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Knowles Lab

Biophysics & Biophysical Chemistry

Studying at Cambridge

 

Publications

naturecommunications
260. Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nat Commun
(2019)
10,
225
259. Physical Determinants of Amyloid Assembly in Biofilm Formation
M Andreasen, G Meisl, JD Taylor, TCT Michaels, A Levin, DE Otzen, MR Chapman, CM Dobson, SJ Matthews, TPJ Knowles
– mBio
(2019)
10,
258. Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism.
C Bortolini, T Kartanas, D Copic, I Condado Morales, Y Zhang, PK Challa, Q Peter, T Jávorfi, R Hussain, M Dong, G Siligardi, TPJ Knowles, J Charmet
– Lab Chip
(2018)
19,
50
257. Mechanobiology of Protein Droplets: Force Arises from Disorder.
TJ Welsh, Y Shen, A Levin, TPJ Knowles
– Cell
(2018)
175,
1457
acsnano
256. Quantifying Co-Oligomer Formation by Alpha-Synuclein
M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, TCT Michaels, D Frenkel, CM Dobson, TPJ Knowles, D Klenerman
– ACS Nano
(2018)
12,
10855
255. Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform.
M Perni, S Casford, FA Aprile, EA Nollen, TPJ Knowles, M Vendruscolo, CM Dobson
– Journal of visualized experiments : JoVE
(2018)
2018,
254. Statistical Mechanics of Globular Oligomer Formation by Protein Molecules
AJ Dear, A Šarić, TCT Michaels, CM Dobson, TPJ Knowles
– Journal of Physical Chemistry B
(2018)
122,
11721
jacs
253. Direct Observation of Murine Prion Protein Replication in Vitro.
JC Sang, G Meisl, AM Thackray, L Hong, A Ponjavic, TPJ Knowles, R Bujdoso, D Klenerman
– Journal of the American Chemical Society
(2018)
140,
14789
252. Observation of molecular self-assembly events in massively parallel microdroplet arrays
Z Toprakcioglu, PK Challa, A Levin, TPJ Knowles
– Lab Chip
(2018)
18,
3303
251. SAR by kinetics for drug discovery in protein misfolding diseases
S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proceedings of the National Academy of Sciences
(2018)
115,
10245
naturecommunications
250. Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity
FS Ruggeri, J Charmet, T Kartanas, Q Peter, S Chia, J Habchi, CM Dobson, M Vendruscolo, TPJ Knowles
– Nature Communications
(2018)
9,
3890
249. Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes
Z Li, J Tuffin, IM Lei, FS Ruggeri, NS Lewis, EL Gill, T Savin, L Huleihel, SF Badylak, T Knowles, SC Satchell, GI Welsh, MA Saleem, YYS Huang
– Acta biomaterialia
(2018)
78,
111
248. Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution.
CG Taylor, G Meisl, MH Horrocks, H Zetterberg, TPJ Knowles, D Klenerman
– Analytical chemistry
(2018)
90,
10385
247. Identification of oxidative stress in red blood cells with nanoscale chemical resolution by infrared nanospectroscopy
FS Ruggeri, C Marcott, S Dinarelli, G Longo, M Girasole, G Dietler, TPJ Knowles
– Int J Mol Sci
(2018)
19,
2582
246. Image-Assisted Microvessel-on-a-Chip Platform for Studying Cancer Cell Transendothelial Migration Dynamics.
C Bertulli, M Gerigk, N Piano, Y Liu, D Zhang, T Müller, TJ Knowles, YYS Huang
– Sci Rep
(2018)
8,
12480
245. DNA-Coated Functional Oil Droplets.
A Caciagli, M Zupkauskas, A Levin, TPJ Knowles, C Mugemana, N Bruns, T O'Neill, WJ Frith, E Eiser
– Langmuir
(2018)
34,
10073
244. Combining Affinity Selection and Specific Ion Mobility for Microchip Protein Sensing.
WE Arter, J Charmet, J Kong, KL Saar, TW Herling, T Müller, UF Keyser, TPJ Knowles
– Anal Chem
(2018)
90,
10302
243. Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions
B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, CM Dobson, M Vendruscolo
– ACS chemical neuroscience
(2018)
9,
2959
242. Self-Assembly-Mediated Release of Peptide Nanoparticles through Jets Across Microdroplet Interfaces
A Levin, TCT Michaels, TO Mason, T Müller, L Adler-Abramovich, L Mahadevan, ME Cates, E Gazit, TPJ Knowles
– ACS Applied Materials & Interfaces
(2018)
10,
27578
241. Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, N Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles
– Journal of neuroscience methods
(2018)
306,
57
240. Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation.
C Månsson, RTP van Cruchten, U Weininger, X Yang, R Cukalevski, P Arosio, CM Dobson, T Knowles, M Akke, S Linse, C Emanuelsson
– Biochemistry
(2018)
57,
4891
239. Origin of metastable oligomers and their effects on amyloid fibril self-assembly.
F Hasecke, T Miti, C Perez, J Barton, D Schölzel, L Gremer, CSR Grüning, G Matthews, G Meisl, TPJ Knowles, D Willbold, P Neudecker, H Heise, G Ullah, W Hoyer, M Muschol
– Chemical Science
(2018)
9,
5937
238. Oligomer diversity during the aggregation of the repeat-region of tau
M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman
– ACS Chemical Neuroscience
(2018)
9,
3060
237. Secondary nucleation in amyloid formation
M Törnquist, TCT Michaels, K Sanagavarapu, X Yang, G Meisl, SIA Cohen, TPJ Knowles, S Linse
– Chem Commun (Camb)
(2018)
54,
8667
236. Kinetic barriers to alpha-synuclein protofilament formation and conversion into mature fibrils
JWP Brown, G Meisl, TPJ Knowles, AK Buell, CM Dobson, C Galvagnion
– Chem Commun (Camb)
(2018)
54,
7854
235. Determination of Polypeptide Conformation with Nanoscale Resolution in Water
G Ramer, FS Ruggeri, A Levin, TPJ Knowles, A Centrone
– ACS nano
(2018)
12,
6612
234. Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, GT Heller, G Meisl, SW Chen, JR Kumita, PK Challa, JB Kirkegaard, SIA Cohen, B Mannini, D Barbut, EAA Nollen, C Cecchi, N Cremades, TPJ Knowles, F Chiti, M Zasloff, M Vendruscolo, CM Dobson
– ACS Chemical Biology
(2018)
13,
2308
233. Enhancing the Resolution of Micro Free Flow Electrophoresis through Spatially Controlled Sample Injection.
KL Saar, T Müller, J Charmet, PK Challa, TPJ Knowles
– Analytical chemistry
(2018)
90,
8998
232. Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.
FS Ruggeri, F Benedetti, TPJ Knowles, HA Lashuel, S Sekatskii, G Dietler
– Proceedings of the National Academy of Sciences
(2018)
115,
7230
pnas
231. On the role of sidechain size and charge in the aggregation of A
X Yang, G Meisl, B Frohm, E Thulin, TPJ Knowles, S Linse
– Proceedings of the National Academy of Sciences of the United States of America
(2018)
115,
E5849
naturecommunications
230. Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils
Y Song, TCT Michaels, Q Ma, Z Liu, H Yuan, S Takayama, TPJ Knowles, HC Shum
– Nature Communications
(2018)
9,
2110
229. Cooperative Assembly of Hsp70 Subdomain Clusters.
MA Wright, FA Aprile, MMJ Bellaiche, TCT Michaels, T Müller, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Biochemistry
(2018)
57,
3641
228. Reaction rate theory for supramolecular kinetics: application to protein aggregation
TCT Michaels, LX Liu, S Curk, PG Bolhuis, A Šarić, TPJ Knowles
– Molecular Physics
(2018)
116,
3055
227. Rapid Growth of Acetylated Aβ(16-20) into Macroscopic Crystals
C Bortolini, LH Klausen, SV Hoffmann, NC Jones, D Saadeh, Z Wang, TPJ Knowles, M Dong
– ACS nano
(2018)
12,
5408
226. Stochastic calculus of protein filament formation under spatial confinement
TCT Michaels, AJ Dear, TPJ Knowles
– NEW JOURNAL OF PHYSICS
(2018)
20,
ARTN 055007
naturechemistry
225. Cholesterol catalyses A beta 42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, FS Ruggeri, M Sanguanini, I Idini, JR Kumita, E Sparr, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Nature Chemistry
(2018)
10,
673
224. On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.
Y Zhang, EV Yates, L Hong, KL Saar, G Meisl, CM Dobson, TPJ Knowles
– Chemical Science
(2018)
9,
3503
223. Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion.
S Sieste, T Mack, CV Synatschke, C Schilling, C Meyer Zu Reckendorf, L Pendi, S Harvey, FS Ruggeri, TPJ Knowles, C Meier, DYW Ng, T Weil, B Knöll
– Advanced healthcare materials
(2018)
7,
1701485
222. Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading
F Kundel, L Hong, B Falcon, WA McEwan, TCT Michaels, G Meisl, N Esteras, AY Abramov, TJP Knowles, M Goedert, D Klenerman
– ACS chemical neuroscience
(2018)
9,
1276
221. Microfluidic approaches for probing amyloid assembly and behaviour.
TW Herling, A Levin, KL Saar, CM Dobson, TPJ Knowles
– Lab on a Chip - Miniaturisation for Chemistry and Biology
(2018)
18,
999
naturechemistry
220. Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-beta peptide
SIA Cohen, R Cukalevski, TCT Michaels, A Šarić, M Törnquist, M Vendruscolo, CM Dobson, AK Buell, TPJ Knowles, S Linse
– Nature Chemistry
(2018)
10,
523
219. Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices
PK Challa, Q Peter, MA Wright, Y Zhang, KL Saar, JA Carozza, JLP Benesch, TPJ Knowles
– Anal Chem
(2018)
90,
3849
218. Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.
TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, CM Dobson, TPJ Knowles
– Annu Rev Phys Chem
(2018)
69,
273
217. Revealing the Mechanism of Amyloid Fibril Formation by Combined Single Molecule FRET and Kinetic Modeling
J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Perretti, S Wu
– BIOPHYSICAL JOURNAL
(2018)
114,
685A
216. Probing the Interaction of ABETA42 Amyloid Species with an Aggregation Suppressor Molecule by Infrared Nanospectroscopy
FS Ruggeri, J Habchi, S Chia, M Vendruscolo, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2018)
114,
224A
215. Molecular Mechanism of AB(42) Peptide-Fibril Adsorption
MMJ Bellaiche, TPJ Knowles, RB Best
– BIOPHYSICAL JOURNAL
(2018)
114,
208A
214. Modulating Amyloid-Beta Aggregation to Reduce the Toxicity of its Oligomeric Aggregates
R Limbocker, B Mannini, S Chia, FS Ruggeri, M Perni, R Cascella, C Xu, J Habchi, JR Kumita, F Chiti, TPJ Knowles, M Vendruscolo, CM Dobson
– BIOPHYSICAL JOURNAL
(2018)
114,
430A
213. Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Amyloid-Beta42 Aggregation in Alzheimer's Disease
S Chia, J Habchi, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– BIOPHYSICAL JOURNAL
(2018)
114,
225A
212. 2-Photon Lithography for Nanofluidic Lab-on-Chip Devices
O Vanderpoorten, PK Challa, Q Peter, J Charmet, N Curry, TPJ Knowles, CF Kaminski
– BIOPHYSICAL JOURNAL
(2018)
114,
689A
211. Biophotonics of Native Silk Fibrils.
U Shimanovich, D Pinotsi, K Shimanovich, N Yu, S Bolisetty, J Adamcik, R Mezzenga, J Charmet, F Vollrath, E Gazit, CM Dobson, GK Schierle, C Holland, CF Kaminski, TPJ Knowles
– Macromolecular bioscience
(2018)
18,
e1700295
210. Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2
J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Wu, S Perrett
– J Am Chem Soc
(2018)
140,
2493
209. Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions.
H Gang, C Galvagnion, G Meisl, T Müller, M Pfammatter, AK Buell, A Levin, CM Dobson, B Mu, TPJ Knowles
– Anal Chem
(2018)
90,
3284
208. Enhancing power density of biophotovoltaics by decoupling storage and power delivery
KL Saar, P Bombelli, DJ Lea-Smith, T Call, EM Aro, T Müller, CJ Howe, TPJ Knowles
– Nature Energy
(2018)
3,
75
207. FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions
S Qamar, G Wang, SJ Randle, FS Ruggeri, JA Varela, JQ Lin, EC Phillips, A Miyashita, D Williams, F Ströhl, W Meadows, R Ferry, VJ Dardov, GG Tartaglia, LA Farrer, GS Kaminski Schierle, CF Kaminski, CE Holt, PE Fraser, G Schmitt-Ulms, D Klenerman, T Knowles, M Vendruscolo, P St George-Hyslop
– Cell
(2018)
173,
720
206. Kinetic Analysis of Amyloid Formation.
G Meisl, TCT Michaels, S Linse, TPJ Knowles
– Methods in molecular biology (Clifton, N.J.)
(2018)
1779,
181
205. C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH.
IM van der Wateren, TPJ Knowles, AK Buell, CM Dobson, C Galvagnion
– Chem Sci
(2018)
9,
5506
204. Microfluidics for Protein Biophysics
J Charmet, P Arosio, TPJ Knowles
– Journal of molecular biology
(2018)
430,
565
203. Mechanism of biosurfactant adsorption to oil/water interfaces from millisecond scale tensiometry measurements
L Kong, KL Saar, R Jacquat, L Hong, A Levin, H Gang, R Ye, B Mu, TPJ Knowles
– Interface focus
(2017)
7,
20170013
202. Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit.
TO Mason, TCT Michaels, A Levin, CM Dobson, E Gazit, TPJ Knowles, AK Buell
– J Am Chem Soc
(2017)
139,
16134
201. Nanoscale click-reactive scaffolds from peptide self-assembly
APM Guttenplan, LJ Young, D Matak-Vinkovic, CF Kaminski, TPJ Knowles, LS Itzhaki
– Journal of Nanobiotechnology
(2017)
15,
70
200. Enhanced Quality Factor Label-free Biosensing with Micro-Cantilevers Integrated into Microfluidic Systems.
T Kartanas, V Ostanin, PK Challa, R Daly, J Charmet, TPJ Knowles
– Analytical chemistry
(2017)
89,
11929
199. Absolute Quantification of Amyloid Propagons by Digital Microfluidics.
M Pfammatter, M Andreasen, G Meisl, CG Taylor, J Adamcik, S Bolisetty, A Sánchez-Ferrer, D Klenerman, CM Dobson, R Mezzenga, TPJ Knowles, A Aguzzi, S Hornemann
– Analytical Chemistry
(2017)
89,
12306
198. Hierarchical Biomolecular Emulsions Using 3-D Microfluidics with Uniform Surface Chemistry.
Z Toprakcioglu, A Levin, TPJ Knowles
– Biomacromolecules
(2017)
18,
3642
197. Kinetic constraints on self-assembly into closed supramolecular structures
TCT Michaels, MMJ Bellaiche, MF Hagan, TPJ Knowles
– Scientific Reports
(2017)
7,
12295
196. Gradient-free determination of isoelectric points of proteins on chip.
U Łapińska, KL Saar, EV Yates, TW Herling, T Müller, PK Challa, CM Dobson, TPJ Knowles
– Physical Chemistry Chemical Physics
(2017)
19,
23060
195. Sequential Release of Proteins from Structured Multishell Microcapsules
U Shimanovich, TCT Michaels, E De Genst, D Matak-Vinkovic, CM Dobson, TPJ Knowles
– Biomacromolecules
(2017)
18,
3052
194. Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates
S Chia, P Flagmeier, J Habchi, V Lattanzi, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proceedings of the National Academy of Sciences
(2017)
114,
8005
naturecommunications
193. Silk micrococoons for protein stabilisation and molecular encapsulation
U Shimanovich, FS Ruggeri, E De Genst, J Adamcik, TP Barros, D Porter, T Müller, R Mezzenga, CM Dobson, F Vollrath, C Holland, TPJ Knowles
– Nature Communications
(2017)
8,
15902
192. Nanobodies raised against monomeric alpha-synuclein inhibit fibril formation and destabilize toxic oligomeric species
M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, FS Ruggeri, T Guilliams, AK Buell, J-E Lee, S Gandhi, SF Lee, CE Bryant, M Vendruscolo, TPJ Knowles, CM Dobson, E De Genst, D Klenerman
– BMC Biol
(2017)
15,
57
191. Self-assembled Protein Fibril-metal Oxide Nanocomposites
A Levin, TO Mason, TPJ Knowles, U Shimanovich
– Israel Journal of Chemistry
(2017)
57,
724
190. A microfluidic platform for quantitative protein studies
TW Herling, P Arosio, T Mueller, DJ O'Connell, MC Bauer, J Persson, U Weininger, S Linse, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S345
189. Ultrasensitive measurement of Ca2+ influx into lipid vesicles induced by protein aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TP Knowles, S Gandhi, CM Dobson, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S237
188. Measuring the prion-like character of tau by TIRF microscopy
F Kundel, B Falcon, L Hong, N Esteras, AJ Dear, AY Abramov, TPJ Knowles, M Goedert, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S240
187. Single amyloid aggregates chemical and structural analysis by infrared nanospectroscopy
FS Ruggeri, J Habchi, C Sean, M Vendruscolo, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S370
186. Mechanisms of Amyloid-beta 42 oligomer formation from kinetic analysis
TC Michaels, A Saric, HW Lazell, P Arosio, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S240
185. Evidence for self-replication of Alzheimer-associated A beta 42 amyloid along the sides of fibrils
M Tornquist, R Cukalevski, U Weininger, G Meisl, TPJ Knowles, T Leiding, M Akke, S Linse
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S242
184. Selective targeting of primary and secondary nucleation pathways in A beta 42 aggregation using a rational antibody scanning method
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo
– Sci Adv
(2017)
3,
e1700488
pnas
183. Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication.
A Munke, J Persson, T Weiffert, E De Genst, G Meisl, P Arosio, A Carnerup, CM Dobson, M Vendruscolo, TPJ Knowles, S Linse
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
6444
182. Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers
P Varilly, AP Willard, JB Kirkegaard, TPJ Knowles, D Chandler
– The Journal of chemical physics
(2017)
146,
135102
181. A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity (vol 114, pg E1009, 2017)
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Mueller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limboker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proceedings of the National Academy of Sciences
(2017)
114,
E2543
180. Exciton Coupling of Phenylalanine Reveals Conformational Changes of Cationic Peptides
C Bortolini, L Liu, SV Hoffmann, NC Jones, TPJ Knowles, M Dong
– ChemistrySelect
(2017)
2,
2476
179. Acceleration of α-synuclein aggregation.
R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, E Sparr, S Linse
– Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
(2017)
24,
20
178. Inhibition of alpha-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between alpha-Synuclein Species
FA Aprile, P Arosio, G Fusco, SW Chen, JR Kumita, A Dhulesia, P Tortora, TPJ Knowles, M Vendruscolo, CM Dobson, N Cremades
– Biochemistry
(2017)
56,
1177
177. Physical principles of filamentous protein self-assembly kinetics
TCT Michaels, LX Liu, G Meisl, TPJ Knowles
– Journal of Physics: Condensed Matter
(2017)
29,
153002
pnas
176. A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, JB Kirkegaard, P Flagmeier, SIA Cohen, R Cascella, SW Chen, R Limbocker, P Sormanni, GT Heller, FA Aprile, N Cremades, C Cecchi, F Chiti, EAA Nollen, TPJ Knowles, M Vendruscolo, A Bax, M Zasloff, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E1009
175. Attenuating the Toxicity of Amyloid-Beta Aggregation with Specific Species
R Limbocker, B Mannini, M Perni, S Chia, G Heller, FS Ruggeri, J Habchi, G Meisl, PK Challa, M Zasloff, TPJ Knowles, M Vendruscolo, CM Dobson
– Biophysical Journal
(2017)
112,
494A
174. Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the A beta 42 peptide and its variants
G Meisl, X Yang, CM Dobson, S Linse, TPJ Knowles
– Chem Sci
(2017)
8,
4352
173. Scaling behaviour and rate-determining steps in filamentous self-assembly.
G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– Chemical Science
(2017)
8,
7087
172. Microfluidic devices fabricated using fast wafer-scale LED-lithography patterning.
PK Challa, T Kartanas, J Charmet, TPJ Knowles
– Biomicrofluidics
(2017)
11,
014113
171. On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products
KL Saar, Y Zhang, T Müller, CP Kumar, S Devenish, A Lynn, U Łapińska, X Yang, S Linse, TPJ Knowles
– Lab on a chip
(2017)
18,
162
170. Secondary nucleation of monomers on fibril surface dominates $\alpha$-synuclein aggregation and provides autocatalytic amyloid amplification
R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, E Sparr, S Linse
– Q Rev Biophys
(2017)
50,
e6
169. Micro- and nanoscale hierarchical structure of core–shell protein microgels
T Müller, TO Mason, TCT Michaels, R Mezzenga, G Dietler, TPJ Knowles
– Journal of Materials Chemistry B
(2016)
4,
7989
168. Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation.
A Šarić, TCT Michaels, A Zaccone, TPJ Knowles, D Frenkel
– Journal of Chemical Physics
(2016)
145,
211926
167. Dynamics of heteromolecular filament formation.
AJ Dear, TCT Michaels, TPJ Knowles
– Journal of Chemical Physics
(2016)
145,
175101
166. β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces
JWP Brown, AK Buell, TCT Michaels, G Meisl, J Carozza, P Flagmeier, M Vendruscolo, TPJ Knowles, CM Dobson, C Galvagnion
– Scientific reports
(2016)
6,
36010
naturecommunications
165. Dynamic microfluidic control of supramolecular peptide self-assembly
ZA Arnon, A Vitalis, A Levin, TCT Michaels, A Caflisch, TPJ Knowles, L Adler-Abramovich, E Gazit
– Nature Communications
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7,
13190
naturecommunications
164. Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces.
Y Song, U Shimanovich, TCT Michaels, Q Ma, J Li, TPJ Knowles, HC Shum
– Nature Communications
(2016)
7,
12934
163. Kinetics of fragmentation and dissociation of two-strand protein filaments: Coarse-grained simulations and experiments.
A Zaccone, I Terentjev, TW Herling, TPJ Knowles, A Aleksandrova, EM Terentjev
– J Chem Phys
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145,
105101
nphys logo
162. Physical determinants of the self-replication of protein fibrils
A Šaric, AK Buell, G Meisl, TCT Michaels, CM Dobson, S Linse, TPJ Knowles, D Frenkel
– Nature Physics
(2016)
12,
874
161. Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.
P Flagmeier, G Meisl, M Vendruscolo, TPJ Knowles, CM Dobson, AK Buell, C Galvagnion
– Proceedings of the National Academy of Sciences
(2016)
113,
10328
160. Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation
Y Zhang, AK Buell, T Müller, E De Genst, J Benesch, CM Dobson, TPJ Knowles
– ChemBioChem
(2016)
17,
1920
jacs
159. Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform
TO Mason, TCT Michaels, A Levin, E Gazit, CM Dobson, AK Buell, TPJ Knowles
– Journal of the American Chemical Society
(2016)
138,
9589
158. Controlling the Physical Dimensions of Peptide Nanotubes by Supramolecular Polymer Coassembly.
L Adler-Abramovich, P Marco, ZA Arnon, RCG Creasey, TCT Michaels, A Levin, DJ Scurr, CJ Roberts, TPJ Knowles, SJB Tendler, E Gazit
– ACS nano
(2016)
10,
7436
nphys logo
157. Elastic instability-mediated actuation by a supra-molecular polymer
B Zhang, L Mahadevan, E Gazit, TPJ Knowles
– Nature Physics
(2016)
12,
926
156. Quantifying Measurement Fluctuations from Stochastic Surface Processes on Sensors with Heterogeneous Sensitivity
J Charmet, TCT Michaels, R Daly, A Prasad, P Thiruvenkathanathan, RS Langley, TPJ Knowles, AA Seshia
– Physical Review Applied
(2016)
5,
ARTN 064016
155. Fluctuations in the Kinetics of Linear Protein Self-Assembly.
TCT Michaels, AJ Dear, JB Kirkegaard, KL Saar, DA Weitz, TPJ Knowles
– Physical Review Letters
(2016)
116,
258103
154. Particle-Based Monte-Carlo Simulations of Steady-State Mass Transport at Intermediate Peclet Numbers
T Müller, P Arosio, L Rajah, SIA Cohen, EV Yates, M Vendruscolo, CM Dobson, TPJ Knowles
– International Journal of Nonlinear Sciences and Numerical Simulation
(2016)
17,
175
AdvMater
153. Amyloid Fibrils as Building Blocks for Natural and Artificial Functional Materials.
TPJ Knowles, R Mezzenga
– Advanced Materials
(2016)
28,
6546
152. A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions.
TW Herling, DJ O'Connell, MC Bauer, J Persson, U Weininger, TPJ Knowles, S Linse
– Biophysical journal
(2016)
110,
1957
151. The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model
V Kakkar, C Månsson, EP de Mattos, S Bergink, M van der Zwaag, MAWH van Waarde, NJ Kloosterhuis, R Melki, RTP van Cruchten, S Al-Karadaghi, P Arosio, CM Dobson, TPJ Knowles, GP Bates, JM van Deursen, S Linse, B van de Sluis, C Emanuelsson, HH Kampinga
– Mol Cell
(2016)
62,
272
150. Analysis of the length distribution of amyloid fibrils by centrifugal sedimentation
P Arosio, T Cedervall, TPJ Knowles, S Linse
– Analytical biochemistry
(2016)
504,
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149. An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation
EV Yates, G Meisl, TPJ Knowles, CM Dobson
– The journal of physical chemistry. B
(2016)
120,
2087
148. Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.
P Arosio, K Hu, FA Aprile, T Müller, TPJ Knowles
– Anal Chem
(2016)
88,
3488
147. A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.
P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo
– ACS Combinatorial Science
(2016)
18,
144
physreviewletters
146. Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation.
E van Dijk, P Varilly, TPJ Knowles, D Frenkel, S Abeln
– Phys Rev Lett
(2016)
116,
078101
145. Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.
M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, AY Abramov, S Gandhi, NW Wood, N Cremades, CM Dobson, TPJ Knowles, D Klenerman
– Proc Natl Acad Sci U S A
(2016)
113,
E1206
144. Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform.
K-L Saar, EV Yates, T Müller, S Saunier, CM Dobson, TPJ Knowles
– Biophysical journal
(2016)
110,
555
143. Neuroscience: An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Ab42 aggregates linked with Alzheimer's disease
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, SIA Cohen, MBD Müller, S Linse, EAA Nollen, CM Dobson, TPJ Knowles, M Vendruscolo
– Science advances
(2016)
2,
e1501244
142. Oligomers of Heat-Shock Proteins: Structures That Don't Imply Function
WM Jacobs, TPJ Knowles, D Frenkel
– PLoS computational biology
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12,
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natureprotocols
141. Molecular mechanisms of protein aggregation from global fitting of kinetic models
G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles
– Nature protocols
(2016)
11,
252
physreviewletters
140. Hamiltonian Dynamics of Protein Filament Formation.
TCT Michaels, SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– Phys Rev Lett
(2016)
116,
038101
139. Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms
M Iljina, GA Garcia, AJ Dear, J Flint, P Narayan, TCT Michaels, CM Dobson, D Frenkel, TPJ Knowles, D Klenerman
– Sci Rep
(2016)
6,
28658
138. Self-assembly of MPG1, a hydrophobin protein from the rice blast fungus that forms functional amyloid coatings, occurs by a surface-driven mechanism.
CLL Pham, A Rey, V Lo, M Soulès, Q Ren, G Meisl, TPJ Knowles, AH Kwan, M Sunde
– Scientific reports
(2016)
6,
25288
137. Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones
JD Taylor, WJ Hawthorne, J Lo, A Dear, N Jain, G Meisl, M Andreasen, C Fletcher, M Koch, N Darvill, N Scull, A Escalera-Maurer, L Sefer, R Wenman, S Lambert, J Jean, Y Xu, B Turner, SG Kazarian, MR Chapman, D Bubeck, A de Simone, TPJ Knowles, SJ Matthews
– Scientific Reports
(2016)
6,
24656
naturecommunications
136. Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation.
P Arosio, TCT Michaels, S Linse, C Månsson, C Emanuelsson, J Presto, J Johansson, M Vendruscolo, CM Dobson, TPJ Knowles
– Nature Communications
(2016)
7,
10948
135. Quantitative thermophoretic study of disease-related protein aggregates
M Wolff, JJ Mittag, TW Herling, ED Genst, CM Dobson, TPJ Knowles, D Braun, AK Buell
– Scientific reports
(2016)
6,
22829
134. Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide
G Meisl, X Yang, B Frohm, TPJ Knowles, S Linse
– Scientific reports
(2016)
6,
18728
133. Scaling and dimensionality in the chemical kinetics of protein filament formation
TCT Michaels, AJ Dear, TPJ Knowles
– International Reviews in Physical Chemistry
(2016)
35,
679
132. Microfluidic devices fabricated using soft lithography for the study of protein structures using synchrotron radiation circular dichroism
J Charmet, C Bortolini, D Copic, IC Morales, Y Zhang, PK Challa, T Jávorfi, R Hussain, G Siligardi, TPJ Knowles
– 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
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1079
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131. Microfluidic diffusion analysis of the sizes and interactions of proteins under native solution conditions
P Arosio, T Müller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, DA White, TW Herling, EJ De Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– ACS Nano
(2016)
10,
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130. N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42
O Szczepankiewicz, B Linse, G Meisl, E Thulin, B Frohm, C Sala Frigerio, MT Colvin, AC Jacavone, RG Griffin, T Knowles, DM Walsh, S Linse
– J Am Chem Soc
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137,
14673
129. The length distribution of frangible biofilaments
TCT Michaels, P Yde, JCW Willis, MH Jensen, D Otzen, CM Dobson, AK Buell, TPJ Knowles
– The Journal of Chemical Physics
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143,
164901
128. Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity.
EV Yates, T Müller, L Rajah, EJ De Genst, P Arosio, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– Nature chemistry
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7,
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127. Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates.
MA Wright, FA Aprile, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Chemical communications (Cambridge, England)
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51,
14425
126. Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers.
MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, M Dalla Serra, TPJ Knowles, CM Dobson, D Klenerman
– Anal Chem
(2015)
87,
8818
125. Dynamics of protein aggregation and oligomer formation governed by secondary nucleation.
TCT Michaels, HW Lazell, P Arosio, TPJ Knowles
– Journal of Chemical Physics
(2015)
143,
054901
124. Force generation by the growth of amyloid aggregates.
TW Herling, GA Garcia, TCT Michaels, W Grentz, J Dean, U Shimanovich, H Gang, T Müller, B Kav, EM Terentjev, CM Dobson, TPJ Knowles
– Proceedings of the National Academy of Sciences
(2015)
112,
9524
123. Molecular Rotors Provide Insights into Microscopic Structural Changes During Protein Aggregation
AJ Thompson, TW Herling, M Kubánková, A Vyšniauskas, TPJ Knowles, MK Kuimova
– The journal of physical chemistry. B
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119,
10170
122. New insights into the mechanism of amyloid formation by alpha-synuclein
AK Buell, C Galvagnion, CM Dobson, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
S100
121. Kinetics of protein aggregation
TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
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120. Crucial role of non-specific interactions in amyloid nucleation
A Saric, YC Chebaro, TPJ Knowles, D Frenkel
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
S161
119. Lipid vesicles trigger alpha-synuclein aggregation by stimulating primary nucleation
C Galvagnion, AK Buell, G Meisl, TC Michaels, M Vendruscolo, TPJ Knowles, CM Dobson
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
S101
118. Rapid sizing of proteins in complex solutions
P Arosio, T Muller, L Rajah, EV Yates, FA Aprile, SIA Cohen, DA White, TW Herling, E de Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44,
S49
117. Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry.
X-M Zhou, U Shimanovich, TW Herling, S Wu, CM Dobson, TPJ Knowles, S Perrett
– ACS nano
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9,
5772
116. Aggregation-Prone Amyloid-β⋅Cu(II) Species Formed on the Millisecond Timescale under Mildly Acidic Conditions.
JT Pedersen, CB Borg, TCT Michaels, TPJ Knowles, P Faller, K Teilum, L Hemmingsen
– ChemBioChem
(2015)
16,
1293
115. Preventing peptide and protein misbehavior
P Arosio, G Meisl, M Andreasen, TPJ Knowles
– Proc Natl Acad Sci U S A
(2015)
112,
5267
114. A microfluidic platform for quantitative measurements of effective protein charges and single ion binding in solution
TW Herling, P Arosio, T Müller, S Linse, TPJ Knowles
– Physical chemistry chemical physics : PCCP
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17,
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113. Structural characterization of toxic oligomers that are kinetically trapped during alpha-synuclein fibril formation
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, EJ De-Genst, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
– Proceedings of the National Academy of Sciences
(2015)
112,
E1994
112. A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers.
M Vendruscolo, J Johansson, CM Dobson, A Fisahn, TPJ Knowles, S Linse
– Nature structural & molecular biology
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22,
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111. The physical basis of protein misfolding disorders
TPJ Knowles, M Vendruscolo, CM Dobson
– Physics Today
(2015)
68,
36
110. On the lag phase in amyloid fibril formation.
P Arosio, TPJ Knowles, S Linse
– Physical chemistry chemical physics : PCCP
(2015)
17,
7606
109. Kinetic theory of protein filament growth: Self-consistent methods and perturbative techniques
TCT Michaels, TPJ Knowles
– International Journal of Modern Physics B
(2015)
29,
1530002
108. Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity
J Dworzak, B Renvoisé, J Habchi, EV Yates, C Combadière, TP Knowles, CM Dobson, C Blackstone, O Paulsen, PM Murphy
– PLoS ONE
(2015)
10,
e0127730
107. The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation.
R Cukalevski, X Yang, G Meisl, U Weininger, K Bernfur, B Frohm, TPJ Knowles, S Linse
– Chemical Science
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6,
4215
naturecommunications
106. A mechanistic model of tau amyloid aggregation based on direct observation of oligomers.
SL Shammas, GA Garcia, S Kumar, M Kjaergaard, MH Horrocks, N Shivji, E Mandelkow, TPJ Knowles, E Mandelkow, D Klenerman
– Nat Commun
(2015)
6,
7025
105. Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants.
L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, N Cremades, CM Dobson, D Klenerman
– Scientific reports
(2015)
5,
16696
104. A high power-density, mediator-free, microfluidic biophotovoltaic device for cyanobacterial cells
P Bombelli, T Müller, TW Herling, CJ Howe, TPJ Knowles
– Advanced Energy Materials
(2015)
5,
1
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103. Protein microgels from amyloid fibril networks.
U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, S Linse, KS Åkerfeldt, CM Dobson, DA Weitz, TPJ Knowles
– ACS Nano
(2015)
9,
43
102. Tetracycline nanoparticles as antibacterial and gene-silencing agents
U Shimanovich, A Lipovsky, D Eliaz, S Zigdon, TPJ Knowles, Y Nitzan, S Michaeli, A Gedanken
– Adv Healthc Mater
(2015)
4,
723
101. Multiphase Protein Microgels
U Shimanovich, Y Song, J Brujic, HC Shum, TPJ Knowles
– Macromol Biosci
(2015)
15,
501
100. Dry-mass sensing for microfluidics
T Mueller, DA White, TPJ Knowles
– Applied Physics Letters
(2014)
105,
214101
99. Interaction of the Molecular Chaperone DNAJB6 with Growing Amyloid-beta 42 (Aβ42) Aggregates Leads to Sub-stoichiometric Inhibition of Amyloid Formation
C Månsson, P Arosio, R Hussein, HH Kampinga, RM Hashem, WC Boelens, CM Dobson, TPJ Knowles, S Linse, C Emanuelsson
– J Biol Chem
(2014)
289,
31066
98. The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation.
AK Buell, CM Dobson, TPJ Knowles
– Essays Biochem
(2014)
56,
11
pnas
97. Differences in nucleation behavior underlie the contrasting aggregation kinetics of the A beta 40 and A beta 42 peptides
G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2014)
111,
9384
96. Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization
TCT Michaels, TPJ Knowles
– J Chem Phys
(2014)
140,
214904
95. The amyloid state and its association with protein misfolding diseases
TPJ Knowles, M Vendruscolo, CM Dobson
– Nat Rev Mol Cell Biol
(2014)
15,
384
94. Asymptotic solutions of the Oosawa model for the length distribution of biofilaments.
TCT Michaels, GA Garcia, TPJ Knowles
– Journal of Chemical Physics
(2014)
140,
194906
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93. Solution conditions determine the relative importance of nucleation and growth processes in alpha-synuclein aggregation
AK Buell, C Galvagnion, R Gaspar, E Sparr, M Vendruscolo, TPJ Knowles, S Linse, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
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111,
7671
92. Mean-field master equation formalism for biofilament growth
TCT Michaels, TPJ Knowles
– American Journal of Physics
(2014)
82,
476
91. Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters
GA Garcia, SIA Cohen, CM Dobson, TPJ Knowles
– Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
(2014)
89,
032712
90. Density-gradient-free microfluidic centrifugation for analytical and preparative separation of nanoparticles.
P Arosio, T Müller, L Mahadevan, TPJ Knowles
– Nano Letters
(2014)
14,
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89. Spatial Propagation of Protein Polymerization
SIA Cohen, L Rajah, CH Yoon, AK Buell, DA White, RA Sperling, M Vendruscolo, EM Terentjev, CM Dobson, DA Weitz, TPJ Knowles
– Physical Review Letters
(2014)
112,
098101
88. Diffuse transition state structure for the unfolding of a leucine-rich repeat protein
SE Kelly, G Meisl, PJE Rowling, SH McLaughlin, T Knowles, LS Itzhaki
– Physical Chemistry Chemical Physics
(2014)
16,
6448
87. The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.
N Lorenzen, SB Nielsen, AK Buell, JD Kaspersen, P Arosio, BS Vad, W Paslawski, G Christiansen, Z Valnickova-Hansen, M Andreasen, JJ Enghild, JS Pedersen, CM Dobson, TPJ Knowles, DE Otzen
– J Am Chem Soc
(2014)
136,
3859
86. Polymer physics inspired approaches for the study of the mechanical properties of amyloid fibrils
LR Volpatti, TPJ Knowles
– Journal of Polymer Science Part B: Polymer Physics
(2014)
52,
281
85. Nanoscale spatially resolved infrared spectra from single microdroplets.
T Müller, FS Ruggeri, AJ Kulik, U Shimanovich, TO Mason, TPJ Knowles, G Dietler
– Lab Chip
(2014)
14,
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84. Insights into the Inhibition Mechanism of Biomolecular Self-Assembly from Chemical Kinetics
P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Biophysical Journal
(2014)
106,
682A
83. Determination of Primary Nucleation Mechanisms of alpha-Synuclein Amyloid Aggregation
FA Aprile, G Meisl, AK Buell, P Flagmeier, CM Dobson, M Vendruscolo, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2014)
106,
267A
82. Expanding the solvent chemical space for self-assembly of dipeptide nanostructures.
TO Mason, DY Chirgadze, A Levin, L Adler-Abramovich, E Gazit, TPJ Knowles, AK Buell
– ACS nano
(2014)
8,
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81. Chemical kinetics for drug discovery to combat protein aggregation diseases.
P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Trends in pharmacological sciences
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35,
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naturecommunications
80. Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers.
A Levin, TO Mason, L Adler-Abramovich, AK Buell, G Meisl, C Galvagnion, Y Bram, SA Stratford, CM Dobson, TPJ Knowles, E Gazit
– Nature Communications
(2014)
5,
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79. Self-assembly of amyloid fibrils that display active enzymes
XM Zhou, A Entwistle, H Zhang, AP Jackson, TO Mason, U Shimanovich, TPJ Knowles, AT Smith, EB Sawyer, S Perrett
– ChemCatChem
(2014)
6,
1961
78. Quantitative Analysis of Diffusive Reactions at the Solid–Liquid Interface in Finite Systems
TCT Michaels, AK Buell, EM Terentjev, TPJ Knowles
– Journal of Physical Chemistry Letters
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5,
695
77. Sonochemically-induced spectral shift as a probe of green fluorescent protein release from nano capsules
U Shimanovich, A Munder, NG Azoia, A Cavaco-Paulo, A Gruzman, TPJ Knowles, A Gedanken
– RSC Adv.
(2014)
4,
10303
76. Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ<inf>42</inf> peptide
B Bolognesi, SIA Cohen, P Aran Terol, EK Esbjörner, S Giorgetti, MF Mossuto, A Natalello, AC Brorsson, TPJ Knowles, CM Dobson, LM Luheshi
– ACS Chemical Biology
(2014)
9,
378
75. Quantitative sensing of microviscosity in protocells and amyloid materials using fluorescence lifetime imaging of molecular rotors
AJ Thompson, TYD Tang, TW Herling, CR Che Hak, S Mann, TPJ Knowles, MK Kuimova
– Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII
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8947,
UNSP 89471C
naturereviews
74. Erratum: The amyloid state and its association with protein misfolding diseases (Nature Reviews Molecular Cell Biology (2014) 15 (384-396))
TPJ Knowles, M Vendruscolo, CM Dobson
– Nature Reviews Molecular Cell Biology
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15,
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73. Easyworm: an open-source software tool to determine the mechanical properties of worm-like chains.
G Lamour, JB Kirkegaard, H Li, TP Knowles, J Gsponer
– Source Code Biol Med
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9,
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72. Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease
G Tóth, SJ Gardai, W Zago, CW Bertoncini, N Cremades, SL Roy, MA Tambe, J-C Rochet, C Galvagnion, G Skibinski, S Finkbeiner, M Bova, K Regnstrom, S-S Chiou, J Johnston, K Callaway, JP Anderson, MF Jobling, AK Buell, TA Yednock, TPJ Knowles, M Vendruscolo, J Christodoulou, CM Dobson, D Schenk, L McConlogue
– PLoS ONE
(2014)
9,
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71. Protein micro- and nano-capsules for biomedical applications
U Shimanovich, GJL Bernardes, TPJ Knowles, A Cavaco-Paulo
– Chemical Society reviews
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43,
1361
jacs
70. Quantification of the Concentration of A beta 42 Propagons during the Lag Phase by an Amyloid Chain Reaction Assay
P Arosio, R Cukalevski, B Frohm, TPJ Knowles, S Linse
– Journal of the American Chemical Society
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136,
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69. A Clear View of Polymorphism, Twist, and Chirality in Amyloid Fibril Formation
LR Volpatti, M Vendruscolo, CM Dobson, TPJ Knowles
– ACS nano
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7,
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68. Three-dimensional domain swapping and supramolecular protein assembly: Insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase
A Pica, A Merlino, AK Buell, TPJ Knowles, E Pizzo, G D'Alessio, F Sica, L Mazzarella
– Acta Crystallographica Section D: Biological Crystallography
(2013)
69,
2116
67. Single-Molecule Measurements of Transient Biomolecular Complexes through Microfluidic Dilution
MH Horrocks, L Rajah, P Jönsson, M Kjaergaard, M Vendruscolo, TPJ Knowles, D Klenerman
– Analytical Chemistry
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85,
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66. Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism.
SIA Cohen, S Linse, LM Luheshi, E Hellstrand, DA White, L Rajah, DE Otzen, M Vendruscolo, CM Dobson, TPJ Knowles
– Proceedings of the National Academy of Sciences
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110,
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65. Integration and characterization of solid wall electrodes in microfluidic devices fabricated in a single photolithography step
TW Herling, T Müller, L Rajah, JN Skepper, M Vendruscolo, TPJ Knowles
– Applied Physics Letters
(2013)
102,
184102
64. Amyloid beta-protein: the influence of intrinsic and extrinsic factors on fibril formation
R Cukalevski, X Yang, SI Cohen, B Boland, B Frohm, E Thulin, DM WalsXh, TP Knowles, S Linse
– JOURNAL OF NEUROCHEMISTRY
(2013)
125,
235
pnas
63. Atomic structure and hierarchical assembly of a cross-β amyloid fibril.
AWP Fitzpatrick, GT Debelouchina, MJ Bayro, DK Clare, MA Caporini, VS Bajaj, CP Jaroniec, L Wang, V Ladizhansky, SA Müller, CE MacPhee, CA Waudby, HR Mott, A De Simone, TPJ Knowles, HR Saibil, M Vendruscolo, EV Orlova, RG Griffin, CM Dobson
– Proceedings of the National Academy of Sciences of the United States of America
(2013)
110,
5468
62. Electrostatic effects in filamentous protein aggregation
AK Buell, P Hung, X Salvatella, ME Welland, CM Dobson, TPJ Knowles
– Biophysical journal
(2013)
104,
1116
61. Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses.
M Yolamanova, C Meier, AK Shaytan, V Vas, CW Bertoncini, F Arnold, O Zirafi, SM Usmani, JA Müller, D Sauter, C Goffinet, D Palesch, P Walther, NR Roan, H Geiger, O Lunov, T Simmet, J Bohne, H Schrezenmeier, K Schwarz, L Ständker, W-G Forssmann, X Salvatella, PG Khalatur, AR Khokhlov, TPJ Knowles, T Weil, F Kirchhoff, J Münch
– Nature Nanotechnology
(2013)
8,
130
60. Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2.
LQ Xu, S Wu, AK Buell, SIA Cohen, LJ Chen, WH Hu, SA Cusack, LS Itzhaki, H Zhang, TPJ Knowles, CM Dobson, ME Welland, GW Jones, S Perrett
– Philosophical transactions of the Royal Society of London. Series B, Biological sciences
(2013)
368,
20110410
59. The Kinetics and Mechanisms of Amyloid Formation
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– None
(2013)
183
58. Connecting macroscopic observables and microscopic assembly events in amyloid formation using coarse grained simulations.
NS Bieler, TPJ Knowles, D Frenkel, R Vácha
– PLoS Computational Biology
(2012)
8,
e1002692
57. Highly non-linear microfluidic resistor elements for flow rate-dependent addressing of microchannels
L Rajah, DA White, TPJ Knowles
– International Journal of Nonlinear Sciences and Numerical Simulation
(2012)
13,
319
56. Fluctuations in water, the hydrophobic effect and self-assembly
PS Varilly, AJ Patel, SN Jamadagni, H Acharya, MF Hagan, S Garde, D Chandler, TPJ Knowles, D Frenkel
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2012)
244,
55. Selenium-Enhanced Electron Microscopic Imaging of Different Aggregate Forms of a Segment of the Amyloid beta Peptide in Cells
EK McGuire, M Motskin, B Bolognesi, SD Bergin, TPJ Knowles, J Skepper, LM Luheshi, DW McComb, CM Dobson, AE Porter
– ACS nano
(2012)
6,
4740
54. Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, NW Wood, TPJ Knowles, CM Dobson, D Klenerman
– Cell
(2012)
149,
1048
53. Detailed analysis of the energy barriers for amyloid fibril growth.
AK Buell, A Dhulesia, DA White, TPJ Knowles, CM Dobson, ME Welland
– Angewandte Chemie - International Edition
(2012)
51,
5247
52. From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– J Mol Biol
(2012)
421,
160
51. Twisting Transition between Crystalline and Fibrillar Phases of Aggregated Peptides
TPJ Knowles, A De Simone, AW Fitzpatrick, A Baldwin, S Meehan, L Rajah, M Vendruscolo, ME Welland, CM Dobson, EM Terentjev
– Physical review letters
(2012)
109,
158101
50. Role of elongation and secondary pathways in S6 amyloid fibril growth
N Lorenzen, SIA Cohen, SB Nielsen, TW Herling, G Christiansen, CM Dobson, TPJ Knowles, D Otzen
– Biophysical Journal
(2012)
102,
2167
49. Probing small molecule binding to amyloid fibrils.
AK Buell, EK Esbjörner, PJ Riss, DA White, FI Aigbirhio, G Toth, ME Welland, CM Dobson, TPJ Knowles
– Physical Chemistry Chemical Physics
(2011)
13,
20044
48. Binding of the Molecular Chaperone αB-Crystallin to Aβ Amyloid Fibrils Inhibits Fibril Elongation
SL Shammas, CA Waudby, S Wang, AK Buell, TPJ Knowles, H Ecroyd, ME Welland, JA Carver, CM Dobson, S Meehan
– Biophysical journal
(2011)
101,
1681
47. Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation
AW Fitzpatrick, TPJ Knowles, CA Waudby, M Vendruscolo, CM Dobson
– PLoS Comput Biol
(2011)
7,
e1002169
46. Observation of spatial propagation of amyloid assembly from single nuclei.
TPJ Knowles, DA White, AR Abate, JJ Agresti, SIA Cohen, RA Sperling, EJ De Genst, CM Dobson, DA Weitz
– Proceedings of the National Academy of Sciences
(2011)
108,
14746
45. Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– The Journal of Chemical Physics
(2011)
135,
065106
44. Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments
SIA Cohen, M Vendruscolo, ME Welland, CM Dobson, EM Terentjev, TPJ Knowles
– The Journal of Chemical Physics
(2011)
135,
065105
43. Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations.
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– Journal of Chemical Physics
(2011)
135,
065107
42. Protein Solubility and Protein Homeostasis: A Generic View of Protein Misfolding Disorders
M Vendruscolo, TPJ Knowles, CM Dobson
– Cold Spring Harbor perspectives in biology
(2011)
3,
a010454
41. Direct observation of the interconversion of normal and pathogenic forms of alpha-synuclein
N Cremades, SIA Cohen, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, TPJ Knowles, CM Dobson, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2011)
40,
215
40. Conserved C-Terminal Charge Exerts a Profound Influence on the Aggregation Rate of α-Synuclein
K Levitan, D Chereau, SIA Cohen, TPJ Knowles, CM Dobson, AL Fink, JP Anderson, JM Goldstein, GL Millhauser
– Journal of Molecular Biology
(2011)
411,
329
39. Perturbation of the stability of amyloid fibrils through alteration of electrostatic interactions.
SL Shammas, TPJ Knowles, AJ Baldwin, CE Macphee, ME Welland, CM Dobson, GL Devlin
– Biophysical Journal
(2011)
100,
2783
jacs
38. Metastability of Native Proteins and the Phenomenon of Amyloid Formation
AJ Baldwin, TPJ Knowles, GG Tartaglia, AW Fitzpatrick, GL Devlin, SL Shammas, CA Waudby, MF Mossuto, S Meehan, SL Gras, J Christodoulou, SJ Anthony-Cahill, PD Barker, M Vendruscolo, CM Dobson
– Journal of the American Chemical Society
(2011)
133,
14160
37. Population of nonnative states of lysozyme variants drives amyloid fibril formation
AK Buell, A Dhulesia, MF Mossuto, N Cremades, JR Kumita, M Dumoulin, ME Welland, TPJ Knowles, X Salvatella, CM Dobson
– J Am Chem Soc
(2011)
133,
7737
36. Relationship between prion propensity and the rates of individual molecular steps of fibril assembly
Y-Q Wang, AK Buell, X-Y Wang, ME Welland, CM Dobson, TPJ Knowles, S Perrett
– J Biol Chem
(2011)
286,
12101
35. Nucleated polymerisation in the presence of pre-formed seed filaments
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
– Int J Mol Sci
(2011)
12,
5844
34. Nanomechanics of functional and pathological amyloid materials.
TPJ Knowles, MJ Buehler
– Nature Nanotechnology
(2011)
6,
469
33. Probing protein aggregation with quartz crystal microbalances
TPJ Knowles, GL Devlin, CM Dobson, ME Welland
– Methods in molecular biology (Clifton, N.J.)
(2011)
752,
137
32. Interactions between Amyloidophilic Dyes and Their Relevance to Studies of Amyloid Inhibitors
AK Buell, CM Dobson, TPJ Knowles, ME Welland
– Biophysical journal
(2010)
99,
3492
pnas
31. Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering
A Sandberg, LM Luheshi, S Söllvander, T Pereira de Barros, B Macao, TPJ Knowles, H Biverstål, C Lendel, F Ekholm-Petterson, A Dubnovitsky, L Lannfelt, CM Dobson, T Härd
– Proceedings of the National Academy of Sciences of the United States of America
(2010)
107,
15595
30. Surface attachment of protein fibrils via covalent modification strategies
AK Buell, DA White, C Meier, ME Welland, TPJ Knowles, CM Dobson
– Journal of Physical Chemistry B
(2010)
114,
10925
physreviewletters
29. Frequency Factors in a Landscape Model of Filamentous Protein Aggregation
AK Buell, JR Blundell, CM Dobson, ME Welland, EM Terentjev, TPJ Knowles
– Phys Rev Lett
(2010)
104,
228101
28. An algorithm and experimental protocol to obtain the kinetic parameters of fibrillar growth from a first-principles general model of breakable filament assembly
SI Cohen, M Sandal, L Rajah, CM Dobson, M Vendruscolo, TPJ Knowles
– FEBS JOURNAL
(2010)
277,
257
jacs
27. Protein aggregation in crowded environments
DA White, AK Buell, TPJ Knowles, ME Welland, CM Dobson
– Journal of the American Chemical Society
(2010)
132,
5170
26. Fabrication and characterisation of protein fibril–elastomer composites
T Oppenheim, TPJ Knowles, SP Lacour, ME Welland
– Acta Biomaterialia
(2010)
6,
1337
25. The Interaction of αB-Crystallin with Mature α-Synuclein Amyloid Fibrils Inhibits Their Elongation
CA Waudby, TPJ Knowles, GL Devlin, JN Skepper, H Ecroyd, JA Carver, ME Welland, J Christodoulou, CM Dobson, S Meehan
– Biophys J
(2010)
98,
843
24. Nanostructured films from hierarchical self-assembly of amyloidogenic proteins
TPJ Knowles, TW Oppenheim, AK Buell, DY Chirgadze, ME Welland
– Nature Nanotechnology
(2010)
5,
204
23. Imaging Alzheimer's disease-related protein aggregates in human cells using a selenium label
EK McGuire, M Motskin, TPJ Knowles, CM Dobson, DW McComb, AE Porter
– Journal of Physics: Conference Series
(2010)
241,
012020
22. Methods and models in neurodegenerative and systemic protein aggregation diseases.
A-C Brorsson, JR Kumita, I MacLeod, B Bolognesi, E Speretta, LM Luheshi, TPJ Knowles, CM Dobson, DC Crowther
– Front Biosci (Landmark Ed)
(2010)
15,
373
21. Quantitative approaches for characterising fibrillar protein nanostructures
DA White, CM Dobson, ME Welland, TPJ Knowles
– Materials Research Society Symposium Proceedings
(2010)
1274,
33
20. An analytical solution to the kinetics of breakable filament assembly
TPJ Knowles, CA Waudby, GL Devlin, SIA Cohen, A Aguzzi, M Vendruscolo, EM Terentjev, ME Welland, CM Dobson
– Science (New York, N.Y.)
(2009)
326,
1533
19. Imaging Amyloid Fibrils within Cells Using a Se-Labelling Strategy
AE Porter, TPJ Knowles, K Muller, S Meehan, E McGuire, J Skepper, ME Welland, CM Dobson
– J Mol Biol
(2009)
392,
868
18. Biosensor-based label-free assays of amyloid growth.
DA White, AK Buell, CM Dobson, ME Welland, TPJ Knowles
– FEBS letters
(2009)
583,
2587
17. Position-Dependent Electrostatic Protection against Protein Aggregation
AK Buell, GG Tartaglia, NR Birkett, CA Waudby, M Vendruscolo, X Salvatella, ME Welland, CM Dobson, TPJ Knowles
– ChemBioChem
(2009)
10,
1309
AdvMater
16. Strength of nanotubes, filaments, and nanowires from sonication-onduced scission
YY Huang, TPJ Knowles, EM Terentjev
– Advanced Materials
(2009)
21,
3945
15. Chemical and biophysical insights into the propagation of prion strains
J Falsig, KP Nilsson, TPJ Knowles, A Aguzzi
– HFSP journal
(2008)
2,
332
14. Highly specific label-free protein detection from lysed cells using internally referenced microcantilever sensors.
W Shu, S Laurenson, TPJ Knowles, P Ko Ferrigno, AA Seshia
– Biosensors & bioelectronics
(2008)
24,
233
13. Label-free detection of amyloid growth with microcantilever sensors.
TPJ Knowles, W Shu, F Huber, HP Lang, C Gerber, CM Dobson, ME Welland
– Nanotechnology
(2008)
19,
384007
12. Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements.
AJ Baldwin, SJ Anthony-Cahill, TPJ Knowles, G Lippens, J Christodoulou, PD Barker, CM Dobson
– Angewandte Chemie International Edition
(2008)
47,
3385
science
11. Role of intermolecular forces in defining material properties of protein nanofibrils
TP Knowles, AW Fitzpatrick, S Meehan, HR Mott, M Vendruscolo, CM Dobson, ME Welland
– Science
(2007)
318,
1900
10. Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alpha A-, alpha beta- and R120G alpha B-Crystallins
S Meehan, TPJ Knowles, AJ Baldwin, JF Smith, AM Squires, P Clements, TM Treweek, H Ecroyd, GG Tartaglia, M Vendruscolo, CE Macphee, CM Dobson, JA Carver
– Journal of Molecular Biology
(2007)
372,
470
pnas
9. Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass
TPJ Knowles, W Shu, GL Devlin, S Meehan, S Auer, CM Dobson, ME Welland
– Proceedings of the National Academy of Sciences of the United States of America
(2007)
104,
10016
8. Analysis of structural order in amyloid fibrils
TPJ Knowles, JF Smith, GL Devlin, CM Dobson, ME Welland
– Nanotechnology
(2007)
18,
044031
7. Enhanced Stability of Human Prion Proteins with Two Disulfide Bridges
TPJ Knowles, R Zahn
– Biophysical Journal
(2006)
91,
1494
6. The Component Polypeptide Chains of Bovine Insulin Nucleate or Inhibit Aggregation of the Parent Protein in a Conformation-dependent Manner
GL Devlin, TPJ Knowles, A Squires, MG McCammon, SL Gras, MR Nilsson, CV Robinson, CM Dobson, CE MacPhee
– Journal of molecular biology
(2006)
360,
497
5. Characterization of the nanoscale properties of individual amyloid fibrils.
JF Smith, TPJ Knowles, CM Dobson, CE Macphee, ME Welland
– Proceedings of the National Academy of Sciences USA
(2006)
103,
15806
4. Spatial Persistence of Angular Correlations in Amyloid Fibrils
TPJ Knowles, JF Smith, A Craig, CM Dobson, ME Welland
– Physical review letters
(2006)
96,
238301
3. Excitations with negative dispersion in a spin vortex
M Buess, TPJ Knowles, R Hollinger, T Haug, U Krey, D Weiss, D Pescia, MR Scheinfein, CH Back
– Physical Review B
(2005)
71,
104415
2. Phase-resolved pulsed precessional motion at a Schottky barrier
M Buess, TPJ Knowles, U Ramsperger, D Pescia, CH Back
– Physical Review B
(2004)
69,
ARTN 174422
1. Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1
PH St George-Hyslop, S Qamar, G Wang, SJ Randle, FS Ruggeri, J Varela, CF Kaminski, GS Kaminski, M Vendruscolo, TPJ Knowles, D Klenerman, CE Holt, Q Lin, W meadows
– Cell
(None)