Publications

376. Correction: Correction: Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions

Z Toprakcioglu, TA Hakala, A Levin, CFW Becker, GJL Bernarde, TPJ Knowles

– Soft matter

(2021)

17,

201

(DOI: 10.1039/d0sm90246b)

375. Chris Dobson (1949-2019) Obituary

TPJ Knowles, M Vendruscolo

– Nature Chemical Biology

(2020)

16,

105

(DOI: 10.1038/s41589-019-0456-6)

374. The catalytic nature of protein aggregation

AJ Dear, G Meisl, TCT Michaels, MR Zimmermann, S Linse, TPJ Knowles

– The Journal of Chemical Physics

(2020)

152,

045101

(DOI: 10.1063/1.5133635)

373. Coating and Stabilization of Liposomes by Clathrin-Inspired DNA Self-Assembly.

KN Baumann, L Piantanida, J García-Nafría, D Sobota, K Voïtchovsky, TPJ Knowles, S Hernández-Ainsa

– ACS Nano

(2020)

14,

acsnano.9b09453

(DOI: 10.1021/acsnano.9b09453)

372. Controllable coacervation of recombinantly produced spider silk protein using kosmotropic salts.

P Mohammadi, C Jonkergouw, G Beaune, P Engelhardt, A Kamada, JVI Timonen, TPJ Knowles, M Penttila, MB Linder

– Journal of colloid and interface science

(2020)

560,

149

(DOI: 10.1016/j.jcis.2019.10.058)

371. Attolitre protein nanogels from droplet nanofluidics for intracellular delivery

Z Toprakcioglu, PK Challa, DB Morse, T Knowles

– Science Advances

(2020)

eaay7952

(DOI: 10.1126/sciadv.aay7952)

370. Rapid Generation of Protein Condensate Phase Diagrams Using Combinatorial Droplet Microfluidics

W Arter, R Qi, G Krainer, T Welsh, Y Xu, PS George-Hyslop, S Alberti, TPJ Knowles

– None

(2020)

(DOI: 10.1101/2020.06.04.132308)

369. Rational design of a conformation-specific antibody for the quantification of Aβ oligomers.

FA Aprile, P Sormanni, M Podpolny, S Chhangur, L-M Needham, FS Ruggeri, M Perni, R Limbocker, GT Heller, T Sneideris, T Scheidt, B Mannini, J Habchi, SF Lee, PC Salinas, TPJ Knowles, CM Dobson, M Vendruscolo

– Proceedings of the National Academy of Sciences

(2020)

117,

201919464

(DOI: 10.1073/pnas.1919464117)

368. Direct digital sensing of proteins in solution through single-molecule optofluidics

G Krainer, K Saar, W Arter, RPB Jacquat, Q Peter, P Challa, C Taylor, D Klenerman, TPJ Knowles

– None

(2020)

(DOI: 10.1101/2020.05.24.113498)

367. Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils.

M Törnquist, R Cukalevski, U Weininger, G Meisl, TPJ Knowles, T Leiding, A Malmendal, M Akke, S Linse

– Proceedings of the National Academy of Sciences of the United States of America

(2020)

117,

11265

(DOI: 10.1073/pnas.1918481117)

366. Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform.

M Koopman, Q Peter, RI Seinstra, M Perni, M Vendruscolo, CM Dobson, TPJ Knowles, EAA Nollen

– Nature Protocols

(2020)

15,

2071

(DOI: 10.1038/s41596-020-0321-9)

365. Kinetic diversity of amyloid oligomers.

AJ Dear, TCT Michaels, G Meisl, D Klenerman, S Wu, S Perrett, S Linse, CM Dobson, TPJ Knowles

– Proceedings of the National Academy of Sciences of the United States of America

(2020)

117,

12087

(DOI: 10.1073/pnas.1922267117)

364. A Microfluidic Co-Flow Route for Human Serum Albumin-Drug–Nanoparticle Assembly

TA Hakala, S Davies, Z Toprakcioglu, B Bernardim, GJL Bernardes, TPJ Knowles

– Chemistry - A European Journal

(2020)

26,

5965

(DOI: 10.1002/chem.202001146)

363. Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

G Krainer, T Welsh, J Joseph, J Espinosa, S Wittmann, ED Csilléry, A Sridhar, Z Toprakcioglu, G Gudiškytė, M Czekalska, W Arter, PS George-Hyslop, A Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles

– None

(2020)

(DOI: 10.1101/2020.05.04.076299)

362. Complexity in Lipid Membrane Composition Induces Resilience to A beta(42) Aggregation

M Sanguanini, KN Baumann, S Preet, S Chia, J Habchi, TPJ Knowles, M Vendruscolo

– ACS chemical neuroscience

(2020)

11,

1347

(DOI: 10.1021/acschemneuro.0c00101)

361. Dynamics of oligomer populations formed during the aggregation of Alzheimer's A beta 42 peptide (vol 12, pg 445, 2020)

TCT Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, AJ Dear, SIA Cohen, CM Dobson, M Vendruscolo, S Linse, TPJ Knowles

– Nature chemistry

(2020)

12,

497

(DOI: 10.1038/s41557-020-0468-6)

360. Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide

TCT Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, AJ Dear, SIA Cohen, CM Dobson, M Vendruscolo, S Linse, TPJ Knowles

– Nature chemistry

(2020)

12,

445

(DOI: 10.1038/s41557-020-0452-1)

359. Single particle zeta-potential measurements reveal the role of electrostatics in protein condensate stability

T Welsh, G Krainer, J Espinosa, J Joseph, A Sridhar, M Jahnel, W Arter, K Saar, S Alberti, R Collepardo-Guevara, TPJ Knowles

– None

(2020)

(DOI: 10.1101/2020.04.20.047910)

358. Digital Sensing and Molecular Computation by an Enzyme-Free DNA Circuit.

WE Arter, Y Yusim, Q Peter, CG Taylor, D Klenerman, UF Keyser, TPJ Knowles

– ACS nano

(2020)

14,

5763

(DOI: 10.1021/acsnano.0c00628)

357. Mechanism of droplet-formation in a supersonic microfluidic spray device

T Kartanas, Z Toprakcioglu, TA Hakala, A Levin, TW Herling, R Daly, J Charmet, TPJ Knowles

– Applied Physics Letters

(2020)

116,

153702

(DOI: 10.1063/1.5145109)

356. Effects of sedimentation, microgravity, hydrodynamic mixing and air-water interface on α-synuclein amyloid formation

J Zhou, FS Ruggeri, MR Zimmermann, G Meisl, G Longo, SK Sekatskii, TPJ Knowles, G Dietler

– Chemical Science

(2020)

11,

3687

(DOI: 10.1039/d0sc00281j)

355. Microfluidic approaches for the analysis of protein–protein interactions in solution

WE Arter, A Levin, G Krainer, TPJ Knowles

– Biophysical Reviews

(2020)

12,

575

(DOI: 10.1007/s12551-020-00679-4)

354. The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.

G Meisl, TP Knowles, D Klenerman

– Current opinion in neurobiology

(2020)

61,

(DOI: 10.1016/j.conb.2020.01.010)

353. Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions (vol 31, pg 125, 2020)

Z Toprakcioglu, TA Hakala, A Levin, CFW Becker, GJL Bernandes, TPJ Knowles

– Soft matter

(2020)

16,

3586

(DOI: 10.1039/d0sm90059a)

352. Ultrathin Polydopamine Films with Phospholipid Nanodiscs Containing a Glycophorin A Domain

T Marchesi D'Alvise, S Harvey, L Hueske, J Szelwicka, L Veith, TPJ Knowles, D Kubiczek, C Flaig, F Port, KE Gottschalk, F Rosenau, B Graczykowski, G Fytas, FS Ruggeri, K Wunderlich, T Weil

– Advanced Functional Materials

(2020)

30,

2000378

(DOI: 10.1002/adfm.202000378)

351. The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils.

FS Ruggeri, P Flagmeier, JR Kumita, G Meisl, DY Chirgadze, MN Bongiovanni, TPJ Knowles, CM Dobson

– ACS Nano

(2020)

14,

5213

(DOI: 10.1021/acsnano.9b09676)

350. Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions

Z Toprakcioglu, TA Hakala, A Levin, CFW Becker, GGL Bernandes, TPJ Knowles

– Soft Matter

(2020)

16,

3082

(DOI: 10.1039/c9sm02274k)

349. Lipid-Stabilized Double Emulsions Generated in Planar Microfluidic Devices.

L Kong, A Levin, Z Toprakcioglu, Y Xu, H Gang, R Ye, B-Z Mu, TPJ Knowles

– Langmuir : the ACS journal of surfaces and colloids

(2020)

36,

2349

(DOI: 10.1021/acs.langmuir.9b03622)

348. Biocompatible Hybrid Organic/Inorganic Microhydrogels Promote Bacterial Adherence and Eradication in Vitro and in Vivo

L Schnaider, Z Toprakcioglu, A Ezra, X Liu, D Bychenko, A Levin, E Gazit, TPJ Knowles

– Nano Letters

(2020)

20,

1590

(DOI: 10.1021/acs.nanolett.9b04290)

347. Quantifying the Thermodynamic Stability of Amyloid Fibrils

KL Callaghan, Q Peter, JR Kumita, TP Knowles, CM Dobson

– BIOPHYSICAL JOURNAL

(2020)

118,

492A

346. Microfluidic Diffusional Sizing for Studying Protein-Protein Interactions

MM Schneider, T Scheidt, CM Dobson, TPJ Knowles

– BIOPHYSICAL JOURNAL

(2020)

118,

512A

345. Molecular Forces in the Liquid-Liquid Phase Separation of Biomolecules

TJ Welsh, G Krainer, TP Knowles

– BIOPHYSICAL JOURNAL

(2020)

118,

373A

(DOI: 10.1016/j.bpj.2019.11.2134)

344. Investigation of Natural and Synthetic Aggregation Inhibitors using Microfluidic Applications

T Scheidt, J Carozza, JL Benesch, P Arosio, S Linse, TPJ Knowles

– BIOPHYSICAL JOURNAL

(2020)

118,

337A

343. Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-beta Peptide Aggregation and Reduces the Toxicity of Its Oligomers

SA Ghadami, S Chia, FS Ruggeri, G Meisl, F Bemporad, J Habchi, R Cascella, CM Dobson, M Vendruscolo, TPJ Knowles, F Chiti

– Biomacromolecules

(2020)

21,

1112

(DOI: 10.1021/acs.biomac.9b01475)

342. Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy

FS Ruggeri, B Mannini, R Schmid, M Vendruscolo, TPJ Knowles

– Nature Communications

(2020)

11,

2945

(DOI: 10.1038/s41467-020-16728-1)

341. Identification of on- and off-pathway oligomers in amyloid fibril formation

AJ Dear, G Meisl, A Šarić, TCT Michaels, M Kjaergaard, S Linse, TPJ Knowles

– Chemical Science

(2020)

11,

6236

(DOI: 10.1039/c9sc06501f)

340. Microfluidic Templating of Spatially Inhomogeneous Protein Microgels.

Y Xu, RPB Jacquat, Y Shen, D Vigolo, D Morse, S Zhang, TPJ Knowles

– Small (Weinheim an der Bergstrasse, Germany)

(2020)

16,

e2000432

(DOI: 10.1002/smll.202000432)

339. Multidimensional protein characterisation using microfluidic post-column analysis

T Scheidt, T Kartanas, Q Peter, MM Schneider, KL Saar, T Müller, PK Challa, A Levin, S Devenish, TPJ Knowles

– Lab on a Chip

(2020)

20,

2663

(DOI: 10.1039/d0lc00219d)

338. Interactions of α-synuclein oligomers with lipid membranes

G Musteikytė, AK Jayaram, CK Xu, M Vendruscolo, G Krainer, TPJ Knowles

– Biochimica et biophysica acta. Biomembranes

(2020)

183536

(DOI: 10.1016/j.bbamem.2020.183536)

337. Environmental Control of Amyloid Polymorphism by Modulation of Hydrodynamic Stress.

J Zhou, L Venturelli, L Keiser, SK Sekatskii, F Gallaire, S Kasas, G Longo, TPJ Knowles, FS Ruggeri, G Dietler

– ACS nano

(2020)

acsnano.0c07570

(DOI: 10.1021/acsnano.0c07570)

336. Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter

R Staats, TCT Michaels, P Flagmeier, S Chia, RI Horne, J Habchi, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo

– Communications Chemistry

(2020)

191

(DOI: 10.1038/s42004-020-00412-y)

335. Physical mechanisms of amyloid nucleation on fluid membranes

J Krausser, TPJ Knowles, A Šarić

– Proceedings of the National Academy of Sciences

(2020)

117,

33090

(DOI: 10.1073/pnas.2007694117)

334. New solution for fast axial scanning in fluorescence microscopy

W Zong

– Light Sci Appl

(2020)

199

(DOI: 10.1038/s41377-020-00442-0)

333. Evolution of Conformation, Nanomechanics, and Infrared Nanospectroscopy of Single Amyloid Fibrils Converting into Microcrystals

J Adamcik, FS Ruggeri, JT Berryman, A Zhang, TPJ Knowles, R Mezzenga

– Advanced Science

(2020)

2002182

(DOI: 10.1002/advs.202002182)

332. Machine learning aided top-down proteomics on a microfluidic platform

Y Zhang, M Wright, K Saar, P Challa, A Morgunov, Q Peter, S Devenish, C Dobson, TPJ Knowles

– None

(2020)

(DOI: 10.1101/2020.11.14.381376)

331. On the Mechanism of Self-Assembly by a Hydrogel-Forming Peptide

GA Braun, BE Ary, AJ Dear, MCH Rohn, AM Payson, DSM Lee, RC Parry, C Friedman, TPJ Knowles, S Linse, KS Åkerfeldt

– Biomacromolecules

(2020)

21,

4781

(DOI: 10.1021/acs.biomac.0c00989)

330. Amyloid precipitation in biofluids using a structure-specific chemical antibody

M Rodrigues, P Bhattacharjee, A Brinkmalm, D Do, C Pearson, S De, A Ponjavic, J Varela, F Ruggeri, I Baudrexel, J Lee, A Carr, K Kulenkampff, T Knowles, H Zetterberg, T Snaddon, S Gandhi, S Lee, D Klenerman

– None

(2020)

(DOI: 10.21203/rs.3.rs-81521/v1)

329. Microscale diffusiophoresis of proteins

Q Peter, R Jacquat, T Herling, P Challa, T Kartanas, T Knowles

– None

(2020)

(DOI: 10.21203/rs.3.rs-90645/v1)

328. Rapid structural, kinetic, and immunochemical analysis of alpha-synuclein oligomers in solution

WE Arter, CK Xu, M Castellana-Cruz, TW Herling, G Krainer, KL Saar, JR Kumita, CM Dobson, TPJ Knowles

– Nano Lett

(2020)

20,

8163

(DOI: 10.1021/acs.nanolett.0c03260)

327. The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils.

D Thacker, K Sanagavarapu, B Frohm, G Meisl, TPJ Knowles, S Linse

– Proceedings of the National Academy of Sciences

(2020)

117,

25272

(DOI: 10.1073/pnas.2002956117)

326. Kinetic fingerprints differentiate the mechanisms of action of anti-A beta antibodies

S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, E Sileikis, M Lundqvist, F Qian, T O'Malley, T Bussiere, PH Weinreb, CK Xu, G Meisl, SRA Devenish, TPJ Knowles, O Hansson

– Nat Struct Mol Biol

(2020)

27,

1125

(DOI: 10.1038/s41594-020-0505-6)

325. Converting lateral scanning into axial focusing to speed up three-dimensional microscopy

T Chakraborty, B Chen, S Daetwyler, B-J Chang, O Vanderpoorten, E Sapoznik, CF Kaminski, TPJ Knowles, KM Dean, R Fiolka

– Light: Science and Applications

(2020)

165

(DOI: 10.1038/s41377-020-00401-9)

324. A rationally designed bicyclic peptide remodels A beta 42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer's disease

T Ikenoue, FA Aprile, P Sormanni, FS Ruggeri, M Perni, GT Heller, CP Haas, C Middel, R Limbocker, B Mannini, TCT Michaels, TPJ Knowles, CM Dobson, M Vendruscolo

– Scientific Reports

(2020)

10,

15280

(DOI: 10.1038/s41598-020-69626-3)

323. Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition

Y Shen, FS Ruggeri, D Vigolo, A Kamada, S Qamar, A Levin, C Iserman, S Alberti, PS George-Hyslop, TPJ Knowles

– Nat Nanotechnol

(2020)

15,

841

(DOI: 10.1038/s41565-020-0731-4)

322. Biomimetic peptide self-assembly for functional materials

A Levin, TA Hakala, L Schnaider, GJL Bernardes, E Gazit, TPJ Knowles

– Nature Reviews Chemistry

(2020)

615

(DOI: 10.1038/s41570-020-0215-y)

321. Microfluidic Antibody Affinity Profiling for In-Solution Characterisation of Alloantibody - HLA Interactions in Human Serum

M Schneider, T Scheidt, A Priddey, C Xu, M Hu, S Devenish, G Meisl, C Dobson, V Kosmoliaptsis, T Knowles

– bioRxiv

(2020)

2020.09.14.296442

(DOI: 10.1101/2020.09.14.296442)

320. Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors.

TCT Michaels, A Šarić, G Meisl, GT Heller, S Curk, P Arosio, S Linse, CM Dobson, M Vendruscolo, TPJ Knowles

– Proc Natl Acad Sci U S A

(2020)

117,

24251

(DOI: 10.1073/pnas.2006684117)

319. Abstract 5879: Spatially-segmented single-cell transcriptomics by diffusional accessibility to a small-molecule dye

DB Morse, M Ceribelli, J De Jonghe, A Michalowski, C Muus, M Vias, S Boyle, DA Weitz, J Brenton, JD Buenrostro, C Thomas, TP Knowles

– Molecular and Cellular Biology / Genetics

(2020)

5879

(DOI: 10.1158/1538-7445.am2020-5879)

318. Kinetic analysis reveals the rates and mechanisms of protein aggregation in a multicellular organism

T Sinnige, G Meisl, T Michaels, M Vendruscolo, TPJ Knowles, R Morimoto

– None

(2020)

(DOI: 10.1101/2020.08.13.249862)

317. Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

R Limbocker, B Mannini, FS Ruggeri, R Cascella, CK Xu, M Perni, S Chia, SW Chen, J Habchi, A Bigi, RP Kreiser, AK Wright, JA Albright, T Kartanas, JR Kumita, N Cremades, M Zasloff, C Cecchi, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson

– Communications Biology

(2020)

435

(DOI: 10.1002/anie.201409050)

316. Microfluidic Templating: Microfluidic Templating of Spatially Inhomogeneous Protein Microgels (Small 32/2020)

Y Xu, RPB Jacquat, Y Shen, D Vigolo, D Morse, S Zhang, TPJ Knowles

– Small

(2020)

16,

2070178

(DOI: 10.1002/smll.202070178)

315. Direct measurement of lipid membrane disruption connects kinetics and toxicity of A beta 42 aggregation

P Flagmeier, S De, TCT Michaels, X Yang, AJ Dear, C Emanuelsson, M Vendruscolo, S Linse, D Klenerman, TPJ Knowles, CM Dobson

– Nature structural & molecular biology

(2020)

27,

886

(DOI: 10.1038/s41594-020-0471-z)

314. Phase Transition and Crystallization Kinetics of a Supramolecular System in a Microfluidic Platform

D Cohen-Gerassi, ZA Arnon, T Guterman, A Levin, M Ghosh, M Aviv, D Levy, TPJ Knowles, Y Shacham-Diamand, L Adler-Abramovich

– Chemistry of Materials

(2020)

32,

8342

(DOI: 10.1021/acs.chemmater.0c02187)

313. Continuous Flow Reactors from Microfluidic Compartmentalization of Enzymes within Inorganic Microparticles.

TA Hakala, F Bialas, Z Toprakcioglu, B Bräuer, KN Baumann, A Levin, GJL Bernardes, CFW Becker, TPJ Knowles

– ACS Applied Materials & Interfaces

(2020)

12,

32951

(DOI: 10.1021/acsami.0c09226)

312. Local micro and nano patterning of microfluidic devices using the solid on liquid deposition process

J Charmet, A Homsy, M Wood, J Covington, L Isa, M Textor, TPJ Knowles, H Keppner

– 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

(2020)

385

311. Microfluidic Affinity Profiling reveals a Broad Range of Target Affinities for Anti-SARS-CoV-2 Antibodies in Plasma of Covid Survivors

MM Schneider, M Emmenegger, CK Xu, I Condado Morales, P Turelli, MR Zimmermann, BM Frey, S Fiedler, V Denninger, G Meisl, V Kosmoliaptsis, H Fiegler, D Trono, TPJ Knowles, AAA Aguzzi

– medRxiv

(2020)

2020.09.20.20196907

(DOI: 10.1101/2020.09.20.20196907)

310. Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils

J Yang, AJ Dear, Q-Q Yao, Z Liu, CM Dobson, TPJ Knowles, S Wu, S Perrett

– Nanoscale

(2020)

12,

18663

(DOI: 10.1039/d0nr01481h)

309. A microfluidic strategy for the detection of membrane protein interactions.

Y Zhang, TW Herling, S Kreida, QAE Peter, T Kartanas, S Törnroth-Horsefield, S Linse, TPJ Knowles

– Lab on a chip

(2020)

20,

3230

(DOI: 10.1039/d0lc00205d)

308. Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses

J Pansieri, IA Iashchishyn, H Fakhouri, L Ostojić, M Malisauskas, G Musteikyte, V Smirnovas, MM Schneider, T Scheidt, CK Xu, G Meisl, TPJ Knowles, E Gazit, R Antoine, LA Morozova-Roche

– Chemical Science

(2020)

11,

7031

(DOI: 10.1039/c9sc05905a)

307. Half a century of amyloids: past, present and future.

PC Ke, R Zhou, LC Serpell, R Riek, TPJ Knowles, HA Lashuel, E Gazit, IW Hamley, TP Davis, M Fändrich, DE Otzen, MR Chapman, CM Dobson, DS Eisenberg, R Mezzenga

– Chem Soc Rev

(2020)

49,

5473

(DOI: 10.1039/c9cs00199a)

306. Trodusquemine enhances A beta(42) aggregation but suppresses its toxicity by displacing oligomers from cell membranes

R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson

– Nature Communications

(2019)

10,

225

(DOI: 10.1038/s41467-018-07699-5)

305. Physical Determinants of Amyloid Assembly in Biofilm Formation

M Andreasen, G Meisl, JD Taylor, TCT Michaels, A Levin, DE Otzen, MR Chapman, CM Dobson, SJ Matthews, TPJ Knowles

– mBio

(2019)

10,

ARTN e02279-18

(DOI: 10.1128/mbio.02279-18)

304. Rapid two-dimensional characterisation of proteins in solution

KL Saar, Q Peter, T Müller, PK Challa, TW Herling, TPJ Knowles

– Microsystems and Nanoengineering

(2019)

(DOI: 10.1038/s41378-019-0072-3)

303. Scalable integration of nano-, and microfluidics with hybrid two-photon lithography

O Vanderpoorten, Q Peter, PK Challa, UF Keyser, J Baumberg, CF Kaminski, TPJ Knowles

– Microsystems and Nanoengineering

(2019)

(DOI: 10.1038/s41378-019-0080-3)

302. Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.

S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman

– Nature communications

(2019)

10,

1541

(DOI: 10.1038/s41467-019-09477-3)

301. Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification

PR Lindstedt, FA Aprile, MJ Matos, M Perni, JB Bertoldo, B Bernardim, Q Peter, G Jiménez-Osés, TPJ Knowles, CM Dobson, F Corzana, M Vendruscolo, GJL Bernardes

– ACS Central Science

(2019)

1417

(DOI: 10.1021/acscentsci.9b00467)

300. Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease

G Heller, F Aprile, T Michaels, R Limbocker, M Perni, FS Ruggeri, B Mannini, T Löhr, M Bonomi, A De Simone, I Felli, R Pierattelli, T Knowles, C Dobson, M Vendruscolo

– None

(2019)

(DOI: 10.1101/729392)

299. Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression

S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman

– Acta neuropathologica communications

(2019)

120

(DOI: 10.1186/s40478-019-0777-4)

298. Analysis of alpha B-crystallin polydispersity in solution through native microfluidic electrophoresis

MA Wright, FS Ruggeri, KL Saar, PK Challa, JLP Benesch, TPJ Knowles

– The Analyst

(2019)

144,

4413

(DOI: 10.1039/C9AN00382G)

297. Universality of filamentous aggregation phenomena

TCT Michaels, AJ Dear, TPJ Knowles

– Physical Review E

(2019)

99,

062415

(DOI: 10.1103/PhysRevE.99.062415)

296. Programmable On-Chip Artificial Cell Producing Post-Translationally Modified Ubiquitinated Protein.

S Zilberzwige-Tal, A Levin, Z Toprakcioglu, TPJ Knowles, E Gazit, J Elbaz

– Small (Weinheim an der Bergstrasse, Germany)

(2019)

15,

e1901780

(DOI: 10.1002/smll.201901780)

295. Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

T Scheidt, U Łapińska, JR Kumita, DR Whiten, D Klenerman, MR Wilson, SIA Cohen, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles, P Arosio

– Science advances

(2019)

eaau3112

(DOI: 10.1126/sciadv.aau3112)

294. The Amyloid Phenomenon and Its Significance in Biology and Medicine

CM Dobson, TPJ Knowles, M Vendruscolo

– Cold Spring Harbor perspectives in biology

(2019)

12,

a033878

(DOI: 10.1101/cshperspect.a033878)

293. Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species

JC Sang, J-E Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, TPJ Knowles, D Klenerman

– Chemical science

(2019)

10,

4588

(DOI: 10.1039/c8sc05627g)

292. Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation

MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, B Bernardim, KL Saar, I Compañón, F Corzana, TPJ Knowles, G Jiménez-Osés, GJL Bernardes

– Angewandte Chemie (International ed. in English)

(2019)

131,

6640

291. Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules.

X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, JR Kumita, M Andreasen, CM Dobson, U Shimanovich, TPJ Knowles

– Macromolecular rapid communications

(2019)

40,

e1800898

(DOI: 10.1002/marc.201800898)

290. A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli.

K Sanagavarapu, E Nüske, I Nasir, G Meisl, JN Immink, P Sormanni, M Vendruscolo, TPJ Knowles, A Malmendal, C Cabaleiro-Lago, S Linse

– Scientific reports

(2019)

3680

(DOI: 10.1038/s41598-019-39216-z)

289. Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated A beta 42 Species A beta 5-42

T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse

– ACS chemical neuroscience

(2019)

10,

2374

(DOI: 10.1021/acschemneuro.8b00676)

288. Targeting the Formation of Amyloid Oligomers using Rationally Designed Antibodies

FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TP Knowles, CM Dobson, M Vendruscolo

– Biophysical Journal

(2019)

116,

28A

(DOI: 10.1016/j.bpj.2018.11.196)

287. Atomic force microscopy for single molecule characterisation of protein aggregation.

R Cataldi, S Chia, K Pisani, FS Ruggeri, CK Xu, T Šneideris, M Perni, S Sarwat, P Joshi, JR Kumita, S Linse, J Habchi, TPJ Knowles, B Mannini, CM Dobson, M Vendruscolo

– Archives of biochemistry and biophysics

(2019)

664,

134

(DOI: 10.1016/j.abb.2019.02.001)

286. Sequence‐Optimized Peptide Nanofibers as Growth Stimulators for Regeneration of Peripheral Neurons

C Schilling, T Mack, S Lickfett, S Sieste, FS Ruggeri, T Sneideris, A Dutta, T Bereau, R Naraghi, D Sinske, TPJ Knowles, CV Synatschke, T Weil, B Knöll

– Advanced Functional Materials

(2019)

29,

1809112

(DOI: 10.1002/adfm.201809112)

285. Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism.

C Bortolini, T Kartanas, D Copic, I Condado Morales, Y Zhang, PK Challa, Q Peter, T Jávorfi, R Hussain, M Dong, G Siligardi, TPJ Knowles, J Charmet

– Lab on a chip

(2019)

19,

(DOI: 10.1039/c8lc00757h)

284. Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy.

FS Ruggeri, T Šneideris, S Chia, M Vendruscolo, TPJ Knowles

– Journal of visualized experiments : JoVE

(2019)

2019,

ARTN e60108

(DOI: 10.3791/60108)

283. Nucleation and Growth of Amino-acid and Peptide Supramolecular Polymers through Liquid-liquid Phase Separation.

X Yan, C Yuan, A Levin, W Chen, R Xing, Q Zou, TW Herling, PK Challa, TPJ Knowles

– Angewandte Chemie (International ed. in English)

(2019)

131,

18116

282. Modulating the Mechanical Performance of Macroscale Fibers through Shear-Induced Alignment and Assembly of Protein Nanofibrils.

A Kamada, A Levin, Z Toprakcioglu, Y Shen, V Lutz-Bueno, KN Baumann, P Mohammadi, MB Linder, R Mezzenga, TPJ Knowles

– Small (Weinheim an der Bergstrasse, Germany)

(2019)

16,

e1904190

(DOI: 10.1002/smll.201904190)

281. RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

Y-C Liao, MS Fernandopulle, G Wang, H Choi, L Hao, CM Drerup, R Patel, S Qamar, J Nixon-Abell, Y Shen, W Meadows, M Vendruscolo, TPJ Knowles, M Nelson, MA Czekalska, G Musteikyte, MA Gachechiladze, CA Stephens, HA Pasolli, LR Forrest, P St George-Hyslop, J Lippincott-Schwartz, ME Ward

– Cell

(2019)

179,

147

(DOI: 10.1016/j.cell.2019.08.050)

280. Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid

R Frankel, M Törnquist, G Meisl, O Hansson, U Andreasson, H Zetterberg, K Blennow, B Frohm, T Cedervall, TPJ Knowles, T Leiding, S Linse

– Communications Biology

(2019)

365

(DOI: 10.1038/s42003-019-0612-2)

279. Homage to Chris Dobson.

J Baum, F Chiti, A De Simone, TPJ Knowles, JR Kumita, SE Radford, CV Robinson, X Salvatella, K Valelli, M Vendruscolo, A Pastore, GG Tartaglia

– Frontiers in Molecular Biosciences

(2019)

137

(DOI: 10.3389/fmolb.2019.00137)

278. Label-Free Analysis of Protein Aggregation and Phase Behavior

Z Toprakcioglu, P Challa, C Xu, TPJ Knowles

– ACS nano

(2019)

13,

13940

(DOI: 10.1021/acsnano.9b05552)

277. Autoantibodies against the prion protein in individuals with PRNP mutations

K Frontzek, MC Carta, M Losa, M Epskamp, G Meisl, A Anane, J-P Brandel, U Camenisch, J Castilla, S Haik, T Knowles, E Lindner, A Lutterotti, EV Minikel, I Roiter, J Safar, R Sanchez-Valle, D Zakova, S Hornemann, A Aguzzi

– None

(2019)

(DOI: 10.1101/19007773)

276. Dynamics and Control of Peptide Self-Assembly and Aggregation

G Meisl, TCT Michaels, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles

– Advances in experimental medicine and biology

(2019)

1174,

(DOI: 10.1007/978-981-13-9791-2_1)

275. Inside Back Cover: Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid–Liquid Phase Separation (Angew. Chem. Int. Ed. 50/2019)

C Yuan, A Levin, W Chen, R Xing, Q Zou, TW Herling, PK Challa, TPJ Knowles, X Yan

– Angewandte Chemie International Edition

(2019)

58,

18297

(DOI: 10.1002/anie.201913848)

274. Innenrücktitelbild: Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid–Liquid Phase Separation (Angew. Chem. 50/2019)

C Yuan, A Levin, W Chen, R Xing, Q Zou, TW Herling, PK Challa, TPJ Knowles, X Yan

– Angewandte Chemie

(2019)

131,

18463

(DOI: 10.1002/ange.201913848)

273. Nanostructured protein capsules

T Knowles

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2019)

258,

272. General sol to gel transition of liquid-liqud phase separated protein under shear

Y Shen, S Qamar, D Vigolo, A Kamada, S Zhang, P St George-Hyslop, T Knowles

– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2019)

48,

S227

271. The presence of autoantibodies against the prion protein is independent of PRNP mutations

K Frontzek, M Carta, M Losa, M Epskamp, G Meisl, U Camenisch, T Knowles, S Hornemann, A Aguzzi, THAUTAN-MC Investigators

– PRION

(2019)

13,

119

270. 3D microfluidics spray nozzle for sample processing and materials deposition

T Kartanas, R Rodrigues, T Müller, T Herling, T Knowles, J Charmet

– 3RD BIOMEDICAL ENGINEERING'S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES

(2019)

2092,

020007

(DOI: 10.1063/1.5096675)

269. Mechanobiology of Protein Droplets: Force Arises from Disorder.

TJ Welsh, Y Shen, A Levin, TPJ Knowles

– Cell

(2018)

175,

1457

(DOI: 10.1016/j.cell.2018.11.020)

268. Quantifying Co-Oligomer Formation by Alpha-Synuclein

M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, TCT Michaels, D Frenkel, CM Dobson, TPJ Knowles, D Klenerman

– ACS Nano

(2018)

12,

10855

(DOI: 10.1021/acsnano.8b03575)

267. Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform

M Perni, S Casford, FA Aprile, EA Nollen, TPJ Knowles, M Vendruscolo, CM Dobson

– Journal of visualized experiments : JoVE

(2018)

2018,

ARTN e58643

(DOI: 10.3791/58643)

266. Statistical Mechanics of Globular Oligomer Formation by Protein Molecules

AJ Dear, A Šarić, TCT Michaels, CM Dobson, TPJ Knowles

– Journal of Physical Chemistry B

(2018)

122,

11721

(DOI: 10.1021/acs.jpcb.8b07805)

265. Direct Observation of Murine Prion Protein Replication in Vitro.

JC Sang, G Meisl, AM Thackray, L Hong, A Ponjavic, TPJ Knowles, R Bujdoso, D Klenerman

– Journal of the American Chemical Society

(2018)

140,

14789

(DOI: 10.1021/jacs.8b08311)

264. Observation of molecular self-assembly events in massively parallel microdroplet arrays

Z Toprakcioglu, PK Challa, A Levin, TPJ Knowles

– Lab on a Chip

(2018)

18,

3303

(DOI: 10.1039/c8lc00862k)

263. SAR by kinetics for drug discovery in protein misfolding diseases

S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo

– Proceedings of the National Academy of Sciences of the United States of America

(2018)

115,

201807884

(DOI: 10.1073/pnas.1807884115)

262. Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity

FS Ruggeri, J Charmet, T Kartanas, Q Peter, S Chia, J Habchi, CM Dobson, M Vendruscolo, TPJ Knowles

– Nature Communications

(2018)

3890

(DOI: 10.1038/s41467-018-06345-4)

261. Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes

Z Li, J Tuffin, IM Lei, FS Ruggeri, NS Lewis, EL Gill, T Savin, L Huleihel, SF Badylak, T Knowles, SC Satchell, GI Welsh, MA Saleem, YYS Huang

– Acta biomaterialia

(2018)

78,

111

(DOI: 10.1016/j.actbio.2018.08.010)

260. Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution.

CG Taylor, G Meisl, MH Horrocks, H Zetterberg, TPJ Knowles, D Klenerman

– Analytical chemistry

(2018)

90,

10385

(DOI: 10.1021/acs.analchem.8b02226)

259. Identification of oxidative stress in red blood cells with nanoscale chemical resolution by infrared nanospectroscopy

FS Ruggeri, C Marcott, S Dinarelli, G Longo, M Girasole, G Dietler, TPJ Knowles

– International journal of molecular sciences

(2018)

19,

2582

(DOI: 10.3390/ijms19092582)

258. Image-Assisted Microvessel-on-a-Chip Platform for Studying Cancer Cell Transendothelial Migration Dynamics.

C Bertulli, M Gerigk, N Piano, Y Liu, D Zhang, T Müller, TJ Knowles, YYS Huang

– Scientific reports

(2018)

12480

(DOI: 10.1038/s41598-018-30776-0)

257. DNA-Coated Functional Oil Droplets.

A Caciagli, M Zupkauskas, A Levin, TPJ Knowles, C Mugemana, N Bruns, T O'Neill, WJ Frith, E Eiser

– Langmuir : the ACS journal of surfaces and colloids

(2018)

34,

10073

(DOI: 10.1021/acs.langmuir.8b01828)

256. Combining Affinity Selection and Specific Ion Mobility for Microchip Protein Sensing.

WE Arter, J Charmet, J Kong, KL Saar, TW Herling, T Müller, UF Keyser, TPJ Knowles

– Analytical chemistry

(2018)

90,

10302

(DOI: 10.1021/acs.analchem.8b02051)

255. Stabilization and Characterization of Cytotoxic Aβ <inf>40</inf> Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions

B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, CM Dobson, M Vendruscolo

– ACS chemical neuroscience

(2018)

2959

(DOI: 10.1021/acschemneuro.8b00141)

254. Self-Assembly-Mediated Release of Peptide Nanoparticles through Jets Across Microdroplet Interfaces

A Levin, TCT Michaels, TO Mason, T Müller, L Adler-Abramovich, L Mahadevan, ME Cates, E Gazit, TPJ Knowles

– ACS Applied Materials and Interfaces

(2018)

10,

27578

(DOI: 10.1021/acsami.8b09511)

253. Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.

M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, N Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles

– Journal of neuroscience methods

(2018)

306,

(DOI: 10.1016/j.jneumeth.2018.02.005)

252. Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation.

C Månsson, RTP van Cruchten, U Weininger, X Yang, R Cukalevski, P Arosio, CM Dobson, T Knowles, M Akke, S Linse, C Emanuelsson

– Biochemistry

(2018)

57,

4891

(DOI: 10.1021/acs.biochem.8b00353)

251. Origin of metastable oligomers and their effects on amyloid fibril self-assembly.

F Hasecke, T Miti, C Perez, J Barton, D Schölzel, L Gremer, CSR Grüning, G Matthews, G Meisl, TPJ Knowles, D Willbold, P Neudecker, H Heise, G Ullah, W Hoyer, M Muschol

– Chemical Science

(2018)

5937

(DOI: 10.1039/c8sc01479e)

250. Oligomer diversity during the aggregation of the repeat-region of tau

M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman

– ACS Chemical Neuroscience

(2018)

3060

(DOI: 10.1021/acschemneuro.8b00250)

249. Secondary nucleation in amyloid formation

M Törnquist, TCT Michaels, K Sanagavarapu, X Yang, G Meisl, SIA Cohen, TPJ Knowles, S Linse

– Chemical communications (Cambridge, England)

(2018)

54,

8667

(DOI: 10.1039/c8cc02204f)

248. Kinetic barriers to alpha-synuclein protofilament formation and conversion into mature fibrils

JWP Brown, G Meisl, TPJ Knowles, AK Buell, CM Dobson, C Galvagnion

– Chemical communications (Cambridge, England)

(2018)

54,

7854

(DOI: 10.1039/c8cc03002b)

247. Determination of Polypeptide Conformation with Nanoscale Resolution in Water

G Ramer, FS Ruggeri, A Levin, TPJ Knowles, A Centrone

– ACS nano

(2018)

12,

6612

(DOI: 10.1021/acsnano.8b01425)

246. Multistep Inhibition of alpha-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, GT Heller, G Meisl, SW Chen, JR Kumita, PK Challa, JB Kirkegaard, SIA Cohen, B Mannini, D Barbut, EAA Nollen, C Cecchi, N Cremades, TPJ Knowles, F Chiti, M Zasloff, M Vendruscolo, CM Dobson

– ACS Chemical Biology

(2018)

13,

2308

(DOI: 10.1021/acschembio.8b00466)

245. Enhancing the Resolution of Micro Free Flow Electrophoresis through Spatially Controlled Sample Injection.

KL Saar, T Müller, J Charmet, PK Challa, TPJ Knowles

– Analytical chemistry

(2018)

90,

8998

(DOI: 10.1021/acs.analchem.8b01205)

244. Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.

FS Ruggeri, F Benedetti, TPJ Knowles, HA Lashuel, S Sekatskii, G Dietler

– Proceedings of the National Academy of Sciences of the United States of America

(2018)

115,

201721220

(DOI: 10.1073/pnas.1721220115)

243. On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations.

X Yang, G Meisl, B Frohm, E Thulin, TPJ Knowles, S Linse

– Proceedings of the National Academy of Sciences of the United States of America

(2018)

115,

201803539

(DOI: 10.1073/pnas.1803539115)

242. Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils

Y Song, TCT Michaels, Q Ma, Z Liu, H Yuan, S Takayama, TPJ Knowles, HC Shum

– Nature Communications

(2018)

2110

(DOI: 10.1038/s41467-018-04510-3)

241. Cooperative Assembly of Hsp70 Subdomain Clusters.

MA Wright, FA Aprile, MMJ Bellaiche, TCT Michaels, T Müller, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles

– Biochemistry

(2018)

57,

3641

(DOI: 10.1021/acs.biochem.8b00151)

240. Reaction rate theory for supramolecular kinetics: application to protein aggregation

TCT Michaels, LX Liu, S Curk, PG Bolhuis, A Šarić, TPJ Knowles

– Molecular Physics

(2018)

116,

(DOI: 10.1080/00268976.2018.1474280)

239. Rapid Growth of Acetylated A beta(16-20) into Macroscopic Crystals

C Bortolini, LH Klausen, SV Hoffmann, NC Jones, D Saadeh, Z Wang, TPJ Knowles, M Dong

– ACS nano

(2018)

12,

5408

(DOI: 10.1021/acsnano.8b00448)

238. Stochastic calculus of protein filament formation under spatial confinement

TCT Michaels, AJ Dear, TPJ Knowles

– NEW JOURNAL OF PHYSICS

(2018)

20,

ARTN 055007

(DOI: 10.1088/1367-2630/aac0bc)

237. Cholesterol catalyses A beta 42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, FS Ruggeri, M Sanguanini, I Idini, JR Kumita, E Sparr, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo

– Nature Chemistry

(2018)

10,

673

(DOI: 10.1038/s41557-018-0031-x)

236. On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.

Y Zhang, EV Yates, L Hong, KL Saar, G Meisl, CM Dobson, TPJ Knowles

– Chemical Science

(2018)

3503

(DOI: 10.1039/c7sc04331g)

235. Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion.

S Sieste, T Mack, CV Synatschke, C Schilling, C Meyer Zu Reckendorf, L Pendi, S Harvey, FS Ruggeri, TPJ Knowles, C Meier, DYW Ng, T Weil, B Knöll

– Advanced healthcare materials

(2018)

e1701485

(DOI: 10.1002/adhm.201701485)

234. Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

F Kundel, L Hong, B Falcon, WA McEwan, TCT Michaels, G Meisl, N Esteras, AY Abramov, TJP Knowles, M Goedert, D Klenerman

– ACS chemical neuroscience

(2018)

1276

(DOI: 10.1021/acschemneuro.8b00094)

233. Microfluidic approaches for probing amyloid assembly and behaviour.

TW Herling, A Levin, KL Saar, CM Dobson, TPJ Knowles

– Lab on a Chip - Miniaturisation for Chemistry and Biology

(2018)

18,

999

(DOI: 10.1039/c7lc01241a)

232. Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-beta peptide

SIA Cohen, R Cukalevski, TCT Michaels, A Šarić, M Törnquist, M Vendruscolo, CM Dobson, AK Buell, TPJ Knowles, S Linse

– Nature Chemistry

(2018)

10,

523

(DOI: 10.1038/s41557-018-0023-x)

231. Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices

PK Challa, Q Peter, MA Wright, Y Zhang, KL Saar, JA Carozza, JLP Benesch, TPJ Knowles

– Analytical chemistry

(2018)

90,

3849

(DOI: 10.1021/acs.analchem.7b04523)

230. Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.

TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, CM Dobson, TPJ Knowles

– ANNUAL REVIEW OF PHYSICAL CHEMISTRY, VOL 69

(2018)

69,

273

(DOI: 10.1146/annurev-physchem-050317-021322)

229. Revealing the Mechanism of Amyloid Fibril Formation by Combined Single Molecule FRET and Kinetic Modeling

J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Perretti, S Wu

– BIOPHYSICAL JOURNAL

(2018)

114,

685A

(DOI: 10.1016/j.bpj.2017.11.3693)

228. Probing the Interaction of ABETA42 Amyloid Species with an Aggregation Suppressor Molecule by Infrared Nanospectroscopy

FS Ruggeri, J Habchi, S Chia, M Vendruscolo, TPJ Knowles

– BIOPHYSICAL JOURNAL

(2018)

114,

224A

(DOI: 10.1016/j.bpj.2017.11.1246)

227. Molecular Mechanism of AB(42) Peptide-Fibril Adsorption

MMJ Bellaiche, TPJ Knowles, RB Best

– BIOPHYSICAL JOURNAL

(2018)

114,

208A

(DOI: 10.1016/j.bpj.2017.11.1165)

226. Modulating Amyloid-Beta Aggregation to Reduce the Toxicity of its Oligomeric Aggregates

R Limbocker, B Mannini, S Chia, FS Ruggeri, M Perni, R Cascella, C Xu, J Habchi, JR Kumita, F Chiti, TPJ Knowles, M Vendruscolo, CM Dobson

– BIOPHYSICAL JOURNAL

(2018)

114,

430A

(DOI: 10.1016/j.bpj.2017.11.2382)

225. Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Amyloid-Beta42 Aggregation in Alzheimer's Disease

S Chia, J Habchi, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo

– BIOPHYSICAL JOURNAL

(2018)

114,

225A

(DOI: 10.1073/pnas.1615613114)

224. 2-Photon Lithography for Nanofluidic Lab-on-Chip Devices

O Vanderpoorten, PK Challa, Q Peter, J Charmet, N Curry, TPJ Knowles, CF Kaminski

– BIOPHYSICAL JOURNAL

(2018)

114,

689A

(DOI: 10.1016/j.bpj.2017.11.3716)

223. Biophotonics of Native Silk Fibrils.

U Shimanovich, D Pinotsi, K Shimanovich, N Yu, S Bolisetty, J Adamcik, R Mezzenga, J Charmet, F Vollrath, E Gazit, CM Dobson, GK Schierle, C Holland, CF Kaminski, TPJ Knowles

– Macromolecular bioscience

(2018)

18,

e1700295

(DOI: 10.1002/mabi.201700295)

222. Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2

J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Wu, S Perrett

– Journal of the American Chemical Society

(2018)

140,

2493

(DOI: 10.1021/jacs.7b10439)

221. Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions.

H Gang, C Galvagnion, G Meisl, T Müller, M Pfammatter, AK Buell, A Levin, CM Dobson, B Mu, TPJ Knowles

– Analytical Chemistry

(2018)

90,

3284

(DOI: 10.1021/acs.analchem.7b04820)

220. Enhancing power density of biophotovoltaics by decoupling storage and power delivery

KL Saar, P Bombelli, DJ Lea-Smith, T Call, EM Aro, T Müller, CJ Howe, TPJ Knowles

– Nature Energy

(2018)

(DOI: 10.1038/s41560-017-0073-0)

219. FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

S Qamar, G Wang, SJ Randle, FS Ruggeri, JA Varela, JQ Lin, EC Phillips, A Miyashita, D Williams, F Ströhl, W Meadows, R Ferry, VJ Dardov, GG Tartaglia, LA Farrer, GS Kaminski Schierle, CF Kaminski, CE Holt, PE Fraser, G Schmitt-Ulms, D Klenerman, T Knowles, M Vendruscolo, P St George-Hyslop

– Cell

(2018)

173,

720

(DOI: 10.1016/j.cell.2018.03.056)

218. Kinetic Analysis of Amyloid Formation.

G Meisl, TCT Michaels, S Linse, TPJ Knowles

– Methods in molecular biology (Clifton, N.J.)

(2018)

1779,

181

(DOI: 10.1007/978-1-4939-7816-8_12)

217. C-terminal truncation of alpha-synuclein promotes amyloid fibril amplification at physiological pH

IM van der Wateren, TPJ Knowles, AK Buell, CM Dobson, C Galvagnion

– Chemical Science

(2018)

5506

(DOI: 10.1039/c8sc01109e)

216. Microfluidics for Protein Biophysics

J Charmet, P Arosio, TPJ Knowles

– Journal of molecular biology

(2018)

430,

565

(DOI: 10.1016/j.jmb.2017.12.015)

215. O2‐02‐02: TARGETING AMYLOID FORMATION USING RATIONALLY DESIGNED ANTIBODIES

FA Aprile, P Sormanni, M Perni, P Arosio, R Limbocker, S Chhangur, B Mannini, S Linse, T Knowles, CM Dobson, M Vendruscolo

– Alzheimer's & Dementia

(2018)

14,

p611

(DOI: 10.1016/j.jalz.2018.06.2646)

214. Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1

PH St George-Hyslop, S Qamar, G Wang, SJ Randle, FS Ruggeri, J Varela, CF Kaminski, GS Kaminski, M Vendruscolo, TPJ Knowles, D Klenerman, CE Holt, Q Lin, W meadows

– Cell

(2018)

(DOI: 10.17863/CAM.21265)

213. On-Chip Measurements of Membrane Protein Interactions

Y Zhang, T Knowles, S Linse

– PROTEIN SCIENCE

(2018)

27,

120

212. Microfluidic Diffusional Sizing Enables Characterisation of Protein-Protein Interactions Under Native Conditions

S Devenish, C Thorne, T Scheidt, J Carozza, P Arosio, Y Zhang, A Buell, T Mueller, A Lynn, J Faherty, M Wright, M Butz, T Knowles

– PROTEIN SCIENCE

(2018)

27,

167

211. Mechanism of biosurfactant adsorption to oil/water interfaces from millisecond scale tensiometry measurements

L Kong, KL Saar, R Jacquat, L Hong, A Levin, H Gang, R Ye, B Mu, TPJ Knowles

– Interface focus

(2017)

20170013

(DOI: 10.1098/rsfs.2017.0013)

210. Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit.

TO Mason, TCT Michaels, A Levin, CM Dobson, E Gazit, TPJ Knowles, AK Buell

– Journal of the American Chemical Society

(2017)

139,

16134

(DOI: 10.1021/jacs.7b00229)

209. Nanoscale click-reactive scaffolds from peptide self-assembly

APM Guttenplan, LJ Young, D Matak-Vinkovic, CF Kaminski, TPJ Knowles, LS Itzhaki

– Journal of Nanobiotechnology

(2017)

15,

(DOI: 10.1186/s12951-017-0300-7)

208. Enhanced Quality Factor Label-free Biosensing with Micro-Cantilevers Integrated into Microfluidic Systems.

T Kartanas, V Ostanin, PK Challa, R Daly, J Charmet, TPJ Knowles

– Analytical chemistry

(2017)

89,

11929

(DOI: 10.1021/acs.analchem.7b01174)

207. Absolute Quantification of Amyloid Propagons by Digital Microfluidics.

M Pfammatter, M Andreasen, G Meisl, CG Taylor, J Adamcik, S Bolisetty, A Sánchez-Ferrer, D Klenerman, CM Dobson, R Mezzenga, TPJ Knowles, A Aguzzi, S Hornemann

– Analytical Chemistry

(2017)

89,

12306

(DOI: 10.1021/acs.analchem.7b03279)

206. Hierarchical Biomolecular Emulsions Using 3-D Microfluidics with Uniform Surface Chemistry.

Z Toprakcioglu, A Levin, TPJ Knowles

– Biomacromolecules

(2017)

18,

3642

(DOI: 10.1021/acs.biomac.7b01159)

205. Kinetic constraints on self-assembly into closed supramolecular structures

TCT Michaels, MMJ Bellaiche, MF Hagan, TPJ Knowles

– Scientific Reports

(2017)

12295

(DOI: 10.1038/s41598-017-12528-8)

204. Gradient-free determination of isoelectric points of proteins on chip.

U Łapińska, KL Saar, EV Yates, TW Herling, T Müller, PK Challa, CM Dobson, TPJ Knowles

– Physical chemistry chemical physics : PCCP

(2017)

19,

23060

(DOI: 10.1039/c7cp01503h)

203. Sequential Release of Proteins from Structured Multishell Microcapsules

U Shimanovich, TCT Michaels, E De Genst, D Matak-Vinkovic, CM Dobson, TPJ Knowles

– Biomacromolecules

(2017)

18,

3052

(DOI: 10.1021/acs.biomac.7b00351)

202. Monomeric and fibrillar alpha-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of A beta 42 aggregates

S Chia, P Flagmeier, J Habchi, V Lattanzi, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo

– Proceedings of the National Academy of Sciences of the United States of America

(2017)

114,

8005

(DOI: 10.1073/pnas.1700239114)

201. Silk micrococoons for protein stabilisation and molecular encapsulation

U Shimanovich, FS Ruggeri, E De Genst, J Adamcik, TP Barros, D Porter, T Müller, R Mezzenga, CM Dobson, F Vollrath, C Holland, TPJ Knowles

– Nature Communications

(2017)

15902

(DOI: 10.1038/ncomms15902)

200. Nanobodies raised against monomeric alpha-synuclein inhibit fibril formation and destabilize toxic oligomeric species

D Klenerman, M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, FS Ruggeri, T Guilliams, AK Buell, J-E Lee, S Gandhi, SF Lee, CE Bryant, M Vendruscolo, TPJ Knowles, CM Dobson, E De Genst, D Klenerman

– BMC biology

(2017)

15,

(DOI: 10.1186/s12915-017-0390-6)

199. Self-assembled Protein Fibril-metal Oxide Nanocomposites

A Levin, TO Mason, TPJ Knowles, U Shimanovich

– Israel Journal of Chemistry

(2017)

57,

724

(DOI: 10.1002/ijch.201600118)

198. A microfluidic platform for quantitative protein studies

TW Herling, P Arosio, T Mueller, DJ O'Connell, MC Bauer, J Persson, U Weininger, S Linse, TPJ Knowles

– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2017)

46,

S345

197. Ultrasensitive measurement of Ca2+ influx into lipid vesicles induced by protein aggregates

P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TP Knowles, S Gandhi, CM Dobson, D Klenerman

– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2017)

129,

7750

(DOI: 10.1002/ange.201700966)

196. Measuring the prion-like character of tau by TIRF microscopy

F Kundel, B Falcon, L Hong, N Esteras, AJ Dear, AY Abramov, TPJ Knowles, M Goedert, D Klenerman

– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2017)

46,

S240

195. Single amyloid aggregates chemical and structural analysis by infrared nanospectroscopy

FS Ruggeri, J Habchi, C Sean, M Vendruscolo, TPJ Knowles

– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2017)

46,

S370

194. Mechanisms of Amyloid-beta 42 oligomer formation from kinetic analysis

TC Michaels, A Saric, HW Lazell, P Arosio, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles

– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2017)

46,

S240

193. Evidence for self-replication of Alzheimer-associated A beta 42 amyloid along the sides of fibrils

M Tornquist, R Cukalevski, U Weininger, G Meisl, TPJ Knowles, T Leiding, M Akke, S Linse

– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2017)

46,

S242

192. Selective targeting of primary and secondary nucleation pathways in A beta 42 aggregation using a rational antibody scanning method

FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo

– Science Advances

(2017)

e1700488

(DOI: 10.1126/sciadv.1700488)

191. Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication.

A Munke, J Persson, T Weiffert, E De Genst, G Meisl, P Arosio, A Carnerup, CM Dobson, M Vendruscolo, TPJ Knowles, S Linse

– Proceedings of the National Academy of Sciences of the United States of America

(2017)

114,

6444

(DOI: 10.1073/pnas.1700407114)

190. Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers

P Varilly, AP Willard, JB Kirkegaard, TPJ Knowles, D Chandler

– The Journal of chemical physics

(2017)

146,

135102

(DOI: 10.1063/1.4977932)

189. A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity (vol 114, pg E1009, 2017)

M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Mueller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson

– Proceedings of the National Academy of Sciences

(2017)

114,

E2543

(DOI: 10.1073/pnas.1701964114)

188. Exciton Coupling of Phenylalanine Reveals Conformational Changes of Cationic Peptides

C Bortolini, L Liu, SV Hoffmann, NC Jones, TPJ Knowles, M Dong

– ChemistrySelect

(2017)

2476

(DOI: 10.1002/slct.201601916)

187. Acceleration of alpha-synuclein aggregation

R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, E Sparr, S Linse

– Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

(2017)

24,

(DOI: 10.1080/13506129.2017.1292904)

186. Inhibition of alpha-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between alpha-Synuclein Species

FA Aprile, P Arosio, G Fusco, SW Chen, JR Kumita, A Dhulesia, P Tortora, TPJ Knowles, M Vendruscolo, CM Dobson, N Cremades

– Biochemistry

(2017)

56,

1177

(DOI: 10.1021/acs.biochem.6b01178)

185. Physical principles of filamentous protein self-assembly kinetics

TCT Michaels, LX Liu, G Meisl, TPJ Knowles

– Journal of Physics: Condensed Matter

(2017)

29,

153002

(DOI: 10.1088/1361-648x/aa5f10)

184. A natural product inhibits the initiation of α-synuclein aggregation & suppresses its toxicity

M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limbocker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson

– Proceedings of the National Academy of Sciences of the United States of America

(2017)

114,

E1009

(DOI: 10.1073/pnas.1610586114)

183. Attenuating the Toxicity of Amyloid-Beta Aggregation with Specific Species

R Limbocker, B Mannini, M Perni, S Chia, G Heller, FS Ruggeri, J Habchi, G Meisl, PK Challa, M Zasloff, TPJ Knowles, M Vendruscolo, CM Dobson

– Biophysical Journal

(2017)

112,

494A

(DOI: 10.1016/j.bpj.2016.11.2673)

182. Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the A beta 42 peptide and its variants

G Meisl, X Yang, CM Dobson, S Linse, TPJ Knowles

– Chemical Science

(2017)

4352

(DOI: 10.1039/c7sc00215g)

181. Scaling behaviour and rate-determining steps in filamentous self-assembly.

G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles

– Chemical Science

(2017)

7087

(DOI: 10.1039/c7sc01965c)

180. Microfluidic devices fabricated using fast wafer-scale LED-lithography patterning.

PK Challa, T Kartanas, J Charmet, TPJ Knowles

– Biomicrofluidics

(2017)

11,

014113

(DOI: 10.1063/1.4976690)

179. On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products

KL Saar, Y Zhang, T Müller, CP Kumar, S Devenish, A Lynn, U Łapińska, X Yang, S Linse, TPJ Knowles

– Lab on a Chip - Miniaturisation for Chemistry and Biology

(2017)

18,

162

(DOI: 10.1039/c7lc00797c)

178. Secondary nucleation of monomers on fibril surface dominates $\alpha$-synuclein aggregation and provides autocatalytic amyloid amplification

R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, E Sparr, S Linse

– Quarterly reviews of biophysics

(2017)

50,

(DOI: 10.1017/S0033583516000172)

177. Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates

P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman

– Angewandte Chemie International Edition

(2017)

56,

7750

(DOI: 10.1002/anie.201700966)

176. Micro- and nanoscale hierarchical structure of core–shell protein microgels

LR Volpatti, U Shimanovich, FS Ruggeri, S Bolisetty, T Müller, TO Mason, TCT Michaels, R Mezzenga, G Dietler, TPJ Knowles

– Journal of Materials Chemistry B

(2016)

7989

(DOI: 10.1039/c6tb02683d)

175. Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation.

A Šarić, TCT Michaels, A Zaccone, TPJ Knowles, D Frenkel

– The Journal of chemical physics

(2016)

145,

211926

(DOI: 10.1063/1.4965040)

174. Dynamics of heteromolecular filament formation.

AJ Dear, TCT Michaels, TPJ Knowles

– The Journal of Chemical Physics

(2016)

145,

175101

(DOI: 10.1063/1.4966571)

173. beta-Synuclein suppresses both the initiation and amplification steps of alpha-synuclein aggregation via competitive binding to surfaces

JWP Brown, AK Buell, TCT Michaels, G Meisl, J Carozza, P Flagmeier, M Vendruscolo, TPJ Knowles, CM Dobson, C Galvagnion

– Scientific reports

(2016)

36010

(DOI: 10.1038/srep36010)

172. Dynamic microfluidic control of supramolecular peptide self-assembly

ZA Arnon, A Vitalis, A Levin, TCT Michaels, A Caflisch, TPJ Knowles, L Adler-Abramovich, E Gazit

– Nature Communications

(2016)

13190

(DOI: 10.1038/ncomms13190)

171. Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces.

Y Song, U Shimanovich, TCT Michaels, Q Ma, J Li, TPJ Knowles, HC Shum

– Nature Communications

(2016)

12934

(DOI: 10.1038/ncomms12934)

170. Kinetics of fragmentation and dissociation of two-strand protein filaments: Coarse-grained simulations and experiments.

A Zaccone, I Terentjev, TW Herling, TPJ Knowles, A Aleksandrova, EM Terentjev

– The Journal of chemical physics

(2016)

145,

105101

(DOI: 10.1063/1.4962366)

169. Physical determinants of the self-replication of protein fibrils

A Šaric, AK Buell, G Meisl, TCT Michaels, CM Dobson, S Linse, TPJ Knowles, D Frenkel

– Nature Physics

(2016)

12,

874

(DOI: 10.1038/nphys3828)

168. Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.

P Flagmeier, G Meisl, M Vendruscolo, TPJ Knowles, CM Dobson, AK Buell, C Galvagnion

– Proceedings of the National Academy of Sciences of the United States of America

(2016)

113,

10328

(DOI: 10.1073/pnas.1604645113)

167. Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation

Y Zhang, AK Buell, T Müller, E De Genst, J Benesch, CM Dobson, TPJ Knowles

– Chembiochem : a European journal of chemical biology

(2016)

17,

1920

(DOI: 10.1002/cbic.201600384)

166. Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform

TO Mason, TCT Michaels, A Levin, E Gazit, CM Dobson, AK Buell, TPJ Knowles

– Journal of the American Chemical Society

(2016)

138,

9589

(DOI: 10.1021/jacs.6b04136)

165. Controlling the Physical Dimensions of Peptide Nanotubes by Supramolecular Polymer Coassembly.

L Adler-Abramovich, P Marco, ZA Arnon, RCG Creasey, TCT Michaels, A Levin, DJ Scurr, CJ Roberts, TPJ Knowles, SJB Tendler, E Gazit

– ACS nano

(2016)

10,

7436

(DOI: 10.1021/acsnano.6b01587)

164. Elastic instability-mediated actuation by a supra-molecular polymer

A Levin, TCT Michaels, L Adler-Abramovich, TO Mason, T Müller, B Zhang, L Mahadevan, E Gazit, TPJ Knowles

– Nature Physics

(2016)

12,

926

(DOI: 10.1038/nphys3808)

163. Quantifying Measurement Fluctuations from Stochastic Surface Processes on Sensors with Heterogeneous Sensitivity

J Charmet, TCT Michaels, R Daly, A Prasad, P Thiruvenkathanathan, RS Langley, TPJ Knowles, AA Seshia

– Physical Review Applied

(2016)

064016

(DOI: 10.1103/physrevapplied.5.064016)

162. Fluctuations in the Kinetics of Linear Protein Self-Assembly.

TCT Michaels, AJ Dear, JB Kirkegaard, KL Saar, DA Weitz, TPJ Knowles

– Physical Review Letters

(2016)

116,

258103

(DOI: 10.1103/PhysRevLett.116.258103)

161. Particle-Based Monte-Carlo Simulations of Steady-State Mass Transport at Intermediate Peclet Numbers

T Müller, P Arosio, L Rajah, SIA Cohen, EV Yates, M Vendruscolo, CM Dobson, TPJ Knowles

– International Journal of Nonlinear Sciences and Numerical Simulation

(2016)

17,

175

(DOI: 10.1515/ijnsns-2015-0056)

160. Amyloid Fibrils as Building Blocks for Natural and Artificial Functional Materials.

TPJ Knowles, R Mezzenga

– Advanced materials (Deerfield Beach, Fla.)

(2016)

28,

6546

(DOI: 10.1002/adma.201505961)

159. A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions.

TW Herling, DJ O'Connell, MC Bauer, J Persson, U Weininger, TPJ Knowles, S Linse

– Biophysical journal

(2016)

110,

1957

(DOI: 10.1016/j.bpj.2016.03.038)

158. The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model

V Kakkar, C Månsson, EP de Mattos, S Bergink, M van der Zwaag, MAWH van Waarde, NJ Kloosterhuis, R Melki, RTP van Cruchten, S Al-Karadaghi, P Arosio, CM Dobson, TPJ Knowles, GP Bates, JM van Deursen, S Linse, B van de Sluis, C Emanuelsson, HH Kampinga

– Molecular Cell

(2016)

62,

272

(DOI: 10.1016/j.molcel.2016.03.017)

157. Analysis of the length distribution of amyloid fibrils by centrifugal sedimentation

P Arosio, T Cedervall, TPJ Knowles, S Linse

– Analytical biochemistry

(2016)

504,

(DOI: 10.1016/j.ab.2016.03.015)

156. An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation

EV Yates, G Meisl, TPJ Knowles, CM Dobson

– The Journal of Physical Chemistry Part B

(2016)

120,

2087

(DOI: 10.1021/acs.jpcb.5b09663)

155. Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.

P Arosio, K Hu, FA Aprile, T Müller, TPJ Knowles

– Analytical chemistry

(2016)

88,

3488

(DOI: 10.1021/acs.analchem.5b02930)

154. A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.

P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo

– ACS Combinatorial Science

(2016)

18,

144

(DOI: 10.1021/acscombsci.5b00129)

153. Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation.

E van Dijk, P Varilly, TPJ Knowles, D Frenkel, S Abeln

– Physical Review Letters

(2016)

116,

078101

(DOI: 10.1103/PhysRevLett.116.078101)

152. Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.

M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, AY Abramov, S Gandhi, NW Wood, N Cremades, CM Dobson, TPJ Knowles, D Klenerman

– Proceedings of the National Academy of Sciences

(2016)

113,

E1206

(DOI: 10.1073/pnas.1524128113)

151. Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform.

K-L Saar, EV Yates, T Müller, S Saunier, CM Dobson, TPJ Knowles

– Biophysical journal

(2016)

110,

555

(DOI: 10.1016/j.bpj.2015.11.3523)

150. An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease

J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, SIA Cohen, MBD Müller, S Linse, EAA Nollen, CM Dobson, TPJ Knowles, M Vendruscolo

– Science advances

(2016)

e1501244

(DOI: 10.1126/sciadv.1501244)

149. Oligomers of Heat-Shock Proteins: Structures That Don't Imply Function

WM Jacobs, TPJ Knowles, D Frenkel

– PLoS computational biology

(2016)

12,

e1004756

(DOI: 10.1371/journal.pcbi.1004756)

148. Molecular mechanisms of protein aggregation from global fitting of kinetic models

G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles

– Nature protocols

(2016)

11,

252

(DOI: 10.1038/nprot.2016.010)

147. Hamiltonian Dynamics of Protein Filament Formation.

TCT Michaels, SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles

– Physical review letters

(2016)

116,

038101

(DOI: 10.1103/PhysRevLett.116.038101)

146. Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms

M Iljina, GA Garcia, AJ Dear, J Flint, P Narayan, TCT Michaels, CM Dobson, D Frenkel, TPJ Knowles, D Klenerman

– Scientific Reports

(2016)

28658

(DOI: 10.1038/srep28658)

145. Self-assembly of MPG1, a hydrophobin protein from the rice blast fungus that forms functional amyloid coatings, occurs by a surface-driven mechanism.

CLL Pham, A Rey, V Lo, M Soulès, Q Ren, G Meisl, TPJ Knowles, AH Kwan, M Sunde

– Scientific reports

(2016)

25288

(DOI: 10.1038/srep25288)

144. Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones

JD Taylor, WJ Hawthorne, J Lo, A Dear, N Jain, G Meisl, M Andreasen, C Fletcher, M Koch, N Darvill, N Scull, A Escalera-Maurer, L Sefer, R Wenman, S Lambert, J Jean, Y Xu, B Turner, SG Kazarian, MR Chapman, D Bubeck, A de Simone, TPJ Knowles, SJ Matthews

– Scientific Reports

(2016)

24656

(DOI: 10.1038/srep24656)

143. Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation.

P Arosio, TCT Michaels, S Linse, C Månsson, C Emanuelsson, J Presto, J Johansson, M Vendruscolo, CM Dobson, TPJ Knowles

– Nature Communications

(2016)

10948

(DOI: 10.1038/ncomms10948)

142. Quantitative thermophoretic study of disease-related protein aggregates

M Wolff, JJ Mittag, TW Herling, ED Genst, CM Dobson, TPJ Knowles, D Braun, AK Buell

– Scientific reports

(2016)

22829

(DOI: 10.1038/srep22829)

141. Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide

G Meisl, X Yang, B Frohm, TPJ Knowles, S Linse

– Scientific reports

(2016)

18728

(DOI: 10.1038/srep18728)

140. Scaling and dimensionality in the chemical kinetics of protein filament formation

TCT Michaels, AJ Dear, TPJ Knowles

– International Reviews in Physical Chemistry

(2016)

35,

679

(DOI: 10.1080/0144235x.2016.1239335)

139. Microfluidic devices fabricated using soft lithography for the study of protein structures using synchrotron radiation circular dichroism

J Charmet, C Bortolini, D Copic, IC Morales, Y Zhang, PK Challa, T Jávorfi, R Hussain, G Siligardi, TPJ Knowles

– 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

(2016)

1079

138. Microfluidic diffusion analysis of the sizes and interactions of proteins under native solution conditions

P Arosio, T Müller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, DA White, TW Herling, EJ De Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles

– ACS Nano

(2016)

10,

333

(DOI: 10.1021/acsnano.5b04713)

137. Combining Single-Molecule Techniques with Microfluidics for Protein Analysis

C Taylor, T Knowles, D Klenerman

– Biophysical Journal

(2016)

110,

195a

(DOI: 10.1016/j.bpj.2015.11.1086)

136. N-Terminal Extensions Retard A beta 42 Fibril Formation but Allow Cross-Seeding and Coaggregation with A beta 42

O Szczepankiewicz, B Linse, G Meisl, E Thulin, B Frohm, C Sala Frigerio, MT Colvin, AC Jacavone, RG Griffin, T Knowles, DM Walsh, S Linse

– Journal of the American Chemical Society

(2015)

137,

14673

(DOI: 10.1021/jacs.5b07849)

135. The length distribution of frangible biofilaments

TCT Michaels, P Yde, JCW Willis, MH Jensen, D Otzen, CM Dobson, AK Buell, TPJ Knowles

– The Journal of chemical physics

(2015)

143,

164901

(DOI: 10.1063/1.4933230)

134. Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity.

EV Yates, T Müller, L Rajah, EJ De Genst, P Arosio, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles

– Nature chemistry

(2015)

802

(DOI: 10.1038/NCHEM.2344)

133. Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates.

MA Wright, FA Aprile, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles

– Chemical communications (Cambridge, England)

(2015)

51,

14425

(DOI: 10.1039/c5cc03689e)

132. Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers.

MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, M Dalla Serra, TPJ Knowles, CM Dobson, D Klenerman

– Analytical Chemistry

(2015)

87,

8818

(DOI: 10.1021/acs.analchem.5b01811)

131. Dynamics of protein aggregation and oligomer formation governed by secondary nucleation.

TCT Michaels, HW Lazell, P Arosio, TPJ Knowles

– The Journal of chemical physics

(2015)

143,

054901

(DOI: 10.1063/1.4927655)

130. Force generation by the growth of amyloid aggregates.

TW Herling, GA Garcia, TCT Michaels, W Grentz, J Dean, U Shimanovich, H Gang, T Müller, B Kav, EM Terentjev, CM Dobson, TPJ Knowles

– Proceedings of the National Academy of Sciences of the United States of America

(2015)

112,

9524

(DOI: 10.1073/pnas.1417326112)

129. Molecular Rotors Provide Insights into Microscopic Structural Changes During Protein Aggregation

AJ Thompson, TW Herling, M Kubánková, A Vyšniauskas, TPJ Knowles, MK Kuimova

– The journal of physical chemistry. B

(2015)

119,

10170

(DOI: 10.1021/acs.jpcb.5b05099)

128. New insights into the mechanism of amyloid formation by alpha-synuclein

AK Buell, C Galvagnion, CM Dobson, TPJ Knowles

– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2015)

44,

S100

127. Kinetics of protein aggregation

T Knowles, M Vendruscolo, C Dobson

– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2015)

284,

S98

126. Lipid vesicles trigger alpha-synuclein aggregation by stimulating primary nucleation

C Galvagnion, AK Buell, G Meisl, TC Michaels, M Vendruscolo, TPJ Knowles, CM Dobson

– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2015)

11,

S101

(DOI: 10.1038/nchembio.1750)

125. Rapid sizing of proteins in complex solutions

P Arosio, T Muller, L Rajah, EV Yates, FA Aprile, SIA Cohen, DA White, TW Herling, E de Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles

– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2015)

44,

S49

124. Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry.

X-M Zhou, U Shimanovich, TW Herling, S Wu, CM Dobson, TPJ Knowles, S Perrett

– ACS nano

(2015)

5772

(DOI: 10.1021/acsnano.5b00061)

123. Aggregation-prone amyloid-β·CuII species formed on the millisecond timescale under mildly acidic conditions

JT Pedersen, CB Borg, TCT Michaels, TPJ Knowles, P Faller, K Teilum, L Hemmingsen

– ChemBioChem

(2015)

16,

1293

(DOI: 10.1002/cbic.201500080)

122. Preventing peptide and protein misbehavior: Fig. 1.

P Arosio, G Meisl, M Andreasen, TPJ Knowles

– Proceedings of the National Academy of Sciences of the United States of America

(2015)

112,

5267

(DOI: 10.1073/pnas.1505170112)

121. A microfluidic platform for quantitative measurements of effective protein charges and single ion binding in solution

TW Herling, P Arosio, T Müller, S Linse, TPJ Knowles

– Physical chemistry chemical physics : PCCP

(2015)

17,

12161

(DOI: 10.1039/c5cp00746a)

120. Structural characterization of toxic oligomers that are kinetically trapped during alpha-synuclein fibril formation

SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, EJ De-Genst, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades

– Proceedings of the National Academy of Sciences of the United States of America

(2015)

112,

E1994

(DOI: 10.1073/pnas.1421204112)

119. A molecular chaperone breaks the catalytic cycle that generates toxic A beta oligomers

SIA Cohen, P Arosio, J Presto, FR Kurudenkandy, H Biverstål, L Dolfe, C Dunning, X Yang, B Frohm, M Vendruscolo, J Johansson, CM Dobson, A Fisahn, TPJ Knowles, S Linse

– Nature Structural and Molecular Biology

(2015)

22,

207

(DOI: 10.1038/nsmb.2971)

118. The physical basis of protein misfolding disorders

TPJ Knowles, M Vendruscolo, CM Dobson

– Physics Today

(2015)

68,

(DOI: 10.1063/PT.3.2719)

117. On the lag phase in amyloid fibril formation.

P Arosio, TPJ Knowles, S Linse

– Physical chemistry chemical physics : PCCP

(2015)

17,

7606

(DOI: 10.1039/c4cp05563b)

116. Kinetic theory of protein filament growth: Self-consistent methods and perturbative techniques

TCT Michaels, TPJ Knowles

– International Journal of Modern Physics B

(2015)

29,

1530002

(DOI: 10.1142/S0217979215300029)

115. Neuronal Cx3cr1 Deficiency Protects against Amyloid beta-Induced Neurotoxicity

J Dworzak, B Renvoisé, J Habchi, EV Yates, C Combadière, TP Knowles, CM Dobson, C Blackstone, O Paulsen, PM Murphy

– PLoS ONE

(2015)

10,

e0127730

(DOI: 10.1371/journal.pone.0127730)

114. The A beta 40 and A beta 42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation

R Cukalevski, X Yang, G Meisl, U Weininger, K Bernfur, B Frohm, TPJ Knowles, S Linse

– Chemical Science

(2015)

4215

(DOI: 10.1039/c4sc02517b)

113. A mechanistic model of tau amyloid aggregation based on direct observation of oligomers.

SL Shammas, GA Garcia, S Kumar, M Kjaergaard, MH Horrocks, N Shivji, E Mandelkow, TPJ Knowles, E Mandelkow, D Klenerman

– Nature communications

(2015)

7025

(DOI: 10.1038/ncomms8025)

112. Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants.

L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, N Cremades, CM Dobson, D Klenerman

– Scientific reports

(2015)

16696

(DOI: 10.1038/srep16696)

111. A high power-density, mediator-free, microfluidic biophotovoltaic device for cyanobacterial cells

P Bombelli, T Müller, TW Herling, CJ Howe, TPJ Knowles

– Advanced Energy Materials

(2015)

1401299

(DOI: 10.1002/aenm.201401299)

110. Protein microgels from amyloid fibril networks.

U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, S Linse, KS Åkerfeldt, CM Dobson, DA Weitz, TPJ Knowles

– Advances in experimental medicine and biology

(2015)

1174,

223

(DOI: 10.1007/978-981-13-9791-2_7)

109. Tetracycline nanoparticles as antibacterial and gene-silencing agents

U Shimanovich, A Lipovsky, D Eliaz, S Zigdon, TPJ Knowles, Y Nitzan, S Michaeli, A Gedanken

– Advanced healthcare materials

(2015)

723

(DOI: 10.1002/adhm.201400631)

108. Multiphase Protein Microgels(a)

U Shimanovich, Y Song, J Brujic, HC Shum, TPJ Knowles

– Macromolecular bioscience

(2015)

15,

501

(DOI: 10.1002/mabi.201400366)

107. ChemInform Abstract: Biophysical Approaches for the Study of Interactions Between Molecular Chaperones and Protein Aggregates

MA Wright, FA Aprile, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles

– ChemInform

(2015)

46,

(DOI: 10.1002/chin.201545294)

106. Sizing and interactions of proteins under native conditions from microfluidic diffusion measurements: application to molecular chaperones and single-step immunoassay

P Arosio, T Mueller, L Rajah, F Aprile, T Scheidt, J Carrozza, M Wright, M Vendruscolo, C Dobson, T Knowles

– PROTEIN SCIENCE

(2015)

24,

105. Crucial role of non-specific interactions in amyloid nucleation

A Saric, YC Chebaro, TPJ Knowles, D Frenkel

– Proceedings of the National Academy of Sciences of the United States of America

(2014)

111,

17869

(DOI: 10.1073/pnas.1410159111)

104. Dry-mass sensing for microfluidics

T Mueller, DA White, TPJ Knowles

– Applied Physics Letters

(2014)

105,

214101

(DOI: 10.1063/1.4902131)

103. Interaction of the Molecular Chaperone DNAJB6 with Growing Arnyloid-beta 42 (A beta 42) Aggregates Leads to Sub-stoichiometric Inhibition of Amyloid Formation

C Månsson, P Arosio, R Hussein, HH Kampinga, RM Hashem, WC Boelens, CM Dobson, TPJ Knowles, S Linse, C Emanuelsson

– The Journal of biological chemistry

(2014)

289,

31066

(DOI: 10.1074/jbc.M114.595124)

102. The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation.

AK Buell, CM Dobson, TPJ Knowles

– Essays in Biochemistry

(2014)

56,

(DOI: 10.1042/bse0560011)

101. Differences in nucleation behavior underlie the contrasting aggregation kinetics of the A beta 40 and A beta 42 peptides

G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse, TPJ Knowles

– Proceedings of the National Academy of Sciences of the United States of America

(2014)

111,

9384

(DOI: 10.1073/pnas.1401564111)

100. Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization

TCT Michaels, TPJ Knowles

– The Journal of chemical physics

(2014)

140,

214904

(DOI: 10.1063/1.4880121)

99. The amyloid state and its association with protein misfolding diseases

TPJ Knowles, M Vendruscolo, CM Dobson

– Nature reviews. Molecular cell biology

(2014)

15,

384

(DOI: 10.1038/nrm3810)

98. Asymptotic solutions of the Oosawa model for the length distribution of biofilaments.

TCT Michaels, GA Garcia, TPJ Knowles

– The Journal of chemical physics

(2014)

140,

194906

(DOI: 10.1063/1.4875897)

97. Solution conditions determine the relative importance of nucleation and growth processes in alpha-synuclein aggregation

AK Buell, C Galvagnion, R Gaspar, E Sparr, M Vendruscolo, TPJ Knowles, S Linse, CM Dobson

– Proceedings of the National Academy of Sciences of the United States of America

(2014)

111,

7671

(DOI: 10.1073/pnas.1315346111)

96. Mean-field master equation formalism for biofilament growth

TCT Michaels, TPJ Knowles

– American Journal of Physics

(2014)

82,

476

(DOI: 10.1119/1.4870004)

95. Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters

GA Garcia, SIA Cohen, CM Dobson, TPJ Knowles

– Physical review. E, Statistical, nonlinear, and soft matter physics

(2014)

89,

ARTN 032712

(DOI: 10.1103/physreve.89.032712)

94. Density-gradient-free microfluidic centrifugation for analytical and preparative separation of nanoparticles.

P Arosio, T Müller, L Mahadevan, TPJ Knowles

– Nano letters

(2014)

14,

2365

(DOI: 10.1021/nl404771g)

93. Spatial Propagation of Protein Polymerization

SIA Cohen, L Rajah, CH Yoon, AK Buell, DA White, RA Sperling, M Vendruscolo, EM Terentjev, CM Dobson, DA Weitz, TPJ Knowles

– Physical Review Letters

(2014)

112,

098101

(DOI: 10.1103/physrevlett.112.098101)

92. Diffuse transition state structure for the unfolding of a leucine-rich repeat protein

SE Kelly, G Meisl, PJE Rowling, SH McLaughlin, T Knowles, LS Itzhaki

– Physical chemistry chemical physics : PCCP

(2014)

16,

6448

(DOI: 10.1039/c3cp54818j)

91. The Role of Stable alpha-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation

N Lorenzen, SB Nielsen, AK Buell, JD Kaspersen, P Arosio, BS Vad, W Paslawski, G Christiansen, Z Valnickova-Hansen, M Andreasen, JJ Enghild, JS Pedersen, CM Dobson, TPJ Knowles, DE Otzen

– Journal of the American Chemical Society

(2014)

136,

3859

(DOI: 10.1021/ja411577t)

90. Polymer physics inspired approaches for the study of the mechanical properties of amyloid fibrils

LR Volpatti, TPJ Knowles

– Journal of Polymer Science Part B: Polymer Physics

(2014)

52,

281

(DOI: 10.1002/polb.23428)

89. Nanoscale spatially resolved infrared spectra from single microdroplets.

T Müller, FS Ruggeri, AJ Kulik, U Shimanovich, TO Mason, TPJ Knowles, G Dietler

– Lab on a chip

(2014)

14,

1315

(DOI: 10.1039/c3lc51219c)

88. Insights into the Inhibition Mechanism of Biomolecular Self-Assembly from Chemical Kinetics

P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles

– Biophysical Journal

(2014)

106,

682A

(DOI: 10.1016/j.bpj.2013.11.3776)

87. Determination of Primary Nucleation Mechanisms of alpha-Synuclein Amyloid Aggregation

FA Aprile, G Meisl, AK Buell, P Flagmeier, CM Dobson, M Vendruscolo, TPJ Knowles

– BIOPHYSICAL JOURNAL

(2014)

106,

267A

(DOI: 10.1016/j.bpj.2013.11.1570)

86. Expanding the solvent chemical space for self-assembly of dipeptide nanostructures.

TO Mason, DY Chirgadze, A Levin, L Adler-Abramovich, E Gazit, TPJ Knowles, AK Buell

– ACS nano

(2014)

1243

(DOI: 10.1021/nn404237f)

85. Chemical kinetics for drug discovery to combat protein aggregation diseases.

P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles

– Trends in pharmacological sciences

(2014)

35,

127

(DOI: 10.1016/j.tips.2013.12.005)

84. Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers.

A Levin, TO Mason, L Adler-Abramovich, AK Buell, G Meisl, C Galvagnion, Y Bram, SA Stratford, CM Dobson, TPJ Knowles, E Gazit

– Nature Communications

(2014)

5219

(DOI: 10.1038/ncomms6219)

83. Self-assembly of amyloid fibrils that display active enzymes

XM Zhou, A Entwistle, H Zhang, AP Jackson, TO Mason, U Shimanovich, TPJ Knowles, AT Smith, EB Sawyer, S Perrett

– ChemCatChem

(2014)

1961

(DOI: 10.1002/cctc.201402125)

82. Quantitative Analysis of Diffusive Reactions at the Solid–Liquid Interface in Finite Systems

TCT Michaels, AK Buell, EM Terentjev, TPJ Knowles

– The journal of physical chemistry letters

(2014)

695

(DOI: 10.1021/jz4024833)

81. Sonochemically-induced spectral shift as a probe of green fluorescent protein release from nano capsules

U Shimanovich, A Munder, NG Azoia, A Cavaco-Paulo, A Gruzman, TPJ Knowles, A Gedanken

– RSC Advances

(2014)

10303

(DOI: 10.1039/c3ra47915c)

80. Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ<inf>42</inf> peptide

B Bolognesi, SIA Cohen, P Aran Terol, EK Esbjörner, S Giorgetti, MF Mossuto, A Natalello, AC Brorsson, TPJ Knowles, CM Dobson, LM Luheshi

– ACS Chemical Biology

(2014)

378

(DOI: 10.1021/cb400616y)

79. Quantitative sensing of microviscosity in protocells and amyloid materials using fluorescence lifetime imaging of molecular rotors

AJ Thompson, TYD Tang, TW Herling, CR Che Hak, S Mann, TPJ Knowles, MK Kuimova

– Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII

(2014)

8947,

89471c-89471c-6

(DOI: 10.1117/12.2037851)

78. The amyloid state and its association with protein misfolding diseases (vol 15, pg 384, 2014)

TPJ Knowles, M Vendruscolo, CM Dobson

– Nature Reviews Molecular Cell Biology

(2014)

15,

496

(DOI: 10.1038/nrm3826)

77. Easyworm: an open-source software tool to determine the mechanical properties of worm-like chains.

G Lamour, JB Kirkegaard, H Li, TP Knowles, J Gsponer

– Source Code for Biology and Medicine

(2014)

(DOI: 10.1186/1751-0473-9-16)

76. Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease

G Tóth, SJ Gardai, W Zago, CW Bertoncini, N Cremades, SL Roy, MA Tambe, J-C Rochet, C Galvagnion, G Skibinski, S Finkbeiner, M Bova, K Regnstrom, S-S Chiou, J Johnston, K Callaway, JP Anderson, MF Jobling, AK Buell, TA Yednock, TPJ Knowles, M Vendruscolo, J Christodoulou, CM Dobson, D Schenk, L McConlogue

– PLoS ONE

(2014)

e87133

(DOI: 10.1371/journal.pone.0087133)

75. Protein micro- and nano-capsules for biomedical applications

U Shimanovich, GJL Bernardes, TPJ Knowles, A Cavaco-Paulo

– Chemical Society reviews

(2014)

43,

1361

(DOI: 10.1039/c3cs60376h)

74. Quantification of the Concentration of A beta 42 Propagons during the Lag Phase by an Amyloid Chain Reaction Assay

P Arosio, R Cukalevski, B Frohm, TPJ Knowles, S Linse

– Journal of the American Chemical Society

(2014)

136,

219

(DOI: 10.1021/ja408765u)

73. Amyloid Beta Peptide A beta 40 and A beta 42 Form Separate Fibrils in Binary Mixtures

X Yang, R Cukalevski, G Meisl, B Frohm, T Knowles, S Linse

– PROTEIN SCIENCE

(2014)

23,

72. ChemInform Abstract: Protein Micro‐ and Nano‐Capsules for Biomedical Applications

U Shimanovich, GJL Bernardes, TPJ Knowles, A Cavaco-Paulo

– ChemInform

(2014)

45,

(DOI: 10.1002/chin.201418286)

71. A Clear View of Polymorphism, Twist, and Chirality in Amyloid Fibril Formation

LR Volpatti, M Vendruscolo, CM Dobson, TPJ Knowles

– ACS nano

(2013)

10443

(DOI: 10.1021/nn406121w)

70. Three-dimensional domain swapping and supramolecular protein assembly: Insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase

A Pica, A Merlino, AK Buell, TPJ Knowles, E Pizzo, G D'Alessio, F Sica, L Mazzarella

– Acta Crystallographica Section D: Biological Crystallography

(2013)

69,

2116

(DOI: 10.1107/S0907444913020507)

69. Single-Molecule Measurements of Transient Biomolecular Complexes through Microfluidic Dilution

MH Horrocks, L Rajah, P Jönsson, M Kjaergaard, M Vendruscolo, TPJ Knowles, D Klenerman

– Analytical Chemistry

(2013)

85,

6855

(DOI: 10.1021/ac4010875)

68. Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism.

SIA Cohen, S Linse, LM Luheshi, E Hellstrand, DA White, L Rajah, DE Otzen, M Vendruscolo, CM Dobson, TPJ Knowles

– Proceedings of the National Academy of Sciences of the United States of America

(2013)

110,

9758

(DOI: 10.1073/pnas.1218402110)

67. Integration and characterization of solid wall electrodes in microfluidic devices fabricated in a single photolithography step

TW Herling, T Müller, L Rajah, JN Skepper, M Vendruscolo, TPJ Knowles

– Applied Physics Letters

(2013)

102,

184102

(DOI: 10.1063/1.4803917)

66. Amyloid beta-protein: the influence of intrinsic and extrinsic factors on fibril formation

R Cukalevski, X Yang, SI Cohen, B Boland, B Frohm, E Thulin, DM WalsXh, TP Knowles, S Linse

– JOURNAL OF NEUROCHEMISTRY

(2013)

125,

682A

(DOI: 10.1016/j.bpj.2013.11.3778)

65. Atomic structure and hierarchical assembly of a cross-beta amyloid fibril

AWP Fitzpatrick, GT Debelouchina, MJ Bayro, DK Clare, MA Caporini, VS Bajaj, CP Jaroniec, L Wang, V Ladizhansky, SA Müller, CE MacPhee, CA Waudby, HR Mott, A De Simone, TPJ Knowles, HR Saibil, M Vendruscolo, EV Orlova, RG Griffin, CM Dobson

– Proceedings of the National Academy of Sciences of the United States of America

(2013)

110,

5468

(DOI: 10.1073/pnas.1219476110)

64. Electrostatic effects in filamentous protein aggregation

AK Buell, P Hung, X Salvatella, ME Welland, CM Dobson, TPJ Knowles

– Biophysical journal

(2013)

104,

1116

(DOI: 10.1016/j.bpj.2013.01.031)

63. Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses.

M Yolamanova, C Meier, AK Shaytan, V Vas, CW Bertoncini, F Arnold, O Zirafi, SM Usmani, JA Müller, D Sauter, C Goffinet, D Palesch, P Walther, NR Roan, H Geiger, O Lunov, T Simmet, J Bohne, H Schrezenmeier, K Schwarz, L Ständker, W-G Forssmann, X Salvatella, PG Khalatur, AR Khokhlov, TPJ Knowles, T Weil, F Kirchhoff, J Münch

– Nature Nanotechnology

(2013)

130

(DOI: 10.1038/NNANO.2012.248)

62. Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2.

LQ Xu, S Wu, AK Buell, SIA Cohen, LJ Chen, WH Hu, SA Cusack, LS Itzhaki, H Zhang, TPJ Knowles, CM Dobson, ME Welland, GW Jones, S Perrett

– Philosophical transactions of the Royal Society of London. Series B, Biological sciences

(2013)

368,

20110410

(DOI: 10.1098/rstb.2011.0410)

61. The Kinetics and Mechanisms of Amyloid Formation

SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles

– None

(2013)

183

(DOI: 10.1002/9783527654185.ch10)

60. Connecting macroscopic observables and microscopic assembly events in amyloid formation using coarse grained simulations.

NS Bieler, TPJ Knowles, D Frenkel, R Vácha

– PLoS Computational Biology

(2012)

e1002692

(DOI: 10.1371/journal.pcbi.1002692)

59. Highly non-linear microfluidic resistor elements for flow rate-dependent addressing of microchannels

L Rajah, DA White, TPJ Knowles

– International Journal of Nonlinear Sciences and Numerical Simulation

(2012)

13,

319

(DOI: 10.1515/ijnsns-2012-0401)

58. Fluctuations in water, the hydrophobic effect and self-assembly

PS Varilly, AJ Patel, SN Jamadagni, H Acharya, MF Hagan, S Garde, D Chandler, TPJ Knowles, D Frenkel

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2012)

244,

57. Selenium-Enhanced Electron Microscopic Imaging of Different Aggregate Forms of a Segment of the Amyloid beta Peptide in Cells

EK McGuire, M Motskin, B Bolognesi, SD Bergin, TPJ Knowles, J Skepper, LM Luheshi, DW McComb, CM Dobson, AE Porter

– ACS nano

(2012)

4740

(DOI: 10.1021/nn204859e)

56. Direct observation of the interconversion of normal and pathogenic forms of alpha-synuclein

N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, NW Wood, TPJ Knowles, CM Dobson, D Klenerman

– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2012)

149,

1048

(DOI: 10.1016/j.cell.2012.03.037)

55. Detailed analysis of the energy barriers for amyloid fibril growth.

AK Buell, A Dhulesia, DA White, TPJ Knowles, CM Dobson, ME Welland

– Angewandte Chemie (International ed. in English)

(2012)

51,

5247

(DOI: 10.1002/anie.201108040)

54. From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation

SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles

– Journal of Molecular Biology

(2012)

421,

160

(DOI: 10.1016/j.jmb.2012.02.031)

53. Twisting Transition between Crystalline and Fibrillar Phases of Aggregated Peptides

TPJ Knowles, A De Simone, AW Fitzpatrick, A Baldwin, S Meehan, L Rajah, M Vendruscolo, ME Welland, CM Dobson, EM Terentjev

– Physical review letters

(2012)

109,

158101

(DOI: 10.1103/physrevlett.109.158101)

52. Role of elongation and secondary pathways in S6 amyloid fibril growth

N Lorenzen, SIA Cohen, SB Nielsen, TW Herling, G Christiansen, CM Dobson, TPJ Knowles, D Otzen

– Biophysical Journal

(2012)

102,

2167

(DOI: 10.1016/j.bpj.2012.03.047)

51. Analyse der Energiebarrieren für das Wachstum von Amyloidfibrillen

AK Buell, A Dhulesia, DA White, TPJ Knowles, CM Dobson, ME Welland

– Angewandte Chemie

(2012)

124,

5339

(DOI: 10.1002/ange.201108040)

50. Probing small molecule binding to amyloid fibrils.

AK Buell, EK Esbjörner, PJ Riss, DA White, FI Aigbirhio, G Toth, ME Welland, CM Dobson, TPJ Knowles

– Physical Chemistry Chemical Physics

(2011)

13,

20044

(DOI: 10.1039/c1cp22283j)

49. Binding of the Molecular Chaperone alpha B-Crystallin to A beta Amyloid Fibrils Inhibits Fibril Elongation

SL Shammas, CA Waudby, S Wang, AK Buell, TPJ Knowles, H Ecroyd, ME Welland, JA Carver, CM Dobson, S Meehan

– Biophysical journal

(2011)

101,

1681

(DOI: 10.1016/j.bpj.2011.07.056)

48. Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation

AW Fitzpatrick, TPJ Knowles, CA Waudby, M Vendruscolo, CM Dobson

– PLoS computational biology

(2011)

e1002169

(DOI: 10.1371/journal.pcbi.1002169)

47. Observation of spatial propagation of amyloid assembly from single nuclei.

TPJ Knowles, DA White, AR Abate, JJ Agresti, SIA Cohen, RA Sperling, EJ De Genst, CM Dobson, DA Weitz

– Proceedings of the National Academy of Sciences of the United States of America

(2011)

108,

14746

(DOI: 10.1073/pnas.1105555108)

46. Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations

SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles

– The Journal of Chemical Physics

(2011)

135,

065106

(DOI: 10.1063/1.3608917)

45. Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

SIA Cohen, M Vendruscolo, ME Welland, CM Dobson, EM Terentjev, TPJ Knowles

– The Journal of Chemical Physics

(2011)

135,

065105

(DOI: 10.1063/1.3608916)

44. Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations.

SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles

– The Journal of Chemical Physics

(2011)

135,

065107

(DOI: 10.1063/1.3608918)

43. Protein Solubility and Protein Homeostasis: A Generic View of Protein Misfolding Disorders

M Vendruscolo, TPJ Knowles, CM Dobson

– Cold Spring Harbor perspectives in biology

(2011)

a010454

(DOI: 10.1101/cshperspect.a010454)

42. Direct observation of the interconversion of normal and pathogenic forms of alpha-synuclein

N Cremades, SIA Cohen, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, TPJ Knowles, CM Dobson, D Klenerman

– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2011)

40,

215

41. Conserved C-Terminal Charge Exerts a Profound Influence on the Aggregation Rate of alpha-Synuclein

K Levitan, D Chereau, SIA Cohen, TPJ Knowles, CM Dobson, AL Fink, JP Anderson, JM Goldstein, GL Millhauser

– Journal of Molecular Biology

(2011)

411,

329

(DOI: 10.1016/j.jmb.2011.05.046)

40. Perturbation of the stability of amyloid fibrils through alteration of electrostatic interactions.

SL Shammas, TPJ Knowles, AJ Baldwin, CE Macphee, ME Welland, CM Dobson, GL Devlin

– Biophysical Journal

(2011)

100,

2783

(DOI: 10.1016/j.bpj.2011.04.039)

39. Metastability of Native Proteins and the Phenomenon of Amyloid Formation

AJ Baldwin, TPJ Knowles, GG Tartaglia, AW Fitzpatrick, GL Devlin, SL Shammas, CA Waudby, MF Mossuto, S Meehan, SL Gras, J Christodoulou, SJ Anthony-Cahill, PD Barker, M Vendruscolo, CM Dobson

– Journal of the American Chemical Society

(2011)

133,

14160

(DOI: 10.1021/ja2017703)

38. Population of nonnative states of lysozyme variants drives amyloid fibril formation

AK Buell, A Dhulesia, MF Mossuto, N Cremades, JR Kumita, M Dumoulin, ME Welland, TPJ Knowles, X Salvatella, CM Dobson

– Journal of the American Chemical Society

(2011)

133,

7737

(DOI: 10.1021/ja109620d)

37. Relationship between prion propensity and the rates of individual molecular steps of fibril assembly

Y-Q Wang, AK Buell, X-Y Wang, ME Welland, CM Dobson, TPJ Knowles, S Perrett

– The Journal of biological chemistry

(2011)

286,

12101

(DOI: 10.1074/jbc.M110.208934)

36. Nucleated polymerisation in the presence of pre-formed seed filaments

SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles

– International Journal of Molecular Sciences

(2011)

12,

5844

(DOI: 10.3390/ijms12095844)

35. Nanomechanics of functional and pathological amyloid materials.

TPJ Knowles, MJ Buehler

– Nature Nanotechnology

(2011)

469

(DOI: 10.1038/nnano.2011.102)

34. Probing protein aggregation with quartz crystal microbalances

TPJ Knowles, GL Devlin, CM Dobson, ME Welland

– Methods in molecular biology (Clifton, N.J.)

(2011)

752,

137

(DOI: 10.1007/978-1-60327-223-0_9)

33. Interactions between Amyloidophilic Dyes and Their Relevance to Studies of Amyloid Inhibitors

AK Buell, CM Dobson, TPJ Knowles, ME Welland

– Biophysical journal

(2010)

99,

3492

(DOI: 10.1016/j.bpj.2010.08.074)

32. Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering.

A Sandberg, LM Luheshi, S Söllvander, T Pereira de Barros, B Macao, TPJ Knowles, H Biverstål, C Lendel, F Ekholm-Petterson, A Dubnovitsky, L Lannfelt, CM Dobson, T Härd

– Proceedings of the National Academy of Sciences of the United States of America

(2010)

107,

15595

(DOI: 10.1073/pnas.1001740107)

31. Surface attachment of protein fibrils via covalent modification strategies

AK Buell, DA White, C Meier, ME Welland, TPJ Knowles, CM Dobson

– The journal of physical chemistry. B

(2010)

114,

10925

(DOI: 10.1021/jp101579n)

30. Frequency Factors in a Landscape Model of Filamentous Protein Aggregation

AK Buell, JR Blundell, CM Dobson, ME Welland, EM Terentjev, TPJ Knowles

– Physical Review Letters

(2010)

104,

228101

(DOI: 10.1103/physrevlett.104.228101)

29. An algorithm and experimental protocol to obtain the kinetic parameters of fibrillar growth from a first-principles general model of breakable filament assembly

SI Cohen, M Sandal, L Rajah, CM Dobson, M Vendruscolo, TPJ Knowles

– FEBS JOURNAL

(2010)

277,

257

28. Protein aggregation in crowded environments

DA White, AK Buell, TPJ Knowles, ME Welland, CM Dobson

– Journal of the American Chemical Society

(2010)

132,

5170

(DOI: 10.1021/ja909997e)

27. Fabrication and characterisation of protein fibril–elastomer composites

T Oppenheim, TPJ Knowles, SP Lacour, ME Welland

– Acta Biomaterialia

(2010)

1337

(DOI: 10.1016/j.actbio.2009.10.013)

26. The Interaction of alpha B-Crystallin with Mature alpha-Synuclein Amyloid Fibrils Inhibits Their Elongation

CA Waudby, TPJ Knowles, GL Devlin, JN Skepper, H Ecroyd, JA Carver, ME Welland, J Christodoulou, CM Dobson, S Meehan

– Biophysical journal

(2010)

98,

843

(DOI: 10.1016/j.bpj.2009.10.056)

25. Nanostructured films from hierarchical self-assembly of amyloidogenic proteins

TPJ Knowles, TW Oppenheim, AK Buell, DY Chirgadze, ME Welland

– Nature Nanotechnology

(2010)

204

(DOI: 10.1038/NNANO.2010.26)

24. Imaging Alzheimer's disease-related protein aggregates in human cells using a selenium label

EK McGuire, M Motskin, TPJ Knowles, CM Dobson, DW McComb, AE Porter

– ELECTRON MICROSCOPY AND ANALYSIS GROUP CONFERENCE 2009 (EMAG 2009)

(2010)

241,

012020

(DOI: 10.1088/1742-6596/241/1/012020)

23. Methods and models in neurodegenerative and systemic protein aggregation diseases.

A-C Brorsson, JR Kumita, I MacLeod, B Bolognesi, E Speretta, LM Luheshi, TPJ Knowles, CM Dobson, DC Crowther

– Frontiers in bioscience (Landmark edition)

(2010)

15,

373

(DOI: 10.2741/3626)

22. Quantitative approaches for characterising fibrillar protein nanostructures

DA White, CM Dobson, ME Welland, TPJ Knowles

– Materials Research Society Symposium Proceedings

(2010)

1274,

(DOI: 10.1557/proc-1274-qq04-05)

21. An analytical solution to the kinetics of breakable filament assembly

TPJ Knowles, CA Waudby, GL Devlin, SIA Cohen, A Aguzzi, M Vendruscolo, EM Terentjev, ME Welland, CM Dobson

– Science (New York, N.Y.)

(2009)

326,

1533

(DOI: 10.1126/science.1178250)

20. Imaging Amyloid Fibrils within Cells Using a Se-Labelling Strategy

AE Porter, TPJ Knowles, K Muller, S Meehan, E McGuire, J Skepper, ME Welland, CM Dobson

– Journal of Molecular Biology

(2009)

392,

868

(DOI: 10.1016/j.jmb.2009.07.061)

19. Biosensor-based label-free assays of amyloid growth.

DA White, AK Buell, CM Dobson, ME Welland, TPJ Knowles

– FEBS letters

(2009)

583,

2587

(DOI: 10.1016/j.febslet.2009.06.008)

18. Position-Dependent Electrostatic Protection against Protein Aggregation

AK Buell, GG Tartaglia, NR Birkett, CA Waudby, M Vendruscolo, X Salvatella, ME Welland, CM Dobson, TPJ Knowles

– Chembiochem : a European journal of chemical biology

(2009)

10,

1309

(DOI: 10.1002/cbic.200900144)

17. Strength of nanotubes, filaments, and nanowires from sonication-onduced scission

YY Huang, TPJ Knowles, EM Terentjev

– Advanced Materials

(2009)

21,

3945

(DOI: 10.1002/adma.200900498)

16. Chemical and biophysical insights into the propagation of prion strains

J Falsig, KP Nilsson, TPJ Knowles, A Aguzzi

– Frontiers in Life Science

(2008)

332

(DOI: 10.2976/1.2990786)

15. Highly specific label-free protein detection from lysed cells using internally referenced microcantilever sensors.

W Shu, S Laurenson, TPJ Knowles, P Ko Ferrigno, AA Seshia

– Biosensors and Bioelectronics

(2008)

24,

233

(DOI: 10.1016/j.bios.2008.03.036)

14. Label-free detection of amyloid growth with microcantilever sensors.

TPJ Knowles, W Shu, F Huber, HP Lang, C Gerber, CM Dobson, ME Welland

– Nanotechnology

(2008)

19,

384007

(DOI: 10.1088/0957-4484/19/38/384007)

13. Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements.

AJ Baldwin, SJ Anthony-Cahill, TPJ Knowles, G Lippens, J Christodoulou, PD Barker, CM Dobson

– Angewandte Chemie (International ed. in English)

(2008)

120,

3385

(DOI: 10.1002/anie.200703915)

12. Role of intermolecular forces in defining material properties of protein nanofibrils

TP Knowles, AW Fitzpatrick, S Meehan, HR Mott, M Vendruscolo, CM Dobson, ME Welland

– Science (New York, N.Y.)

(2007)

318,

1900

(DOI: 10.1126/science.1150057)

11. Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alpha A-, alpha beta- and R120G alpha B-Crystallins

S Meehan, TPJ Knowles, AJ Baldwin, JF Smith, AM Squires, P Clements, TM Treweek, H Ecroyd, GG Tartaglia, M Vendruscolo, CE Macphee, CM Dobson, JA Carver

– Journal of Molecular Biology

(2007)

372,

470

(DOI: 10.1016/j.jmb.2007.06.060)

10. Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass

TPJ Knowles, W Shu, GL Devlin, S Meehan, S Auer, CM Dobson, ME Welland

– Proceedings of the National Academy of Sciences of the United States of America

(2007)

104,

10016

(DOI: 10.1073/pnas.0610659104)

9. Analysis of structural order in amyloid fibrils

TPJ Knowles, JF Smith, GL Devlin, CM Dobson, ME Welland

– Nanotechnology

(2007)

18,

044031

(DOI: 10.1088/0957-4484/18/4/044031)

8. Enhanced Stability of Human Prion Proteins with Two Disulfide Bridges

TPJ Knowles, R Zahn

– Biophysical Journal

(2006)

91,

1494

(DOI: 10.1529/biophysj.106.081653)

7. The Component Polypeptide Chains of Bovine Insulin Nucleate or Inhibit Aggregation of the Parent Protein in a Conformation-dependent Manner

GL Devlin, TPJ Knowles, A Squires, MG McCammon, SL Gras, MR Nilsson, CV Robinson, CM Dobson, CE MacPhee

– Journal of molecular biology

(2006)

360,

497

(DOI: 10.1016/j.jmb.2006.05.007)

6. Characterization of the nanoscale properties of individual amyloid fibrils.

JF Smith, TPJ Knowles, CM Dobson, CE Macphee, ME Welland

– Proceedings of the National Academy of Sciences of the United States of America

(2006)

103,

15806

(DOI: 10.1073/pnas.0604035103)

5. Spatial Persistence of Angular Correlations in Amyloid Fibrils

TPJ Knowles, JF Smith, A Craig, CM Dobson, ME Welland

– Physical Review Letters

(2006)

96,

238301

(DOI: 10.1103/PhysRevLett.96.238301)

4. Excitations with negative dispersion in a spin vortex

M Buess, TPJ Knowles, R Hollinger, T Haug, U Krey, D Weiss, D Pescia, MR Scheinfein, CH Back

– Physical Review B - Condensed Matter and Materials Physics

(2005)

71,

104415

(DOI: 10.1103/physrevb.71.104415)

3. Phase-resolved pulsed precessional motion at a Schottky barrier

M Buess, TPJ Knowles, U Ramsperger, D Pescia, CH Back

– Physical Review B - Condensed Matter and Materials Physics

(2004)

69,

174422

(DOI: 10.1103/PhysRevB.69.174422)

2. Clathrin-Inspired Coating and Stabilization of Liposomes by DNA Self-Assembly

KN Baumann, L Piantanida, J García-Nafría, D Sobota, K Voïtchovsky, TPJ Knowles, S HERNANDEZ AINSA

– None

(None)

(DOI: 10.26434/chemrxiv.8859017)

1. Infrared Nanospectroscopy Reveals the Molecular Interaction Fingerprint of an Aggregation Inhibitor with Single Ab42 Oligomers

F Ruggeri, J Habchi, SKR Chia, R Horne, M Vendruscolo, T Knowles

– Nature Communications

(None)

Study at Cambridge

About the University

Research at Cambridge