– Angewandte Chemie (International ed. in English)
(2019)
131,
282. Modulating the Mechanical Performance of Macroscale Fibers through Shear-Induced Alignment and Assembly of Protein Nanofibrils.
A Kamada, A Levin, Z Toprakcioglu, Y Shen, V Lutz-Bueno, KN Baumann, P Mohammadi, MB Linder, R Mezzenga, TPJ Knowles
– Small (Weinheim an der Bergstrasse, Germany)
(2019)
16,
281. RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
Y-C Liao, MS Fernandopulle, G Wang, H Choi, L Hao, CM Drerup, R Patel, S Qamar, J Nixon-Abell, Y Shen, W Meadows, M Vendruscolo, TPJ Knowles, M Nelson, MA Czekalska, G Musteikyte, MA Gachechiladze, CA Stephens, HA Pasolli, LR Forrest, P St George-Hyslop, J Lippincott-Schwartz, ME Ward
– Cell
(2019)
179,
280. Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid
R Frankel, M Törnquist, G Meisl, O Hansson, U Andreasson, H Zetterberg, K Blennow, B Frohm, T Cedervall, TPJ Knowles, T Leiding, S Linse
– Communications Biology
(2019)
2,
279. Homage to Chris Dobson.
J Baum, F Chiti, A De Simone, TPJ Knowles, JR Kumita, SE Radford, CV Robinson, X Salvatella, K Valelli, M Vendruscolo, A Pastore, GG Tartaglia
– Frontiers in Molecular Biosciences
(2019)
6,
278. Label-Free Analysis of Protein Aggregation and Phase Behavior
Z Toprakcioglu, P Challa, C Xu, TPJ Knowles
– ACS nano
(2019)
13,
277. Autoantibodies against the prion protein in individuals with PRNP mutations
K Frontzek, MC Carta, M Losa, M Epskamp, G Meisl, A Anane, J-P Brandel, U Camenisch, J Castilla, S Haik, T Knowles, E Lindner, A Lutterotti, EV Minikel, I Roiter, J Safar, R Sanchez-Valle, D Zakova, S Hornemann, A Aguzzi
– None
(2019)
276. Dynamics and Control of Peptide Self-Assembly and Aggregation
G Meisl, TCT Michaels, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Advances in experimental medicine and biology
(2019)
1174,
275. Inside Back Cover: Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid–Liquid Phase Separation (Angew. Chem. Int. Ed. 50/2019)
C Yuan, A Levin, W Chen, R Xing, Q Zou, TW Herling, PK Challa, TPJ Knowles, X Yan
– Angewandte Chemie International Edition
(2019)
58,
274. Innenrücktitelbild: Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid–Liquid Phase Separation (Angew. Chem. 50/2019)
C Yuan, A Levin, W Chen, R Xing, Q Zou, TW Herling, PK Challa, TPJ Knowles, X Yan
– Angewandte Chemie
(2019)
131,
273. Nanostructured protein capsules
T Knowles
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
258,
272. General sol to gel transition of liquid-liqud phase separated protein under shear
Y Shen, S Qamar, D Vigolo, A Kamada, S Zhang, P St George-Hyslop, T Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2019)
48,
271. The presence of autoantibodies against the prion protein is independent of PRNP mutations
K Frontzek, M Carta, M Losa, M Epskamp, G Meisl, U Camenisch, T Knowles, S Hornemann, A Aguzzi, THAUTAN-MC Investigators
– PRION
(2019)
13,
270. 3D microfluidics spray nozzle for sample processing and materials deposition
T Kartanas, R Rodrigues, T Müller, T Herling, T Knowles, J Charmet
– 3RD BIOMEDICAL ENGINEERING'S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES
(2019)
2092,
269. Mechanobiology of Protein Droplets: Force Arises from Disorder.
TJ Welsh, Y Shen, A Levin, TPJ Knowles
– Cell
(2018)
175,
268. Quantifying Co-Oligomer Formation by Alpha-Synuclein
M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, TCT Michaels, D Frenkel, CM Dobson, TPJ Knowles, D Klenerman
– ACS Nano
(2018)
12,
267. Automated Behavioral Analysis of Large <em>C. elegans</em> Populations Using a Wide Field-of-view Tracking Platform
M Perni, S Casford, FA Aprile, EA Nollen, TPJ Knowles, M Vendruscolo, CM Dobson
– Journal of visualized experiments : JoVE
(2018)
2018,
266. Statistical Mechanics of Globular Oligomer Formation by Protein Molecules
AJ Dear, A Šarić, TCT Michaels, CM Dobson, TPJ Knowles
– Journal of Physical Chemistry B
(2018)
122,
265. Direct Observation of Murine Prion Protein Replication in Vitro.
JC Sang, G Meisl, AM Thackray, L Hong, A Ponjavic, TPJ Knowles, R Bujdoso, D Klenerman
– Journal of the American Chemical Society
(2018)
140,
264. Observation of molecular self-assembly events in massively parallel microdroplet arrays
Z Toprakcioglu, PK Challa, A Levin, TPJ Knowles
– Lab on a Chip
(2018)
18,
263. SAR by kinetics for drug discovery in protein misfolding diseases
S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2018)
115,
262. Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity
FS Ruggeri, J Charmet, T Kartanas, Q Peter, S Chia, J Habchi, CM Dobson, M Vendruscolo, TPJ Knowles
– Nature Communications
(2018)
9,
261. Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes
Z Li, J Tuffin, IM Lei, FS Ruggeri, NS Lewis, EL Gill, T Savin, L Huleihel, SF Badylak, T Knowles, SC Satchell, GI Welsh, MA Saleem, YYS Huang
– Acta biomaterialia
(2018)
78,
260. Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution.
CG Taylor, G Meisl, MH Horrocks, H Zetterberg, TPJ Knowles, D Klenerman
– Analytical chemistry
(2018)
90,
259. Identification of oxidative stress in red blood cells with nanoscale chemical resolution by infrared nanospectroscopy
FS Ruggeri, C Marcott, S Dinarelli, G Longo, M Girasole, G Dietler, TPJ Knowles
– International journal of molecular sciences
(2018)
19,
258. Image-Assisted Microvessel-on-a-Chip Platform for Studying Cancer Cell Transendothelial Migration Dynamics.
C Bertulli, M Gerigk, N Piano, Y Liu, D Zhang, T Müller, TJ Knowles, YYS Huang
– Scientific reports
(2018)
8,
257. DNA-Coated Functional Oil Droplets.
A Caciagli, M Zupkauskas, A Levin, TPJ Knowles, C Mugemana, N Bruns, T O'Neill, WJ Frith, E Eiser
– Langmuir : the ACS journal of surfaces and colloids
(2018)
34,
256. Combining Affinity Selection and Specific Ion Mobility for Microchip Protein Sensing.
WE Arter, J Charmet, J Kong, KL Saar, TW Herling, T Müller, UF Keyser, TPJ Knowles
– Analytical chemistry
(2018)
90,
255. Stabilization and Characterization of Cytotoxic Aβ <inf>40</inf> Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions
B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, CM Dobson, M Vendruscolo
– ACS chemical neuroscience
(2018)
9,
254. Self-Assembly-Mediated Release of Peptide Nanoparticles through Jets Across Microdroplet Interfaces
A Levin, TCT Michaels, TO Mason, T Müller, L Adler-Abramovich, L Mahadevan, ME Cates, E Gazit, TPJ Knowles
– ACS Applied Materials and Interfaces
(2018)
10,
253. Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, N Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles
– Journal of neuroscience methods
(2018)
306,
252. Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation.
C Månsson, RTP van Cruchten, U Weininger, X Yang, R Cukalevski, P Arosio, CM Dobson, T Knowles, M Akke, S Linse, C Emanuelsson
– Biochemistry
(2018)
57,
251. Origin of metastable oligomers and their effects on amyloid fibril self-assembly.
F Hasecke, T Miti, C Perez, J Barton, D Schölzel, L Gremer, CSR Grüning, G Matthews, G Meisl, TPJ Knowles, D Willbold, P Neudecker, H Heise, G Ullah, W Hoyer, M Muschol
– Chemical Science
(2018)
9,
250. Oligomer diversity during the aggregation of the repeat-region of tau
M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman
– ACS Chemical Neuroscience
(2018)
9,
249. Secondary nucleation in amyloid formation
M Törnquist, TCT Michaels, K Sanagavarapu, X Yang, G Meisl, SIA Cohen, TPJ Knowles, S Linse
– Chemical communications (Cambridge, England)
(2018)
54,
248. Kinetic barriers to alpha-synuclein protofilament formation and conversion into mature fibrils
JWP Brown, G Meisl, TPJ Knowles, AK Buell, CM Dobson, C Galvagnion
– Chemical communications (Cambridge, England)
(2018)
54,
247. Determination of Polypeptide Conformation with Nanoscale Resolution in Water
G Ramer, FS Ruggeri, A Levin, TPJ Knowles, A Centrone
– ACS nano
(2018)
12,
246. Multistep Inhibition of alpha-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, GT Heller, G Meisl, SW Chen, JR Kumita, PK Challa, JB Kirkegaard, SIA Cohen, B Mannini, D Barbut, EAA Nollen, C Cecchi, N Cremades, TPJ Knowles, F Chiti, M Zasloff, M Vendruscolo, CM Dobson
– ACS Chemical Biology
(2018)
13,
245. Enhancing the Resolution of Micro Free Flow Electrophoresis through Spatially Controlled Sample Injection.
KL Saar, T Müller, J Charmet, PK Challa, TPJ Knowles
– Analytical chemistry
(2018)
90,
244. Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.
FS Ruggeri, F Benedetti, TPJ Knowles, HA Lashuel, S Sekatskii, G Dietler
– Proceedings of the National Academy of Sciences of the United States of America
(2018)
115,
243. On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations.
X Yang, G Meisl, B Frohm, E Thulin, TPJ Knowles, S Linse
– Proceedings of the National Academy of Sciences of the United States of America
(2018)
115,
242. Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils
Y Song, TCT Michaels, Q Ma, Z Liu, H Yuan, S Takayama, TPJ Knowles, HC Shum
– Nature Communications
(2018)
9,
241. Cooperative Assembly of Hsp70 Subdomain Clusters.
MA Wright, FA Aprile, MMJ Bellaiche, TCT Michaels, T Müller, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Biochemistry
(2018)
57,
240. Reaction rate theory for supramolecular kinetics: application to protein aggregation
TCT Michaels, LX Liu, S Curk, PG Bolhuis, A Šarić, TPJ Knowles
– Molecular Physics
(2018)
116,
239. Rapid Growth of Acetylated A beta(16-20) into Macroscopic Crystals
C Bortolini, LH Klausen, SV Hoffmann, NC Jones, D Saadeh, Z Wang, TPJ Knowles, M Dong
– ACS nano
(2018)
12,
238. Stochastic calculus of protein filament formation under spatial confinement
TCT Michaels, AJ Dear, TPJ Knowles
– NEW JOURNAL OF PHYSICS
(2018)
20,
237. Cholesterol catalyses A beta 42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, FS Ruggeri, M Sanguanini, I Idini, JR Kumita, E Sparr, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Nature Chemistry
(2018)
10,
236. On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.
Y Zhang, EV Yates, L Hong, KL Saar, G Meisl, CM Dobson, TPJ Knowles
– Chemical Science
(2018)
9,
235. Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion.
S Sieste, T Mack, CV Synatschke, C Schilling, C Meyer Zu Reckendorf, L Pendi, S Harvey, FS Ruggeri, TPJ Knowles, C Meier, DYW Ng, T Weil, B Knöll
– Advanced healthcare materials
(2018)
7,
234. Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading
F Kundel, L Hong, B Falcon, WA McEwan, TCT Michaels, G Meisl, N Esteras, AY Abramov, TJP Knowles, M Goedert, D Klenerman
– ACS chemical neuroscience
(2018)
9,
233. Microfluidic approaches for probing amyloid assembly and behaviour.
TW Herling, A Levin, KL Saar, CM Dobson, TPJ Knowles
– Lab on a Chip - Miniaturisation for Chemistry and Biology
(2018)
18,
232. Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-beta peptide
SIA Cohen, R Cukalevski, TCT Michaels, A Šarić, M Törnquist, M Vendruscolo, CM Dobson, AK Buell, TPJ Knowles, S Linse
– Nature Chemistry
(2018)
10,
231. Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices
PK Challa, Q Peter, MA Wright, Y Zhang, KL Saar, JA Carozza, JLP Benesch, TPJ Knowles
– Analytical chemistry
(2018)
90,
230. Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.
TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, CM Dobson, TPJ Knowles
– ANNUAL REVIEW OF PHYSICAL CHEMISTRY, VOL 69
(2018)
69,
229. Revealing the Mechanism of Amyloid Fibril Formation by Combined Single Molecule FRET and Kinetic Modeling
J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Perretti, S Wu
– BIOPHYSICAL JOURNAL
(2018)
114,
228. Probing the Interaction of ABETA42 Amyloid Species with an Aggregation Suppressor Molecule by Infrared Nanospectroscopy
FS Ruggeri, J Habchi, S Chia, M Vendruscolo, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2018)
114,
227. Molecular Mechanism of AB(42) Peptide-Fibril Adsorption
MMJ Bellaiche, TPJ Knowles, RB Best
– BIOPHYSICAL JOURNAL
(2018)
114,
226. Modulating Amyloid-Beta Aggregation to Reduce the Toxicity of its Oligomeric Aggregates
R Limbocker, B Mannini, S Chia, FS Ruggeri, M Perni, R Cascella, C Xu, J Habchi, JR Kumita, F Chiti, TPJ Knowles, M Vendruscolo, CM Dobson
– BIOPHYSICAL JOURNAL
(2018)
114,
225. Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Amyloid-Beta42 Aggregation in Alzheimer's Disease
S Chia, J Habchi, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– BIOPHYSICAL JOURNAL
(2018)
114,
224. 2-Photon Lithography for Nanofluidic Lab-on-Chip Devices
O Vanderpoorten, PK Challa, Q Peter, J Charmet, N Curry, TPJ Knowles, CF Kaminski
– BIOPHYSICAL JOURNAL
(2018)
114,
223. Biophotonics of Native Silk Fibrils.
U Shimanovich, D Pinotsi, K Shimanovich, N Yu, S Bolisetty, J Adamcik, R Mezzenga, J Charmet, F Vollrath, E Gazit, CM Dobson, GK Schierle, C Holland, CF Kaminski, TPJ Knowles
– Macromolecular bioscience
(2018)
18,
222. Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2
J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Wu, S Perrett
– Journal of the American Chemical Society
(2018)
140,
221. Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions.
H Gang, C Galvagnion, G Meisl, T Müller, M Pfammatter, AK Buell, A Levin, CM Dobson, B Mu, TPJ Knowles
– Analytical Chemistry
(2018)
90,
220. Enhancing power density of biophotovoltaics by decoupling storage and power delivery
KL Saar, P Bombelli, DJ Lea-Smith, T Call, EM Aro, T Müller, CJ Howe, TPJ Knowles
– Nature Energy
(2018)
3,
219. FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions
S Qamar, G Wang, SJ Randle, FS Ruggeri, JA Varela, JQ Lin, EC Phillips, A Miyashita, D Williams, F Ströhl, W Meadows, R Ferry, VJ Dardov, GG Tartaglia, LA Farrer, GS Kaminski Schierle, CF Kaminski, CE Holt, PE Fraser, G Schmitt-Ulms, D Klenerman, T Knowles, M Vendruscolo, P St George-Hyslop
– Cell
(2018)
173,
218. Kinetic Analysis of Amyloid Formation.
G Meisl, TCT Michaels, S Linse, TPJ Knowles
– Methods in molecular biology (Clifton, N.J.)
(2018)
1779,
217. C-terminal truncation of alpha-synuclein promotes amyloid fibril amplification at physiological pH
IM van der Wateren, TPJ Knowles, AK Buell, CM Dobson, C Galvagnion
– Chemical Science
(2018)
9,
216. Microfluidics for Protein Biophysics
J Charmet, P Arosio, TPJ Knowles
– Journal of molecular biology
(2018)
430,
215. O2‐02‐02: TARGETING AMYLOID FORMATION USING RATIONALLY DESIGNED ANTIBODIES
FA Aprile, P Sormanni, M Perni, P Arosio, R Limbocker, S Chhangur, B Mannini, S Linse, T Knowles, CM Dobson, M Vendruscolo
– Alzheimer's & Dementia
(2018)
14,
214. Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1
PH St George-Hyslop, S Qamar, G Wang, SJ Randle, FS Ruggeri, J Varela, CF Kaminski, GS Kaminski, M Vendruscolo, TPJ Knowles, D Klenerman, CE Holt, Q Lin, W meadows
– Cell
(2018)
213. On-Chip Measurements of Membrane Protein Interactions
Y Zhang, T Knowles, S Linse
– PROTEIN SCIENCE
(2018)
27,
212. Microfluidic Diffusional Sizing Enables Characterisation of Protein-Protein Interactions Under Native Conditions
S Devenish, C Thorne, T Scheidt, J Carozza, P Arosio, Y Zhang, A Buell, T Mueller, A Lynn, J Faherty, M Wright, M Butz, T Knowles
– PROTEIN SCIENCE
(2018)
27,
211. Mechanism of biosurfactant adsorption to oil/water interfaces from millisecond scale tensiometry measurements
L Kong, KL Saar, R Jacquat, L Hong, A Levin, H Gang, R Ye, B Mu, TPJ Knowles
– Interface focus
(2017)
7,
210. Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit.
TO Mason, TCT Michaels, A Levin, CM Dobson, E Gazit, TPJ Knowles, AK Buell
– Journal of the American Chemical Society
(2017)
139,
209. Nanoscale click-reactive scaffolds from peptide self-assembly
APM Guttenplan, LJ Young, D Matak-Vinkovic, CF Kaminski, TPJ Knowles, LS Itzhaki
– Journal of Nanobiotechnology
(2017)
15,
208. Enhanced Quality Factor Label-free Biosensing with Micro-Cantilevers Integrated into Microfluidic Systems.
T Kartanas, V Ostanin, PK Challa, R Daly, J Charmet, TPJ Knowles
– Analytical chemistry
(2017)
89,
207. Absolute Quantification of Amyloid Propagons by Digital Microfluidics.
M Pfammatter, M Andreasen, G Meisl, CG Taylor, J Adamcik, S Bolisetty, A Sánchez-Ferrer, D Klenerman, CM Dobson, R Mezzenga, TPJ Knowles, A Aguzzi, S Hornemann
– Analytical Chemistry
(2017)
89,
206. Hierarchical Biomolecular Emulsions Using 3-D Microfluidics with Uniform Surface Chemistry.
Z Toprakcioglu, A Levin, TPJ Knowles
– Biomacromolecules
(2017)
18,
205. Kinetic constraints on self-assembly into closed supramolecular structures
TCT Michaels, MMJ Bellaiche, MF Hagan, TPJ Knowles
– Scientific Reports
(2017)
7,
204. Gradient-free determination of isoelectric points of proteins on chip.
U Łapińska, KL Saar, EV Yates, TW Herling, T Müller, PK Challa, CM Dobson, TPJ Knowles
– Physical chemistry chemical physics : PCCP
(2017)
19,
203. Sequential Release of Proteins from Structured Multishell Microcapsules
U Shimanovich, TCT Michaels, E De Genst, D Matak-Vinkovic, CM Dobson, TPJ Knowles
– Biomacromolecules
(2017)
18,
202. Monomeric and fibrillar alpha-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of A beta 42 aggregates
S Chia, P Flagmeier, J Habchi, V Lattanzi, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
201. Silk micrococoons for protein stabilisation and molecular encapsulation
U Shimanovich, FS Ruggeri, E De Genst, J Adamcik, TP Barros, D Porter, T Müller, R Mezzenga, CM Dobson, F Vollrath, C Holland, TPJ Knowles
– Nature Communications
(2017)
8,
200. Nanobodies raised against monomeric alpha-synuclein inhibit fibril formation and destabilize toxic oligomeric species
D Klenerman, M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, FS Ruggeri, T Guilliams, AK Buell, J-E Lee, S Gandhi, SF Lee, CE Bryant, M Vendruscolo, TPJ Knowles, CM Dobson, E De Genst, D Klenerman
– BMC biology
(2017)
15,
199. Self-assembled Protein Fibril-metal Oxide Nanocomposites
A Levin, TO Mason, TPJ Knowles, U Shimanovich
– Israel Journal of Chemistry
(2017)
57,
198. A microfluidic platform for quantitative protein studies
TW Herling, P Arosio, T Mueller, DJ O'Connell, MC Bauer, J Persson, U Weininger, S Linse, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
197. Ultrasensitive measurement of Ca2+ influx into lipid vesicles induced by protein aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TP Knowles, S Gandhi, CM Dobson, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
129,
196. Measuring the prion-like character of tau by TIRF microscopy
F Kundel, B Falcon, L Hong, N Esteras, AJ Dear, AY Abramov, TPJ Knowles, M Goedert, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
195. Single amyloid aggregates chemical and structural analysis by infrared nanospectroscopy
FS Ruggeri, J Habchi, C Sean, M Vendruscolo, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
194. Mechanisms of Amyloid-beta 42 oligomer formation from kinetic analysis
TC Michaels, A Saric, HW Lazell, P Arosio, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
193. Evidence for self-replication of Alzheimer-associated A beta 42 amyloid along the sides of fibrils
M Tornquist, R Cukalevski, U Weininger, G Meisl, TPJ Knowles, T Leiding, M Akke, S Linse
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
192. Selective targeting of primary and secondary nucleation pathways in A beta 42 aggregation using a rational antibody scanning method
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo
– Science Advances
(2017)
3,
191. Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication.
A Munke, J Persson, T Weiffert, E De Genst, G Meisl, P Arosio, A Carnerup, CM Dobson, M Vendruscolo, TPJ Knowles, S Linse
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
190. Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers
P Varilly, AP Willard, JB Kirkegaard, TPJ Knowles, D Chandler
– The Journal of chemical physics
(2017)
146,
189. A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity (vol 114, pg E1009, 2017)
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Mueller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proceedings of the National Academy of Sciences
(2017)
114,
188. Exciton Coupling of Phenylalanine Reveals Conformational Changes of Cationic Peptides
C Bortolini, L Liu, SV Hoffmann, NC Jones, TPJ Knowles, M Dong
– ChemistrySelect
(2017)
2,
187. Acceleration of alpha-synuclein aggregation
R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, E Sparr, S Linse
– Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
(2017)
24,
186. Inhibition of alpha-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between alpha-Synuclein Species
FA Aprile, P Arosio, G Fusco, SW Chen, JR Kumita, A Dhulesia, P Tortora, TPJ Knowles, M Vendruscolo, CM Dobson, N Cremades
– Biochemistry
(2017)
56,
185. Physical principles of filamentous protein self-assembly kinetics
TCT Michaels, LX Liu, G Meisl, TPJ Knowles
– Journal of Physics: Condensed Matter
(2017)
29,
184. A natural product inhibits the initiation of α-synuclein aggregation & suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limbocker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
183. Attenuating the Toxicity of Amyloid-Beta Aggregation with Specific Species
R Limbocker, B Mannini, M Perni, S Chia, G Heller, FS Ruggeri, J Habchi, G Meisl, PK Challa, M Zasloff, TPJ Knowles, M Vendruscolo, CM Dobson
– Biophysical Journal
(2017)
112,
182. Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the A beta 42 peptide and its variants
G Meisl, X Yang, CM Dobson, S Linse, TPJ Knowles
– Chemical Science
(2017)
8,
181. Scaling behaviour and rate-determining steps in filamentous self-assembly.
G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– Chemical Science
(2017)
8,
180. Microfluidic devices fabricated using fast wafer-scale LED-lithography patterning.
PK Challa, T Kartanas, J Charmet, TPJ Knowles
– Biomicrofluidics
(2017)
11,
179. On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products
KL Saar, Y Zhang, T Müller, CP Kumar, S Devenish, A Lynn, U Łapińska, X Yang, S Linse, TPJ Knowles
– Lab on a Chip - Miniaturisation for Chemistry and Biology
(2017)
18,
178. Secondary nucleation of monomers on fibril surface dominates $\alpha$-synuclein aggregation and provides autocatalytic amyloid amplification
R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, E Sparr, S Linse
– Quarterly reviews of biophysics
(2017)
50,
177. Ultrasensitive Measurement of Ca<sup>2+</sup> Influx into Lipid Vesicles Induced by Protein Aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman
– Angewandte Chemie International Edition
(2017)
56,
176. Micro- and nanoscale hierarchical structure of core–shell protein microgels
LR Volpatti, U Shimanovich, FS Ruggeri, S Bolisetty, T Müller, TO Mason, TCT Michaels, R Mezzenga, G Dietler, TPJ Knowles
– Journal of Materials Chemistry B
(2016)
4,
175. Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation.
A Šarić, TCT Michaels, A Zaccone, TPJ Knowles, D Frenkel
– The Journal of chemical physics
(2016)
145,
174. Dynamics of heteromolecular filament formation.
AJ Dear, TCT Michaels, TPJ Knowles
– The Journal of Chemical Physics
(2016)
145,
173. beta-Synuclein suppresses both the initiation and amplification steps of alpha-synuclein aggregation via competitive binding to surfaces
JWP Brown, AK Buell, TCT Michaels, G Meisl, J Carozza, P Flagmeier, M Vendruscolo, TPJ Knowles, CM Dobson, C Galvagnion
– Scientific reports
(2016)
6,
172. Dynamic microfluidic control of supramolecular peptide self-assembly
ZA Arnon, A Vitalis, A Levin, TCT Michaels, A Caflisch, TPJ Knowles, L Adler-Abramovich, E Gazit
– Nature Communications
(2016)
7,
171. Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces.
Y Song, U Shimanovich, TCT Michaels, Q Ma, J Li, TPJ Knowles, HC Shum
– Nature Communications
(2016)
7,
170. Kinetics of fragmentation and dissociation of two-strand protein filaments: Coarse-grained simulations and experiments.
A Zaccone, I Terentjev, TW Herling, TPJ Knowles, A Aleksandrova, EM Terentjev
– The Journal of chemical physics
(2016)
145,
169. Physical determinants of the self-replication of protein fibrils
A Šaric, AK Buell, G Meisl, TCT Michaels, CM Dobson, S Linse, TPJ Knowles, D Frenkel
– Nature Physics
(2016)
12,
168. Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.
P Flagmeier, G Meisl, M Vendruscolo, TPJ Knowles, CM Dobson, AK Buell, C Galvagnion
– Proceedings of the National Academy of Sciences of the United States of America
(2016)
113,
167. Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation
Y Zhang, AK Buell, T Müller, E De Genst, J Benesch, CM Dobson, TPJ Knowles
– Chembiochem : a European journal of chemical biology
(2016)
17,
166. Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform
TO Mason, TCT Michaels, A Levin, E Gazit, CM Dobson, AK Buell, TPJ Knowles
– Journal of the American Chemical Society
(2016)
138,
165. Controlling the Physical Dimensions of Peptide Nanotubes by Supramolecular Polymer Coassembly.
L Adler-Abramovich, P Marco, ZA Arnon, RCG Creasey, TCT Michaels, A Levin, DJ Scurr, CJ Roberts, TPJ Knowles, SJB Tendler, E Gazit
– ACS nano
(2016)
10,
164. Elastic instability-mediated actuation by a supra-molecular polymer
A Levin, TCT Michaels, L Adler-Abramovich, TO Mason, T Müller, B Zhang, L Mahadevan, E Gazit, TPJ Knowles
– Nature Physics
(2016)
12,
163. Quantifying Measurement Fluctuations from Stochastic Surface Processes on Sensors with Heterogeneous Sensitivity
J Charmet, TCT Michaels, R Daly, A Prasad, P Thiruvenkathanathan, RS Langley, TPJ Knowles, AA Seshia
– Physical Review Applied
(2016)
5,
162. Fluctuations in the Kinetics of Linear Protein Self-Assembly.
TCT Michaels, AJ Dear, JB Kirkegaard, KL Saar, DA Weitz, TPJ Knowles
– Physical Review Letters
(2016)
116,
161. Particle-Based Monte-Carlo Simulations of Steady-State Mass Transport at Intermediate Peclet Numbers
T Müller, P Arosio, L Rajah, SIA Cohen, EV Yates, M Vendruscolo, CM Dobson, TPJ Knowles
– International Journal of Nonlinear Sciences and Numerical Simulation
(2016)
17,
160. Amyloid Fibrils as Building Blocks for Natural and Artificial Functional Materials.
TPJ Knowles, R Mezzenga
– Advanced materials (Deerfield Beach, Fla.)
(2016)
28,
159. A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions.
TW Herling, DJ O'Connell, MC Bauer, J Persson, U Weininger, TPJ Knowles, S Linse
– Biophysical journal
(2016)
110,
158. The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model
V Kakkar, C Månsson, EP de Mattos, S Bergink, M van der Zwaag, MAWH van Waarde, NJ Kloosterhuis, R Melki, RTP van Cruchten, S Al-Karadaghi, P Arosio, CM Dobson, TPJ Knowles, GP Bates, JM van Deursen, S Linse, B van de Sluis, C Emanuelsson, HH Kampinga
– Molecular Cell
(2016)
62,
157. Analysis of the length distribution of amyloid fibrils by centrifugal sedimentation
P Arosio, T Cedervall, TPJ Knowles, S Linse
– Analytical biochemistry
(2016)
504,
156. An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation
EV Yates, G Meisl, TPJ Knowles, CM Dobson
– The Journal of Physical Chemistry Part B
(2016)
120,
155. Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.
P Arosio, K Hu, FA Aprile, T Müller, TPJ Knowles
– Analytical chemistry
(2016)
88,
154. A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.
P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo
– ACS Combinatorial Science
(2016)
18,
153. Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation.
E van Dijk, P Varilly, TPJ Knowles, D Frenkel, S Abeln
– Physical Review Letters
(2016)
116,
152. Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.
M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, AY Abramov, S Gandhi, NW Wood, N Cremades, CM Dobson, TPJ Knowles, D Klenerman
– Proceedings of the National Academy of Sciences
(2016)
113,
151. Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform.
K-L Saar, EV Yates, T Müller, S Saunier, CM Dobson, TPJ Knowles
– Biophysical journal
(2016)
110,
150. An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, SIA Cohen, MBD Müller, S Linse, EAA Nollen, CM Dobson, TPJ Knowles, M Vendruscolo
– Science advances
(2016)
2,
149. Oligomers of Heat-Shock Proteins: Structures That Don't Imply Function
WM Jacobs, TPJ Knowles, D Frenkel
– PLoS computational biology
(2016)
12,
148. Molecular mechanisms of protein aggregation from global fitting of kinetic models
G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles
– Nature protocols
(2016)
11,
147. Hamiltonian Dynamics of Protein Filament Formation.
TCT Michaels, SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– Physical review letters
(2016)
116,
146. Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms
M Iljina, GA Garcia, AJ Dear, J Flint, P Narayan, TCT Michaels, CM Dobson, D Frenkel, TPJ Knowles, D Klenerman
– Scientific Reports
(2016)
6,
145. Self-assembly of MPG1, a hydrophobin protein from the rice blast fungus that forms functional amyloid coatings, occurs by a surface-driven mechanism.
CLL Pham, A Rey, V Lo, M Soulès, Q Ren, G Meisl, TPJ Knowles, AH Kwan, M Sunde
– Scientific reports
(2016)
6,
144. Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones
JD Taylor, WJ Hawthorne, J Lo, A Dear, N Jain, G Meisl, M Andreasen, C Fletcher, M Koch, N Darvill, N Scull, A Escalera-Maurer, L Sefer, R Wenman, S Lambert, J Jean, Y Xu, B Turner, SG Kazarian, MR Chapman, D Bubeck, A de Simone, TPJ Knowles, SJ Matthews
– Scientific Reports
(2016)
6,
143. Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation.
P Arosio, TCT Michaels, S Linse, C Månsson, C Emanuelsson, J Presto, J Johansson, M Vendruscolo, CM Dobson, TPJ Knowles
– Nature Communications
(2016)
7,
142. Quantitative thermophoretic study of disease-related protein aggregates
M Wolff, JJ Mittag, TW Herling, ED Genst, CM Dobson, TPJ Knowles, D Braun, AK Buell
– Scientific reports
(2016)
6,
141. Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide
G Meisl, X Yang, B Frohm, TPJ Knowles, S Linse
– Scientific reports
(2016)
6,
140. Scaling and dimensionality in the chemical kinetics of protein filament formation
TCT Michaels, AJ Dear, TPJ Knowles
– International Reviews in Physical Chemistry
(2016)
35,
139. Microfluidic devices fabricated using soft lithography for the study of protein structures using synchrotron radiation circular dichroism
J Charmet, C Bortolini, D Copic, IC Morales, Y Zhang, PK Challa, T Jávorfi, R Hussain, G Siligardi, TPJ Knowles
– 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
(2016)
138. Microfluidic diffusion analysis of the sizes and interactions of proteins under native solution conditions
P Arosio, T Müller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, DA White, TW Herling, EJ De Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– ACS Nano
(2016)
10,
137. Combining Single-Molecule Techniques with Microfluidics for Protein Analysis
C Taylor, T Knowles, D Klenerman
– Biophysical Journal
(2016)
110,
136. N-Terminal Extensions Retard A beta 42 Fibril Formation but Allow Cross-Seeding and Coaggregation with A beta 42
O Szczepankiewicz, B Linse, G Meisl, E Thulin, B Frohm, C Sala Frigerio, MT Colvin, AC Jacavone, RG Griffin, T Knowles, DM Walsh, S Linse
– Journal of the American Chemical Society
(2015)
137,
135. The length distribution of frangible biofilaments
TCT Michaels, P Yde, JCW Willis, MH Jensen, D Otzen, CM Dobson, AK Buell, TPJ Knowles
– The Journal of chemical physics
(2015)
143,
134. Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity.
EV Yates, T Müller, L Rajah, EJ De Genst, P Arosio, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– Nature chemistry
(2015)
7,
133. Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates.
MA Wright, FA Aprile, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Chemical communications (Cambridge, England)
(2015)
51,
132. Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers.
MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, M Dalla Serra, TPJ Knowles, CM Dobson, D Klenerman
– Analytical Chemistry
(2015)
87,
131. Dynamics of protein aggregation and oligomer formation governed by secondary nucleation.
TCT Michaels, HW Lazell, P Arosio, TPJ Knowles
– The Journal of chemical physics
(2015)
143,
130. Force generation by the growth of amyloid aggregates.
TW Herling, GA Garcia, TCT Michaels, W Grentz, J Dean, U Shimanovich, H Gang, T Müller, B Kav, EM Terentjev, CM Dobson, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
112,
129. Molecular Rotors Provide Insights into Microscopic Structural Changes During Protein Aggregation
AJ Thompson, TW Herling, M Kubánková, A Vyšniauskas, TPJ Knowles, MK Kuimova
– The journal of physical chemistry. B
(2015)
119,
128. New insights into the mechanism of amyloid formation by alpha-synuclein
AK Buell, C Galvagnion, CM Dobson, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
127. Kinetics of protein aggregation
T Knowles, M Vendruscolo, C Dobson
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
284,
126. Lipid vesicles trigger alpha-synuclein aggregation by stimulating primary nucleation
C Galvagnion, AK Buell, G Meisl, TC Michaels, M Vendruscolo, TPJ Knowles, CM Dobson
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
11,
125. Rapid sizing of proteins in complex solutions
P Arosio, T Muller, L Rajah, EV Yates, FA Aprile, SIA Cohen, DA White, TW Herling, E de Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
124. Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry.
X-M Zhou, U Shimanovich, TW Herling, S Wu, CM Dobson, TPJ Knowles, S Perrett
– ACS nano
(2015)
9,
123. Aggregation-prone amyloid-β·Cu<sup>II</sup> species formed on the millisecond timescale under mildly acidic conditions
JT Pedersen, CB Borg, TCT Michaels, TPJ Knowles, P Faller, K Teilum, L Hemmingsen
– ChemBioChem
(2015)
16,
122. Preventing peptide and protein misbehavior: Fig. 1.
P Arosio, G Meisl, M Andreasen, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
112,
121. A microfluidic platform for quantitative measurements of effective protein charges and single ion binding in solution
TW Herling, P Arosio, T Müller, S Linse, TPJ Knowles
– Physical chemistry chemical physics : PCCP
(2015)
17,
120. Structural characterization of toxic oligomers that are kinetically trapped during alpha-synuclein fibril formation
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, EJ De-Genst, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
– Proceedings of the National Academy of Sciences of the United States of America
(2015)
112,
119. A molecular chaperone breaks the catalytic cycle that generates toxic A beta oligomers
SIA Cohen, P Arosio, J Presto, FR Kurudenkandy, H Biverstål, L Dolfe, C Dunning, X Yang, B Frohm, M Vendruscolo, J Johansson, CM Dobson, A Fisahn, TPJ Knowles, S Linse
– Nature Structural and Molecular Biology
(2015)
22,
118. The physical basis of protein misfolding disorders
TPJ Knowles, M Vendruscolo, CM Dobson
– Physics Today
(2015)
68,
117. On the lag phase in amyloid fibril formation.
P Arosio, TPJ Knowles, S Linse
– Physical chemistry chemical physics : PCCP
(2015)
17,
116. Kinetic theory of protein filament growth: Self-consistent methods and perturbative techniques
TCT Michaels, TPJ Knowles
– International Journal of Modern Physics B
(2015)
29,
115. Neuronal Cx3cr1 Deficiency Protects against Amyloid beta-Induced Neurotoxicity
J Dworzak, B Renvoisé, J Habchi, EV Yates, C Combadière, TP Knowles, CM Dobson, C Blackstone, O Paulsen, PM Murphy
– PLoS ONE
(2015)
10,
114. The A beta 40 and A beta 42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation
R Cukalevski, X Yang, G Meisl, U Weininger, K Bernfur, B Frohm, TPJ Knowles, S Linse
– Chemical Science
(2015)
6,
113. A mechanistic model of tau amyloid aggregation based on direct observation of oligomers.
SL Shammas, GA Garcia, S Kumar, M Kjaergaard, MH Horrocks, N Shivji, E Mandelkow, TPJ Knowles, E Mandelkow, D Klenerman
– Nature communications
(2015)
6,
112. Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants.
L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, N Cremades, CM Dobson, D Klenerman
– Scientific reports
(2015)
5,
111. A high power-density, mediator-free, microfluidic biophotovoltaic device for cyanobacterial cells
P Bombelli, T Müller, TW Herling, CJ Howe, TPJ Knowles
– Advanced Energy Materials
(2015)
5,
110. Protein microgels from amyloid fibril networks.
U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, S Linse, KS Åkerfeldt, CM Dobson, DA Weitz, TPJ Knowles
– Advances in experimental medicine and biology
(2015)
1174,
109. Tetracycline nanoparticles as antibacterial and gene-silencing agents
U Shimanovich, A Lipovsky, D Eliaz, S Zigdon, TPJ Knowles, Y Nitzan, S Michaeli, A Gedanken
– Advanced healthcare materials
(2015)
4,
108. Multiphase Protein Microgels(a)
U Shimanovich, Y Song, J Brujic, HC Shum, TPJ Knowles
– Macromolecular bioscience
(2015)
15,
107. ChemInform Abstract: Biophysical Approaches for the Study of Interactions Between Molecular Chaperones and Protein Aggregates
MA Wright, FA Aprile, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– ChemInform
(2015)
46,
106. Sizing and interactions of proteins under native conditions from microfluidic diffusion measurements: application to molecular chaperones and single-step immunoassay
P Arosio, T Mueller, L Rajah, F Aprile, T Scheidt, J Carrozza, M Wright, M Vendruscolo, C Dobson, T Knowles
– PROTEIN SCIENCE
(2015)
24,
105. Crucial role of non-specific interactions in amyloid nucleation
A Saric, YC Chebaro, TPJ Knowles, D Frenkel
– Proceedings of the National Academy of Sciences of the United States of America
(2014)
111,
104. Dry-mass sensing for microfluidics
T Mueller, DA White, TPJ Knowles
– Applied Physics Letters
(2014)
105,
103. Interaction of the Molecular Chaperone DNAJB6 with Growing Arnyloid-beta 42 (A beta 42) Aggregates Leads to Sub-stoichiometric Inhibition of Amyloid Formation
C Månsson, P Arosio, R Hussein, HH Kampinga, RM Hashem, WC Boelens, CM Dobson, TPJ Knowles, S Linse, C Emanuelsson
– The Journal of biological chemistry
(2014)
289,
102. The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation.
AK Buell, CM Dobson, TPJ Knowles
– Essays in Biochemistry
(2014)
56,
101. Differences in nucleation behavior underlie the contrasting aggregation kinetics of the A beta 40 and A beta 42 peptides
G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2014)
111,
100. Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization
TCT Michaels, TPJ Knowles
– The Journal of chemical physics
(2014)
140,
99. The amyloid state and its association with protein misfolding diseases
TPJ Knowles, M Vendruscolo, CM Dobson
– Nature reviews. Molecular cell biology
(2014)
15,
98. Asymptotic solutions of the Oosawa model for the length distribution of biofilaments.
TCT Michaels, GA Garcia, TPJ Knowles
– The Journal of chemical physics
(2014)
140,
97. Solution conditions determine the relative importance of nucleation and growth processes in alpha-synuclein aggregation
AK Buell, C Galvagnion, R Gaspar, E Sparr, M Vendruscolo, TPJ Knowles, S Linse, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
(2014)
111,
96. Mean-field master equation formalism for biofilament growth
TCT Michaels, TPJ Knowles
– American Journal of Physics
(2014)
82,
95. Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters
GA Garcia, SIA Cohen, CM Dobson, TPJ Knowles
– Physical review. E, Statistical, nonlinear, and soft matter physics
(2014)
89,
94. Density-gradient-free microfluidic centrifugation for analytical and preparative separation of nanoparticles.
P Arosio, T Müller, L Mahadevan, TPJ Knowles
– Nano letters
(2014)
14,
93. Spatial Propagation of Protein Polymerization
SIA Cohen, L Rajah, CH Yoon, AK Buell, DA White, RA Sperling, M Vendruscolo, EM Terentjev, CM Dobson, DA Weitz, TPJ Knowles
– Physical Review Letters
(2014)
112,
92. Diffuse transition state structure for the unfolding of a leucine-rich repeat protein
SE Kelly, G Meisl, PJE Rowling, SH McLaughlin, T Knowles, LS Itzhaki
– Physical chemistry chemical physics : PCCP
(2014)
16,
91. The Role of Stable alpha-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation
N Lorenzen, SB Nielsen, AK Buell, JD Kaspersen, P Arosio, BS Vad, W Paslawski, G Christiansen, Z Valnickova-Hansen, M Andreasen, JJ Enghild, JS Pedersen, CM Dobson, TPJ Knowles, DE Otzen
– Journal of the American Chemical Society
(2014)
136,
90. Polymer physics inspired approaches for the study of the mechanical properties of amyloid fibrils
LR Volpatti, TPJ Knowles
– Journal of Polymer Science Part B: Polymer Physics
(2014)
52,
89. Nanoscale spatially resolved infrared spectra from single microdroplets.
T Müller, FS Ruggeri, AJ Kulik, U Shimanovich, TO Mason, TPJ Knowles, G Dietler
– Lab on a chip
(2014)
14,
88. Insights into the Inhibition Mechanism of Biomolecular Self-Assembly from Chemical Kinetics
P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Biophysical Journal
(2014)
106,
87. Determination of Primary Nucleation Mechanisms of alpha-Synuclein Amyloid Aggregation
FA Aprile, G Meisl, AK Buell, P Flagmeier, CM Dobson, M Vendruscolo, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2014)
106,
86. Expanding the solvent chemical space for self-assembly of dipeptide nanostructures.
TO Mason, DY Chirgadze, A Levin, L Adler-Abramovich, E Gazit, TPJ Knowles, AK Buell
– ACS nano
(2014)
8,
85. Chemical kinetics for drug discovery to combat protein aggregation diseases.
P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Trends in pharmacological sciences
(2014)
35,
84. Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers.
A Levin, TO Mason, L Adler-Abramovich, AK Buell, G Meisl, C Galvagnion, Y Bram, SA Stratford, CM Dobson, TPJ Knowles, E Gazit
– Nature Communications
(2014)
5,
83. Self-assembly of amyloid fibrils that display active enzymes
XM Zhou, A Entwistle, H Zhang, AP Jackson, TO Mason, U Shimanovich, TPJ Knowles, AT Smith, EB Sawyer, S Perrett
– ChemCatChem
(2014)
6,
82. Quantitative Analysis of Diffusive Reactions at the Solid–Liquid Interface in Finite Systems
TCT Michaels, AK Buell, EM Terentjev, TPJ Knowles
– The journal of physical chemistry letters
(2014)
5,
81. Sonochemically-induced spectral shift as a probe of green fluorescent protein release from nano capsules
U Shimanovich, A Munder, NG Azoia, A Cavaco-Paulo, A Gruzman, TPJ Knowles, A Gedanken
– RSC Advances
(2014)
4,
80. Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ<inf>42</inf> peptide
B Bolognesi, SIA Cohen, P Aran Terol, EK Esbjörner, S Giorgetti, MF Mossuto, A Natalello, AC Brorsson, TPJ Knowles, CM Dobson, LM Luheshi
– ACS Chemical Biology
(2014)
9,
79. Quantitative sensing of microviscosity in protocells and amyloid materials using fluorescence lifetime imaging of molecular rotors
AJ Thompson, TYD Tang, TW Herling, CR Che Hak, S Mann, TPJ Knowles, MK Kuimova
– Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII
(2014)
8947,
78. The amyloid state and its association with protein misfolding diseases (vol 15, pg 384, 2014)
TPJ Knowles, M Vendruscolo, CM Dobson
– Nature Reviews Molecular Cell Biology
(2014)
15,
77. Easyworm: an open-source software tool to determine the mechanical properties of worm-like chains.
G Lamour, JB Kirkegaard, H Li, TP Knowles, J Gsponer
– Source Code for Biology and Medicine
(2014)
9,
76. Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease
G Tóth, SJ Gardai, W Zago, CW Bertoncini, N Cremades, SL Roy, MA Tambe, J-C Rochet, C Galvagnion, G Skibinski, S Finkbeiner, M Bova, K Regnstrom, S-S Chiou, J Johnston, K Callaway, JP Anderson, MF Jobling, AK Buell, TA Yednock, TPJ Knowles, M Vendruscolo, J Christodoulou, CM Dobson, D Schenk, L McConlogue
– PLoS ONE
(2014)
9,
75. Protein micro- and nano-capsules for biomedical applications
U Shimanovich, GJL Bernardes, TPJ Knowles, A Cavaco-Paulo
– Chemical Society reviews
(2014)
43,
74. Quantification of the Concentration of A beta 42 Propagons during the Lag Phase by an Amyloid Chain Reaction Assay
P Arosio, R Cukalevski, B Frohm, TPJ Knowles, S Linse
– Journal of the American Chemical Society
(2014)
136,
73. Amyloid Beta Peptide A beta 40 and A beta 42 Form Separate Fibrils in Binary Mixtures
X Yang, R Cukalevski, G Meisl, B Frohm, T Knowles, S Linse
– PROTEIN SCIENCE
(2014)
23,
72. ChemInform Abstract: Protein Micro‐ and Nano‐Capsules for Biomedical Applications
U Shimanovich, GJL Bernardes, TPJ Knowles, A Cavaco-Paulo
– ChemInform
(2014)
45,
71. A Clear View of Polymorphism, Twist, and Chirality in Amyloid Fibril Formation
LR Volpatti, M Vendruscolo, CM Dobson, TPJ Knowles
– ACS nano
(2013)
7,
70. Three-dimensional domain swapping and supramolecular protein assembly: Insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase
A Pica, A Merlino, AK Buell, TPJ Knowles, E Pizzo, G D'Alessio, F Sica, L Mazzarella
– Acta Crystallographica Section D: Biological Crystallography
(2013)
69,
69. Single-Molecule Measurements of Transient Biomolecular Complexes through Microfluidic Dilution
MH Horrocks, L Rajah, P Jönsson, M Kjaergaard, M Vendruscolo, TPJ Knowles, D Klenerman
– Analytical Chemistry
(2013)
85,
68. Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism.
SIA Cohen, S Linse, LM Luheshi, E Hellstrand, DA White, L Rajah, DE Otzen, M Vendruscolo, CM Dobson, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2013)
110,
67. Integration and characterization of solid wall electrodes in microfluidic devices fabricated in a single photolithography step
TW Herling, T Müller, L Rajah, JN Skepper, M Vendruscolo, TPJ Knowles
– Applied Physics Letters
(2013)
102,
66. Amyloid beta-protein: the influence of intrinsic and extrinsic factors on fibril formation
R Cukalevski, X Yang, SI Cohen, B Boland, B Frohm, E Thulin, DM WalsXh, TP Knowles, S Linse
– JOURNAL OF NEUROCHEMISTRY
(2013)
125,
65. Atomic structure and hierarchical assembly of a cross-beta amyloid fibril
AWP Fitzpatrick, GT Debelouchina, MJ Bayro, DK Clare, MA Caporini, VS Bajaj, CP Jaroniec, L Wang, V Ladizhansky, SA Müller, CE MacPhee, CA Waudby, HR Mott, A De Simone, TPJ Knowles, HR Saibil, M Vendruscolo, EV Orlova, RG Griffin, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
(2013)
110,
64. Electrostatic effects in filamentous protein aggregation
AK Buell, P Hung, X Salvatella, ME Welland, CM Dobson, TPJ Knowles
– Biophysical journal
(2013)
104,
63. Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses.
M Yolamanova, C Meier, AK Shaytan, V Vas, CW Bertoncini, F Arnold, O Zirafi, SM Usmani, JA Müller, D Sauter, C Goffinet, D Palesch, P Walther, NR Roan, H Geiger, O Lunov, T Simmet, J Bohne, H Schrezenmeier, K Schwarz, L Ständker, W-G Forssmann, X Salvatella, PG Khalatur, AR Khokhlov, TPJ Knowles, T Weil, F Kirchhoff, J Münch
– Nature Nanotechnology
(2013)
8,
62. Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2.
LQ Xu, S Wu, AK Buell, SIA Cohen, LJ Chen, WH Hu, SA Cusack, LS Itzhaki, H Zhang, TPJ Knowles, CM Dobson, ME Welland, GW Jones, S Perrett
– Philosophical transactions of the Royal Society of London. Series B, Biological sciences
(2013)
368,
61. The Kinetics and Mechanisms of Amyloid Formation
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– None
(2013)
60. Connecting macroscopic observables and microscopic assembly events in amyloid formation using coarse grained simulations.
NS Bieler, TPJ Knowles, D Frenkel, R Vácha
– PLoS Computational Biology
(2012)
8,
59. Highly non-linear microfluidic resistor elements for flow rate-dependent addressing of microchannels
L Rajah, DA White, TPJ Knowles
– International Journal of Nonlinear Sciences and Numerical Simulation
(2012)
13,
58. Fluctuations in water, the hydrophobic effect and self-assembly
PS Varilly, AJ Patel, SN Jamadagni, H Acharya, MF Hagan, S Garde, D Chandler, TPJ Knowles, D Frenkel
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2012)
244,
57. Selenium-Enhanced Electron Microscopic Imaging of Different Aggregate Forms of a Segment of the Amyloid beta Peptide in Cells
EK McGuire, M Motskin, B Bolognesi, SD Bergin, TPJ Knowles, J Skepper, LM Luheshi, DW McComb, CM Dobson, AE Porter
– ACS nano
(2012)
6,
56. Direct observation of the interconversion of normal and pathogenic forms of alpha-synuclein
N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, NW Wood, TPJ Knowles, CM Dobson, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2012)
149,
55. Detailed analysis of the energy barriers for amyloid fibril growth.
AK Buell, A Dhulesia, DA White, TPJ Knowles, CM Dobson, ME Welland
– Angewandte Chemie (International ed. in English)
(2012)
51,
54. From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– Journal of Molecular Biology
(2012)
421,
53. Twisting Transition between Crystalline and Fibrillar Phases of Aggregated Peptides
TPJ Knowles, A De Simone, AW Fitzpatrick, A Baldwin, S Meehan, L Rajah, M Vendruscolo, ME Welland, CM Dobson, EM Terentjev
– Physical review letters
(2012)
109,
52. Role of elongation and secondary pathways in S6 amyloid fibril growth
N Lorenzen, SIA Cohen, SB Nielsen, TW Herling, G Christiansen, CM Dobson, TPJ Knowles, D Otzen
– Biophysical Journal
(2012)
102,
51. Analyse der Energiebarrieren für das Wachstum von Amyloidfibrillen
AK Buell, A Dhulesia, DA White, TPJ Knowles, CM Dobson, ME Welland
– Angewandte Chemie
(2012)
124,
50. Probing small molecule binding to amyloid fibrils.
AK Buell, EK Esbjörner, PJ Riss, DA White, FI Aigbirhio, G Toth, ME Welland, CM Dobson, TPJ Knowles
– Physical Chemistry Chemical Physics
(2011)
13,
49. Binding of the Molecular Chaperone alpha B-Crystallin to A beta Amyloid Fibrils Inhibits Fibril Elongation
SL Shammas, CA Waudby, S Wang, AK Buell, TPJ Knowles, H Ecroyd, ME Welland, JA Carver, CM Dobson, S Meehan
– Biophysical journal
(2011)
101,
48. Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation
AW Fitzpatrick, TPJ Knowles, CA Waudby, M Vendruscolo, CM Dobson
– PLoS computational biology
(2011)
7,
47. Observation of spatial propagation of amyloid assembly from single nuclei.
TPJ Knowles, DA White, AR Abate, JJ Agresti, SIA Cohen, RA Sperling, EJ De Genst, CM Dobson, DA Weitz
– Proceedings of the National Academy of Sciences of the United States of America
(2011)
108,
46. Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– The Journal of Chemical Physics
(2011)
135,
45. Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments
SIA Cohen, M Vendruscolo, ME Welland, CM Dobson, EM Terentjev, TPJ Knowles
– The Journal of Chemical Physics
(2011)
135,
44. Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations.
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– The Journal of Chemical Physics
(2011)
135,
43. Protein Solubility and Protein Homeostasis: A Generic View of Protein Misfolding Disorders
M Vendruscolo, TPJ Knowles, CM Dobson
– Cold Spring Harbor perspectives in biology
(2011)
3,
42. Direct observation of the interconversion of normal and pathogenic forms of alpha-synuclein
N Cremades, SIA Cohen, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, TPJ Knowles, CM Dobson, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2011)
40,
41. Conserved C-Terminal Charge Exerts a Profound Influence on the Aggregation Rate of alpha-Synuclein
K Levitan, D Chereau, SIA Cohen, TPJ Knowles, CM Dobson, AL Fink, JP Anderson, JM Goldstein, GL Millhauser
– Journal of Molecular Biology
(2011)
411,
40. Perturbation of the stability of amyloid fibrils through alteration of electrostatic interactions.
SL Shammas, TPJ Knowles, AJ Baldwin, CE Macphee, ME Welland, CM Dobson, GL Devlin
– Biophysical Journal
(2011)
100,
39. Metastability of Native Proteins and the Phenomenon of Amyloid Formation
AJ Baldwin, TPJ Knowles, GG Tartaglia, AW Fitzpatrick, GL Devlin, SL Shammas, CA Waudby, MF Mossuto, S Meehan, SL Gras, J Christodoulou, SJ Anthony-Cahill, PD Barker, M Vendruscolo, CM Dobson
– Journal of the American Chemical Society
(2011)
133,
38. Population of nonnative states of lysozyme variants drives amyloid fibril formation
AK Buell, A Dhulesia, MF Mossuto, N Cremades, JR Kumita, M Dumoulin, ME Welland, TPJ Knowles, X Salvatella, CM Dobson
– Journal of the American Chemical Society
(2011)
133,
37. Relationship between prion propensity and the rates of individual molecular steps of fibril assembly
Y-Q Wang, AK Buell, X-Y Wang, ME Welland, CM Dobson, TPJ Knowles, S Perrett
– The Journal of biological chemistry
(2011)
286,
36. Nucleated polymerisation in the presence of pre-formed seed filaments
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– International Journal of Molecular Sciences
(2011)
12,
35. Nanomechanics of functional and pathological amyloid materials.
TPJ Knowles, MJ Buehler
– Nature Nanotechnology
(2011)
6,
34. Probing protein aggregation with quartz crystal microbalances
TPJ Knowles, GL Devlin, CM Dobson, ME Welland
– Methods in molecular biology (Clifton, N.J.)
(2011)
752,
33. Interactions between Amyloidophilic Dyes and Their Relevance to Studies of Amyloid Inhibitors
AK Buell, CM Dobson, TPJ Knowles, ME Welland
– Biophysical journal
(2010)
99,
32. Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering.
A Sandberg, LM Luheshi, S Söllvander, T Pereira de Barros, B Macao, TPJ Knowles, H Biverstål, C Lendel, F Ekholm-Petterson, A Dubnovitsky, L Lannfelt, CM Dobson, T Härd
– Proceedings of the National Academy of Sciences of the United States of America
(2010)
107,
31. Surface attachment of protein fibrils via covalent modification strategies
AK Buell, DA White, C Meier, ME Welland, TPJ Knowles, CM Dobson
– The journal of physical chemistry. B
(2010)
114,
30. Frequency Factors in a Landscape Model of Filamentous Protein Aggregation
AK Buell, JR Blundell, CM Dobson, ME Welland, EM Terentjev, TPJ Knowles
– Physical Review Letters
(2010)
104,
29. An algorithm and experimental protocol to obtain the kinetic parameters of fibrillar growth from a first-principles general model of breakable filament assembly
SI Cohen, M Sandal, L Rajah, CM Dobson, M Vendruscolo, TPJ Knowles
– FEBS JOURNAL
(2010)
277,
28. Protein aggregation in crowded environments
DA White, AK Buell, TPJ Knowles, ME Welland, CM Dobson
– Journal of the American Chemical Society
(2010)
132,
27. Fabrication and characterisation of protein fibril–elastomer composites
T Oppenheim, TPJ Knowles, SP Lacour, ME Welland
– Acta Biomaterialia
(2010)
6,
26. The Interaction of alpha B-Crystallin with Mature alpha-Synuclein Amyloid Fibrils Inhibits Their Elongation
CA Waudby, TPJ Knowles, GL Devlin, JN Skepper, H Ecroyd, JA Carver, ME Welland, J Christodoulou, CM Dobson, S Meehan
– Biophysical journal
(2010)
98,
25. Nanostructured films from hierarchical self-assembly of amyloidogenic proteins
TPJ Knowles, TW Oppenheim, AK Buell, DY Chirgadze, ME Welland
– Nature Nanotechnology
(2010)
5,
24. Imaging Alzheimer's disease-related protein aggregates in human cells using a selenium label
EK McGuire, M Motskin, TPJ Knowles, CM Dobson, DW McComb, AE Porter
– ELECTRON MICROSCOPY AND ANALYSIS GROUP CONFERENCE 2009 (EMAG 2009)
(2010)
241,
23. Methods and models in neurodegenerative and systemic protein aggregation diseases.
A-C Brorsson, JR Kumita, I MacLeod, B Bolognesi, E Speretta, LM Luheshi, TPJ Knowles, CM Dobson, DC Crowther
– Frontiers in bioscience (Landmark edition)
(2010)
15,
22. Quantitative approaches for characterising fibrillar protein nanostructures
DA White, CM Dobson, ME Welland, TPJ Knowles
– Materials Research Society Symposium Proceedings
(2010)
1274,
21. An analytical solution to the kinetics of breakable filament assembly
TPJ Knowles, CA Waudby, GL Devlin, SIA Cohen, A Aguzzi, M Vendruscolo, EM Terentjev, ME Welland, CM Dobson
– Science (New York, N.Y.)
(2009)
326,
20. Imaging Amyloid Fibrils within Cells Using a Se-Labelling Strategy
AE Porter, TPJ Knowles, K Muller, S Meehan, E McGuire, J Skepper, ME Welland, CM Dobson
– Journal of Molecular Biology
(2009)
392,
19. Biosensor-based label-free assays of amyloid growth.
DA White, AK Buell, CM Dobson, ME Welland, TPJ Knowles
– FEBS letters
(2009)
583,
18. Position-Dependent Electrostatic Protection against Protein Aggregation
AK Buell, GG Tartaglia, NR Birkett, CA Waudby, M Vendruscolo, X Salvatella, ME Welland, CM Dobson, TPJ Knowles
– Chembiochem : a European journal of chemical biology
(2009)
10,
17. Strength of nanotubes, filaments, and nanowires from sonication-onduced scission
YY Huang, TPJ Knowles, EM Terentjev
– Advanced Materials
(2009)
21,
16. Chemical and biophysical insights into the propagation of prion strains
J Falsig, KP Nilsson, TPJ Knowles, A Aguzzi
– Frontiers in Life Science
(2008)
2,
15. Highly specific label-free protein detection from lysed cells using internally referenced microcantilever sensors.
W Shu, S Laurenson, TPJ Knowles, P Ko Ferrigno, AA Seshia
– Biosensors and Bioelectronics
(2008)
24,
14. Label-free detection of amyloid growth with microcantilever sensors.
TPJ Knowles, W Shu, F Huber, HP Lang, C Gerber, CM Dobson, ME Welland
– Nanotechnology
(2008)
19,
13. Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements.
AJ Baldwin, SJ Anthony-Cahill, TPJ Knowles, G Lippens, J Christodoulou, PD Barker, CM Dobson
– Angewandte Chemie (International ed. in English)
(2008)
120,
12. Role of intermolecular forces in defining material properties of protein nanofibrils
TP Knowles, AW Fitzpatrick, S Meehan, HR Mott, M Vendruscolo, CM Dobson, ME Welland
– Science (New York, N.Y.)
(2007)
318,
11. Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alpha A-, alpha beta- and R120G alpha B-Crystallins
S Meehan, TPJ Knowles, AJ Baldwin, JF Smith, AM Squires, P Clements, TM Treweek, H Ecroyd, GG Tartaglia, M Vendruscolo, CE Macphee, CM Dobson, JA Carver
– Journal of Molecular Biology
(2007)
372,
10. Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass
TPJ Knowles, W Shu, GL Devlin, S Meehan, S Auer, CM Dobson, ME Welland
– Proceedings of the National Academy of Sciences of the United States of America
(2007)
104,
9. Analysis of structural order in amyloid fibrils
TPJ Knowles, JF Smith, GL Devlin, CM Dobson, ME Welland
– Nanotechnology
(2007)
18,
8. Enhanced Stability of Human Prion Proteins with Two Disulfide Bridges
TPJ Knowles, R Zahn
– Biophysical Journal
(2006)
91,
7. The Component Polypeptide Chains of Bovine Insulin Nucleate or Inhibit Aggregation of the Parent Protein in a Conformation-dependent Manner
GL Devlin, TPJ Knowles, A Squires, MG McCammon, SL Gras, MR Nilsson, CV Robinson, CM Dobson, CE MacPhee
– Journal of molecular biology
(2006)
360,
6. Characterization of the nanoscale properties of individual amyloid fibrils.
JF Smith, TPJ Knowles, CM Dobson, CE Macphee, ME Welland
– Proceedings of the National Academy of Sciences of the United States of America
(2006)
103,
5. Spatial Persistence of Angular Correlations in Amyloid Fibrils
TPJ Knowles, JF Smith, A Craig, CM Dobson, ME Welland
– Physical Review Letters
(2006)
96,
4. Excitations with negative dispersion in a spin vortex
M Buess, TPJ Knowles, R Hollinger, T Haug, U Krey, D Weiss, D Pescia, MR Scheinfein, CH Back
– Physical Review B - Condensed Matter and Materials Physics
(2005)
71,
3. Phase-resolved pulsed precessional motion at a Schottky barrier
M Buess, TPJ Knowles, U Ramsperger, D Pescia, CH Back
– Physical Review B - Condensed Matter and Materials Physics
(2004)
69,
2. Clathrin-Inspired Coating and Stabilization of Liposomes by DNA Self-Assembly
KN Baumann, L Piantanida, J García-Nafría, D Sobota, K Voïtchovsky, TPJ Knowles, S HERNANDEZ AINSA
– None
(None)
1. Infrared Nanospectroscopy Reveals the Molecular Interaction Fingerprint of an Aggregation Inhibitor with Single Ab42 Oligomers
F Ruggeri, J Habchi, SKR Chia, R Horne, M Vendruscolo, T Knowles
– Nature Communications
(None)